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1. 发明公开

EP1647229A2 Retraction device for port access multivessel coronary artery bypass surgery 失效
标题翻译： Retraktor zum multivascularen Portzugang bei der coronaren Arterienbypasschirurgie
公开(公告)号：EP1647229A2
公开(公告)日：2006-04-19
申请号：EP05024076.1
申请日：1996-05-31
申请人： HEARTPORT, INC.
发明人： Boyd, Stephen W. , Vaska, Matthias , Rapacki, Alan R. , Peters, William S. , Donlon, Brian S. , Stevens, John H.
IPC分类号： A61B17/02 , A61B17/28 , A61B19/00 , A61F7/10
CPC分类号： A61F7/10 , A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/2804 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/36 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/00637 , A61B2017/00663 , A61B2017/0237 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2912 , A61B2017/2927 , A61B2017/2932 , A61B2017/2943 , A61B2017/306 , A61B2017/308 , A61B2017/320056 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61B2090/306 , A61B2217/005 , A61F2/2427 , A61F2007/0001 , A61F2007/0054 , A61F2007/101 , A61M25/1011 , A61M39/0247 , A61M2025/0003 , A61M2025/028 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M2230/005
摘要： Surgical instruments that are disclosed for performing port-access or closed-chest coronary artery by pass (CABG surgery). In particular, a surgical retraction device (190) is described which comprises a shaft (191) with proximal and distal ends, a contact surface (192) adjacent to the distal end for manipulating or retracting living tissue within a body cavity and means (194) for applying a vacuum at the contact surface. A surgical retraction device (170) is also described for retracting a body structure with a curved external surface (171) within a body cavity which comprises a rigid shaft (172) with proximal and distal ends, a contact surface (171) near the distal end with a curvature to conform to the external surface of the body structure and a textured porous material (174) attached to the contact surface for frictionally engaging the structure. The distal portion of the shaft, including the contact surface and the porous material, is dimensioned such that it may be introduced into a body cavity through an opening with a maximum diameter of about 12 mm.
摘要翻译：披露用于通过口腔进入或闭合胸腔冠状动脉（CABG手术）的手术器械。特别地，描述了一种手术缩回装置（190），其包括具有近端和远端的轴（191），与远端相邻的用于操纵或缩回体腔内的生物组织的接触表面（192），以及装置），用于在接触表面处施加真空。还描述了一种外科缩回装置（170），用于在体腔内具有弯曲的外表面（171）缩回身体结构，该外表面包括具有近端和远端的刚性轴（172），靠近远端的接触表面（171）端部具有曲率以符合主体结构的外表面，以及附着到接触表面的纹理多孔材料（174），用于与结构摩擦接合。包括接触表面和多孔材料的轴的远端部分的尺寸被设计成使得其可以通过最大直径为约12mm的开口引入体腔中。

2. 发明授权

EP0937439B1 Endovascular aortic valve replacement device 失效
标题翻译：一种用于血管内替换主动脉瓣
公开(公告)号：EP0937439B1
公开(公告)日：2003-09-17
申请号：EP99108298.3
申请日：1992-07-15
申请人： HEARTPORT, INC.
发明人： Stevens, John H.
IPC分类号： A61F2/24
CPC分类号： A61M25/10 , A61B17/32002 , A61B17/320725 , A61B17/320758 , A61B2017/22097 , A61B2018/00232 , A61B2018/00261 , A61F2/2427 , A61F2/2433 , A61F2/2436 , A61F2220/0016 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0125 , A61M2025/0078 , A61M2025/028 , A61M2025/1047 , A61M2025/1077 , A61M2210/125 , Y10S623/904

3. 发明公开

EP1283027A3 Endovascular aortic valve replacement 失效
标题翻译：主动脉腔内心脏瓣膜置换
公开(公告)号：EP1283027A3
公开(公告)日：2003-04-23
申请号：EP02019355.3
申请日：1992-07-15
申请人： HEARTPORT, INC.
发明人： Stevens, John H.
IPC分类号： A61F2/24
CPC分类号： A61M25/10 , A61B17/32002 , A61B17/320725 , A61B17/320758 , A61B2017/22097 , A61B2018/00232 , A61B2018/00261 , A61F2/2427 , A61F2/2433 , A61F2/2436 , A61F2220/0016 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0125 , A61M2025/0078 , A61M2025/028 , A61M2025/1047 , A61M2025/1077 , A61M2210/125 , Y10S623/904
摘要： The subject invention relates to a valve replacement system together with methods of preparation and use, are provided for endovascular replacement of a heart valve in a host. The valve replacement system includes up to five components: (1) a prosthetic valve device, (2) a valve introducer device, (3) an intraluminal procedure device, (4) a procedure device capsule, and (5) a tissue cutter. The system provides for endovascular removal of a malfunctioning valve and subsequent replacement with a permanent prosthetic heart valve.

4. 发明公开

EP1208867A2 Endovascular system for arresting the heart 失效
标题翻译： Endovaskulares系统zum Erzeugen eineskünstlichenHerzstillstandes
公开(公告)号：EP1208867A2
公开(公告)日：2002-05-29
申请号：EP02001320.7
申请日：1994-09-01
申请人： HEARTPORT, INC.
发明人： Evard, Philip C. , Machold, Timothy R. , Stevens, John H.
IPC分类号： A61M25/01
CPC分类号： A61M25/10 , A61B2018/00232 , A61B2018/00261 , A61F2/2427 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0125 , A61M25/0662 , A61M2025/0078 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2025/1077 , A61M2025/1095 , A61M2202/047 , A61M2210/125 , A61M2210/127
摘要： The invention provides an endovascular device (20) for partitioning the ascending aorta and a system for arresting the heart to facilitate the performance of procedures such as heart valve replacement or coronary artery bypass grafting without the need for a thoracotomy. According to the invention, an endovascular device (20) for partitioning a patient's ascending aorta comprises a flexible shaft (22) having a distal end (24), a proximal end (26), and a first inner lumen (29) therebetween with an opening (31) at the distal end (24). The shaft (22) may have a preshaped distal portion (32) with a curvature generally corresponding to the curvature of the patient's aortic arch. Expandable means (28) are disposed near the distal end (24) of the shaft (22) proximal to the opening (31) in the first inner lumen (20) for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles. Means (90) for delivering cardioplegic fluid may be connected to the proximal end (26) of the device to infuse cardioplegic fluid into the coronary arteries for arresting the heart. The endovascular device of the invention is readily positionable in the ascending aorta, resists displacement caused by systolic blood flow, and maintains axial alignment with the center of the ascending aorta and aortic valve.
摘要翻译：本发明提供了一种用于分隔升主动脉的血管内装置（20）和用于阻止心脏的系统，以便于执行诸如心脏瓣膜置换或冠状动脉旁路移植的手术，而不需要开胸手术。根据本发明，用于分隔患者上升主动脉的血管内装置（20）包括具有远端（24），近端（26）和其间的第一内腔（29）的柔性轴（22），其间具有在远端（24）处的开口（31）。轴（22）可以具有通常对应于患者主动脉弓曲率的曲率的预成形远端部分（32）。可膨胀装置（28）设置在靠近第一内腔（20）中的开口（31）附近的轴（22）的远端（24）附近，用于闭塞升主动脉，从而阻止基本上所有的血液流过其中多个心动周期。用于输送心脏停搏液的装置（90）可以连接到装置的近端（26），以将心脏停搏液注入冠状动脉以阻止心脏。本发明的血管内装置易于在升主动脉中定位，抵抗由收缩期血流引起的置换，并且与升主动脉和主动脉瓣的中心保持轴向对准。

5. 发明公开

EP1188417A2 Method and apparatus for delivery of therapeutic agents to the heart 审中-公开
标题翻译：用于治疗剂递送至心脏的方法和装置
公开(公告)号：EP1188417A2
公开(公告)日：2002-03-20
申请号：EP01307612.0
申请日：2001-09-07
申请人： HEARTPORT, INC.
发明人： Stevens, John H. , Brewer, Richard , Rosenman, Daniel C. , Gifford, Hanson S.
IPC分类号： A61B19/00
CPC分类号： A61B18/24 , A61B2017/00247 , A61B2017/22051 , A61B2018/00392 , A61B2018/2272 , A61F2/82 , A61F2250/0067 , A61L31/16 , A61L2300/414 , A61M1/3613 , A61M1/3666 , A61M25/0021 , A61M25/0023 , A61M25/0032 , A61M25/005 , A61M25/0662 , A61M2025/0031 , A61M2025/0034 , A61M2025/105 , A61M2025/1052 , A61M2210/127
摘要： A method and system for delivering a therapeutic agent directly to the heart employing minimally invasive techniques and concepts. In particular. the delivery of vascular endothelial growth factors (VEGF) is performed endovascularly or endoscopically to a region of a patient's heart treated with transmyocardial revascularization (TMR). A system is provided for inducing cardioplegic arrest. An aortic occlusion device has an inflatable balloon which occludes the ascending aorta when inflated. Cardioplegic fluid may be infused through a lumen of the aortic occlusion device to stop the heart while the patient's circulatory system is supported on cardiopulmonary bypass. A side-firing fiberoptic laser is introduced through the aortic occlusion device in the endovascular technique to perform TMR. Subsequently, a therapeutic agent delivery catheter is directed into one of the coronary arteries to deliver and dissipate the VEGF into the surrounding vascular plexus to promote angiogenesis stimulation. Alternatively, a therapeutic agent delivery material saturated or coated with VEGF could be sutured to the epicardial surface of the heart, using thoracoscopic techniques.
摘要翻译：一种用于直接将治疗剂递送至心脏用人微创技术和概念的方法和系统。特别。血管内皮生长因子的递送（VEGF）是血管内或内窥镜执行到患者的心脏与心肌血运重建术（TMR）治疗的区域。系统提供了诱导心脏停搏。主动脉阻塞装置具有充气气球阻塞升主动脉，当充气。心脏停跳液可以通过主动脉闭塞装置内腔被注入心脏停止跳动，而病人的循环系统支撑在体外循环。侧面发射的光纤激光器通过主动脉阻塞装置在血管内技术来执行TMR引入。随后，将治疗剂递送导管被引导到冠状动脉中的一个输送和消散VEGF到周围血管丛促进血管发生的刺激。可替代地，饱和的或与VEGF涂覆在治疗剂递送的材料可使用胸腔镜技术缝合到心脏的心外膜表面。

6. 发明公开

EP1185320A1 DEVICE AND METHODS FOR CANNULATING A BLOOD VESSEL 审中-公开
标题翻译：装置血管的装置和方法
公开(公告)号：EP1185320A1
公开(公告)日：2002-03-13
申请号：EP00925959.9
申请日：2000-04-13
申请人： HEARTPORT, INC.
发明人： MOSHE, Meir , KOMTEBEDDE, Jan , DECKMAN, Robert
IPC分类号： A61M5/00
CPC分类号： A61M25/0041 , A61M25/0009 , A61M25/005 , A61M2025/0063
摘要： A cannula (2) has a distal portion (6) which is angled relative to a proximal portion (4). The distal portion (6) is straightened during introduction with a stiffening element (14). After introduction, the stiffening element (14) is removed so that the distal portion (6) angulates relative to the proximal portion so that the cannula (2) can be moved out of the surgical field. The cannula (2) preferably includes a stabilizing ring (30) having suture holders. The stabilizing ring is also preferably angled relative to the cannula (2).
摘要翻译：套管（2）具有相对于近侧部分（4）成角度的远侧部分（6）。在引入加强元件（14）期间，远侧部分（6）被拉直。在引入之后，去除加强元件（14），使得远侧部分（6）相对于近侧部分成角度，使得套管（2）能够移出手术区域。套管（2）优选地包括具有缝合线保持器的稳定环（30）。稳定环也优选相对于套管（2）成角度。

7. 发明公开

EP0888144A4 CANNULA AND METHOD OF MANUFACTURE AND USE 失效
标题翻译： KANNULA和方法及应用
公开(公告)号：EP0888144A4
公开(公告)日：2001-10-10
申请号：EP97908922
申请日：1997-03-07
申请人： HEARTPORT INC
发明人： SNOW DAVID W
IPC分类号： A61B17/12 , A61B17/34 , A61B19/00 , A61F2/958 , A61M25/00 , A61M25/01 , A61M25/02 , A61M25/06 , A61M25/16
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/3417 , A61B2018/00232 , A61B2018/00261 , A61B2090/064 , A61B2090/306 , A61M25/0009 , A61M25/0012 , A61M25/0041 , A61M25/0045 , A61M25/005 , A61M25/0054 , A61M25/0133 , A61M25/0155 , A61M25/02 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M25/1006 , A61M25/1036 , A61M2025/0002 , A61M2025/0046 , A61M2025/028 , A61M2025/1047 , A61M2025/1052 , A61M2210/127
摘要： An elongate member (207) is coated with a coating (209), preferably by co-extrusion, and the coated elongate member (207) is wound in a helical manner around a mandrel (213). The coated elongate member (207) preferably has a square cross-sectional shape so that adjacent portions of the coated elongate member (207) engage one another when the coated elongate member (207) is wound around the mandrel (213). The coated elongate member (207) is then heated so that the coating (209) on adjacent portions of the coated elongate member (207) fuse together to form an integral structure. Another layer (225) of material may be provided on the radially inner or outer wall of the coated elongate member (207).

8. 发明公开

EP1129744A1 Cardiopulmonary bypass system for closed-chest intervention 失效
标题翻译： Kardiopulmonaler BypassfürEingriffe bei geschlossenem Thorax
公开(公告)号：EP1129744A1
公开(公告)日：2001-09-05
申请号：EP01112373.4
申请日：1994-11-10
申请人： HEARTPORT, INC.
发明人： Stevens, John H. , Sterman, Wesley D. , Machold, Timothy R. , Gifford, Hanson S.
IPC分类号： A61M25/00 , A61M1/10
CPC分类号： A61M25/10 , A61B2018/00232 , A61B2018/00261 , A61M1/3653 , A61M1/3659 , A61M25/0041 , A61M25/0125 , A61M25/0147 , A61M25/0152 , A61M25/0155 , A61M25/0158 , A61M2025/0078 , A61M2025/015 , A61M2025/0161 , A61M2025/028 , A61M2025/1047 , A61M2025/1077 , A61M2210/125
摘要： The invention provides a system and method for establishing cardiopulmonary bypass and performing an interventional procedure in a patient's heart or great vessel with a minimum of arterial and venous penetrations. In one embodiment, a bypass cannula (180) configured for introduction into a patient's artery includes a blood flow lumen (188) which may be connected to a cardiopulmonary bypass system (92,94,96,100). A catheter shaft (202) is coupled to the bypass cannula, usually within the blood flow lumen, and has a member (216) at its distal end for performing an interventional procedure within the heart or great vessel. In a particular embodiment, the catheter shaft has an expandable member such as an inflatable balloon disposed near its distal for occluding the ascending aorta so as to substantially block all blood flow therethrough for a plurality of cardiac cycles. The catheter shaft has an inner lumen (212) through which cardio-plegic fluid may be delivered upstream of the occluding member to infuse cardio-plegic fluid into the coronary arteries for arresting the heart. The blood flow lumen in the bypass cannula is connected to a cardiopulmonary bypass system, which receives deoxygenated blood from the patient's venous system, oxygenates the blood, and delivers the oxygenated blood to the patient's arterial system through the blood flow lumen.
摘要翻译：本发明提供一种用于建立心肺分流术并在患者的心脏或大血管中进行介入手术的系统和方法，其具有最小的动脉和静脉穿刺。在一个实施例中，配置用于引入到患者动脉中的旁路插管（180）包括可以连接到体外循环系统（92,94,96,100）的血流腔（188）。导管轴（202）通常在血流腔内联接到旁路插管，并且在其远端具有用于在心脏或大容器内进行介入手术的构件（216）。在特定实施例中，导管轴具有可膨胀构件，例如设置在其远端附近的可膨胀气囊，用于闭塞升主动脉，以便基本上阻挡通过其中的所有血液流过多个心动周期。导管轴具有内腔（212），心脏 - 皮肤液体可以通过该内腔（212）被输送到阻塞构件的上游，以将心脏 - 止血液注入冠状动脉以阻止心脏。旁路插管中的血流腔连接到心肺旁路系统，其接收来自患者静脉系统的脱氧血液，使血液充氧，并通过血流腔将氧合血液输送到患者的动脉系统。

9. 发明公开

EP1129737A1 Catheter system and devices for providing cardiopulmonary bypass support during heart surgery 失效
标题翻译： Kathetersystem zurkardiopulmonärenBypassunterstützungwährendeines Herzeingriffs
公开(公告)号：EP1129737A1
公开(公告)日：2001-09-05
申请号：EP01112737.0
申请日：1995-05-26
申请人： HEARTPORT, INC.
发明人： Sweezer, William P. , Coleman, Ronald L. , Jimison, James
IPC分类号： A61M1/10
CPC分类号： A61M1/10 , A61M1/1006 , A61M1/1018 , A61M1/1039 , A61M1/3659 , A61M25/0068 , A61M25/007 , A61M25/0082 , A61M25/1011 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61M2025/1015 , A61M2025/1052 , A61M2210/125
摘要： A catheter system and devices for achieving total cardiopulmonary bypass during heart surgery are provided. The venous perfusion catheter has first and second balloons occluding the inferior and superior vena cava thereby precluding blood flow into the right atrium. An arterial perfusion catheter is inserted, advanced and positioned in the ascending aorta cephalid of the junction of the coronary arteries with the aortic root. A second flexible arterial cannula is mounted in sliding relationship with the first flexible cannula and carries an inflatable balloon adjacent its distal end to provide for occlusion of the ascending aorta. A first flexible cannula has a first lumen and an arterial venting orifice communicating with the first lumen defining a single flow path for the passage of cardioplegia solution to arrest the heart or for the evacuation of blood from the aortic root. A third lumen extends axially through the first flexible arterial cannula and communicates with a multiplicity of openings in the distal tip for suctioning blood from the left ventricle. The second flexible cannula of the arterial perfusion catheter has a first cavity extending axially therethrough that communicates with an opening at its distal tip to permit the passage of blood delivered by the cardiopulmonary bypass pump into arterial circulation. Both the venous and arterial perfusion catheters have a plurality of radially and oppositely spaced steering lumens and a plurality of steering cables fixed to the distal ends to achieve omnidirectional articulation.
摘要翻译：提供了用于在心脏手术期间实现总体心肺旁路的导管系统和装置。静脉灌注导管具有封闭下腔静脉和上腔静脉的第一和第二气囊，从而排除血液流入右心房。将动脉灌注导管插入，进行并定位于冠状动脉与主动脉根的交界处的升主动脉头皮。第二柔性动脉插管与第一柔性插管滑动关系安装，并且在其远端附近携带可充气气囊以提供上升主动脉的闭塞。第一柔性插管具有与第一内腔连通的第一内腔和动脉通气孔，所述第一腔限定单个流路，用于通过心麻痹液以阻止心脏或从主动脉根部排出血液。第三腔轴向延伸穿过第一柔性动脉插管并与远侧末端中的多个开口连通，用于抽吸来自左心室的血液。动脉灌注导管的第二柔性插管具有轴向延伸穿过其中的第一腔，其与其远侧末端处的开口连通，以允许心肺旁路泵输送的血液通过动脉循环。静脉和动脉灌注导管都具有多个径向和相对间隔的转向腔和固定到远端的多个转向电缆以实现全向关节运动。

10. 发明公开

EP0983015A4 METHODS AND DEVICES FOR OCCLUDING THE ASCENDING AORTA AND MAINTAINING CIRCULATION OF OXYGENATED BLOOD IN THE PATIENT WHEN THE PATIENT'S HEART IS ARRESTED 有权
标题翻译：方法和设备闭幕上升主动脉在维持血氧丰富的患者身体循环心脏骤停后
公开(公告)号：EP0983015A4
公开(公告)日：2000-09-27
申请号：EP99903285
申请日：1999-01-22
申请人： HEARTPORT INC
发明人： GRIMES KEVIN V , KOMTEBEDDE JAN , ROSENMAN DANIEL C , GIFFORD HANSON S III , GARRISON MICHI E , STERMAN WESLEY D , TAYLOR DAVID M , SHARKAWY A ADAM , RAY PINAKI
IPC分类号： A61B17/00 , A61B17/02 , A61B17/34 , A61F2/958 , A61B1/00
CPC分类号： A61B17/3417 , A61B17/0206 , A61B17/3421 , A61B2017/00243 , A61M25/10 , A61M25/1002 , A61M2025/1052 , A61M2025/1084 , A61M2210/127
摘要： A method and device for occluding a patient's ascending aorta, maintaining circulation of oxygenated blood in the patient and delivering cardioplegic fluid to arrest the patient's heart. An aortic occlusion catheter has an occluding member for occluding the ascending aorta. The aortic occlusion catheter passes through a cannula. Delivery of oxygenated blood is accomplished through either the cannula or the aortic occlusion catheter. In another aspect of the invention, an arterial cannula having a curved or angled distal portion. An introducer straightens the distal portion for introduction into the patient. In still another aspect of the invention, an open-mesh stabilizer is used to stabilize a discoid occluding member.

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