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1. 发明公开

EP3351280A1 MULTIPLE INJECTION NEEDLE ASSEMBLY 审中-公开
公开(公告)号：EP3351280A1
公开(公告)日：2018-07-25
申请号：EP17152798.9
申请日：2017-01-24
申请人： Terumo Europe NV
发明人： CASTELEYN, Pieter , DANIELS, Ludo , ROYEN, Veerle , FRIPON, Christian
IPC分类号： A61M5/32
CPC分类号： A61M5/32 , A61M5/329 , A61M5/3291 , A61M5/3295
摘要： Injection needle assembly comprising:
• at least N injection needles where N is at least four and a multiple of two,
• a first liquid port adapted to be connected to an injection device,
• N second liquid ports, each connected to one of the N injection needles,
• N 2 main liquid pathways each having an entrance connected to the first liquid port and an exit,
wherein it further comprises N 2 secondary liquid pathways comprising:
• two extremities each opening on one of the N second liquid ports, and
• a mid portion connected to the exit of one of the main liquid pathways;
and wherein the main liquid pathways and the secondary liquid pathways define N liquid flow paths between the first liquid port and the N second liquid ports and are dimensioned so that a pressure drop between the first liquid port and each of the N second liquid ports is similar.

2. 发明公开

EP2683429A2 RETRACTABLE SYRINGE WITH LOCKING PLUNGER 审中-公开
标题翻译：与制动活塞回缩式注射器
公开(公告)号：EP2683429A2
公开(公告)日：2014-01-15
申请号：EP12754794.1
申请日：2012-03-06
申请人： Midland Medical Devices Holdings, LLC
发明人： CAIZZA, Richard , BOJAN, Jay
IPC分类号： A61M5/34 , A61M5/315 , A61M5/50
CPC分类号： A61M5/3234 , A61M5/1782 , A61M5/3295 , A61M5/346 , A61M5/347 , A61M2005/3239
摘要： A retractable needle syringe having a plunger rod configured to lock in place after retraction of the needle. The plunger rod distal end has a seal configured to advance past a retaining ledge after retraction of the needle, whereby the retaining ledge restricts or inhibits the plunger from proximal movement.

3. 发明公开

EP2653184A1 Multi-needle injection system 有权
标题翻译： Intektionssystem mit mehreren Nadeln
公开(公告)号：EP2653184A1
公开(公告)日：2013-10-23
申请号：EP13164738.0
申请日：2013-04-22
申请人： Cook Medical Technologies LLC
发明人： Rodenberg, Jennifer , Bourdeau, William , Baxter, Charles , Charlebois, Steven , Wagner, Zach , Sherman, Sara
IPC分类号： A61M25/00
CPC分类号： A61M5/3295 , A61M25/0084 , A61M25/0097 , A61M2025/0008 , A61M2025/0086 , A61M2025/0087
摘要： A medical device (10) for treating stress urinary incontinence is provided. The device includes a cannula (20) with a plurality of apertures (34a, 34b, 34c). A plurality of needles (41, 42, 43) is disposed within a lumen (26) of the cannula. A handle (50) includes a housing (52) and a shifter mechanism (60) to translate the plurality of needles from a first position in which the needles are disposed within the lumen of the cannula, to a second position in which a distal portion of each needle extends out of the lumen through respective apertures. The handle also includes a slot (55) including a transversal track (55d) defining a potential range of rotational motion of the shifter mechanism with respect to the housing, and a plurality of longitudinal tracks (55a, 55b, 55c) defining a potential range of translational motion of the shifter mechanism with respect to the housing.
摘要翻译：提供了一种用于治疗压力性尿失禁的医疗装置（10）。该装置包括具有多个孔（34a，34b，34c）的套管（20）。多个针（41,42,43）设置在套管的内腔（26）内。手柄（50）包括壳体（52）和移位机构（60），用于将多个针从布置在套管内腔中的第一位置平移到第二位置，在第二位置，远端部分每个针通过相应的孔延伸出管腔。手柄还包括一个狭槽（55），它包括横向轨道（55d），该横向轨迹限定换挡机构相对于壳体的旋转运动的潜在范围，以及多个纵向轨迹（55a，55b，55c）移位机构相对于壳体的平移运动。

4. 发明公开

EP1625870A2 Needle for intradermal delivery of substances having penetration limiting means 无效
标题翻译： Intramerdalen针用于与装置输送的物质用于限制的穿透深度
公开(公告)号：EP1625870A2
公开(公告)日：2006-02-15
申请号：EP05021412.1
申请日：2001-06-29
申请人： Becton, Dickinson and Company
发明人： Pettis, Ronald J. , Down, James A. , Harvey, Noel G.
IPC分类号： A61M37/00 , A61M5/158 , A61M5/46
CPC分类号： A61M5/46 , A61K38/28 , A61K38/29 , A61M5/158 , A61M5/32 , A61M5/3286 , A61M5/3291 , A61M5/3295 , A61M37/0015 , A61M2037/0038 , A61M2037/0061
摘要： The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage.
摘要翻译：本发明提供了用于ID递送药物和其他物质对人或动物的改进方法。该方法采用小规格针，爱尤其微针，在皮内空间放置到作为推注或通过输注递送所述物质到皮内空间。已经发现没有皮肤与针出口的暴露高度内针出口的位置是通过小规格针有效递送的活性物质，以防止该物质的泄漏出皮肤并内提高吸收临界皮内空间。雅丁输送到本发明的方法激素类药物的药代动力学已被发现是非常类似于传统的SC递送的药代动力学，这表明没有ID管理雅丁到本发明的方法很可能产生类似的临床结果（即，相似的疗效）与减少或消除疼痛对于患者的优点。哪个地方的针出口处的皮内空间的适当的深度和控制音量和流体输送的速率递送装置提供准确输送的物质的到所需的位置，而不泄漏。

5. 发明公开

EP3148614A1 DIFFERENTIAL GEAR MECHANISM FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE 无效
标题翻译：不同寻常的组合FÜREINE ARZNEIMITTELABGABEVORRICHTUNG UND ARZNEIMITTELABGABEVORRICHTUNG
公开(公告)号：EP3148614A1
公开(公告)日：2017-04-05
申请号：EP15724315.5
申请日：2015-05-27
申请人： Sanofi-Aventis Deutschland GmbH
发明人： JONES, Matthew , STEEL, Samuel , BLUNDRED, Neal Alexander , BUTLER, Joseph , VEASEY, Robert , PLUMPTRE, David Aubrey , MORRIS, Anthony Paul
IPC分类号： A61M5/19 , A61M5/20 , A61M5/178
CPC分类号： A61M5/31575 , A61M5/19 , A61M5/2448 , A61M5/31515 , A61M5/31528 , A61M5/31538 , A61M5/31551 , A61M5/31561 , A61M5/31585 , A61M5/31591 , A61M5/31593 , A61M5/31596 , A61M5/3295 , A61M2005/1787 , A61M2005/244 , A61M2005/3126
摘要： The disclosure is directed to a differential gear mechanism for a drug delivery device with a primary drug delivery assembly and a secondary drug delivery assembly, wherein the primary drug delivery assembly comprises a primary dose dial sleeve and wherein the secondary drug delivery assembly comprises a secondary drive sleeve. The disclosure is also directed to a respective drug delivery device.
摘要翻译：本发明涉及一种用于具有初级药物递送组件（3）和辅助药物递送组件（4）的药物递送装置的差速齿轮机构（26），其中主要药物递送组件（3）包括主剂量拨号套管（17），并且其中所述次级药物输送组件（4）包括次级驱动套筒（24）。本发明还涉及各自的药物递送装置。

6. 发明公开

EP2683430A4 RETRACTABLE SYRINGE WITH SEGMENTED RETAINING LEDGE 有权
标题翻译：具有分段的支持STEG回缩式注射器
公开(公告)号：EP2683430A4
公开(公告)日：2014-08-27
申请号：EP12755069
申请日：2012-03-06
申请人： MIDLAND MEDICAL DEVICES HOLDINGS LLC
发明人： CAIZZA RICHARD
IPC分类号： A61M5/34 , A61M5/50
CPC分类号： A61M5/3234 , A61M5/1782 , A61M5/3295 , A61M5/346 , A61M5/347 , A61M2005/3239

7. 发明公开

EP2732835A1 Needle assembly magazine 审中-公开
标题翻译： Nadelanordnungsmagazin
公开(公告)号：EP2732835A1
公开(公告)日：2014-05-21
申请号：EP12192514.3
申请日：2012-11-14
申请人： Sanofi-Aventis Deutschland GmbH
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61M5/00
CPC分类号： A61M5/3295 , A61M5/002 , A61M5/3202 , A61M5/3257 , A61M5/3272 , A61M5/3276 , A61M5/3287 , A61M2005/004 , A61M2005/3206
摘要： Described is a needle assembly magazine (1) comprising a body (2), and a plurality of needle assembly compartments (3) formed in the body (2). Each needle assembly compartment (3) includes at least one track (19) adapted to receive a follower pin (25) coupled to a needle assembly (4). The at least one track (19) comprises a substantially horizontal proximal portion (20) coupled to a substantially vertical longitudinal portion (22) coupled to a substantially horizontal distal portion (21). The needle assembly (4) is restricted to rotational movement relative to the needle assembly compartment (3) when the follower pin (25) is in the proximal portion (20) and the distal portion (21) and restricted to axial movement when the follower pin (25) is in the longitudinal portion (22).
摘要翻译：描述了包括主体（2）和形成在主体（2）中的多个针组件隔间（3）的针组合盒（1）。每个针组合隔间（3）包括至少一个轨道（19），其适于接纳耦合到针组件（4）的从动销（25）。所述至少一个轨道（19）包括联接到大致垂直的纵向部分（22）的基本上水平的近端部分（20），该近似部分联接到基本水平的远端部分（21）。当从动销（25）位于近端部分（20）和远端部分（21）中时，针组件（4）被限制为相对于针组件隔间（3）的旋转运动，并且当从动件销（25）在纵向部分（22）中。

8. 发明公开

EP2335755A1 Device and method for delivery of two or more drug agents 审中-公开
标题翻译：装置和方法，用于分配两个或三个活性药物成分
公开(公告)号：EP2335755A1
公开(公告)日：2011-06-22
申请号：EP09179724.1
申请日：2009-12-17
申请人： Sanofi-Aventis Deutschland GmbH
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61M5/172 , A61M5/142 , A61M5/315 , A61M5/00
CPC分类号： A61M5/19 , A61M5/14244 , A61M5/14248 , A61M5/1723 , A61M5/20 , A61M5/24 , A61M5/31511 , A61M5/31525 , A61M5/31546 , A61M5/31583 , A61M5/3202 , A61M5/3294 , A61M5/3295 , A61M5/347 , A61M2005/2407 , A61M2005/2411 , A61M2005/2496 , A61M2005/3126 , A61M2005/31518 , A61M2005/31588 , A61M2205/14 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/6063 , A61M2205/6072 , A61M2205/8206
摘要： A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit (300). An electro-mechanical drive unit (500,600) is operably coupled to the control unit and a primary reservoir (90) for a first medicament and a secondary reservoir (100) for a second medicament. An operator interface (60) is in communication with the control unit (300). A single dispense assembly (200) is configured for fluid communication with the primary (90) and the secondary (100) reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose, the control unit (300) is configured to determine a dose or range of the second medicament. Alternatively, the control unit determines or calculates a dose or range of a third medicament.
Further, a dispense interface for use with a drug delivery device is disclosed.
摘要翻译：一种计算机化机电药物输送装置被配置为递送两种或更多种药剂的至少一个剂量。该装置包括一个控制单元（300）。一种电 - 机械驱动单元（500,600）可操作地耦合到所述控制单元和用于第一药剂的主贮存器（90）和用于第二药剂的副储存器（100）。在与操作者界面上的控制单元通信（60）（300）。一个单一的分配组件（200）被配置用于与主（90）和次级（100）储存器流体连通。操作面板的激活设定从主储存器中的第一剂量和基于所述第一剂量，所述控制单元（300）被配置为确定矿第二药剂的剂量或范围。可替换地，控制单元确定的地雷或计算的第三药剂的剂量或范围。此外，对于与药物输送装置中使用的分配接口游离缺失盘。

9. 发明公开

EP1880743A1 Microneedle for delivering a substance into the dermis 审中-公开
标题翻译：米克隆德尔Zur Verabreichung einer Substanz在die Haut
公开(公告)号：EP1880743A1
公开(公告)日：2008-01-23
申请号：EP07117551.7
申请日：2001-06-29
申请人： Becton, Dickinson and Company
发明人： Pettis, Ronald J. , Down, James A. , Harvey, Noel G.
IPC分类号： A61M37/00
CPC分类号： A61M5/46 , A61K38/28 , A61K38/29 , A61M5/158 , A61M5/32 , A61M5/3286 , A61M5/3291 , A61M5/3295 , A61M37/0015 , A61M2037/0038 , A61M2037/0061
摘要： A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between .3 mm and 2 mm such that the delivery of the substance occurs at a depth between .3mm and 2 mm.
摘要翻译：一种用于直接递送的方法，其中物质被引入到哺乳动物皮肤内的真皮内空间，其包括通过至少一个具有暴露高度在0和1mm之间的出口的小规模中空针管来施用该物质。将出口插入到皮肤中，深度介于0.3mm和2mm之间，使得物质的输送发生在0.3mm和2mm之间的深度。

10. 发明公开

EP1625870A3 Needle for intradermal delivery of substances having penetration limiting means 无效
标题翻译： Intramerdalen针用于与装置输送的物质用于限制的穿透深度
公开(公告)号：EP1625870A3
公开(公告)日：2006-04-19
申请号：EP05021412.1
申请日：2001-06-29
申请人： Becton, Dickinson and Company
发明人： Pettis, Ronald J. , Down, James A. , Harvey, Noel G.
IPC分类号： A61M5/32 , A61M5/46 , A61M37/00 , A61M5/158
CPC分类号： A61M5/46 , A61K38/28 , A61K38/29 , A61M5/158 , A61M5/32 , A61M5/3286 , A61M5/3291 , A61M5/3295 , A61M37/0015 , A61M2037/0038 , A61M2037/0061
摘要： The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage.

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