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1. 发明授权

EP2849780B1 FISH VACCINE 有权转让
标题翻译：鱼类疫苗
公开(公告)号：EP2849780B1
公开(公告)日：2017-11-29
申请号：EP13728683.7
申请日：2013-05-14
申请人： Norges Miljø-Og Biovitenskapelige Universitet (NMBU)
发明人： SØRUM, Henning
IPC分类号： A61K39/02 , A61K39/116
CPC分类号： A61K39/0208 , A61K39/107 , A61K39/116 , A61K2039/521 , A61K2039/552 , A61K2039/70 , C07K16/1239

2. 发明授权

EP2477649B1 VACCINE AGAINST CHOLERA AND ENTEROTOXIGENIC E. COLI (ETEC) DIARRHEA 有权转让
标题翻译：霍乱疫苗和产肠毒素的大肠杆菌（ETEC）-DIARRHÖE
公开(公告)号：EP2477649B1
公开(公告)日：2016-11-23
申请号：EP10817520.9
申请日：2010-09-16
申请人： MSD Wellcome Trust Hilleman Laboratories Pvt Ltd.
发明人： HOLMGREN, Jan , LEBENS, Michael
IPC分类号： A61K39/106 , A61K39/108 , A61P31/04
CPC分类号： A61K39/107 , A61K2039/521 , A61K2039/523 , Y02A50/472
摘要： A vaccine against cholera and/or ETEC is provided, comprising a Vibrio cholerae O1 cell, characterized in that said cell comprises O1 antigens of both Ogawa and lnaba serotypes. Genetically modified Vibrio cholerae O1 cells for use in such vaccines, DNA-constructs for the modification, uses for the vaccine and methods of making a vaccine are also provided.

3. 发明公开

EP2854822A4 POLYSACCHARIDE COMPOSITIONS AND METHODS OF USE 无效
标题翻译：多丽莎白葡萄酒VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP2854822A4
公开(公告)日：2015-12-02
申请号：EP13798089
申请日：2013-05-30
申请人： BRIGHAM & WOMENS HOSPITAL
发明人： PIER GERALD B , CYWES-BENTLEY COLETTE , SKURNIK DAVID
IPC分类号： A61K31/715 , A61P31/04 , A61P31/10 , G01N33/53 , G01N33/569
CPC分类号： A61K39/085 , A61K31/715 , A61K39/0002 , A61K39/002 , A61K39/015 , A61K39/0208 , A61K39/025 , A61K39/04 , A61K39/07 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/107 , A61K39/385 , A61K47/6415 , A61K47/646 , A61K2039/505 , A61K2039/572 , A61K2039/6031 , C07K16/12 , C07K16/14 , C07K16/20 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C08B37/0006 , G01N33/569 , G01N33/56938 , G01N2400/00 , G01N2469/10
摘要： The invention relates, in part, to the use of compositions of poly N-acetylated glucosamine (PNAG) and antibodies specific to PNAG in the prevention and treatment of infections by certain PNAG-positive pathogens and in detection (including diagnostic) methods.
摘要翻译：本发明部分涉及聚N-乙酰化葡糖胺（PNAG）组合物和PNAG特异性抗体在预防和治疗某些PNAG阳性病原体感染和检测（包括诊断）方法中的用途。

4. 发明公开

EP2771453A4 DIATOM-BASED VACCINES 审中-公开
标题翻译：硅藻为基础的疫苗
公开(公告)号：EP2771453A4
公开(公告)日：2015-07-08
申请号：EP12844478
申请日：2012-10-26
申请人： UNIV CALIFORNIA , SYNAPTIC RES LLC
发明人： DAVIS AUBREY , SCHRIER RACHEL , OYLER GEORGE A , ROSENBERG JULIAN N
IPC分类号： C12N1/13 , A61K39/106 , A61K39/112 , C12N15/62
CPC分类号： A61K39/295 , A61K36/06 , A61K39/00 , A61K39/102 , A61K39/107 , A61K2039/51 , A61K2039/517 , A61K2039/523 , A61K2039/541 , A61K2039/542 , A61K2039/57 , C12N1/12 , C12N7/00 , C12N15/79 , C12N2760/18534
摘要： This invention provides diatom-based vaccines.

5. 发明公开

EP2849780A1 FISH VACCINE 有权转让
标题翻译： FISCHIMPFSTOFF
公开(公告)号：EP2849780A1
公开(公告)日：2015-03-25
申请号：EP13728683.7
申请日：2013-05-14
申请人： Norges Miljø-Og Biovitenskapelige Universitet (NMBU)
发明人： SØRUM, Henning
IPC分类号： A61K39/02 , A61K39/116
CPC分类号： A61K39/0208 , A61K39/107 , A61K39/116 , A61K2039/521 , A61K2039/552 , A61K2039/70 , C07K16/1239
摘要： The present invention relates to novel compositions for medical use, particularly for use as vaccines. The present invention relies upon the dependence of the bacteria of the species
Alliivibrio
wodanis (formerly
Vibrio wodanis ) in the pathogenesis in the unrecognized, novel disease wodanosis (Norwegian: odinose), as well as in the chronic disease stages of winter ulcer in a composition together with
Moritella viscosa (
M.viscosa ). in addition, it is also related herein to a composition comprising inactivated bacteria of one or more culture(s) of the species
M. viscosa cultivated in physical contact with cells of
A. wodanis to improve the technical composition and protection of a vaccine against winter ulcer. The invention also relates to use of such vaccine compositions in prevention and/or treatment of wodanosis and winter ulcer, methods for the production of such vaccines, and to methods for preventing, controlling and combating
Alliivibno
wodanis infection and chronic winter ulcer in fish.
摘要翻译：本发明涉及用于医疗用途的新型组合物，特别是用作疫苗。本发明依赖于未鉴定的新型疾病万古霉素（挪威语：odinose）以及组合物中冬季溃疡的慢性疾病阶段中Alliivibrio wodanis（以前称为弧菌属）的细菌在发病机理中的依赖性与粘杆菌（M. viscosa）一起。此外，在本文中还涉及包含与A.wodanis细胞物理接触培养的M.midosa种的一种或多种培养物的灭活细菌的组合物，以改善疫苗对冬季的技术组成和保护溃疡。本发明还涉及这样的疫苗组合物在预防和/或治疗牙垢病和冬季溃疡中的用途，用于生产这种疫苗的方法，以及用于预防，控制和防治鱼类中的Alliivibno wodanis感染和慢性冬季溃疡的方法。

6. 发明公开

EP2659912A3 Conjugate purification 审中-公开
标题翻译： Konjugatreinigung
公开(公告)号：EP2659912A3
公开(公告)日：2013-12-04
申请号：EP13164183.9
申请日：2008-07-17
申请人： Novartis AG
发明人： BIGIO, Massimo , AVERANI, Giovanni , NORELLI, Francesco , BERTI, Francesco , BELLUCCI, Cinzia
IPC分类号： A61K47/48 , A61P31/04 , A61K39/09 , B01D15/38 , B01J20/04 , C07K1/16
CPC分类号： A61K47/48261 , A61K39/0275 , A61K39/085 , A61K39/092 , A61K39/095 , A61K39/104 , A61K39/107 , A61K47/64 , A61K47/6415 , A61K47/642 , A61K47/646 , A61K2039/6037 , B01D15/3847 , B01J20/048 , C07K1/165 , Y02A50/484
摘要： This application relates to methods for the purification of saccharide antigen-carrier protein conjugates. In particular, the invention provides a method for purifying saccharide antigen-carrier protein conjugates from free carrier protein, such as CRM197, using hydroxyapatite. The invention further relates to methods of preparing vaccines, using this method.

7. 发明公开

EP2421529A2 SIDEROPHORE CONJUGATE IMMUNOGENIC COMPOSITIONS AND VACCINES 审中-公开
标题翻译： ON SIDEROPHORKONJUGAT基于免疫原性组合物和疫苗
公开(公告)号：EP2421529A2
公开(公告)日：2012-02-29
申请号：EP10767606.6
申请日：2010-04-20
申请人： University of Florida Research Foundation, Inc.
发明人： BERGERON, Raymond, J.
IPC分类号： A61K31/42 , A61K31/40 , A61K39/395 , A61K9/16 , A61K9/14 , A61P7/00 , A61P3/00
CPC分类号： A61K47/48276 , A61K39/107 , A61K39/385 , A61K47/6425 , A61K47/643 , A61K47/646 , A61K2039/6031 , A61K2039/6068 , A61K2039/6081 , C07K16/1239 , Y02A50/472
摘要： An immunogenic composition comprising a siderophore covalently linked to a pharmaceutically acceptable carrier molecule wherein the antigenicity of the siderophore moiety is sufficient to stimulate an immunologic response to the siderophore when the composition is circulating in the bloodstream of a human or non-human animal and vaccine.

8. 发明公开

EP1696953A1 RECOMBINANT VIBRIO CHOLERAE STRAIN AND VACCINE COMPRISING SAID STRAIN 有权
标题翻译：重组霍乱弧菌躯干和疫苗，这些STEM CONTAINS
公开(公告)号：EP1696953A1
公开(公告)日：2006-09-06
申请号：EP04820442.4
申请日：2004-12-17
申请人： Berna Biotech AG
发明人： FAVRE, Didier , DIETRICH, Guido , VIRET, Jean, François
IPC分类号： A61K39/108 , C12N1/21
CPC分类号： C07K14/245 , A61K39/0258 , A61K39/107 , A61K2039/523 , Y02A50/472 , Y02A50/474
摘要： The present invention relates to a recombinant Vibrio cholerae strain, a vaccine comprising said strain, the use of said strain, and methods for its production. The recombinant strain according to the invention is comprising DNA sequences coding for at least the ETEC pili CFA/I, CS3 and CS6, wherein the DNA sequences are operationally linked to one or more promoters. The strain of the invention may be used in a vaccine composition for immunization against ETEC and/or cholera. The present invention further relates to methods for enhancing the surface expression of ETEC pili in a V. cholerae strain.

9. 发明公开

EP1650315A1 Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof 有权
标题翻译： Vibrio CholeraStämmeVCUSM1和VCUSM4，Verfahren zu dessen Herstellung und Impstoffderivate davon
公开(公告)号：EP1650315A1
公开(公告)日：2006-04-26
申请号：EP04025319.7
申请日：2004-10-25
申请人： UNIVERSITI SAINS MALAYSIA
发明人： Ravichandran, Manickam, Dr. , Ali, Syed Atif , Rashid, Nur Haslindawaty Abdul , Pattabiraman, Lalitha , Zainuddin, Zainul Fadziruddin
IPC分类号： C12R1/63 , A61K39/106
CPC分类号： C12R1/63 , A61K39/107 , Y02A50/472
摘要： Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained from a parent strain originally isolated from a patient's coproculture having all the identifying characteristics of Vibrio cholerae 0139 synonym Bengal is described. In this strain the hem A gene is mutated by inserting a kanamycin resistant gene cassette. Another metabolic auxotroph of Vibrio cholerae 01 E1 Tor where the hem A gene is mutated by a frame shift mutation is disclosed. Methods of producing the strains are disclosed.
摘要翻译：霍乱弧菌的代谢营养缺陷型0139同义词孟加拉，其在其下摆A基因中具有突变，并且不能从头合成氨基乙酰丙酸（ALA），从最初从具有所有鉴定特征的患者的共培养物中分离的亲本菌株获得 Vibrio cholerae 0139同义词孟加拉描述。在该菌株中，通过插入卡那霉素抗性基因盒突变下摆A基因。公开了通过帧移位突变突变的下摆A基因的霍乱弧菌01E1T2的另一代谢营养缺陷型。公开了生产菌株的方法。

10. 发明公开

EP1614426A1 ATTENUATED STRAINS OF VIBRIO CHOLERAE AND LYOPHILISED VACCINES CONTAINING SAME 有权
标题翻译： DIGESCHWÄCHTESTÄMMEVON VIBRIO CHOLERAE UND DIEE ENTHALTENDE LYOPHILISIERTE VAKZINE
公开(公告)号：EP1614426A1
公开(公告)日：2006-01-11
申请号：EP04712469.8
申请日：2004-02-19
申请人： Centro Nacional De Investigaciones Cientificas (CNIC)
发明人： CAMPOS GOMEZ, Javier , MOREIRA HERNANDEZ, Tomás Marcelino , RODRIGUEZ GONZALEZ, Boris Luis , MARRERO DOMINGUEZ, Karen , MARTINEZ GUTIERREZ, Eriel , LEDON PEREZ, Talena Yamilé , SILVA LARRANAGA, Yussuan , SUZARTE PORTAL, Edith , DELGADO RODR GUEZ, Herminia de la Caridad , URRA VILLAVICENCIO, Caridad , FANDO CALZADA, Rafael Alfredo
IPC分类号： A61K39/106 , C12N7/00 , C07K14/28 , A61P37/04
CPC分类号： C07K14/28 , A61K39/107 , A61K2039/522 , C12N9/52 , Y02A50/472
摘要： The present invention discloses new live attenuated strains for oral immunization against cholera that are provided in freeze dried formulations for long term storage and administration to humans. These strains combine the two most important properties of live attenuated cholera vaccine candidates. One such property is being well tolerated by people ingesting them. This was achieved by virtue of mutations already described in the art. The second property is having enhanced environmental safety due to the absence of VGJΦ DNA in their genomes and also due to null mutations in the mshA gene or other spontaneous mutations conducive to the lack of MSHA type IV fimbria on the bacterial surface. This was done envisioning that VGJΦ is a filamentous phage able to recombine with CTXΦ and disseminate the cholera toxin genes. This VGJΦ phage as well as the VGJΦ-CTXΦ recombinants uses the MSHA fibers as receptor. Being devoid of MSHA fimbria the vaccine candidates are protected from acquiring CTXΦ from the recombinant hybrid VGJΦ-CTXΦ. Being devoid of VGJΦ, the vaccine candidates are impaired in the dissemination of CTXΦ, via VGJΦ.
摘要翻译：本发明公开了用于长期储存和给予人的冷冻干燥制剂中提供的针对霍乱的口服免疫的新的减毒菌株。这些菌株结合了活的减毒霍乱疫苗候选者的两个最重要的性质。一个这样的财产被人们摄取的容忍性很好。这是通过本领域已经描述的突变来实现的。由于在其基因组中不存在VGJ？DNA，并且由于mshA基因中的无效突变或其他有助于在细菌表面缺乏MSHA IV型毛霉素的其他自发突变，第二种物质具有增强的环境安全性。这是想象VGJ是一种能够与CTX®重组并扩散霍乱毒素基因的丝状噬菌体。该VGJ？噬菌体以及VGJ|-CTX？重组体使用MSHA纤维作为受体。没有MSHA fimbria，疫苗候选者被保护不从重组杂交体VGJ|-CTX中获得CTX。由于没有VGJ，疫苗候选人在通过VGJ的传播CTX®方面受损。

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