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    • 8. 发明公开
    • Biodegradable medical devices with enhanced mechanical strength and pharmacological functions
    • Bioabbaubare medizinische Vorrichtungen mit verbesserter mechanischer Festigkeit und pharmakologischer Funktion
    • EP1721625A2
    • 2006-11-15
    • EP06250728.0
    • 2006-02-10
    • Cordis Corporation
    • Zhao, Jonathon
    • A61L31/10A61L31/08A61K31/06A61K31/02A61K31/12
    • A61K31/02A61K31/06A61K31/12A61L31/08A61L31/10A61L31/124A61L31/128A61L2420/04C08L67/04
    • The present invention is directed to a medical device, specifically a prosthesis which utilizes a novel class of blends between biodegradable polymers and biocerannics for medical device applications allowing one to capitalize on the biodegradable nature of these two distinct materials while enhancing the strength of these devices through the addition of various amounts ofbioactive ceramic and glasses to biodegradable polymers. The blend may be fabricated into a medical device such as a stent or a distal protection device, and may incorporate various agents to enhance radioapacity and/or pharmacological function-In addition, the blend may be used as a coating to a medical device.
      In one embodiment a medical device comprises a biodegradable polymer in the form of particles; and a bioactive ceramic in the form of particles wherein the combination of biodegradable polymer particles and bioactive ceramic particles arc blended together.
    • 本发明涉及医疗装置,特别是一种假体,其利用可生物降解的聚合物和生物卫生学之间的新型混合物用于医疗装置应用,从而允许利用这两种不同材料的可生物降解性质,同时增强这些装置的强度 向可生物降解的聚合物中加入各种量的生物活性陶瓷和玻璃。 共混物可以制成诸如支架或远端保护装置的医疗装置,并且可以结合各种试剂以增强放射性能力和/或药理功能。此外,该共混物可以用作医疗装置的涂层。 在一个实施方案中,医疗装置包括颗粒形式的可生物降解的聚合物; 以及颗粒形式的生物活性陶瓷,其中可生物降解的聚合物颗粒和生物活性陶瓷颗粒的组合被混合在一起。