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    • 9. 发明公开
    • METHOD FOR PRODUCING POLYSACCHARIDE MONOLITH STRUCTURE
    • 生产多糖单体结构的方法
    • EP3211028A1
    • 2017-08-30
    • EP15853157.4
    • 2015-10-01
    • JNC Corporation
    • OKANIWA, NatukiNAKAMA, TsuyoshiIWAMOTO, EriSASAKI, ShujiIKEDA, Takuo
    • C08J9/26B01J20/24B01J20/30G01N30/88
    • B01J20/24B01J20/28042B01J20/281B01J20/285B01J20/30B01J41/05B01J41/07B01J41/16C07K1/16C07K1/18C08J9/26G01N30/88
    • Provided is a manufacturing method for monolithic structure that is a porous body formed of polysaccharide being a naturally-occurring polymer, has continuous pores with an average pore diameter suitable for biomolecule separation, and allows formation into arbitrary shape. The polysaccharide monolithic structure is manufactured by a method including a first step of obtaining a polysaccharide solution by dissolving polysaccharide into a mixed solvent of a first component and a second component at temperature lower than a boiling point of the mixed solvent, and a second step of obtaining polysaccharide monolithic structure by cooling the polysaccharide solution, wherein the first component is a solvent selected from lactate, and the second component is a solvent selected from water, lower alcohol, and a combination thereof. The monolithic structure obtained is a porous body having continuous pores with an average pore diameter of 0.01 to 20.0 micrometers, and a thickness of 100 micrometers or more.
    • 本发明提供一种单片结构体的制造方法,该单体结构体是由作为天然聚合物的多糖类形成的多孔体,具有适于生物分子分离的平均孔径连续的细孔,并且可以形成为任意的形状。 多糖整体结构体的制造方法包括:第1工序,在比混合溶剂的沸点低的温度下将多糖类溶解于第1成分和第2成分的混合溶剂中得到多糖类溶液;以及第2工序 通过冷却多糖溶液获得多糖整体结构,其中第一组分为选自乳酸盐的溶剂,第二组分为选自水,低级醇及其组合的溶剂。 得到的整体结构体是具有平均孔径为0.01〜20.0μm的连续气孔,厚度为100μm以上的多孔体。