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1. 发明授权

EP2679257B1 BLOOD PURIFICATION DEVICE 有权
公开(公告)号：EP2679257B1
公开(公告)日：2018-10-17
申请号：EP12750266.4
申请日：2012-02-23
申请人： Asahi Kasei Medical Co., Ltd.
发明人： OKAZAKI, Soichiro
IPC分类号： A61M1/14 , A61M1/34
CPC分类号： A61M1/16 , A61M1/1633 , A61M1/168 , A61M1/1682 , A61M1/169 , A61M1/3427 , A61M1/3434 , A61M2205/7554 , A61M2205/7563
摘要： Burdens on doctors and nurses are reduced in a blood purification therapy, and burdens on patients are also reduced while the cost reduction of the blood purification therapy is attained. A blood purification device 1 include a blood circuit 10 having two blood purifiers 20 and 21 parallelly connected thereto, switch means 11 capable of selectively supplying blood to the blood purifiers 20 and 21, and cleaning fluid supply means 12 capably of selectively supplying cleaning fluid to the blood purifiers 20 and 21. The cleaning fluid is supplied to the second blood purifier 21 while the blood is supplied to the first blood purifier 20, and the cleaning fluid is supplied to the first blood purifier 20 while the blood is supplied to the second blood purifier 21.

2. 发明公开

EP2368583A3 Hemodialysis systems 失效
标题翻译：血液透析系统
公开(公告)号：EP2368583A3
公开(公告)日：2012-04-25
申请号：EP11075125.2
申请日：2004-11-05
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Kelly, Thomas D. , Childers, Robert W. , Busby, Don , Roger, Rodolfo , El Sayyid, Waleed Mutasem , Din, Shahid Q.
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1037 , A61M1/1039 , A61M1/1062 , A61M1/1081 , A61M1/1086 , A61M1/16 , A61M1/1601 , A61M1/1607 , A61M1/1613 , A61M1/1621 , A61M1/1629 , A61M1/1633 , A61M1/1635 , A61M1/1656 , A61M1/166 , A61M1/1668 , A61M1/167 , A61M1/1672 , A61M1/1696 , A61M1/267 , A61M1/288 , A61M1/341 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3444 , A61M1/3451 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M1/3472 , A61M1/3486 , A61M1/3624 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3656 , A61M2202/0413 , A61M2205/12 , A61M2205/13 , A61M2205/15 , A61M2205/18 , A61M2205/276 , A61M2205/3317 , A61M2205/3324 , A61M2205/3327 , A61M2205/3331 , A61M2205/3334 , A61M2205/3337 , A61M2205/3344 , A61M2205/3368 , A61M2205/3379 , A61M2205/3393 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/75
摘要： A hemodialysis system (110) is described. The system comprises: an on-line dialysate generation source (112); a dialysate pump (22, 24) configured to pump dialysate generated by the generation source (112) to a dialyzer (20, 30); a conductivity sensor (63) located adjacent to a temperature sensor (62) upstream of the dialyzer (20, 30); a blood pump (48); an air detector (54); and a disposable cassette (100). The disposable cassette comprises: a dialysate flow path (60) for carrying dialysate pumped by the dialysate pump (22, 24), a conductivity sensor location (T2) and a temperature sensor location (62) for receiving the conductivity sensor (63) and the temperature sensor (62), respectively, and an extracorporeal circuit (50) for carrying blood pumped by the blood pump (48).
摘要翻译：描述血液透析系统（110）。该系统包括：在线透析液产生源（112）; 透析液泵（22,24），其被配置为将由所述生成源（112）生成的透析液泵送至透析器（20,30）; 位于透析器（20,30）上游的温度传感器（62）附近的电导率传感器（63）; 血泵（48）; 一个空气检测器（54）; 和一次性盒子（100）。一次性盒子包括：透析液流动路径（60），用于携带由透析液泵（22,24）泵送的透析液，电导率传感器位置（T2）和用于接收电导率传感器（63）的温度传感器位置（62）;以及温度传感器62以及用于携带由血液泵48泵送的血液的体外回路50。

3. 发明公开

EP2368582A3 Hemodialysis and hemofiltration systems 失效转让
标题翻译：血液透析和血液滤过系统
公开(公告)号：EP2368582A3
公开(公告)日：2012-04-18
申请号：EP11075124.5
申请日：2004-11-05
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Kelly, Thomas D. , Childers, Robert W. , Busby, Don , Roger, Rodolfo , El Sayyid, Waleed Mutasem , Din, Shahid Q.
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1037 , A61M1/1039 , A61M1/1062 , A61M1/1081 , A61M1/1086 , A61M1/16 , A61M1/1601 , A61M1/1607 , A61M1/1613 , A61M1/1621 , A61M1/1629 , A61M1/1633 , A61M1/1635 , A61M1/1656 , A61M1/166 , A61M1/1668 , A61M1/167 , A61M1/1672 , A61M1/1696 , A61M1/267 , A61M1/288 , A61M1/341 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3444 , A61M1/3451 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M1/3472 , A61M1/3486 , A61M1/3624 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3656 , A61M2202/0413 , A61M2205/12 , A61M2205/13 , A61M2205/15 , A61M2205/18 , A61M2205/276 , A61M2205/3317 , A61M2205/3324 , A61M2205/3327 , A61M2205/3331 , A61M2205/3334 , A61M2205/3337 , A61M2205/3344 , A61M2205/3368 , A61M2205/3379 , A61M2205/3393 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/75
摘要： A renal therapy system is described. The system comprises: a filter (20, 30, 312); an arterial blood flowpath (44a) in fluid communication with the filter (20, 30, 312); a venous blood flowpath (44b) in fluid communication with the filter (20, 30, 312); an extracorporeal circuit (50) including the filter (20, 30, 312), the arterial blood flowpath (44a) and the venous blood flowpath (44b); a renal therapy fluid flowpath (314, 328) in fluid communication with the extracorporeal circuit; a plurality of valves (56); and first and second rotary peristaltic pumps (820, 830). The system (810) is configured to open and close the plurality of valves (56) so that the first rotary peristaltic pump (820) pumps renal therapy fluid through the renal therapy fluid flowpath for a number of first pump rotations and the second rotary peristaltic pump (830) pumps renal therapy fluid through the renal therapy fluid flowpath for a number of second pump rotations.
摘要翻译：描述肾脏治疗系统。该系统包括：过滤器（20,30,312）; 与过滤器（20,30,312）流体连通的动脉血流路径（44a）; 与过滤器（20,30,312）流体连通的静脉血流路径（44b）; 包括所述过滤器（20,30,312），所述动脉血流路径（44a）和所述静脉血流路径（44b）的体外回路（50）; 与所述体外回路流体连通的肾脏治疗流体流动路径（314,328）多个阀（56）; 和第一和第二旋转蠕动泵（820,830）。系统（810）配置成打开和关闭多个阀（56），使得第一旋转蠕动泵（820）将肾脏治疗流体泵送通过肾脏治疗流体流动路径以进行多次第一泵旋转和第二旋转蠕动泵（830）将肾脏治疗液泵送通过肾脏治疗液体流动路径进行多次第二泵旋转。

4. 发明公开

EP2368587A2 Hemodialysis systems 失效
标题翻译：血液透析系统
公开(公告)号：EP2368587A2
公开(公告)日：2011-09-28
申请号：EP11075129.4
申请日：2004-11-05
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Kelly, Thomas D. , Childers, Robert W. , Busby, Don , Roger, Rodolfo , El Sayyid, Waleed Mutasem , Din, Shahid Q.
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1037 , A61M1/1039 , A61M1/1062 , A61M1/1081 , A61M1/1086 , A61M1/16 , A61M1/1601 , A61M1/1607 , A61M1/1613 , A61M1/1621 , A61M1/1629 , A61M1/1633 , A61M1/1635 , A61M1/1656 , A61M1/166 , A61M1/1668 , A61M1/167 , A61M1/1672 , A61M1/1696 , A61M1/267 , A61M1/288 , A61M1/341 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3444 , A61M1/3451 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M1/3472 , A61M1/3486 , A61M1/3624 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3656 , A61M2202/0413 , A61M2205/12 , A61M2205/13 , A61M2205/15 , A61M2205/18 , A61M2205/276 , A61M2205/3317 , A61M2205/3324 , A61M2205/3327 , A61M2205/3331 , A61M2205/3334 , A61M2205/3337 , A61M2205/3344 , A61M2205/3368 , A61M2205/3379 , A61M2205/3393 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/75
摘要： A dialysis system (300f) is described. The system comprises: a fresh dialysis fluid membrane pump (22, 24); a spent dialysis fluid membrane pump (26,28); and a dialysis fluid cassette (100). The dialysis fluid cassette (100) includes a first rigid portion (96) and a second rigid portion (98) which together define a chamber. A flexible sheet (346) is located between the rigid portions (96, 98) which divides the chamber in two to form a balance chamber (340) having a fresh dialysis fluid compartment (344) and a spent dialysis fluid compartment (342). The fresh dialysis fluid membrane pump (22, 24) is in fluid communication with the fresh dialysis fluid compartment (344) and the spent dialysis fluid membrane pump (26, 28) is in fluid communication with the spent dialysis fluid compartment (342).
摘要翻译：描述了透析系统（300f）。该系统包括：新鲜的透析液膜泵（22,24）; 用过的透析液膜泵（26,28）; 和透析液盒（100）。透析液盒（100）包括一起限定腔室的第一刚性部分（96）和第二刚性部分（98）。柔性片（346）位于将室分成两部分的刚性部分（96,98）之间，以形成具有新鲜透析液室（344）和用过的透析液室（342）的平衡室（340）。新鲜透析液膜泵（22,24）与新鲜透析液室（344）流体连通并且用过的透析流体膜泵（26,28）与用过的透析液室（342）流体连通。

5. 发明授权

EP1283064B1 Blood processing system 有权
标题翻译：血液处理系统
公开(公告)号：EP1283064B1
公开(公告)日：2007-05-23
申请号：EP02016979.3
申请日：2002-08-02
申请人： KURARAY CO., LTD.
发明人： Inoue, Masao , Ike, Akihiro , Nakaji, Shuhei
IPC分类号： A61M1/34 , A61M1/36
CPC分类号： A61M1/3472 , A61M1/342 , A61M1/3427 , A61M1/3441 , A61M1/3448 , A61M1/3482 , A61M1/3486 , A61M1/3693 , A61M1/3696 , A61M2205/18

6. 发明授权

EP1218040B1 MEMBRANMODUL ZUR HEMODIAFILTRATION MIT INTEGRIERTER VOR- ODER NACHVERDÜNNUNG DES BLUTS 有权
标题翻译：膜组织化学抑制剂麻醉剂整合剂VOR- ODERNACHVERDÜNNUNGDES BLUTS
公开(公告)号：EP1218040B1
公开(公告)日：2005-05-04
申请号：EP00964208.3
申请日：2000-09-20
申请人： Membrana GmbH
发明人： BAURMEISTER, Ulrich
IPC分类号： A61M1/34 , B01D61/58
CPC分类号： A61M1/342 , A61M1/3427 , A61M1/3434 , A61M1/3437 , A61M1/3444 , A61M1/3465 , A61M1/3635 , B01D61/145 , B01D61/243 , B01D61/58
摘要： The invention relates to a membrane module for the hemodiafiltration. The inventive module comprises a cylinder-shaped housing (1) and a bundle of hollow fibre membranes (2) that can be flown through. The bundle is oriented in the direction of the longitudinal extension of the housing (1). The ends of the hollow fibre membranes are fluid-tightly embedded in a first and a second casting compound (3, 4) that is fluid-tightly connected to the inner wall of the housing. The outer chamber which is configured around the hollow fibre membranes (2) and is defined by the first and the second casting compound (3, 4) as well as the inner wall of the housing is divided into a dialysate chamber (11) and a substituate chamber (10) along the longitudinal extension of the housing (1) and by means of a partition wall (9) that encompasses each hollow fibre membrane (2), extends essentially crosswise in relation to the hollow fibre membranes (2) and essentially consists of a dimensionally stable material. The dialysate chamber (11) and the substituate chamber (10) are provided with at least one opening respectively for leading a fluid in or out (13, 14). At least one throttle is arranged in the outer chamber. The dialysate chamber (11) and the substituate chamber (10) are fluidically connected to each other via said throttle.
摘要翻译：一种用于血液透析滤膜的膜组件，其具有圆柱形壳体和能够支撑流体流动并沿着壳体的纵向方向布置的中空纤维膜束。中空纤维膜的端部以流体密封的方式嵌入在以流体密封方式连接到壳体内壁的第一和第二密封化合物中。围绕中空纤维膜形成并由第一和第二密封化合物和壳体内壁限定的外部空间沿着壳体的纵向范围被分割成透析液空间和由分隔壁形成的取代空间，该分隔壁由基本上尺寸稳定的材料。分隔壁包围每个中空纤维膜并且基本上横向于中空纤维膜布置。透析液空间和取代空间各自具有用于引入或排出流体的至少一个开口。在外部空间中，布置至少一个节流阀，通过该节流阀，透析液空间和取代空间彼此流体连通。

7. 发明公开

EP1433490A1 Dialyzer and method for manufacturing the same 有权
标题翻译：透析器和dessen Herstellungsverfahren
公开(公告)号：EP1433490A1
公开(公告)日：2004-06-30
申请号：EP03029711.3
申请日：2003-12-23
申请人： Nipro Corporation
发明人： Sunohara, Takashi, Nipro Corporation , Anbo, Hidehiko, Nipro Corporation , Masuda, Toshiaki, Nipro Corporation
IPC分类号： A61M1/16
CPC分类号： A61M1/16 , A61M1/1627 , A61M1/3427 , A61M1/3465 , B01D61/30 , B01D63/02 , B01D63/021 , B01D65/00 , B01D65/02 , B01D2313/23 , B01D2321/04
摘要： A dialyzer including a substantially cylindrical case 2, a hollow fiber bundle 3 made of a plurality of hollow fiber membranes provided in the case 2, a blood flow path formed by lumens of the hollow fiber membranes, a dialysate flow path formed by a gap between the inner wall of the case 2 and the hollow fiber membranes, and a cylindrical elastic tube 4 inserted in the gap between the inner wall of the case 2 and the hollow fiber bundle 3.
摘要翻译：一种透析器，包括基本上为圆筒形的壳体2，由设置在壳体2中的多个中空纤维膜制成的中空纤维束3，由中空纤维膜的内腔形成的血流路径，由透明液流路形成的透析液流路，壳体2的内壁和中空纤维膜，以及插入壳体2的内壁和中空纤维束3之间的间隙中的圆筒形弹性管4。

8. 发明授权

EP0637989B1 DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT 失效
标题翻译： VORRICHTUNG ZURAUSSERKÖRPERLICHENBLUTBEHANDLUNG
公开(公告)号：EP0637989B1
公开(公告)日：2004-04-14
申请号：EP93904972.2
申请日：1993-02-08
申请人： HEMOCLEANSE, INC.
发明人： ASH, Stephen, R.
IPC分类号： A61M1/30 , B01D61/24 , B01D65/08
CPC分类号： B01D65/08 , A61M1/1005 , A61M1/1006 , A61M1/1037 , A61M1/1062 , A61M1/1627 , A61M1/1643 , A61M1/1649 , A61M1/1692 , A61M1/1696 , A61M1/26 , A61M1/267 , A61M1/30 , A61M1/304 , A61M1/308 , A61M1/3417 , A61M1/3427 , A61M1/3434 , A61M1/3437 , A61M1/3458 , A61M1/3472 , A61M1/3475 , A61M1/3493 , A61M2205/12 , A61M2205/7563 , B01D61/00 , B01D61/145 , B01D61/243 , B01D61/58 , B01D63/16 , B01D2321/2083 , Y10T436/255
摘要： Method and device for extracorporeal treatment of blood to effectively remove toxins therefrom and from patients are disclosed. The method includes the steps of passing the blood and dialysate through a plate dialyzer (30) comprising a blood inlet (39), a blood outlet (40) and a dialysate inlet (29), a dialysate outlet (35) and the blood side is separated from the dialysate side by dialyzer membranes. The method also includes passing a sorbent suspension through dialysate side and applying alternating negative pressure and positive pressure on the dialysate side of the dialyzer via an accumulateur (22) to expand and contract dialyzer membranes and agitate the sorbent suspension to prevent settling and mix it to maintain chemical gradients across the membrane. A positive pressure gradient is maintained throughout the cycle from the blood side to the dialysate side of the dialyzer.
摘要翻译：公开了优选的装置和方法，其提供血液的体外治疗以有效且一致地从其中长时间地从患者中去除毒素。

9. 发明公开

EP1283064A2 Blood processing system 有权
标题翻译：血液处理系统
公开(公告)号：EP1283064A2
公开(公告)日：2003-02-12
申请号：EP02016979.3
申请日：2002-08-02
申请人： Kuraray Co., Ltd.
发明人： Inoue, Masao , Ike, Akihiro , Nakaji, Shuhei
IPC分类号： A61M1/34 , A61M1/36
CPC分类号： A61M1/3472 , A61M1/342 , A61M1/3427 , A61M1/3441 , A61M1/3448 , A61M1/3482 , A61M1/3486 , A61M1/3693 , A61M1/3696 , A61M2205/18
摘要： To provide a blood processing system easy to operate and excellent in safety factor, the blood processing system includes a plasma separating unit for separating a plasma from a blood; a plasma purifying unit for purifying the separated plasma to which the plasma is introduced into the plasma purifying unit through a plasma introducing fluid circuit by means of a plasma feed pump; and a plasma return fluid circuit for returning the plasma, which has been purified by the plasma purifying unit, back to the plasma separating unit. A plasma inlet pressure gauge measures a pressure of the plasma at the plasma intake port of the plasma feed pump. A bypass fluid circuit extending between the plasma introducing fluid circuit and the plasma return fluid circuit for bypassing the plasma feed pump and the plasma purifying unit has a valve disposed therein for opening the bypass circuit. A control unit controls the plasma feed pump in reference to the plasma inlet pressure measured by the plasma inlet pressure gauge to render the plasma inlet pressure to fall within a predetermined range with respect to a preset pressure.
摘要翻译：为了提供一种易于操作且安全系数优异的血液处理系统，该血液处理系统包括用于从血液中分离血浆的血浆分离单元; 等离子体净化单元，用于通过等离子体输入泵通过等离子体引入流体回路来净化等离子体被引入到等离子体净化单元中的分离的等离子体; 以及等离子体返回流体回路，用于将已经被等离子体净化单元净化的等离子体返回到等离子体分离单元。等离子体入口压力计测量等离子体进料泵的等离子体进入口处的等离子体的压力。在等离子体引入流体回路和等离子体返回流体回路之间延伸以绕过等离子体供给泵和等离子体净化单元的旁路流体回路具有布置在其中用于打开旁通回路的阀。控制单元参照由等离子体入口压力计测量的等离子体入口压力来控制等离子体供给泵，以使等离子体入口压力相对于预设压力落入预定范围内。

10. 发明公开

EP1202757A1 MICRODIALYSIS PROBE 有权
标题翻译：探头微透析
公开(公告)号：EP1202757A1
公开(公告)日：2002-05-08
申请号：EP00950170.1
申请日：2000-07-14
申请人： CMA/MICRODIALYSIS AB
发明人： JOHANSSON, Roger
IPC分类号： A61M1/00 , A61M25/095
CPC分类号： A61B5/145 , A61B5/14528 , A61M1/1678 , A61M1/1682 , A61M1/3427 , A61M25/003 , A61M2025/0042
摘要： The invention concerns a microdialysis probe, comprising a dialysis membrane (115, 415) located and supported between a closed distal end of the probe and a proximal end of the same, said membrane (115, 415) essentially surrounding a space (118, 418) for passage of perfusion liquid; said probe having inlet and outlet means (107, 108; 407, 408) for perfusion liquid, characterized by presence of a position indicating object imparting such characteristics to the distal part of the probe as to allow non-invasive examination of the location of the distal part of the microdialysis probe.

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