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1. 发明授权

EP3420885B1 LASER ENDOSCOPE DEVICE 有权
公开(公告)号：EP3420885B1
公开(公告)日：2022-12-21
申请号：EP17756619.7
申请日：2017-02-23
发明人： MIZOGUCHI, Akira , TANAKA, Koji , TOIYAMA, Yuji , TANAKA, Kyosuke , WANG, Shujie , KAITO, Aika , SAI, Kousyoku , KIMURA, Kazushi
IPC分类号： A61B1/00 , A61B1/04 , A61B1/045 , A61B1/06 , A61K49/00

2. 发明授权

EP2837660B1 CURABLE COMPOSITION, AND CURED SYNTHETIC RESIN USING SAME 有权
公开(公告)号：EP2837660B1
公开(公告)日：2021-07-14
申请号：EP13775529.4
申请日：2013-04-02
发明人： NAKAMURA, Shuhei , TANAKA, Yoshimi , KANO, Mikihito , MIYATA, Kazuyo , MURAKAMI, Yasushi
IPC分类号： C08K5/59 , C08G101/00 , C08L101/00 , C08G18/22 , C08G77/08 , C08K5/057 , C09J175/04 , C08K5/07 , C08G77/18 , C08K5/31 , C08L43/04 , C08L71/00 , C08G18/48 , C08L83/04 , C08F8/42 , C08G18/73 , C08G77/16

3. 发明授权

EP2992759B1 ATOPIC DERMATITIS MODEL ANIMAL AND USE THEREOF 有权
公开(公告)号：EP2992759B1
公开(公告)日：2019-07-31
申请号：EP14791230.7
申请日：2014-04-30
申请人： Hyogo College Of Medicine , Mie University
发明人： YAMANISHI, Kiyofumi , MIZUTANI, Hitoshi , IMAI, Yasutomo , YOSHIMOTO, Tomohiro , NAKANISHI, Kenji
IPC分类号： A01K67/027 , G01N33/15 , G01N33/50 , C12N15/09

4. 发明授权

EP2628798B1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR FIBROSIS 有权
公开(公告)号：EP2628798B1
公开(公告)日：2019-03-27
申请号：EP11832611.5
申请日：2011-10-14
申请人： Mie University , Otsuka Pharmaceutical Co., Ltd.
发明人： GABAZZA, Esteban C. , KOBAYASHI, Tetsu , TOYOBUKU, Hidekazu , FUKUDA, Ayako , HASEGAWA, Tetsuya
IPC分类号： C12N15/113 , A61K31/7105 , A61K48/00 , A61P11/00 , A61P43/00

5. 发明公开

EP3311866A1 NEEDLELESS SYRINGE AND METHOD FOR INTRODUCING DNA INTO INJECTION TARGET AREA USING SAME 有权
标题翻译：无菌注射器和使用相同方法将DNA引入注射靶区的方法
公开(公告)号：EP3311866A1
公开(公告)日：2018-04-25
申请号：EP16811658.0
申请日：2016-06-15
申请人： Mie University , Daicel Corporation
发明人： SHIKU, Hiroshi , YAMAMOTO, Yuzo , MASUMOTO, Takaya
IPC分类号： A61M5/303 , A61D7/00 , A61K31/7088 , A61K39/00 , A61P35/00
CPC分类号： A61D1/025 , A61D7/00 , A61K9/0019 , A61K31/7088 , A61K39/00 , A61K39/0011 , A61K2039/53 , A61K2039/54 , A61K2039/552 , A61M5/2046 , A61M5/30
摘要： A needleless injector which can selectively induce the immune response and a method for introducing DNA including a region coding for an antigen to selectively produce an antibody in a living body of a mammal by using the needleless injector are provided. Disclosed is a needleless injector for injecting a DNA solution into an injection target area without using any injection needle; the needleless injector comprising an accommodating unit which accommodates the DNA solution; a predetermined ignition device; and a nozzle unit having a discharge port through which the DNA solution pressurized by the combustion of the predetermined igniter powder in the ignition device flows so that the DNA solution is discharged to the injection target area; wherein a temperature of the predetermined combustion product, which is provided during the pressurization, changes to a neighborhood of ordinary temperature within 20 msec after a pressure, which is applied to the DNA solution on account of the combustion of the igniter powder, reaches an initial peak discharge force during a pressurization process for discharging the DNA solution.
摘要翻译：本发明提供一种能够选择性地诱导免疫应答的无针注射器和使用该无针注射器导入包含编码抗原的区域的DNA，从而在哺乳动物的生物体内选择性地产生抗体的方法。公开了一种无针注射器，用于在不使用任何注射针的情况下将DNA溶液注射到注射目标区域; 该无针注射器包括容纳DNA溶液的容纳单元; 预定的点火装置; 以及具有排出口的喷嘴单元，通过该排出口，通过点火装置中的预定点火剂粉末的燃烧而被加压的DNA溶液流动，使得DNA溶液被排出到注入目标区域; 其中在加压期间提供的预定燃烧产物的温度在由于点火器粉末的燃烧而施加到DNA溶液的压力达到初始值之后的20毫秒内变为常温附近在用于排出DNA溶液的加压过程期间的峰值排出力。

6. 发明公开

EP3287135A1 THERAPEUTIC AGENT ASSOCIATED WITH SUPPRESSION OF PROLIFERATION AND METASTASIS OF TUMOR, WHICH COMPRISES EXOSOMES RELEASED FROM CYTOTOXIC T CELLS AND TARGETS CANCER STROMAL/MESENCHYMAL CELLS 审中-公开
标题翻译：与抑制肿瘤增殖和转移有关的治疗剂，其包含从细胞毒T细胞释放的外来体和靶向癌基质/间质细胞
公开(公告)号：EP3287135A1
公开(公告)日：2018-02-28
申请号：EP16768689.8
申请日：2016-03-18
申请人： Mie University , Kyoto University
发明人： SHIKU, Hiroshi , SEO, Naohiro , AKIYOSHI, Kazunari , HARADA, Naozumi , MOMOSE, Fumiyasu
IPC分类号： A61K35/17 , A61K9/08 , A61K31/7105 , A61P35/00 , A61P35/04 , A61P43/00 , C12N5/078
CPC分类号： A61K31/7105 , A61K9/0019 , A61K9/08 , A61K35/17 , A61K45/06 , A61P35/00 , C12N5/0663 , C12N2503/02 , C12Q1/6876 , C12Q2600/178
摘要： [Problem to be solved] To provide a therapeutic agent which can suppress cell proliferation and metastasis of a tumor or the like.
[Solution] Provided is a therapeutic agent for cell-proliferative diseases, which comprises extracellular vesicles (exosomes) released from cytotoxic T cells. The therapeutic agent targets cancer stromal / mesenchymal cells and can suppress the proliferation and metastasis of a tumor including cancer.
摘要翻译： [要解决的问题]提供能够抑制肿瘤等的细胞增殖和转移的治疗剂。 [解决方案]提供用于细胞增殖性疾病的治疗剂，其包含从细胞毒性T细胞释放的细胞外囊泡（外来体）。该治疗剂靶向癌症基质/间充质细胞并且可以抑制包括癌症的肿瘤的增殖和转移。

7. 发明授权

EP2587585B1 Electrolyte for lithium air battery and lithium air battery including the same 有权
标题翻译： ElektrolytfürLithiumluftbatterie und Lithiumluftbatterie damit
公开(公告)号：EP2587585B1
公开(公告)日：2016-12-28
申请号：EP12187845.8
申请日：2012-10-09
申请人： Samsung Electronics Co., Ltd , National University Corporation Mie University
发明人： Lee, Dong-joon , Roev, Victor , Ryu, Young-gyoon , Im, Dong-min , Park, Min-sik , Ma, Sang-bok , Yamamoto, Osamu , Imanishi, Nobuyuki , Takeda, Yasuo
IPC分类号： H01M12/06 , H01M12/08 , H01M10/0565 , H01M10/052 , H01M10/0525 , H01M10/0569 , H01M4/36
CPC分类号： H01M12/06 , H01M4/364 , H01M4/366 , H01M10/052 , H01M10/0525 , H01M10/0565 , H01M10/0569 , H01M12/08 , H01M2300/0085 , Y02E60/128

8. 发明公开

EP2674491A1 METHOD FOR PRODUCING VIRUS VECTOR FOR GENE TRANSFER 有权
标题翻译：用于生产病毒载体基因转移
公开(公告)号：EP2674491A1
公开(公告)日：2013-12-18
申请号：EP12744339.8
申请日：2012-02-08
申请人： Mie University , BioComo Inc.
发明人： FUKUMURA, Masayuki , KAWANO, Mitsuo , NOSAKA, Tetsuya , OHTSUKA, Junpei
IPC分类号： C12N15/09 , A61K35/76 , A61P37/04 , C12N5/10
CPC分类号： C12N15/64 , A61K48/00 , C12N7/00 , C12N2760/18622 , C12N2760/18643 , C12N2760/18651 , C12N2760/18652
摘要： The present invention discloses a cell system, as a host cell to be infected with an F gene-deficient virus, which can constitutively and stably express the F protein, and a method for producing an F gene-deficient virus by utilizing the cell. A non-proliferative human parainfluenza type 2 virus vector is produced by co-culturing an F gene-deficient human parainfluenza type 2 virus with a Vero cell having the F gene of human parainfluenza type 2 virus in such a manner that the F gene is non-inducibly expressed, and isolating viral particles from a culture supernatant.

9. 发明公开

EP2628798A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR FIBROSIS 审中-公开
标题翻译： PROPHYLAKTISCHER ODER治疗师WIRKSTOFF GEGEN FIBROSE
公开(公告)号：EP2628798A1
公开(公告)日：2013-08-21
申请号：EP11832611.5
申请日：2011-10-14
申请人： Mie University , Otsuka Pharmaceutical Co., Ltd.
发明人： GABAZZA, Esteban C. , KOBAYASHI, Tetsu , TOYOBUKU, Hidekazu , FUKUDA, Ayako , HASEGAWA, Tetsuya
IPC分类号： C12N15/113 , A61K31/7105 , A61K48/00 , A61P11/00 , A61P43/00
CPC分类号： C12N15/1136 , A61K31/713 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2320/30
摘要： Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA. An siRNA having a full length of 30 or fewer nucleotides and targeting a sequence consisting of 17 to 23 consecutive bases selected from the group consisting of bases at positions 1285 to 1318, bases at positions 1398 to 1418, bases at positions 1434 to 1463, bases at positions 1548 to 1579, bases at positions 1608 to 1628, bases at positions 1700 to 1726, bases at positions 1778 to 1798, bases at positions 1806 to 1826, and bases at positions 1887 to 1907 of SEQ ID NO: 1.
摘要翻译：提供了对于治疗纤维化有效的siRNA和含有siRNA的药物。具有30个或更少核苷酸的全长的siRNA，靶向由17至23个连续碱基组成的序列，所述序列选自1285至1318位的碱基，1398至1418位的碱基，1434至1463位的碱基，位置1548至1579，第1608至1628位的碱基，位置1700至1726的碱基，1778至1798位的碱基，位置1806至1826的碱基和SEQ ID NO：1的1887至1907的碱基。

10. 发明公开

EP1962086A2 Responsive glass membrane for ion selective electrode and ion selective electrode 审中-公开
标题翻译： Reaktive Glasmembranfüreine ionenselektive Elektrode und ionenselektive Elektrode
公开(公告)号：EP1962086A2
公开(公告)日：2008-08-27
申请号：EP08003377.2
申请日：2008-02-25
申请人： HORIBA, LTD. , Mie University
发明人： Nishio, Yuji , Iwamoto, Yasukazu , Tadanori, Hashimoto
IPC分类号： G01N27/36
CPC分类号： G01N27/36 , C03C3/21 , C03C4/18
摘要： The present claimed invention intends to provide a responsive glass membrane for ion selective electrode glass and an ion selective electrode comprising the responsive glass membrane that produces a self-cleaning function when the ultraviolet rays are irradiated although no change is brought in a composition of a sample solution as being an object to be measured and that is low in electric resistance value and superior in responsivity under an ordinary measurement environment.
The responsive glass membrane for ion selective electrode is made of titanium-containing oxide glass that contains 20 - 80 mol% of titanium dioxide and lithium oxide.
摘要翻译：本发明的目的在于提供一种用于离子选择性电极玻璃的响应性玻璃膜和一种离子选择电极，其包括响应性玻璃膜，其在照射紫外线时产生自清洁功能，尽管样品组成没有变化溶液作为测量对象，并且在普通测量环境下的电阻值低和响应性优异。用于离子选择电极的响应性玻璃膜由含有20-80mol％的二氧化钛和氧化锂的含钛氧化物玻璃制成。

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