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1. 发明授权

EP2087836B1 Apparatus and method for determining a physiological parameter 有权
标题翻译：装置和方法用于确定生理参数
公开(公告)号：EP2087836B1
公开(公告)日：2012-04-04
申请号：EP08101369.0
申请日：2008-02-07
申请人： Pulsion Medical Systems AG
发明人： Dr. Joeken, Stephan
IPC分类号： A61B5/021 , A61B5/029
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/0215 , A61B5/024 , A61B5/029 , A61B5/7257 , G06F19/00
摘要： An apparatus for determining a physiological parameter of a patient, such as cardiac output, comprises a pressure sensor device providing readings of an arterial blood pressure, memory means storing said readings as a pressure curve over time, evaluation means determining a mean arterial blood pressure from the pressure curve and determining the physiological parameter using the mean arterial blood pressure is provided. The evaluation means determine a spectral density of said pressure curve and/or a variance of said arterial blood pressure. The evaluation means also determine at least one model parameter representing an effective value of a heart beat using the mean arterial blood pressure and said spectral density and/or variance. The effective value is selected from an effective amplitude of the heart beat, an effective duration of the heart beat and an effective area under the heart beat. The physiological parameter is determined using at least one of the model parameters.

2. 发明授权

EP2062528B1 Central venous sensor assembly for measuring physiological data for cardiac output determination and method of determining cardiac output 有权
标题翻译：中央静脉传感器组件，用于测量用于确定心输出量的生理数据，以及方法，用于确定心脏输出量
公开(公告)号：EP2062528B1
公开(公告)日：2012-03-14
申请号：EP07121386.2
申请日：2007-11-23
申请人： Pulsion Medical Systems AG
发明人： Goedje, Oliver, Dr. , Joeken, Stephan, Dr. , Scheier, Jörg, Dr. , Veeck, Marcus
IPC分类号： A61B5/027 , A61B5/028 , G01F1/68
CPC分类号： A61B5/028 , A61B5/02028 , A61B5/6852 , G01F1/7044 , G01F1/7084 , G01F15/0755 , G06F19/00
摘要： The central venous sensor assembly (1) comprises a catheter body (2) with several proximal ports (3a, 3b, 3c, 3d). The catheter portion placed in the vena cava superior (4) is equipped with a proximal flux measurement unit (6), and the catheter portion placed in the vena cava inferior (5) is equipped with a distal flux measurement unit (7). A first input channel (8) supplies a measurement signal indicative of a flux vp to the evaluation unit (10) from which the latter calculates a blood flow in the vena cava superior (4). Likewise, a second input channel (9) supplies a measurement signal indicative of a flux vd to the evaluation unit (10) from which the latter calculates a blood flow rate in the vena cava inferior (5). Due to continuity, the sum of the flow rates in the upper and lower central veins (4, 5) corresponds to the flow rate through the right heart (11) and in the pulmonary artery (12) and thus to cardiac output.

3. 发明公开

EP2394144A1 VORRICHTUNG UND VERFAHREN ZUR KONTINUIERLICHEN MESSUNG DER FLUSSGESCHWINDIGKEIT UND DER GESAMTMENGE EINER FLÜSSIGKEIT, INSBESONDERE DES URINS 审中-公开
标题翻译：设备和方法，连续地测定特别是尿流速和总的液体，
公开(公告)号：EP2394144A1
公开(公告)日：2011-12-14
申请号：EP09779026.5
申请日：2009-02-09
申请人： Pulsion Medical Systems AG
发明人： VEECK, Marcus , REHO, Rossana , JOEKEN, Stephan
IPC分类号： G01F1/00 , A61B5/20
CPC分类号： G01F1/00 , A61B5/208
摘要： The invention relates to a device for continuously measuring the flow velocity of a fluid, in particular of urine of living creatures, comprising at least two collection containers (2, 3) for receiving the fluid, a tube or hose-shaped connecting part (4) at the lower end of the first collection container (2) connecting the first collection container (2) to the second collection container (3), a first closure (6a/6b) between the first collection container (2) and the second collection container (3) on the tube or hose-shaped connecting part (4), a second closure (7) at the lower end of the second collection container (3), and a riser (8) connected to the second collection container (3), wherein a measuring device (10) is disposed in the area of the upper end of the riser (8).

4. 发明公开

EP2281504A1 Apparatus and method for determining a physiological parameter 审中-公开
标题翻译： Vorrichtung und Verfahren zur Bestimmung eines physiologischen参数
公开(公告)号：EP2281504A1
公开(公告)日：2011-02-09
申请号：EP09167137.0
申请日：2009-08-04
申请人： Pulsion Medical Systems AG
发明人： Joeken, Stefan, Dr.
IPC分类号： A61B5/00 , A61B5/021 , A61B5/024 , A61B5/029
CPC分类号： A61B5/029 , A61B5/02028 , A61B5/021 , A61B5/02416 , A61B5/7257
摘要： An apparatus for determining a physiological parameter of a patient, such as cardiac output, comprises a sensor device providing readings of a blood variable, memory means storing said readings as a curve over time, evaluation means determining a mean value from the curve and determining the physiological parameter using the mean value is provided. The sensor device includes a plethysmography and/or pulse-oximetry sensor setup. The evaluation means determine a spectral density of said curve and/or a variance. The evaluation means also determine at least one model parameter representing an effective value of a heart beat using the mean value and said spectral density and/or variance. The effective value is selected from an effective amplitude of the heart beat, an effective duration of the heart beat and an effective area under the heart beat. The physiological parameter is determined using at least one of the model parameters.
摘要翻译：用于确定患者的生理参数（例如心输出量）的装置包括提供血液变量读数的传感器装置，存储所述读数作为曲线随时间变化的存储装置，评估装置根据曲线确定平均值，并确定提供使用平均值的生理参数。传感器装置包括体积描记法和/或脉搏血氧饱和度传感器装置。评估装置确定所述曲线的频谱密度和/或方差。评估装置还使用平均值和所述频谱密度和/或方差来确定表示心跳的有效值的至少一个模型参数。有效值选自心跳的有效幅度，心搏的有效持续时间和心跳下的有效面积。使用至少一个模型参数来确定生理参数。

5. 发明公开

EP2263528A1 Apparatus and method for determining physiologic parameters of a patient 审中-公开
标题翻译： Vorrichtung und Verfahren zur Bestimmung physlogischer参数eines Patienten
公开(公告)号：EP2263528A1
公开(公告)日：2010-12-22
申请号：EP09162663.0
申请日：2009-06-15
申请人： Pulsion Medical Systems AG
发明人： Dr. Gödje, Oliver , Dr. Scheier, Jörg
IPC分类号： A61B5/0205 , A61B5/029
CPC分类号： A61B5/0215 , A61B5/0205 , A61B5/0402
摘要： The apparatus comprises a patient monitor (4) reading in a pressure signal from a pressure sensor (2) measuring an arterial pressure of the patient (6) employing an arterial catheter (1). The patient monitor (4) can also read in an electrocardiography signal from an ECG device (15) The patient monitor (4) determines curve characteristics indicative for a breathing state and/or a heart rhythm state of the patient (6) and switches from a first volume responsiveness indication state to a second volume responsiveness indication state, if a first condition is met by the curve characteristics, and from the second volume responsiveness indication state to the first volume responsiveness indication state, if a second condition is met. Thus, two visually and/or audibly distinguishable indication states are provided depending on
- whether the relevant curve characteristics indicate that the patient is in an arrhythmic condition, and/or
- whether the relevant curve characteristics indicate that the patient is breathing spontaneously.
摘要翻译：该装置包括从使用动脉导管（1）测量患者（6）的动脉压的压力传感器（2）读取压力信号的患者监护仪（4）。患者监护仪（4）还可以从ECG装置读取心电图信号（15）。患者监护仪（4）确定指示患者（6）的呼吸状态和/或心律状态的曲线特征，并从如果第一条件满足曲线特性，则从第二卷响应指示状态到第二音量响应指示状态，如果满足第二条件，则从第二音量响应指示状态到第一音量响应指示状态。因此，取决于 - 相关曲线特征是否指示患者处于心律失常状态，和/或 - 相关曲线特征是否指示患者自发呼吸，提供两个视觉和/或听觉上可区分的指示状态。

6. 发明授权

EP1658806B1 Kalibrierreflektorvorrichtung und damit ausgestattete Sondenanordnung 有权
标题翻译：校准反射器，并配备探针组件
公开(公告)号：EP1658806B1
公开(公告)日：2009-08-26
申请号：EP04105835.5
申请日：2004-11-17
申请人： Pulsion Medical Systems AG
发明人： Pfeiffer, Ulrich J. Dr. , Moulas, Daniel
IPC分类号： A61B5/1459
CPC分类号： A61B5/14542 , A61B5/1459 , A61B5/1495 , A61B5/412 , A61B2560/0233

7. 发明公开

EP1884189A1 Apparatus and method for determining a physiologic parameter of a patient applying fourier transformation 审中-公开
标题翻译： Apparat und Verfahren zur Bestimmung eines physiologischen参数eines Patienten mittels Fouriertransformation
公开(公告)号：EP1884189A1
公开(公告)日：2008-02-06
申请号：EP06118387.7
申请日：2006-08-03
申请人： Pulsion Medical Systems AG
发明人： Dr. Joeken, Stephan
IPC分类号： A61B5/029
CPC分类号： A61B5/029 , A61B5/7257 , G06F19/00
摘要： The apparatus comprises a pressure sensor providing readings of a blood pressure of the patient and storage means for storing the readings as a pressure curve over time. Blood pressure is measured (S1). The frequency difference between heart rate and breathing rate is used to separate the respiratory effect from the heart activity. In particular, the Fourier transform of the blood pressure and the spectral density are used to determine the contribution of each frequency (S2, S3). The respiratory and cardiac power spectra are determined (S4, S5). The ratio between both powers is calculated as the quotient of the integrals over the cardiac power spectrum and the respiratory power spectrum (S6). A parameter usable to characterize volume responsiveness is determined (S7) using above ratio and a correction factor.
摘要翻译：该装置包括提供患者血压读数的压力传感器和用于将读数存储为随时间的压力曲线的存储装置。测量血压（S1）。心率和呼吸频率之间的频率差用于分离呼吸效应与心脏活动。特别地，使用血压的傅立叶变换和频谱密度来确定每个频率的贡献（S2，S3）。确定呼吸和心脏功率谱（S4，S5）。两个功率之间的比值被计算为心脏功率谱和呼吸功率谱上积分的商（S6）。使用上述比率和校正因子确定可用于表征体积响应性的参数（S7）。

8. 发明公开

EP1848329A1 VORRICHTUNG ZUR BESTIMMUNG KARDIOPULMONALER VOLUMINA UND FLÜSSE EINES LEBEWESENS 有权
标题翻译：一种用于确定心肺量和河流生活
公开(公告)号：EP1848329A1
公开(公告)日：2007-10-31
申请号：EP06700675.9
申请日：2006-01-03
申请人： Pulsion Medical Systems AG
发明人： PFEIFFER, Ulrich J. , KNOLL, Reinhold , MICHARD, Frédéric
IPC分类号： A61B5/028 , A61B5/029
CPC分类号： A61B5/02028 , A61B5/028 , A61B5/029
摘要： The invention relates to a device for determining cardiopulmonary volumes and flows of a living being. According to the invention, the evaluation unit (14) of a transpulmonary measuring array, preferably comprising a central venous and arterial catheter (11, 12), is programmed so as to take into account a possible short circuit current from the right to the left half of the heart (RL shunt) and/or from the left to the right half of the heart (LR shunt) of the living being without requiring the use of a right cardiac catheter or having to revert to measured pulmonary arterial values at all. To this avail, a basic model is provided which includes the y function (system response) corresponding to a dilution curve as a convolution of a disruptive function I with several expressions that contain characteristic times as model parameters. Said expressions correspond to ideally mixed volumes or delays which are formulated in a simplified manner for the right atrium (RA), the right ventricle (RV), the pulmonary blood volume (PBV), the extravascular thermal volume (ETV), the left atrium (LA), and the left ventricle (LV).

9. 发明授权

EP1210906B1 Vorrichtung zur Bestimmung von Gewebeperfusion 有权
标题翻译：一种用于组织灌注的确定
公开(公告)号：EP1210906B1
公开(公告)日：2006-06-07
申请号：EP01128066.6
申请日：2001-11-26
申请人： Pulsion Medical Systems AG
发明人： Pfeiffer, Ulrich, J., Dr. , Becker, Andreas, Dr. , Eder, Norbert , Burger, Thorsten, Dr. , Töns, Christian, Dr.
IPC分类号： A61B5/00
CPC分类号： H04N5/2256 , A61B5/0059 , A61B5/0261 , A61B5/0275 , H04N5/33

10. 发明公开

EP1434141A3 Vorrichtung zur Bestimmung kardiovaskulärer Parameter 审中-公开
标题翻译：用于确定心血管参数的装置
公开(公告)号：EP1434141A3
公开(公告)日：2006-02-22
申请号：EP03104552.9
申请日：2003-12-04
申请人： Pulsion Medical Systems AG
发明人： Pfeiffer, Ulrich J. , Burger, Thorsten
IPC分类号： G06F17/00
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/02108 , A61B5/02152 , A61B5/1135
摘要： Die Vorrichtung (4) fragt über den Eingangskanal (5a) kontinuierlich den vom Drucksensor (6) in einer Arterie (7) gemessenen arteriellen Druck ab, welcher als näherungsweise dem Aortendruck entsprechende Meßgröße Pao aufzufassen ist. Grundsätzlich kann der arterielle Druck in der Aorta (2), deren Nähe oder im Arterienbaum gemessen werden. Als zweite Meßgröße fragt die Vorrichtung (4) über den Eingangskanal (5b) kontinuierlich den vom Drucksensor (8) in der Zentralvene (3) gemessenen zentralvenösen Druck CVP ab, welcher als näherungsweise dem intrathorakalen Druck ITP entsprechender Druck P IT betrachtet wird. Als dritte Meßgröße wird über den Eingangskanal (5c) eine die Thoraxausdehnung wiedergebende Meßgröße Z eingelesen. Mittels bekannter Algorithmen der Pulskonturanalyse berechnet die entsprechend programmtechnisch eingerichtete Vorrichtung (4) die Schlagvolumenvariation SW, wobei der nach der Formel

P transmural = P ao - f(C) · PIT

berechnete transmurale Druck als maßgeblicher Druck verwendet wird. Der Volumenreaktionsindikator des Herzens CVRI wird nach der Formel

CVRI = k · (SW / ΔCVP)

für mechanische Positivdruckbeatmung bzw. nach der Formel

CVRI = I - m · (ΔCVP / SVV)

für Spontanatmung berechnet.

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