发明公开
EP1650315A1 Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof
有权
基本信息:
- 专利标题： Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof
- 专利标题（中）：Vibrio CholeraStämmeVCUSM1和VCUSM4，Verfahren zu dessen Herstellung und Impstoffderivate davon
- 申请号：EP04025319.7 申请日：2004-10-25
- 公开(公告)号：EP1650315A1 公开(公告)日：2006-04-26
- 发明人： Ravichandran, Manickam, Dr. , Ali, Syed Atif , Rashid, Nur Haslindawaty Abdul , Pattabiraman, Lalitha , Zainuddin, Zainul Fadziruddin
- 申请人： UNIVERSITI SAINS MALAYSIA
- 申请人地址： 11800 Pulau Pinang, USM MY
- 专利权人： UNIVERSITI SAINS MALAYSIA
- 当前专利权人： UNIVERSITI SAINS MALAYSIA
- 当前专利权人地址： 11800 Pulau Pinang, USM MY
- 代理机构： Krauss, Jan
- 主分类号： C12R1/63
- IPC分类号： C12R1/63 ; A61K39/106
摘要：
Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained from a parent strain originally isolated from a patient's coproculture having all the identifying characteristics of Vibrio cholerae 0139 synonym Bengal is described. In this strain the hem A gene is mutated by inserting a kanamycin resistant gene cassette. Another metabolic auxotroph of Vibrio cholerae 01 E1 Tor where the hem A gene is mutated by a frame shift mutation is disclosed. Methods of producing the strains are disclosed.
摘要（中）：
霍乱弧菌的代谢营养缺陷型0139同义词孟加拉，其在其下摆A基因中具有突变，并且不能从头合成氨基乙酰丙酸（ALA），从最初从具有所有鉴定特征的患者的共培养物中分离的亲本菌株获得 Vibrio cholerae 0139同义词孟加拉描述。 在该菌株中，通过插入卡那霉素抗性基因盒突变下摆A基因。 公开了通过帧移位突变突变的下摆A基因的霍乱弧菌01E1T2的另一代谢营养缺陷型。 公开了生产菌株的方法。