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1. 发明公开

EP1083883A1 STABILIZERS FOR LYOPHILIZED VACCINES 审中-公开
标题翻译：稳定剂冻干疫苗
公开(公告)号：EP1083883A1
公开(公告)日：2001-03-21
申请号：EP99955214.4
申请日：1999-05-28
申请人： MERCK & CO., INC.
发明人： VOLKIN, David, B. , BURKE, Carl, J. , SHEU, Su-Pi
IPC分类号： A61K9/19 , A61K31/045 , A61K39/12 , C07H3/04 , C12N7/00
CPC分类号： A61K39/165 , A61K9/0019 , A61K9/19 , A61K39/0015 , A61K39/12 , A61K39/13 , A61K39/20 , A61K39/25 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/42 , A61K2039/5254 , A61K2039/70 , C12N2710/16734 , C12N2760/18434 , C12N2760/18734 , C12N2770/36234 , Y02A50/466
摘要： Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0.

2. 发明公开

EP3041505A4 METHODS OF IMMUNIZATION WITH VARICELLA ZOSTER VIRUS ANTIGEN 审中-公开
标题翻译：免疫缺陷病毒
公开(公告)号：EP3041505A4
公开(公告)日：2017-04-19
申请号：EP14842756
申请日：2014-09-02
申请人： MERCK SHARP & DOHME
发明人： MEYER BRIAN K , EVANS ROBERT K , BEALS CHANNING R , KASLOW DAVID C
IPC分类号： A61K39/25 , A61P31/22 , C12N7/04
CPC分类号： A61K39/25 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/102 , A61K39/12 , A61K39/13 , A61K39/145 , A61K39/165 , A61K39/20 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , C12N7/00 , C12N2710/16734 , C12N2760/16034 , C12N2760/18434 , C12N2770/32634 , C12N2770/36234
摘要： The present invention relates to a method of vaccinating a patient against varicella zoster virus (VZV) by delivery of an effective amount of a live attenuated VZV vaccine to the epidermis or the dermis of a patient's skin at a depth of between about 100 and about 700 microns from the surface of the skin, which is useful for preventing herpes zoster or reducing the severity or duration thereof. In embodiments of the invention, the patient is 50 years of age or older and has been previously exposed to VZV. The invention also relates to a method of preventing VZV infection in an individual who was not previously infected with VZV comprising administering an effective amount of a live attenuated VZV vaccine to the epidermis or the dermis of the individual's skin at a depth of between about 100 and about 700 microns from the surface of the skin.
摘要翻译：本发明涉及一种通过将有效量的活减毒VZV疫苗递送至患者皮肤的表皮或真皮的约100至约700埃的深度来接种患者抗水痘带状疱疹病毒（VZV）的方法微粒从皮肤表面，其可用于预防带状疱疹或降低其严重性或持续时间。在本发明的实施方案中，患者是50岁或以上，并且先前已经暴露于VZV。本发明还涉及预防VZV感染未曾感染VZV的个体的VZV感染的方法，该方法包括以约100至约100埃的深度施用有效量的活减毒VZV疫苗至个体皮肤的表皮或真皮，距皮肤表面约700微米。

3. 发明公开

EP3153175A1 ADJUVANT FOR MUCOSAL VACCINE 有权转让
标题翻译： ADJUVANSFÜRSCHLEIMHAUTIMPFSTOFF
公开(公告)号：EP3153175A1
公开(公告)日：2017-04-12
申请号：EP15803250.8
申请日：2015-06-02
申请人： Osaka University
发明人： JONAI Nao , FUJINAGA Yukako , YUTANI Masahiro , SUGAWARA Yo , MATSUMURA Takuhiro
IPC分类号： A61K39/39 , A61K39/02 , A61K39/04 , A61K39/08 , A61K39/09 , A61K39/095 , A61K39/10 , A61K39/102 , A61K39/106 , A61K39/12 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15
CPC分类号： A61K39/39 , A61K39/02 , A61K39/04 , A61K39/08 , A61K39/09 , A61K39/095 , A61K39/102 , A61K39/12 , A61K39/125 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/155 , A61K39/165 , A61K39/20 , A61K39/21 , A61K39/215 , A61K39/235 , A61K39/245 , A61K39/25 , A61K39/29 , A61K2039/541 , A61K2039/543 , A61K2039/55516 , Y02A50/386 , Y02A50/39 , Y02A50/466 , Y02A50/472
摘要： An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response in a mucosal membrane. According to the present invention, an adjuvant for a mucosal vaccine containing a protein complex composed of hemagglutinin (HA) subcomponents HA1 and HA2, and mutant subcomponent HA3 of botulinum toxin is provided.
摘要翻译：本发明的目的是提供一种具有高安全性的粘膜疫苗佐剂，其在粘膜中诱导足够的免疫应答。根据本发明，提供了含有由血凝素（HA）亚组分HA1和HA2组成的蛋白质复合物和肉毒杆菌毒素的突变体亚组分HA3的粘膜疫苗佐剂。

4. 发明公开

EP2035033A1 PHARMACEUTICAL COMPOSITION FOR THE SUBLINGUAL ADMINISTRATION OF VACCINES, METHOD FOR THE PREPARATION OF THE SAME AND USES THEREOF 审中-公开
标题翻译：药物组合物及其制备方法和用途的提供疫苗SUBLINQUALEN的，过程
公开(公告)号：EP2035033A1
公开(公告)日：2009-03-18
申请号：EP07766519.8
申请日：2007-06-06
申请人： Silvestrini, Bruno , Bonanomi, Michele
发明人： Silvestrini, Bruno , Bonanomi, Michele
IPC分类号： A61K39/00 , A61K39/02 , A61K39/12 , A61K39/35 , A61K39/295 , A61K9/20
CPC分类号： A61K9/19 , A61K9/006 , A61K9/009 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/12 , A61K39/145 , A61K39/20 , A61K47/26 , A61K2039/541 , A61K2039/542 , C12N2710/16734 , C12N2760/16134 , C12N2770/36234
摘要： The subject of the present invention is a pharmaceutical composition for the sublingual administration of vaccines, a method for its preparation and the use thereof for modulating the absorption rate and substantially improving its effectiveness and safety. Said sublingual composition is applicable both to immunizing vaccines, which are employed against infections, and to desensitising vaccines, which have allergies as therapeutic indication.

5. 发明公开

EP0946193A1 STABILIZERS FOR LYOPHILIZED VACCINES 失效
标题翻译：稳定剂FPR冻干疫苗
公开(公告)号：EP0946193A1
公开(公告)日：1999-10-06
申请号：EP97954795.0
申请日：1997-12-18
申请人： MERCK & CO., INC.
发明人： VOLKIN, David, B. , BURKE, Carl, J. , SHEU, Su-Pi
IPC分类号： C12N7 , A61K9 , A61K39 , A61P31 , A61K47
CPC分类号： A61K39/25 , A61K9/19 , A61K39/0015 , A61K39/12 , A61K39/13 , A61K39/165 , A61K39/20 , A61K47/26 , A61K47/42 , A61K2039/5254 , A61K2039/70 , C12N2710/16734 , C12N2760/18434 , C12N2760/18734 , C12N2770/36234 , Y02A50/466
摘要： Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increased amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0.

6. 发明公开

EP0353108A1 Procédé de stabilisation des vaccins et associations de vaccins à virus atténués conservés sous forme lyophilisée, et compositions obtenues 有权转让
标题翻译：，减毒疫苗冻干和组合物的关联获得用于疫苗的稳定化过程。
公开(公告)号：EP0353108A1
公开(公告)日：1990-01-31
申请号：EP89401599.9
申请日：1989-06-09
申请人： PASTEUR MERIEUX SERUMS ET VACCINS
发明人： Françon, Alain Jean-Louis , Montagnon, Bernard Jean
IPC分类号： A61K39/12
CPC分类号： A61K39/165 , A61K39/0015 , A61K39/12 , A61K39/20 , A61K2039/70 , C12N2760/18434 , C12N2760/18734 , C12N2770/36234 , Y10S514/97
摘要： Dans le but de stabiliser les vaccins et associations de vaccins à virus atténués qui sont conservés sous forme lyophilisée en présence d'au moins un excipient de lyophilisation, on ajoute, de préférence avant la lyophilisation, une quantité appropriée d'au moins un produit répondant à la formule générale:
dans laquelle R1 est un atome d'oxygène ou un atome de soufre et R2 un groupement NH₂ ou une chaîne linéaire, insaturée ou non, du type :-O-C..., -NH-C... ou-C... avec, éventuellement, des substitutions hydroxyle.
摘要翻译：与存储在冻干形式在至少一个冷冻干燥的赋形剂，至少一个产品的对应于通式的合适的量的存在下是稳定伊辛疫苗和疫苗组合包含减毒病毒的对象：... ...其中R1 是类型-OC的氧原子或硫原子，R 2以NH 2基团或在不饱和或饱和的直链...，-NH-C ...或C ...，被羟基取代的位置适当，则加入，优选冻干之前。

7. 发明公开

EP4442281A1 NASAL VACCINE-SPRAYING FORMULATION FOR SIMULTANEOUSLY TARGETING NASAL MUCOSA AND NASOPHARYNX 审中-公开
公开(公告)号：EP4442281A1
公开(公告)日：2024-10-09
申请号：EP22901414.7
申请日：2022-12-01
申请人： Toko Yakuhin Kogyo Co., Ltd.
发明人： KAMISHITA, Taizou , MIYAZAKI, Takashi
IPC分类号： A61K47/32
CPC分类号： Y02A50/30 , A61K47/10 , A61K47/32 , A61K48/00 , A61P31/06 , A61K39/29 , A61P31/04 , A61K39/09 , A61P31/12 , A61K39/098 , A61K39/12 , A61K35/76 , A61K39/235 , A61K39/215 , A61K47/02 , A61P31/18 , A61P31/16 , A61P31/14 , A61K9/08 , A61K39/02 , A61K39/25 , A61P31/22 , A61K39/20 , A61K39/00 , A61K39/245 , A61K39/102 , A61K39/145 , A61K47/18
摘要： The present invention relates to a formulation base prepared by adding polyethylene glycol to crosslinked polyacrylic acid, and a formulation for spraying nasal vaccine comprising an antigen, which have optimized spray pattern targeting simultaneously both of nasal mucosa and nasopharynx.

8. 发明公开

EP3053595A4 MUCOSAL VACCINE COMPOSITION 有权
标题翻译： SCHLEIMHAUTIMPFSTOFFZUSAMMENSETZUNG
公开(公告)号：EP3053595A4
公开(公告)日：2017-04-19
申请号：EP14850476
申请日：2014-10-02
申请人： NITTO DENKO CORP
发明人： FUKASAKA MASAHIRO , HORI MITSUHIKO , OKUBO KATSUYUKI , ASARI DAISUKE , OKAZAKI ARIMICHI , KIYOTOH EIJI , MATSUSHITA KYOHEI
IPC分类号： A61K39/00 , A61K39/145 , A61K39/39 , A61P31/16 , A61P37/04
CPC分类号： A61K39/385 , A61K9/006 , A61K39/04 , A61K39/08 , A61K39/092 , A61K39/12 , A61K39/13 , A61K39/145 , A61K39/15 , A61K39/155 , A61K39/165 , A61K39/20 , A61K39/205 , A61K39/25 , A61K39/29 , A61K39/292 , A61K2039/541 , A61K2039/55572 , A61K2039/575 , C12N7/00 , C12N2710/16734 , C12N2710/20034 , C12N2720/12334 , C12N2730/10134 , C12N2760/16034 , C12N2760/16134 , C12N2760/16234 , C12N2760/18434 , C12N2760/18734 , C12N2760/20134 , C12N2770/24134 , C12N2770/32434 , C12N2770/32634 , C12N2770/36234
摘要： The present invention aims at providing a mucosal vaccine composition that can be administered to an intraoral mucous membrane, ocular mucous membrane, ear mucous membrane, genital mucous membrane, pharyngeal mucous membrane, respiratory tract mucous membrane, bronchial mucous membrane, pulmonary mucous membrane, gastric mucous membrane, enteric mucous membrane, or rectal mucous membrane, that is useful as a prophylactic or therapeutic agent for infectious diseases or cancers, and is capable of safely and effectively inducing the systemic immune response and mucosal immune response. The present invention provides a mucosal vaccine composition to be administered to at least one mucous membrane selected from the group consisting of a human or animal intraoral mucous membrane, ocular mucous membrane, ear mucous membrane, genital mucous membrane, pharyngeal mucous membrane, respiratory tract mucous membrane, bronchial mucous membrane, pulmonary mucous membrane, gastric mucous membrane, enteric mucous membrane, and rectal mucous membrane, containing: at least one antigen; and as an adjuvant, a lipopolysaccharide derived from at least one gram-negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or a salt thereof.
摘要翻译：本发明的目的是提供一种粘膜疫苗组合物，其可以施用于口内粘膜，眼粘膜，耳粘膜，生殖器粘膜，咽粘膜，呼吸道粘膜，支气管粘膜，肺粘膜，胃粘膜，肠粘膜或直肠粘膜，其可用作感染性疾病或癌症的预防或治疗剂，并且能够安全有效地诱导全身免疫应答和粘膜免疫应答。本发明提供一种粘膜疫苗组合物，其用于至少一种选自人或动物口腔内粘膜，眼粘膜，耳粘膜，生殖器粘膜，咽粘膜，呼吸道粘液的粘膜膜，支气管粘膜，肺粘膜，胃粘膜，肠粘膜和直肠粘膜，含有至少一种抗原; 并且作为佐剂，来自至少一种选自沙雷氏菌属（Salratia），莱克氏菌属（Leclercia），拉氏梭菌（Rahnella），酸性d螨属（Acidicaldus），酸性，螨属（Acidical，，，，，era era era era era era era era，，，，，，，as as as as as，ia ia ia ia ia ia ia ia occus occus occus occus，ia ia ia ia，，，，，，，，，，，，，，，，（Leahibacter），红球菌属（Myocosococcus），梭状芽胞杆菌属（Streptologica），拟青霉属（Lactobacter），泛菌属，和肠杆菌属或其盐。

9. 发明公开

EP2806894A4 METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENTS 审中-公开
标题翻译：方法和组合物治疗学
公开(公告)号：EP2806894A4
公开(公告)日：2015-11-04
申请号：EP13741121
申请日：2013-01-25
申请人： VARIATION BIOTECHNOLOGIES INC
发明人： KIRCHMEIER MARC J , ANDERSON DAVID E
IPC分类号： A61K47/28 , A61K9/127 , A61K9/19 , A61K39/00 , A61K39/12 , A61K39/165 , A61K39/20 , A61K39/295 , A61K39/395 , A61K47/14 , A61K47/24 , C07K16/32 , C12N7/00
CPC分类号： A61K47/14 , A61K9/1272 , A61K39/0015 , A61K39/12 , A61K39/165 , A61K39/20 , A61K39/295 , A61K39/39591 , A61K47/24 , A61K47/28 , A61K2039/5254 , A61K2039/55555 , A61K2039/70 , C07K16/32 , C12N7/00 , C12N2760/18434 , C12N2760/18734 , C12N2770/36234
摘要： The present disclosure provides inter alia compositions that comprise therapeutic agents (e.g., live attenuated viral antigens, therapeutic proteins, etc.) and a lipid component. The lipid component may comprise or consist of different types of lipid or lipids as described herein. In some embodiments the therapeutic agents are thermolabile. The present disclosure also provides methods for preparing compositions, including the aforementioned compositions (e.g., melt methods and spray injection methods among others).

10. 发明公开

EP2699266A1 COMPOSITIONS AND METHODS FOR STABILIZATION OF ACTIVE AGENTS 有权
标题翻译：组合物和稳定剂的方法
公开(公告)号：EP2699266A1
公开(公告)日：2014-02-26
申请号：EP12774253.4
申请日：2012-04-23
申请人： Trustees of Tufts College
发明人： KAPLAN, David L. , OMENETTO, Fiorenzo
IPC分类号： A61K47/42 , A61K39/12 , A61J1/00 , B82Y5/00 , A61K35/76 , A61K39/00 , A61M5/00
CPC分类号： A61K39/20 , A61K9/0019 , A61K9/06 , A61K9/146 , A61K9/19 , A61K9/5026 , A61K9/5063 , A61K9/7007 , A61K38/00 , A61K39/0015 , A61K39/02 , A61K39/04 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/099 , A61K39/12 , A61K39/165 , A61K47/42 , A61K47/46 , A61K2039/5252 , A61K2039/5254 , A61K2039/6031 , A61K2039/622 , A61K2039/64 , A61K2039/70 , B82Y5/00 , C12N2760/18434 , C12N2760/18734 , C12N2770/36234 , Y02A50/388 , Y02A50/39 , Y02A50/466 , Y02A50/484
摘要： Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of the active agents upon storage and/or transportation. In some embodiments, the storage-stable vaccine-silk compositions are also provided herein.

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