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1. 发明公开

EP0681431A1 PRODUCTION OF HUMAN RECOMBINANT COLLAGEN IN THE MILK OF TRANSGENIC ANIMALS 失效
标题翻译：人重组胶原蛋白的转基因-PET的牛奶产量。
公开(公告)号：EP0681431A1
公开(公告)日：1995-11-15
申请号：EP94906698.0
申请日：1994-01-19
申请人： COLLAGEN CORPORATION
发明人： BERG, Richard A.
IPC分类号： A01K67 , A23C9 , A23J1 , A23J3 , C07H21 , C07K14 , C12N5 , C12N15 , C12P21
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/01 , A23C9/20 , A23C2230/05 , A23J1/20 , A23J3/06 , C07K14/78 , Y10S119/01 , Y10S514/801 , Y10S530/832
摘要： Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mamals. For example, expression systems can be microinjected into fertilized oocytes and reimplanted in foster mothers and carried to term in order to obtain transgenic non-human mammals capable of producing milk containing recombinant human procollagen or collagen. Human procollagen or collagen produced in this manner can be made of a single collagen type uncontaminated by other human or non-human collagens.

2. 发明授权

EP1330552B1 MARKER ASSISTED SELECTION OF BOVINE FOR IMPROVED MILK PRODUCTION USING DIACYLGLYCEROL ACYLTRANSFERASE GENE DGAT1 无效
标题翻译：标记辅助选择改良牛牛奶生产使用甘油二酯酰基转移酶基因DGAT1
公开(公告)号：EP1330552B1
公开(公告)日：2007-01-24
申请号：EP01992795.3
申请日：2001-10-31
申请人： Georges, Michel Alphonse Julien , Coppieters, Wouter Herman Robert , Grisart, Bernard Marie-Josee Jean , Snell, Russell Grant , Reid, Suzanne Jean , Ford, Christine Ann , Spelman, Richard John
发明人： Georges, Michel Alphonse Julien , Coppieters, Wouter Herman Robert , Grisart, Bernard Marie-Josee Jean , Snell, Russell Grant , Reid, Suzanne Jean , Ford, Christine Ann , Spelman, Richard John
IPC分类号： C12N15/54 , C12N15/11 , C12N15/63 , C12N15/90 , C12N9/10 , C12N1/21 , C12N5/10 , C07K16/40 , C12Q1/68 , A01K67/027
CPC分类号： C12Q1/6876 , A01K2217/05 , A01K2217/075 , A01K2227/101 , A01K2267/02 , A23C2230/05 , C12N9/1029 , C12N15/8509 , C12N2800/204 , C12N2840/20 , C12Q2600/124 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides a method of genotyping bovine for improved milk production traits by determining the DGAT1 genotypic state of said bovine, wherein the DGAT1 gene and polymorphisms within said gene have been found to be associated with such improved milk production traits.

3. 发明授权

EP0845939B1 LYSOSOMAL PROTEINS PRODUCED IN THE MILK OF NONHUMAN TRANSGENIC ANIMALS 失效
标题翻译：溶酶体蛋白产生了牛奶非人类转基因动物
公开(公告)号：EP0845939B1
公开(公告)日：2003-05-21
申请号：EP96928405.8
申请日：1996-07-31
申请人： Pharming Intellectual Property BV , Erasmus Universiteit Rotterdam , Academic Hospital Rotterdam
发明人： REUSER, Arnold, J., J. , VAN DER PLOEG, Ans, T. , PIEPER, Frank, R. , VERBEET, Martin, Ph.
IPC分类号： A01K67/027 , A61K38/43 , A23C23/00 , C12N9/24 , C12N15/12
CPC分类号： A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/10 , A01K2227/105 , A01K2227/107 , A01K2267/01 , A23C9/20 , A23C2230/05 , A23C2230/15 , A61K38/47 , C07K14/4732 , C07K2319/00 , C07K2319/02 , C12N9/2408 , C12N15/85 , C12N15/8509 , C12N2830/008 , C12N2830/85 , C12Y302/0102 , Y10S119/01
摘要： The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.

4. 发明公开

EP0845939A2 LYSOSOMAL PROTEINS PRODUCED IN THE MILK OF TRANSGENIC ANIMALS 失效
标题翻译：溶酶体蛋白生产转基因动物的乳汁
公开(公告)号：EP0845939A2
公开(公告)日：1998-06-10
申请号：EP96928405.0
申请日：1996-07-31
申请人： PHARMING B.V. , Erasmus Universiteit Rotterdam , Academic Hospital Rotterdam
发明人： REUSER, Arnold, J., J. , VAN DER PLOEG, Ans, T. , PIEPER, Frank, R. , VERBEET, Martin, Ph.
IPC分类号： A01K67 , A23C9 , A23C23 , A61K31 , A61K35 , A61K38 , A61P43 , C12N9 , C12N15
CPC分类号： A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/10 , A01K2227/105 , A01K2227/107 , A01K2267/01 , A23C9/20 , A23C2230/05 , A23C2230/15 , A61K38/47 , C07K14/4732 , C07K2319/00 , C07K2319/02 , C12N9/2408 , C12N15/85 , C12N15/8509 , C12N2830/008 , C12N2830/85 , C12Y302/0102 , Y10S119/01
摘要： The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.

5. 发明公开

EP0681431A4 PRODUCTION OF HUMAN RECOMBINANT COLLAGEN IN THE MILK OF TRANSGENIC ANIMALS. 失效
标题翻译：人重组胶原蛋白的转基因-PET的牛奶产量。
公开(公告)号：EP0681431A4
公开(公告)日：1997-02-26
申请号：EP94906698
申请日：1994-01-19
申请人： COLLAGEN CORP
发明人： BERG RICHARD A
IPC分类号： A01K67/027 , A23C9/152 , A23C9/20 , A23J1/00 , A23J1/20 , A23J3/06 , C07H21/04 , C07K14/78 , C12N5/10 , C12N15/09 , C12N15/85 , C12P21/02 , A23C9/00 , C07H15/00 , C07K1/00 , C07K14/00 , C07K17/00 , C12N5/00 , C12N15/00 , C12P21/06 , C07K15/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/01 , A23C9/20 , A23C2230/05 , A23J1/20 , A23J3/06 , C07K14/78 , Y10S119/01 , Y10S514/801 , Y10S530/832
摘要： Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mamals. For example, expression systems can be microinjected into fertilized oocytes and reimplanted in foster mothers and carried to term in order to obtain transgenic non-human mammals capable of producing milk containing recombinant human procollagen or collagen. Human procollagen or collagen produced in this manner can be made of a single collagen type uncontaminated by other human or non-human collagens.

6. 发明授权

EP1252184B1 HUMAN C1 INHIBITOR PRODUCED IN THE MILK OF TRANSGENIC MAMMALS 有权
标题翻译： HUMAN C1抑制剂MADE IN转基因哺乳动物的乳中
公开(公告)号：EP1252184B1
公开(公告)日：2008-01-02
申请号：EP01906428.6
申请日：2001-01-31
申请人： Pharming Intellectual Property B.V.
发明人： NUIJENS, Johannes, Henricus , VAN VEEN, Henricus, Antonius , PIEPER, Frank, R. , HEUS, Joris, Jan
IPC分类号： C07K14/47
CPC分类号： C07K14/8121 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2227/107 , A01K2267/01 , A23C2230/05 , A61K38/00 , C12N15/8509
摘要： The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring immunosuppression.

7. 发明公开

EP1330552A1 MARKER ASSISTED SELECTION OF BOVINE FOR IMPROVED MILK PRODUCTION USING DIACYLGLYCEROL ACYLTRANSFERASE GENE DGAT1 无效
标题翻译：标记辅助选择改良牛牛奶生产使用甘油二酯酰基转移酶基因DGAT1
公开(公告)号：EP1330552A1
公开(公告)日：2003-07-30
申请号：EP01992795.3
申请日：2001-10-31
申请人： Georges, Michel Alphonse Julien , Coppieters, Wouter Herman Robert , Grisart, Bernard Marie-Josee Jean , Snell, Russell Grant , Reid, Suzanne Jean , Ford, Christine Ann
发明人： Georges, Michel Alphonse Julien , Coppieters, Wouter Herman Robert , Grisart, Bernard Marie-Josee Jean , Snell, Russell Grant , Reid, Suzanne Jean , Ford, Christine Ann
IPC分类号： C12Q1/68 , C12N15/12 , A01K67/027 , C07K16/40
CPC分类号： C12Q1/6876 , A01K2217/05 , A01K2217/075 , A01K2227/101 , A01K2267/02 , A23C2230/05 , C12N9/1029 , C12N15/8509 , C12N2800/204 , C12N2840/20 , C12Q2600/124 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides a method of genotyping bovine for improved milk production traits by determining the DGAT1 genotypic state of said bovine, wherein the DGAT1 gene and polymorphisms within said gene have been found to be associated with such improved milk production traits.

8. 发明公开

EP0832981A1 DNA sequences to target proteins to the mammary gland for efficient secretion 失效
标题翻译： DNA-Sequenzen die蛋白质zwecks effizienter Abscheidung zurMilchdrüseleiten
公开(公告)号：EP0832981A1
公开(公告)日：1998-04-01
申请号：EP97203192.6
申请日：1988-02-10
申请人： Pharming B.V.
发明人： Rosen, Jeffrey M.
IPC分类号： C12N15/85 , A01K67/027
CPC分类号： A01K67/0275 , A01K67/02 , A01K2217/05 , A01K2217/20 , A01K2227/10 , A01K2227/105 , A01K2227/108 , A01K2267/01 , A23C9/20 , A23C2230/05 , C07K14/4732 , C07K2319/00 , C07K2319/02 , C07K2319/61 , C12N9/1033 , C12N15/85 , C12N15/8509 , C12N15/89 , C12N2830/008 , C12N2830/42 , C12N2830/85
摘要： The invention provides the use of an enhancer sequence in effecting targeted mammary gland expression in a transgenic non-human mammal of a coding sequence derived from a gene coding for a biologically active agent, said enhancer sequence being employed, together with said coding sequence, in the form of a recombinant DNA gene complex incorporated into the germ line of said mammal.
摘要翻译：本发明提供增强子序列用于在转基因非人哺乳动物中实现来自编码生物活性剂的基因的编码序列的靶向乳腺表达的用途，所述增强子序列与所述编码序列一起被用于结合到所述哺乳动物的种系中的重组DNA基因复合物的形式。

9. 发明公开

EP0699752A2 Mutated recombinant collagens 失效
标题翻译：多克隆重组体Kollagen
公开(公告)号：EP0699752A2
公开(公告)日：1996-03-06
申请号：EP95108307.0
申请日：1995-05-30
申请人： COLLAGEN CORPORATION
发明人： Berg, Richard A. , Toman, Paul David , Wallace, Donald G.
IPC分类号： C12N15/12 , C07K14/78 , C12N5/10 , A61K38/39
CPC分类号： A23C9/20 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/01 , A23C2230/05 , A23J1/20 , A23J3/06 , A61K38/00 , C07K14/78 , C12N15/8509
摘要： The invention provides recombinant procollagen chains having a natural collagen chain separated from one or two propeptides by one or two non-natural site-specific proteolytic agent ( e . g ., protease) recognition sites. A wide variety of propeptides and site-specific proteolytic agent recognition sites may be used: the selection of particular site-specific proteolytic agent/recognition site pairs is based on the conformation of the resulting procollagen, the availability of the site-specific proteolytic agent, the compatibility of the proteolysis with production of mature collagen, among other factors. Recombinant collagens chains are produced by contacting the subject recombinant procollagen chains with the appropriate site-specific proteolytic agents. Nucleic acids encoding the subject procollagen chains operably linked to transcription regulatory elements are used in vectors and cells for the production of recombinant collagen. Such collagen is used in tissue and cell cultureware and therapeutically, such as in biodegradable surgical materials and for tissue augmentation.
摘要翻译：本发明提供具有通过一个或两个非天然位点特异性蛋白水解剂（例如蛋白酶）识别位点从一个或两个前肽分离的天然胶原链的重组前胶原链。可以使用多种前肽和位点特异性蛋白水解剂识别位点：特定位点特异性蛋白水解物/识别位点对的选择基于所得原胶原的构象，位点特异性蛋白水解剂的可用性，蛋白水解与成熟胶原蛋白的相容性等因素。通过使本发明的重组原胶原链与适当的位点特异性蛋白水解剂接触来产生重组胶原链。编码与转录调节元件可操作连接的对象前胶原链的核酸用于生产重组胶原的载体和细胞中。这种胶原蛋白被用于组织和细胞培养物质中，并且在治疗上使用，例如可生物降解的手术材料和组织增强。

10. 发明授权

EP0681431B1 PRODUCTION OF HUMAN RECOMBINANT COLLAGEN IN THE MILK OF TRANSGENIC ANIMALS 失效
标题翻译：重组人胶原蛋白的转基因，兽产奶
公开(公告)号：EP0681431B1
公开(公告)日：2005-07-13
申请号：EP94906698.9
申请日：1994-01-19
申请人： COLLAGEN CORPORATION
发明人： BERG, Richard A.
IPC分类号： C12N15/00 , C07H15/00 , C07K1/00 , C07K17/00 , C12N5/10 , A01K67/027 , A23J1/20 , A23C9/20 , C07K14/78 , A23J3/06
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/01 , A23C9/20 , A23C2230/05 , A23J1/20 , A23J3/06 , C07K14/78 , Y10S119/01 , Y10S514/801 , Y10S530/832
摘要： Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mamals. For example, expression systems can be microinjected into fertilized oocytes and reimplanted in foster mothers and carried to term in order to obtain transgenic non-human mammals capable of producing milk containing recombinant human procollagen or collagen. Human procollagen or collagen produced in this manner can be made of a single collagen type uncontaminated by other human or non-human collagens.

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