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1. 发明公开

EP2189111A1 Apparatus and method for determining a physiologic parameter 审中-公开
标题翻译： Vorrichtung und Verfahren zur Bestimmung eines physiologischen参数
公开(公告)号：EP2189111A1
公开(公告)日：2010-05-26
申请号：EP08169615.5
申请日：2008-11-21
申请人： Pulsion Medical Systems AG
发明人： Dr. Joeken, Stephan
IPC分类号： A61B5/0205 , A61B5/029
CPC分类号： A61B5/0205 , A61B5/0215 , A61B5/02152 , A61B5/02158 , A61B5/024 , A61B5/029 , A61B5/0816 , A61B5/7239
摘要： An apparatus for determining physiologic parameters of a patient (6) comprises a pressure sensor adapted to provide readings of a blood pressure of said patient (6), which are stored as at least one pressure curve over time or a derivative thereof with respect to time, and evaluation means (4) adapted to determine, from said pressure curve or said derivative, at least one cardiac activity state variable representing cardiac activity over time and/or variation of cardiac activity over time, and to determine at least one cardiac preload state variable representing cardiac preload over time and/or variation of cardiac preload over time. The evaluation means (4) are further adapted to determine said physiologic parameter as a sum of a plurality of sum terms, at least one of which is a monotonous function of a cardiac activity state variable and at least another one of which is a monotonous function of a cardiac preload state variable.
摘要翻译：用于确定患者（6）的生理参数的装置包括适于提供所述患者（6）的血压读数的压力传感器，所述读数随时间被存储为至少一个压力曲线或相对于时间的导数以及适于从所述压力曲线或所述导数确定至少一个心脏活动状态变量的评估装置（4），所述至少一个心脏活动状态变量表示随时间的心脏活动和/或心脏活动随时间的变化，并且确定至少一个心脏预压状态随着时间的推移，代表心脏预压的变量和/或心脏预压随时间的变化。评估装置（4）还适于将所述生理参数确定为多个和项的和，其中至少一个是心脏活动状态变量的单调函数，并且至少另一个是单调函数的心脏预压状态变量。

2. 发明授权

EP2087836B1 Apparatus and method for determining a physiological parameter 有权
标题翻译：装置和方法用于确定生理参数
公开(公告)号：EP2087836B1
公开(公告)日：2012-04-04
申请号：EP08101369.0
申请日：2008-02-07
申请人： Pulsion Medical Systems AG
发明人： Dr. Joeken, Stephan
IPC分类号： A61B5/021 , A61B5/029
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/0215 , A61B5/024 , A61B5/029 , A61B5/7257 , G06F19/00
摘要： An apparatus for determining a physiological parameter of a patient, such as cardiac output, comprises a pressure sensor device providing readings of an arterial blood pressure, memory means storing said readings as a pressure curve over time, evaluation means determining a mean arterial blood pressure from the pressure curve and determining the physiological parameter using the mean arterial blood pressure is provided. The evaluation means determine a spectral density of said pressure curve and/or a variance of said arterial blood pressure. The evaluation means also determine at least one model parameter representing an effective value of a heart beat using the mean arterial blood pressure and said spectral density and/or variance. The effective value is selected from an effective amplitude of the heart beat, an effective duration of the heart beat and an effective area under the heart beat. The physiological parameter is determined using at least one of the model parameters.

3. 发明公开

EP1884189A1 Apparatus and method for determining a physiologic parameter of a patient applying fourier transformation 审中-公开
标题翻译： Apparat und Verfahren zur Bestimmung eines physiologischen参数eines Patienten mittels Fouriertransformation
公开(公告)号：EP1884189A1
公开(公告)日：2008-02-06
申请号：EP06118387.7
申请日：2006-08-03
申请人： Pulsion Medical Systems AG
发明人： Dr. Joeken, Stephan
IPC分类号： A61B5/029
CPC分类号： A61B5/029 , A61B5/7257 , G06F19/00
摘要： The apparatus comprises a pressure sensor providing readings of a blood pressure of the patient and storage means for storing the readings as a pressure curve over time. Blood pressure is measured (S1). The frequency difference between heart rate and breathing rate is used to separate the respiratory effect from the heart activity. In particular, the Fourier transform of the blood pressure and the spectral density are used to determine the contribution of each frequency (S2, S3). The respiratory and cardiac power spectra are determined (S4, S5). The ratio between both powers is calculated as the quotient of the integrals over the cardiac power spectrum and the respiratory power spectrum (S6). A parameter usable to characterize volume responsiveness is determined (S7) using above ratio and a correction factor.
摘要翻译：该装置包括提供患者血压读数的压力传感器和用于将读数存储为随时间的压力曲线的存储装置。测量血压（S1）。心率和呼吸频率之间的频率差用于分离呼吸效应与心脏活动。特别地，使用血压的傅立叶变换和频谱密度来确定每个频率的贡献（S2，S3）。确定呼吸和心脏功率谱（S4，S5）。两个功率之间的比值被计算为心脏功率谱和呼吸功率谱上积分的商（S6）。使用上述比率和校正因子确定可用于表征体积响应性的参数（S7）。

4. 发明公开

EP2087836A1 Apparatus and method for determining a physiological parameter 有权
标题翻译： Vorrichtung und Verfahren zur Bestimmung eines physiologischen参数
公开(公告)号：EP2087836A1
公开(公告)日：2009-08-12
申请号：EP08101369.0
申请日：2008-02-07
申请人： Pulsion Medical Systems AG
发明人： Dr. Joeken, Stephan
IPC分类号： A61B5/021 , A61B5/029
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/0215 , A61B5/024 , A61B5/029 , A61B5/7257 , G06F19/00
摘要： An apparatus for determining a physiological parameter of a patient, such as cardiac output, comprises a pressure sensor device providing readings of an arterial blood pressure, memory means storing said readings as a pressure curve over time, evaluation means determining a mean arterial blood pressure from the pressure curve and determining the physiological parameter using the mean arterial blood pressure is provided. The evaluation means determine a spectral density of said pressure curve and/or a variance of said arterial blood pressure. The evaluation means also determine at least one model parameter representing an effective value of a heart beat using the mean arterial blood pressure and said spectral density and/or variance. The effective value is selected from an effective amplitude of the heart beat, an effective duration of the heart beat and an effective area under the heart beat. The physiological parameter is determined using at least one of the model parameters.
摘要翻译：用于确定患者的生理参数（例如心输出量）的装置包括提供动脉血压读数的压力传感器装置，将所述读数存储为随着时间的压力曲线的记录装置，评估装置，用于确定平均动脉血压提供压力曲线并使用平均动脉血压确定生理参数。评估装置确定所述压力曲线的频谱密度和/或所述动脉血压的方差。评估装置还使用平均动脉血压和所述频谱密度和/或方差来确定表示心搏的有效值的至少一个模型参数。有效值选自心跳的有效幅度，心搏的有效持续时间和心跳下的有效面积。使用至少一个模型参数来确定生理参数。

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