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1. 发明授权

EP2832743B1 HIGH-PURITY CYCLOPEPTIDE CRYSTAL AS WELL AS PREPARATION METHOD AND USE THEREOF 有权
公开(公告)号：EP2832743B1
公开(公告)日：2018-07-18
申请号：EP13767887.6
申请日：2013-03-29
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd
发明人： LIU, Shidong , ZHANG, Zhaoli , WANG, Xiusheng , ZHANG, Xiao , TANG, Zhijun , JI, Xiaoming
IPC分类号： C07K7/56 , C07K1/14 , A61K38/12 , A61P31/10
CPC分类号： C07K7/56 , A61K38/00
摘要： A high purity cyclopeptide crystal has a structure shown by Formula I. R represents H or a cation forming a pharmaceutically acceptable salt. Also disclosed are a preparation method and a use of the high-purity cyclopeptide crystal.

2. 发明公开

EP2803657A1 CRYSTAL FORM OF PROSTAGLANDIN ANALOGUE, AND PREPARATION METHOD AND USE THEREOF 有权
标题翻译： KRISTALLFORM VON PROSTAGLANDINANALOGA SOWIE HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNG DAVON
公开(公告)号：EP2803657A1
公开(公告)日：2014-11-19
申请号：EP13736169.7
申请日：2013-01-10
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd
发明人： TANG, Zhijun , LIU, Yubin , HE, Bingming , YANG, Jun , JI, Xiaoming
IPC分类号： C07C59/72 , C07C51/43 , A61K31/5575 , A61K31/192 , A61P9/12 , A61P9/00
CPC分类号： C07C59/72 , C07C51/43 , C07C2603/14
摘要： Provided are a crystal form A of a compound having the structure as represented by formula I, and preparation method and use thereof. The X-ray powder diffraction (XRPD) chart of the crystal form A has characteristic peaks at the following diffraction angles: 2.9±0.2°, 13.6±0.2°, 17.3±0.2° and 18.6±0.2°.
摘要翻译：提供具有式I所示结构的化合物的结晶形式A及其制备方法和用途。晶体形式A的X射线粉末衍射图（XRPD）在以下衍射角具有特征峰：2.9±0.2°，13.6±0.2°，17.3±0.2°和18.6±0.2°。

3. 发明公开

EP2623511A1 PROCESS FOR PURIFYING CYCLIC LIPOPEPTIDE COMPOUNDS OR SALTS THEREOF 有权
标题翻译： VERFAHREN ZUR REINIGUNG VON ZYKLISCHEN LIPOPEPTIDVERBINDUNGEN ODER SALZEN DAVON
公开(公告)号：EP2623511A1
公开(公告)日：2013-08-07
申请号：EP11828114.6
申请日：2011-09-27
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd
发明人： ZHANG, Zhaoli , LIU, Shidong , ZHUO, Zhonghao , JI, Xiaoming
IPC分类号： C07K1/14 , C07K7/56
CPC分类号： C07K1/22 , C07K7/56
摘要： A process for purifying cyclic lipopeptide compounds or salts thereof comprising the steps of: (1) charging a crude compound of Formula I onto a macroporous adsorption resin; (2) washing the macroporous adsorption resin using water, an organic solvent or a mixed solution of an organic solvent and water as a washing liquid; and (3) eluting the compound of Formula I from the macroporous adsorption resin using water, an organic solvent or a mixed solution of an organic solvent and water as an eluent. The purification method has the advantages of using a small amount of organic solvents, using no silica gel, and causing little damage to the environment; the purity of the collected compound of formula I is also improved as compared with the methods previously disclosed.
摘要翻译：一种用于纯化环状脂肽化合物或其盐的方法，包括以下步骤：（1）将式I的粗制化合物装入大孔吸附树脂中; （2）使用水，有机溶剂或有机溶剂和水的混合溶液作为洗涤液洗涤大孔吸附树脂; 和（3）使用水，有机溶剂或有机溶剂和水的混合溶液作为洗脱剂，从大孔吸附树脂中洗脱式I化合物。净化方法的优点是使用少量的有机溶剂，不使用硅胶，对环境几乎没有损害; 与以前公开的方法相比，所收集的式I化合物的纯度也得到改善。

4. 发明授权

EP1642964B1 THE MICROORGANISM AND THE PROCESS FOR PREPARATION OF PRAVASTATIN 有权
标题翻译：微生物及其制备普伐他汀方法
公开(公告)号：EP1642964B1
公开(公告)日：2009-01-14
申请号：EP04738297.3
申请日：2004-06-28
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd.
发明人： MEI, Minquan , JI, Xiaoming , GAO, Xiaoliang , CHEN, Yi , XU, JIng , LI, Yan , ZHUO, Zhonghao , YAO, Yong
IPC分类号： C12N1/20 , C12P7/42 , C12P17/06
CPC分类号： C12P7/42 , C12P17/06 , C12R1/01 , C12R1/365
摘要： The present invention related to the microorganism for producing pravastatin and the process for producing pravastatin using the microorganism. The Micropolyspora roseoalba CGMCC 0624 of the present invention has a stronger tolerance to Mevastatin, has also a strong transformation activity and has low production cost.

5. 发明公开

EP1642964A1 THE MICROORGANISM AND THE PROCESS FOR PREPARATION OF PRAVASTATIN 有权
标题翻译：维多利亚州立大学维多利亚州
公开(公告)号：EP1642964A1
公开(公告)日：2006-04-05
申请号：EP04738297.3
申请日：2004-06-28
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd.
发明人： MEI, Minquan , JI, Xiaoming , GAO, Xiaoliang , ZHENG, Fusang , CHEN, Yi , XU, JIng
IPC分类号： C12N1/20 , C12P7/42
CPC分类号： C12P7/42 , C12P17/06 , C12R1/01 , C12R1/365
摘要： The invention provides a novel microorganism producing pravastatin sodium, as well as the method for producing pravastatin sodium by using this microorganism. Micropolyspora roseoalba CGMCC 0624 of the invention is highly tolerant to mevastatin sodium, and has a high transformation rate of mevastatin sodium, and can produce pravastatin sodium with a high efficiency and low cost.
摘要翻译：本发明提供了一种生产普伐他汀钠的新型微生物，以及通过使用该微生物生产普伐他汀钠的方法。本发明的微孢子虫CGMCC 0624对美伐他汀钠具有高度耐受性，并具有高的美伐他汀钠转化率，能以高效率和低成本生产普伐他汀钠。

6. 发明授权

EP3150622B1 CRYSTALLINE POWDER OF CYCLIC PEPTIDE COMPOUND, PREPARATION METHOD FOR SAME, AND USES THEREOF 有权
公开(公告)号：EP3150622B1
公开(公告)日：2019-04-24
申请号：EP15799703.2
申请日：2015-05-29
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd
发明人： LIU, Shidong , WANG, Xiusheng , TANG, Zhijun , JI, Xiaoming
IPC分类号： C07K7/56 , C07K1/02 , A61K38/12 , A61P31/10

7. 发明授权

EP2848685B1 IMMOBILIZED CYCLOALIPHATIC PEPTIDE ACYLTRANSFERASE AND PREPARATION METHOD AND USES THEREOF 有权
公开(公告)号：EP2848685B1
公开(公告)日：2018-12-26
申请号：EP13788659.4
申请日：2013-05-10
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd
发明人： LIU, Shidong , ZHANG, Zhaoli , JI, Xiaoming
IPC分类号： C12N11/00 , C12N11/14 , C12N9/80 , C12P21/04 , C07K7/56 , C12P21/02 , C12N11/08
CPC分类号： C12N11/14 , C07K7/56 , C12N9/80 , C12N9/86 , C12N11/08 , C12P21/02
摘要： Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic acyltransferase gene and transforming thereafter; the material of the carrier is selected from an inorganic carrier or a polypropylene resin carrier. Also disclosed in the present invention are the preparation method for the immobilized cycloaliphatic peptide acyltransferase and uses thereof.

8. 发明公开

EP3239165A1 COMPOSITION CONTAINING NITROGEN HETEROCYCLIC HEXAPEPTIDE PRECURSOR AND PREPARATION METHOD AND APPLICATION THEREOF 审中-公开
标题翻译：含有氮杂环六肽前体的组合物及其制备方法和应用
公开(公告)号：EP3239165A1
公开(公告)日：2017-11-01
申请号：EP15871972.4
申请日：2015-12-24
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd
发明人： LIU, Shidong , WANG, Xiusheng , JI, Xiaoming
IPC分类号： C07K1/30 , C07K7/56
CPC分类号： C07K1/30 , A61K38/12 , A61K47/10 , A61K47/18 , C07D487/14 , C07K1/34 , C07K7/56
摘要： Disclosed is a preparation method of a composition containing a nitrogen heterocyclic hexapeptide precursor, composition A and B containing a nitrogen heterocyclic hexapeptide precursor of a compound having formula I and formula II obtained by the method, and an application of the composition used for preparing a compound having formula III.
摘要翻译：本发明公开了含有氮杂环六肽前体的组合物的制备方法，含有通过该方法获得的式I和式II化合物的氮杂环六肽前体的组合物A和B，以及用于制备化合物具有公式III。

9. 发明授权

EP2803657B1 CRYSTAL FORM OF PROSTAGLANDIN ANALOGUE, AND PREPARATION METHOD AND USE THEREOF 有权
标题翻译：前列腺素类似物的晶体形式及其制备方法和用途
公开(公告)号：EP2803657B1
公开(公告)日：2017-09-13
申请号：EP13736169.7
申请日：2013-01-10
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd
发明人： TANG, Zhijun , LIU, Yubin , HE, Bingming , YANG, Jun , JI, Xiaoming
IPC分类号： C07C59/72 , C07C51/43 , A61K31/5575 , A61K31/192 , A61P9/12 , A61P9/00
CPC分类号： C07C59/72 , C07C51/43 , C07C2603/14

10. 发明公开

EP3150623A1 SOLVATE OF CYCLIC PEPTIDE COMPOUND, PREPARATION METHOD FOR SAME, AND USES THEREOF 有权
标题翻译： SOLVAT EINER CYCLISCHEN PEPTIDVERBINDUNG，HERSTELLUNGSVERFAHREN UND VERWENDUNGEN DAVON
公开(公告)号：EP3150623A1
公开(公告)日：2017-04-05
申请号：EP15800267.5
申请日：2015-05-29
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd
发明人： LIU, Shidong , WANG, Xiusheng , JI, Xiaoming
IPC分类号： C07K7/56 , C07K1/02 , A61K38/12 , A61P31/10
CPC分类号： C07K7/56 , A61K38/00 , A61K38/12 , C07K1/02 , C07K1/306
摘要： Provided in the invention is a solvate of a cyclic peptide compound, represented byformula I is the structural formula of the cyclic peptide compound, and, also disclosed are a preparation method for same and uses thereof.
摘要翻译：本发明提供环状肽化合物的溶剂化物，由式I表示，是环状肽化合物的结构式，并且还公开了其与其用途的制备方法和用途。

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