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1. 发明公开

EP3189853A4 IMMUNE-INDUCTION-PROMOTING COMPOSITION INCLUDING NUCLEAR RECEPTOR LIGAND, AND VACCINE PHARMACEUTICAL COMPOSITION 审中-公开
公开(公告)号：EP3189853A4
公开(公告)日：2018-07-11
申请号：EP15829798
申请日：2015-08-04
申请人： NITTO DENKO CORP
发明人： SHISHIDO TAKUYA , ASARI DAISUKE , MATSUSHITA KYOHEI , HORI MITSUHIKO
IPC分类号： A61K39/39 , A61K45/00 , A61P37/02 , A61P43/00
CPC分类号： A61K39/39 , A61K45/00 , A61K2039/54 , A61K2039/572 , A61K2039/575
摘要： The present invention aims to provide a composition for promoting immunity induction and a vaccine pharmaceutical composition which are universally usable for inducing immunity to various antigens and capable of exerting a high immunity inducing effect. The present invention relates to a composition for promoting immunity induction containing at least one nuclear receptor ligand and also relates to a vaccine pharmaceutical composition for inducing immunity containing an antigen and a composition for promoting immunity induction that is at least one nuclear receptor ligand.

2. 发明公开

EP3189852A4 BISPHOSPHONATE-CONTAINING PHARMACEUTICAL VACCINE COMPOSITION FOR HUMORAL IMMUNITY 有权
公开(公告)号：EP3189852A4
公开(公告)日：2018-02-14
申请号：EP15837618
申请日：2015-09-02
申请人： NITTO DENKO CORP
发明人： SHISHIDO TAKUYA , ASARI DAISUKE , HORI MITSUHIKO
IPC分类号： A61K39/00 , A61K31/663 , A61K39/39 , A61P37/04
CPC分类号： A61K39/395 , A61K31/663 , A61K39/00 , A61K39/39 , A61K47/48084 , A61K2039/55511 , A61K2039/58
摘要： The present invention aims to provide a vaccine pharmaceutical composition universally usable for induction of humoral immunity against various antigens and exerting a high antibody production inducing effect. The present invention relates to a vaccine pharmaceutical composition for inducing humoral immunity, including: an antigen; and an immunity induction promoter that is a bisphosphonate.

3. 发明公开

EP3053591A4 INJECTABLE VACCINE COMPOSITION 审中-公开
标题翻译： INJIZIERBARE IMPFSTOFFZUSAMMENSETZUNG
公开(公告)号：EP3053591A4
公开(公告)日：2017-04-19
申请号：EP14850351
申请日：2014-10-02
申请人： NITTO DENKO CORP
发明人： MATSUSHITA KYOHEI , FUKASAKA MASAHIRO , OKAZAKI ARIMICHI , KIYOTOH EIJI , OKUBO KATSUYUKI , ASARI DAISUKE , HORI MITSUHIKO
IPC分类号： A61K39/00 , A61K39/145 , A61K39/39 , A61P31/16 , A61P37/04
CPC分类号： A61K39/39 , A61K9/0019 , A61K39/00 , A61K2039/55572
摘要： The present invention aims at providing an injectable vaccine composition that is safe, useful as a prophylactic or therapeutic agent for cancers or infectious diseases, and capable of inducing the systemic immune response safely and effectively. The present invention is an injectable vaccine composition to be administered by injection to a human being or an animal, containing: at least one antigen, and as an adjuvant, a lipopolysaccharide derived from at least one gram negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or a salt thereof.
摘要翻译：本发明的目的在于提供一种安全有效的可用作癌症或感染性疾病的预防或治疗剂并且能够安全有效地诱导全身免疫应答的可注射疫苗组合物。本发明是通过注射给人或动物施用的可注射疫苗组合物，其包含至少一种抗原和佐剂，衍生自至少一种革兰氏阴性细菌的脂多糖，所述至少一种革兰氏阴性细菌选自沙雷氏菌属，Leclercia，Rahnella，Acidicaldus，Acidiphilium，Acidisphaera，Acidocella，Acidomonas，Asaia，Belnapia，Craurococcus，Gluconacetobacter，Gluconobacter，Kozakia，Leahibacter，Muricoccus，Neoasaia，Oleomonas，Paracraurococcus，Rhodopila，Roseococcus，Rubritepida，Saccharibacter，Stella，Swaminathania，Teichococcus ，Zavarzinia，假单胞菌属，无色杆菌属，芽孢杆菌属，甲烷球菌属，甲烷球菌属，梭菌属，微球菌属，黄杆菌属，泛菌属，醋杆菌属，发酵单胞菌属，黄单胞菌属，肠杆菌属或其盐。

4. 发明公开

EP2399574A4 INTRAORAL FILM-LIKE BASE AGENT AND FORMULATION 有权转让
标题翻译：味觉资金膜状基础及配方
公开(公告)号：EP2399574A4
公开(公告)日：2013-08-28
申请号：EP09839222
申请日：2009-03-06
申请人： NITTO DENKO CORP
发明人： ASARI DAISUKE , HORI MITSUHIKO , OGAWA KEIKO
IPC分类号： A61K9/70 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38
CPC分类号： A61K9/0056 , A61K9/7007 , A61K47/26 , A61K47/38

5. 发明公开

EP3189854A4 VACCINE PHARMACEUTICAL COMPOSITION FOR CELL-MEDIATED IMMUNITY CONTAINING BISPHOSPHONATES 有权
公开(公告)号：EP3189854A4
公开(公告)日：2018-02-21
申请号：EP15838615
申请日：2015-09-02
申请人： NITTO DENKO CORP
发明人： SHISHIDO TAKUYA , ASARI DAISUKE , HORI MITSUHIKO
IPC分类号： A61K45/00 , A61K31/047 , A61K31/05 , A61K31/085 , A61K31/195 , A61K31/222 , A61K31/341 , A61K31/355 , A61K31/4184 , A61K31/4192 , A61K31/439 , A61K31/663 , A61K31/675 , A61K31/685 , A61K33/00 , A61K38/00 , A61K39/00 , A61P37/04
CPC分类号： A61K39/0005 , A61K9/00 , A61K31/047 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/12 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/198 , A61K31/216 , A61K31/235 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/37 , A61K31/375 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/4375 , A61K31/4745 , A61K31/5415 , A61K31/616 , A61K31/635 , A61K31/663 , A61K31/675 , A61K31/685 , A61K31/7048 , A61K33/00 , A61K33/04 , A61K38/00 , A61K38/10 , A61K39/00 , A61K45/06 , A61K2300/00
摘要： The present invention aims to provide a vaccine pharmaceutical composition universally usable for induction of cellular immunity against various antigens and exerting a high cellular immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition for inducing cellular immunity, containing: an antigen; and a first cellular immunity induction promoter that is a bisphosphonate.

6. 发明公开

EP3178491A4 COMPOSITION FOR ENHANCING INDUCTION OF HUMORAL IMMUNITY, AND VACCINE PHARMACEUTICAL COMPOSITION 审中-公开
公开(公告)号：EP3178491A4
公开(公告)日：2018-01-24
申请号：EP15828998
申请日：2015-08-04
申请人： NITTO DENKO CORP
发明人： SHISHIDO TAKUYA , ASARI DAISUKE , MATSUSHITA KYOHEI , HORI MITSUHIKO
IPC分类号： A61K39/39 , A61K39/00
CPC分类号： A61K39/39 , A61K39/00 , A61K2039/54 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/575
摘要： The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.

7. 发明公开

EP3178495A4 LIQUID IMMUNITY INDUCTION-PROMOTING COMPOSITION AND VACCINE PHARMACEUTICAL COMPOSITION THAT INCLUDE THROMBOSIS TREATMENT DRUG 有权
公开(公告)号：EP3178495A4
公开(公告)日：2018-01-17
申请号：EP15829891
申请日：2015-08-04
申请人： NITTO DENKO CORP
发明人： SHISHIDO TAKUYA , ASARI DAISUKE , MATSUSHITA KYOHEI , HORI MITSUHIKO
IPC分类号： A61K45/00 , A61K39/00 , A61P7/02 , A61P37/04 , A61P43/00
CPC分类号： A61K39/00 , A61K45/00 , A61K2039/55588
摘要： The present invention aims to provide a humoral immunity induction-promoting composition and a vaccine pharmaceutical composition which can universally be used for inducing humoral immunity to various antigens and exert a high antibody production inducing effect. The present invention relates to a vaccine pharmaceutical composition for inducing humoral immunity containing an antigen and a humoral immunity induction promoter whose active ingredient is a thrombosis treatment drug.

8. 发明公开

EP3100744A4 COMPOSITION FOR ACCELERATING PENETRATION THROUGH SKIN, PREPARATION FOR TRANSDERMAL ADMINISTRATION, AND SKIN PATCH PREPARATION 审中-公开
标题翻译： ZUSAMMENSETZUNG ZUR BESCHLEUNIGUNG DER渗透教堂DieHätte，PRÄPARATZUR TRANSDERMALEN VERABREICHUNG UNDHAUTPFLASTERPRÄPARAT
公开(公告)号：EP3100744A4
公开(公告)日：2017-08-30
申请号：EP15744038
申请日：2015-01-28
申请人： NITTO DENKO CORP
发明人： MAEDA YOSHIKI , MATSUSHITA KYOHEI , LI WENJING , OKUBO KATSUYUKI , HORI MITSUHIKO
IPC分类号： A61K47/22 , A61K9/00 , A61K9/70 , A61K31/192 , A61K38/00 , A61K47/08
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/7053 , A61K31/137 , A61K31/366 , A61K31/437 , A61K31/616 , A61K38/00 , A61K47/08 , A61K47/22 , A61K2300/00
摘要： The present invention provides a skin penetration-accelerating composition that eliminates the need for forming a drug into a particle structure and dramatically improves the skin penetration properties of a drug without breaking the skin tissue. The present invention also provides a preparation for transdermal administration containing the skin penetration-accelerating composition and a patch preparation containing the skin penetration-accelerating composition. The present invention provides a skin penetration-accelerating composition containing a flavonoid compound and used for accelerating skin penetration of a drug.
摘要翻译：本发明提供促进皮肤渗透性组合物，其不需要将药物形成为颗粒结构，并且在不破坏皮肤组织的情况下显着改善药物的皮肤渗透性。本发明还提供含有促进皮肤渗透性组合物的经皮给药制剂和含有该皮肤渗透促进组合物的贴剂。本发明提供含有类黄酮化合物并用于促进药物皮肤渗透的皮肤渗透促进组合物。

9. 发明公开

EP3202417A4 VACCINE PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL ADMINISTRATION 无效
公开(公告)号：EP3202417A4
公开(公告)日：2018-04-25
申请号：EP15846575
申请日：2015-10-01
申请人： NITTO DENKO CORP
发明人： SHISHIDO TAKUYA , ASARI DAISUKE , MATSUSHITA KYOHEI , OKUBO KATSUYUKI , HORI MITSUHIKO
IPC分类号： A61K39/00 , A61K9/70 , A61K39/02 , A61K39/12 , A61K39/39 , A61P31/00 , A61P35/00 , A61P37/04
CPC分类号： A61K39/39 , A61K9/70 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K2039/54 , A61K2039/55572 , A61K2039/575 , A61K2039/70
摘要： The present invention aims to provide a vaccine pharmaceutical composition for transdermal administration which is safe, usable as a prophylactic or therapeutic agent for cancer or infectious diseases, and capable of safely and effectively inducing a systemic immune response. The present invention relates to a vaccine pharmaceutical composition for transdermal administration to be administered to a human or animal skin, the vaccine pharmaceutical composition including: a lipopolysaccharide derived from at least one gram-negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or its salt as an immunostimulant; and at least one antigen, the vaccine pharmaceutical composition having a mass ratio between the immunostimulant and the antigen, the total mass of the immunostimulant/the total mass of the antigen, of 0.002 to 500.

10. 发明公开

EP3100743A4 COMPOSITION FOR ACCELERATING PENETRATION THROUGH SKIN, PREPARATION FOR TRANSDERMAL ADMINISTRATION, AND SKIN PATCH PREPARATION 审中-公开
标题翻译： ZUSAMMENSETZUNG ZUR BESCHLEUNIGUNG DER渗透教堂DieHätte，PRÄPARATZUR TRANSDERMALEN VERABREICHUNG UNDHAUTPFLASTERPRÄPARAT
公开(公告)号：EP3100743A4
公开(公告)日：2017-08-30
申请号：EP15743986
申请日：2015-01-28
申请人： NITTO DENKO CORP
发明人： MATSUSHITA KYOHEI , MAEDA YOSHIKI , LI WENJING , OKUBO KATSUYUKI , HORI MITSUHIKO
IPC分类号： A61K47/22 , A61K9/00 , A61K9/70 , A61K31/192 , A61K31/616 , A61K38/00 , A61K38/45 , A61K47/08 , A61P29/00
CPC分类号： A61K47/22 , A61K9/0014 , A61K9/7053 , A61K31/192 , A61K31/352 , A61K31/366 , A61K31/616 , A61K38/45 , A61K47/08 , C12Y207/10001 , A61K2300/00

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