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1. 发明公开

EP3359208A1 CURABLE CALCIUM PHOSPHATE COMPOSITIONS FOR USE WITH POROUS STRUCTURES AND METHODS OF USING THE SAME 有权
公开(公告)号：EP3359208A1
公开(公告)日：2018-08-15
申请号：EP16784677.3
申请日：2016-10-07
申请人： Zimmer Knee Creations, Inc.
发明人： ANGLE, Siddhesh , STRUNK, Michael , CHANG, Tak Lung , COALE, Bradford J. , STEBBINS, Greg , LIEPINS, Imants
IPC分类号： A61L27/12 , A61L27/42 , A61L27/46 , A61L27/56
CPC分类号： A61L27/20 , A61L27/12 , A61L27/306 , A61L27/3608 , A61L27/3616 , A61L27/365 , A61L27/422 , A61L27/427 , A61L27/46 , A61L27/56 , A61L2400/06 , A61L2400/08 , A61L2430/02 , A61L2430/24 , C08L5/04 , C08L1/28
摘要： Various embodiments disclosed relate to curable calcium phosphate compositions for use with porous structures and methods of using the same. In various embodiments, the present invention provides a curable calcium phosphate composition or a cured product thereof, with the curable calcium phosphate composition including calcium phosphate and a perfusion modifier. In various embodiments, the present invention provides an apparatus comprising a porous structure at least partially in contact with the curable calcium phosphate composition or a cured product thereof. The porous structure can include a porous substrate including a plurality of ligaments that define pores of the porous substrate, and a biocompatible metal coating on the plurality of ligaments of the porous substrate.

2. 发明授权

EP2991695B1 KERAMISCHES KNOCHENERSATZ-MATERIAL UND VERFAHREN ZU SEINER HERSTELLUNG 有权
标题翻译：陶瓷骨替换材料及其制造方法
公开(公告)号：EP2991695B1
公开(公告)日：2017-12-20
申请号：EP14724015.4
申请日：2014-04-28
申请人： CeramTec GmbH , Friedrich-Alexander-Universität Erlangen-Nürnberg
发明人： WECKER, Heinrich , KELNBERGER, Alfons , GREIL, Peter , FEY, Tobias , SCHMIDT, Johanna , ZIERATH, Bodo
IPC分类号： A61L27/56 , A61F2/28 , A61F2/44
CPC分类号： A61L27/56 , A61F2/28 , A61F2/3094 , A61F2/4455 , A61F2002/30013 , A61F2002/3028 , A61F2002/3092 , A61L27/10 , A61L27/105 , A61L2400/08 , A61L2430/02 , A61L2430/38

3. 发明公开

EP2762173A4 PREPARATION METHOD FOR MEDICAL POROUS TANTALUM IMPLANT MATERIAL 有权
标题翻译：工艺，一种生产多孔钽电容器医疗植入材料
公开(公告)号：EP2762173A4
公开(公告)日：2015-08-19
申请号：EP12835956
申请日：2012-09-27
申请人： CHONGQING RUNZE PHARMACEUTICAL
发明人： YE LEI
IPC分类号： A61L27/04 , A61L27/56 , C22C1/08 , C22C27/02
CPC分类号： A61L27/047 , A61L27/56 , A61L2400/08 , A61L2430/02 , A61L2430/24 , B22F3/1137 , B22F2999/00 , B32B5/18 , C22C27/02 , B22F3/22 , B22F2202/01
摘要： A preparation method for medical porous tantalum implant material is provided, which includes mixing polyethylene glycol aqueous solution and tantalum powder to form tantalum slurry, casting the tantalum slurry into an organic foam body through vibrant pressurization, and going through steps of drying, degreasing, vacuum sintering and thermal treatment to obtain the porous tantalum. The solution is a 2-8 wt% polyethylene glycol aqueous solution, the frequency of vibration is 20-80 times/min, the thermal treatment is performed under 10 -4 -10 -3 Pa of vacuity and the temperature is increased to 800-900°C at a rate of 10-20°C/min and keeping the temperature for 240-480 minutes, then decreased to 400°C at a rate of 2-5°C/min and keeping the temperature for 120-300 minutes, and cooled down to the room temperature naturally in the furnace. Accordingly, the porous tantalum made by the method of the present invention is a suitable for medical implantation as an alternative support of bony tissue, and assured good biocompatibility and mechanical properties. Furthermore, the reagents and the organic foam body, which are can be decomposed and resulting no residue during sintering, are used to guarantee the bio-safety of the medical porous tantalum implant material.

4. 发明公开

EP2762173A1 PREPARATION METHOD FOR MEDICAL POROUS TANTALUM IMPLANT MATERIAL 有权
标题翻译： VERFAHREN ZUR HERSTELLUNGPORÖSERMEDISINISCHER TANTALIMPLANTATMATERIALIEN
公开(公告)号：EP2762173A1
公开(公告)日：2014-08-06
申请号：EP12835956.9
申请日：2012-09-27
申请人： Chongqing Runze Pharmaceutical Company Limited
发明人： YE, Lei
IPC分类号： A61L27/04 , A61L27/56 , C22C1/08 , C22C27/02
CPC分类号： A61L27/047 , A61L27/56 , A61L2400/08 , A61L2430/02 , A61L2430/24 , B22F3/1137 , B22F2999/00 , B32B5/18 , C22C27/02 , B22F3/22 , B22F2202/01
摘要： A preparation method for medical porous tantalum implant material is provided, which includes mixing polyethylene glycol aqueous solution and tantalum powder to form tantalum slurry, casting the tantalum slurry into an organic foam body through vibrant pressurization, and going through steps of drying, degreasing, vacuum sintering and thermal treatment to obtain the porous tantalum. The solution is a 2-8 wt% polyethylene glycol aqueous solution, the frequency of vibration is 20-80 times/min, the thermal treatment is performed under 10 -4 -10 -3 Pa of vacuity and the temperature is increased to 800-900°C at a rate of 10-20°C/min and keeping the temperature for 240-480 minutes, then decreased to 400°C at a rate of 2-5°C/min and keeping the temperature for 120-300 minutes, and cooled down to the room temperature naturally in the furnace. Accordingly, the porous tantalum made by the method of the present invention is a suitable for medical implantation as an alternative support of bony tissue, and assured good biocompatibility and mechanical properties. Furthermore, the reagents and the organic foam body, which are can be decomposed and resulting no residue during sintering, are used to guarantee the bio-safety of the medical porous tantalum implant material.
摘要翻译：提供了一种医用多孔钽植入材料的制备方法，其包括将聚乙二醇水溶液和钽粉混合以形成钽浆料，通过充分的加压将钽浆浇铸成有机泡沫体，并经过干燥，脱脂，真空烧结和热处理得到多孔钽。溶液为2-8重量％聚乙二醇水溶液，振动频率为20-80次/ min，热处理在10 -4 -10 -3 Pa的真空下进行，温度升至800〜 900℃，速度为10-20℃/ min，保持温度为240-480分钟，然后以2-5℃/ min的速度降至400℃，保持温度为120-300分钟并在炉内自然冷却至室温。因此，通过本发明的方法制造的多孔钽适用于医学植入，作为骨组织的替代支持，并确保良好的生物相容性和机械性能。此外，可以将分解并在烧结期间不产生残留物的试剂和有机泡沫体用于保证医用多孔钽植入材料的生物安全性。

5. 发明公开

EP2663343A2 DEVICES AND METHODS FOR TISSUE ENGINEERING 失效
标题翻译：用于组织工程的装置和方法
公开(公告)号：EP2663343A2
公开(公告)日：2013-11-20
申请号：EP12734153.5
申请日：2012-01-09
申请人： Bio2 Technologies, Inc.
发明人： LIU, James, Jenq , KREVOLIN, Janet, L.
IPC分类号： A61L27/56 , A61F2/01 , A61F2/02 , A61L27/40 , A61F2/44
CPC分类号： A61F2/36 , A61B17/8095 , A61F2/30907 , A61F2/3094 , A61F2/30965 , A61F2/442 , A61F2002/30011 , A61F2002/30909 , A61F2002/3092 , A61F2002/30971 , A61F2002/4495 , A61F2310/00023 , A61L27/06 , A61L27/50 , A61L27/56 , A61L2400/08 , A61L2430/02 , A61L2430/38
摘要： A tissue engineering scaffold of interconnected and bonded fiber having a property with a value that is spatially distributed in at least two regions is provided. The scaffold has at least two regions with properties, such as porosity, strength, elastic modulus, osteoconductivity, and bioactivity that can be controlled and modified through fabrication processes that alter the pore size, pore size distribution, composition, and bonding of fiber and other additives. The value of the property can be provided with a gradient between each of the adjacent spatially distributed regions.
摘要翻译：提供了具有在至少两个区域中空间分布的值的性质的互连和粘合纤维的组织工程支架。支架具有至少两个区域，其具有诸如孔隙率，强度，弹性模量，骨传导性和生物活性等性质，其可通过改变孔尺寸，孔尺寸分布，组成以及纤维和其他的结合的制造工艺来控制和改性添加剂。可以在每个相邻的空间分布区域之间提供该属性的值以具有梯度。

6. 发明公开

EP1976460A4 INJECTABLE AND MOLDABLE BONE SUBSTITUTE MATERIALS 审中-公开
标题翻译：注射剂和成型的骨替代材料
公开(公告)号：EP1976460A4
公开(公告)日：2012-06-20
申请号：EP07718335
申请日：2007-01-19
申请人： WARSAW ORTHOPEDIC INC
发明人： WINTERBOTTOM JOHN , KAES DAVID R , TUNC DEGER C , BOYCE TODD M , KNAACK DAVID , RUSSELL JAMES , BHATTACHARYYA SUBHABRATA
IPC分类号： A61F2/00 , A61F2/28 , A61L27/44 , A61L27/46 , A61L27/56
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02

7. 发明公开

EP2882465A4 METHODS OF MANUFACTURING HYDROGEL MICROPARTICLES HAVING LIVING CELLS, AND COMPOSITIONS FOR MANUFACTURING A SCAFFOLD FOR TISSUE ENGINEERING 审中-公开
标题翻译：用于活细胞和组成用于生产组织科技脚手架PRODUCING HYDROGELMIKROTEILCHEN
公开(公告)号：EP2882465A4
公开(公告)日：2016-04-06
申请号：EP13828142
申请日：2013-07-26
申请人： UNIV NANYANG TECH
发明人： WANG DONGAN , LAU TING TING , LEONG WENYAN
IPC分类号： A61L27/52 , A61L27/14 , A61L27/22 , A61L27/38 , A61L27/56
CPC分类号： A61L27/52 , A61L27/14 , A61L27/222 , A61L27/38 , A61L27/3817 , A61L27/56 , A61L2400/06 , A61L2400/08 , A61L2430/00 , A61L2430/06
摘要： Method of manufacturing hydrogel microparticles comprising one or more species of living cells attached thereon and/or encapsulated therein is provided. The method includes dissolving a hydrogel-forming agent in an aqueous medium to form a solution; suspending one or more species of living cells in the solution to form a cell suspension; dispersing the cell suspension into an organic oil to form a microemulsion; and subjecting the microemulsion to conditions that allow the hydrogel-forming agent to form hydrogel microparticles comprising one or more species of living cells attached thereon and/or encapsulated therein. Composition comprising a mixture of a degradable hydrogel and at least one hydrogel microparticle having one or more species of living cells, and method of manufacturing a scaffold for tissue engineering are also provided.

8. 发明公开

EP2943163A1 HIGH STRENGTH INJECTION MOLDED ORTHOPEDIC DEVICES 审中-公开
标题翻译：高强度喷铸骨科器械
公开(公告)号：EP2943163A1
公开(公告)日：2015-11-18
申请号：EP14738021.6
申请日：2014-01-08
申请人： Praxis Powder Technology, Inc.
发明人： GROHOWSKI, Jr., Joseph A.
IPC分类号： A61F2/28
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/2835 , A61L27/04 , A61L27/06 , A61L27/50 , A61L2400/08 , A61L2430/02 , B22F3/1137 , B22F3/225 , B22F5/00 , B22F7/06 , B22F2999/00 , B33Y10/00 , B33Y80/00 , Y02P10/295 , B22F3/22 , B22F5/007 , B22F3/1055
摘要： High strength implantable devices having complex surfaces are injection molded from powder metal wherein the surface is defined by a monolithic insert made by additive manufacturing. The insert defines the surface texture of the device and may also include a portion to form an ingrowth texture and a portion to form a substrate interface texture. The tensile bond strength of the texture is 20 Mega Pascal or greater.

9. 发明公开

EP2776079A4 INJECTABLE SILK FIBROIN FOAMS AND USES THEREOF 有权
标题翻译：可注射丝绸纤维烟雾及其用途
公开(公告)号：EP2776079A4
公开(公告)日：2015-05-27
申请号：EP12846855
申请日：2012-11-09
申请人： TUFTS COLLEGE
发明人： LEISK GARY G , LO TIM JIA-CHING , LI LEI , BELLAS EVANGELIA , KAPLAN DAVID L
IPC分类号： A61L27/22 , A61K38/17 , A61L27/14 , A61L27/36 , A61L27/38 , A61L27/40 , A61L27/48 , A61L27/54 , A61L27/56 , C12N5/0789
CPC分类号： A61L27/227 , A61K38/1767 , A61L27/3604 , A61L27/3834 , A61L27/48 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/34 , C08L89/00
摘要： The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.

10. 发明公开

EP2867298A1 BIOCOMPATIBLE POLYACRYLATE COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：生物相容性POLYACRYLATZUSAMMENSETZUNGEN和使用方法
公开(公告)号：EP2867298A1
公开(公告)日：2015-05-06
申请号：EP13809673.0
申请日：2013-03-13
申请人： University Of South Florida
发明人： GREENHALGH, Kerriann, Robyn , TUROS, Edward , ESPINOSA, Julio
IPC分类号： C08L33/04 , C08J3/03 , C08F20/10 , A61L31/10 , A61P9/10
CPC分类号： A61L31/10 , A61L15/24 , A61L15/44 , A61L15/46 , A61L24/0015 , A61L24/06 , A61L26/0014 , A61L26/0019 , A61L26/0066 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/624 , A61L2400/04 , A61L2400/08 , A61L2400/12 , C08F220/14 , C08F220/18 , C08L33/08
摘要： A biocompatible polymer material is described that exhibits mechanical and physical properties that are fundamental to many medical devices and treatment of many medical diseases and disorders. The material is composed of a combination of acrylate monomers polymerized via a microemulsion polymerization. Multiple applications of the polymer material are presented.

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