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    • 4. 发明公开
    • FRAGRANCE PRECURSOR COMPOUNDS
    • RIECHSTOFFVORLÄUFERVERBINDUNGEN
    • EP0989970A1
    • 2000-04-05
    • EP98937522.5
    • 1998-06-22
    • GIVAUDAN-ROURE (INTERNATIONAL) S.A.
    • ANDERSON, DeniseFRATER, Georg
    • C07C69/675C07C69/007C11D3/50A61K7/32A61K7/46C07C235/02C07C235/06C07C311/39
    • C07C69/007A23L27/75C07C69/675C07C235/06C07C235/10C07C317/40C11D3/507
    • Compounds having formula (I) in which n is 1, 2 or 3 and R1 to R6 represent, independently, branched or unbranched, substituted or unsubstituted alkyl-, alkenyl-, alkinyl-, cycloalkyl-, cycloalkenyl- or aromatic-radicals or hydrogen wherein these radicals may in addition contain one or more - O - and /or (a) - groups, whereby one or two rings can be built by the combination of the respective R1 to R6 and this/these ring(s) can be further substituted by an alkyl-group, in which X is either O and R7 represents a radical of an alcohol or phenol R7OH, or X is N and R7 represents the radical of an amine R7'R7''NH, whereby R?7' and R7''¿ represent independently, branched or unbranched, substituted or unsubstituted alkyl-, alkenyl-, alkinyl-, cycloalkyl-, cycloalkenyl- or aromatic radicals or either R7'R7'' may be hydrogen, whereby the amine is a fragrant amine or the amine has more than 9 C atoms, whereby R7 of the alcohol or phenol and R7' and/or R7'' of the amine, respectively, may further contain at least one remaining part C(OH)R?1R2-CR3R4-(CR5R6)¿n-CO- of formula (I), are useful as precursors for the delivery of odoriferous and/or antibacterial compounds in cosmetic compositions, cosmetic products, air fresheners, hard surface cleaners or laundry products.
    • 具有式(I)的化合物,其中n为1,2或3,R 1至R 6独立地表示支链或非支链的取代或未取代的烷基 - ,烯基 - ,炔基 - ,环烷基 - ,环烯基 - 或芳族基团或氢 其中这些基团可以另外含有一个或多个-O-和/或(a) - 基团,由此可以通过相应的R 1至R 6的组合来构建一个或两个环,并且该/这些环可以进一步 被烷基取代,其中X为O,R 7表示醇或苯酚R 7 OH基团,或X为N,R 7表示胺R 7'R 7'NH的基团,其中R 7'和R 7' 代表独立的,支链或非支链的,取代或未取代的烷基 - ,烯基 - ,炔基 - ,环烷基 - ,环烯基 - 或芳族基团,或者R 7'R 7“可以是氢,由此胺是芳香胺, 大于9个C原子,其中醇或酚的R 7和胺的R 7'和/或R 7“分别可以进一步连接 n至少一种式(I)的剩余部分C(OH)R 1 R 2 -CR 3 R 4 - (CR 5 R 6)n -CO-可用作在化妆品组合物,化妆品,空气清新剂中递送有气味和/或抗菌化合物的前体 ,硬表面清洁剂或洗衣产品。
    • 8. 发明公开
    • Aryl-acrylic acid esters useful as precursors for organoleptic compounds
    • 可用作感官化合物前体的芳基丙烯酸酯
    • EP0936211A3
    • 1999-08-25
    • EP99810036.6
    • 1999-01-19
    • Givaudan Roure (International) S.A.
    • Anderson, Denise, Dr.Frater, Georg, Dr.
    • C07C69/732C07C229/44C11D3/50A61K7/46
    • A61Q13/00A24B15/301A61K8/37A61K2800/57C07C69/732C07C229/44C11B9/0061C11D3/48C11D3/507
    • The acrylic acid esters of formula I
      wherein
      A is a benzene or naphthalene ring, R 1 is a saturated or unsaturated, straight or branched, alicyclic or aromatic C 10 -C 30 hydrocarbon residue which can contain heteroatoms and can be substituted by an ionic substituent, R 2 in 2- or 3-position is hydrogen, a straight or branched C 1 -C 6 residue; an optionally substituted aromatic or optionally substituted heterocyclic residue, R 3 and R 4 stand for hydrogen, a straight or branched C 1 -C 6 alkyl or C 1 -C 6 alkoxy residue, a substituted or condensed heterocyclic residue, -OH, -NO 2 , -NH 2 , -N(C 1 -C 6 alkyl) 2 , -N(hydroxyalkyl) 2 , -NHCO 2 CH 3 or -NH(heterocycle), R 2 , R 3 and R 4 may be the same or different, X stands for -OH or NHR 6 , wherein R 6 is hydrogen a saturated or unsaturated, straight or branched C 1 -C 20 hydrocarbon or an optionally substituted aromatic or heterocyclic residue, and the acrylic double bond is of the E configuration, are useful for the delivery of organoleptic compounds, especially for flavours, fragrances and masking agents and antimicrobial compounds. They can also deliver fluorescent whitening agents.
    • 其中A是苯环或萘环的式I的丙烯酸酯,R 1是饱和或不饱和的直链或支链,脂环族或芳香族C 10 -C 30烃残基,其可以含有杂原子并且可以被离子取代基取代,R 2是 2-或3-位是氢,直链或支链C 1 -C 6残基; 任选取代的芳族或任选取代的杂环残基,R 3和R 4代表氢,直链或支链C 1 -C 6烷基或C 1 -C 6烷氧基残基,取代或稠合杂环残基,-OH,-NO 2,-NH 2,-N (C1-C6烷基)2,-N(羟烷基)2,-NHCO2CH3或-NH(杂环),R2,R3和R4可以相同或不同,X代表-OH或NHR6,其中R6是氢,饱和 或不饱和的直链或支链C 1 -C 20烃或任选取代的芳族或杂环残基,且丙烯酸双键为E构型,可用于递送感官化合物,特别是用于香料,香料和掩蔽剂和抗微生物化合物 。 他们还可以提供荧光增白剂。