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1. 发明授权

EP2292190B1 Expandable medical device for delivery of beneficial agent 有权
标题翻译：用于递送有益药剂的可扩展医疗装置
公开(公告)号：EP2292190B1
公开(公告)日：2017-11-08
申请号：EP10011317.4
申请日：2001-09-21
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F.
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2/0077 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2250/0068

2. 发明授权

EP1765223B1 BALLOON CATHETER SYSTEM FOR SECURING A STENT 有权
标题翻译：球囊导管和系统的固定支架
公开(公告)号：EP1765223B1
公开(公告)日：2013-07-24
申请号：EP05764479.1
申请日：2005-06-30
申请人： Conor Medsystems, Inc.
发明人： FISHER, Beau, M.
IPC分类号： A61F2/958
CPC分类号： A61F2/958 , A61F2002/9583

3. 发明公开

EP2289593A1 Flexible medical device 审中-公开
标题翻译：灵活的医疗设备
公开(公告)号：EP2289593A1
公开(公告)日：2011-03-02
申请号：EP10010946.1
申请日：1999-03-26
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F.
IPC分类号： A61M29/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2250/0018 , A61F2250/0029 , A61F2250/0036 , A61F2250/0068
摘要： A tissue supporting device comprises an array of elongated struts and ductile hinges, the ductile hinges permitting the tissue supporting device to radially expand by first elastically and then plastically deforming, wherein a beneficial agent is contained in holes in the struts.
摘要翻译：组织支撑装置包括细长支柱和延性铰链的阵列，延性铰链允许组织支撑装置通过首先弹性地然后塑性变形而径向扩张，其中有益物质容纳在支柱中的孔中。

4. 发明授权

EP1905477B1 Beneficial agent delivery system 有权
标题翻译：系统治疗剂的释放
公开(公告)号：EP1905477B1
公开(公告)日：2009-08-19
申请号：EP07023181.6
申请日：2004-03-29
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Parker, Theodore J. , Eigler, Neal L.
IPC分类号： A61M31/00 , A61F2/82 , A61K9/00
CPC分类号： A61M25/007 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2250/0068 , A61M25/10 , A61M29/02 , A61M31/002 , A61M2025/105

5. 发明公开

EP1863408A2 SYSTEM AND METHOD FOR LOADING A BENEFICIAL AGENT INTO A MEDICAL DEVICE 有权
标题翻译：方法和设备用于充填治疗剂到医疗设备
公开(公告)号：EP1863408A2
公开(公告)日：2007-12-12
申请号：EP06740016.8
申请日：2006-03-28
申请人： Conor Medsystems, Inc.
发明人： DIAZ, Stephen, Hunter , PARKER, Theodore, L. , SHANLEY, John, F.
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/91575 , A61F2002/91583 , A61F2210/0076 , A61F2250/0068 , A61L2300/00
摘要： A system for delivery of a beneficial agent in the form of a viscous liquid or paste allows holes in a medical device to be loaded in a single step process. Another system for loading a beneficial agent into holes in a medical device includes a punch system for punching plugs of beneficial agent from a thin sheet into the holes in the medical device. The loading of a beneficial agent in a paste form or from a thin film also provides the ability to deliver large and potentially sensitive molecules including proteins, enzymes, antibodies, antisense, ribozymes, gene/vector constructs, and cells including endothelial cells.

6. 发明公开

EP1774928A2 Expandable medical device for delivery of beneficial agent 审中-公开
标题翻译：膨胀剂药剂Vorrichtung zumzuführeneines Heilsmittels
公开(公告)号：EP1774928A2
公开(公告)日：2007-04-18
申请号：EP07001395.8
申请日：2002-06-05
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Eigler, Neal L. , Edelmann, Elazer R.
IPC分类号： A61F2/90
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0031 , A61F2250/0068 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/622
摘要： An expandable medical device comprises: a plurality of substantially cylindrical tissue supporting bodies (12) which are each expandable from a cylinder having a first diameter to a cylinder having a second diameter; a plurality of flexible bridging members (14) connecting the substantially cylindrical tissue supporting bodies (12) to form an expandable device; and a plurality of openings formed in the flexible bridging members (14), the openings containing a beneficial agent for delivery to tissue.
摘要翻译：一种可扩张的医疗装置包括：多个基本上圆柱形的组织支撑体（12），它们均可从具有第一直径的圆柱体扩展到具有第二直径的圆筒; 多个柔性桥接构件（14），其连接所述基本上圆柱形的组织支撑体（12）以形成可扩张装置; 以及形成在所述柔性桥接构件（14）中的多个开口，所述开口包含用于递送至组织的有益剂。

7. 发明公开

EP1765223A2 BALLOON CATHETER AND METHOD AND SYSTEM FOR SECURING A STENT TO A BALLOON CATHETER 有权
标题翻译：球囊导管和系统的固定支架
公开(公告)号：EP1765223A2
公开(公告)日：2007-03-28
申请号：EP05764479.1
申请日：2005-06-30
申请人： Conor Medsystems, Inc.
发明人： FISHER, Beau, M.
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2002/9583
摘要： A stent is retained on a balloon catheter with a stent retention feature in the form of a pillow which minimizes sliding of the stent on the balloon during stent delivery and deployment. The balloon catheter/stent assembly includes a balloon catheter having an elongated catheter shaft and a balloon positioned at a distal end of the elongated catheter shaft. An inflation lumen extends within the elongated catheter shaft for inflation and deflation of the balloon. The stent is mounted and crimped onto the balloon and at least one pillow is formed on the balloon adjacent the ends of the stent. The at least one pillow is formed from the balloon and has an outer diameter larger than the outer diameter of the mounted and crimped stent.

8. 发明公开

EP1753451A2 LOCAL DELIVERY OF GROWTH FACTORS FOR STEM CELL TRANSPLANTATION 审中-公开
标题翻译：干细胞移植生长因子局部分布
公开(公告)号：EP1753451A2
公开(公告)日：2007-02-21
申请号：EP05760250.0
申请日：2005-06-07
申请人： Conor Medsystems, Inc.
发明人： LITVACK, Frank
IPC分类号： A61K38/18 , A61F2/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2250/0068 , A61K35/34 , A61K38/18 , A61K38/193 , A61K38/195 , A61L27/3826 , A61L27/383 , A61L27/3843 , A61L27/3873 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/414 , A61L2300/45 , C08L89/00 , A61K2300/00
摘要： A method and apparatus for local delivery of growth factors which enhances stem cell regeneration of the heart is disclosed. In one example, a stent containing growth factor within openings in the stent delivers the growth factor into a coronary artery to improve effectiveness of the stem cell transplantation therapy. The stent may also be used to transplant stem cells and deliver other bioactive factors.

9. 发明公开

EP1682038A1 EXPANDABLE MEDICAL DEVICE WITH BENEFICIAL AGENT MATRIX FORMED BY A MULTI SOLVENT SYSTEM 审中-公开
标题翻译：形成与多溶剂中的SYSTEM有益MATRIX张开的医疗设备
公开(公告)号：EP1682038A1
公开(公告)日：2006-07-26
申请号：EP04800923.7
申请日：2004-11-10
申请人： Conor Medsystems, Inc.
发明人： PARKER, Theodore, L. , SHANLEY, John, F. , MARKEY, Micheline, Lisa
IPC分类号： A61F2/02
CPC分类号： A61L31/148 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0068 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/606 , A61L2300/61 , A61L2420/02 , A61L2420/08
摘要： A multi solvent drug delivery matrix formation method is used to place layers into a reservoir in a stmt in a stepwise manner to achieve extended delivery of water soluble, sensitive, or difficult to deliver drugs. The multi solvent matrix formation method allows the formation of a drug reservoir with a layered morphology in which the mixing between layers is limited to allow the different layers to perform different functions in controlling drug delivery. A stmt having a drug delivery matrix includes a first beneficial agent layer affixed to the stmt by depositing a first solution of a first polymer and a first solvent, and a second beneficial agent layer affixed to the first beneficial agent layer by depositing a second solution of a second polymer and a second solvent. The second solvent is selected so that the first polymer is substantially insoluble in the second solvent to prevent degradation of the first polymer during deposition of the second polymer. A therapeutic agent is provided in the first beneficial agent layer or the second beneficial agent layer to form a drug delivery matrix.

10. 发明公开

EP1676547A1 Expandable medical device 审中-公开
标题翻译：膨胀剂medizinische Vorrichtung
公开(公告)号：EP1676547A1
公开(公告)日：2006-07-05
申请号：EP06006885.5
申请日：2002-02-04
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F.
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2002/91591 , A61F2230/0054 , A61F2250/0004
摘要： An expandable medical device is disclosed, comprising: a cylindrical expandable body (200;200') of Nitinol; and a locking feature for locking the expanded body (200;200') in an expanded position, wherein the locking mechanism prevents recoil of the expanded body (200;200') of greater than 6 percent.
Also disclosed is a method of processing an expandable medical device, the method comprising: fabricating a cylindrical expandable medical device (200;200') from martensitic Nitinol, wherein the expandable medical device (200;200') has a first unexpanded diameter; expanding the cylindrical expandable medical device (200;200') to an expanded second diameter, wherein deformation during expansion is confined to a hinge (250;250') and the deformation is below the elastic limit of the material; processing the expandable medical device (200;200'); and restoring the expandable medical device (200;200') to the unexpanded first diameter by applying heat to the expandable medical device (200;200').
摘要翻译：公开了一种可膨胀医疗装置，包括：镍钛诺的圆柱形可膨胀体（200; 200'）; 以及用于将扩展体（200; 200'）锁定在扩展位置的锁定特征，其中所述锁定机构防止所述膨胀体（200; 200'）的后坐力大于6％。还公开了一种处理可扩张医疗装置的方法，所述方法包括：从马氏体镍钛诺制造圆柱形可膨胀医疗装置（200; 200'），其中所述可膨胀医疗装置（200; 200'）具有第一未膨胀直径; 将所述圆柱形可膨胀医疗装置（200; 200'）膨胀至扩张的第二直径，其中膨胀期间的变形限于铰链（250; 250'），并且所述变形低于所述材料的弹性极限; 处理所述可扩张医疗装置（200; 200'）; 以及通过向所述可扩张医疗装置（200; 200'）施加热而将所述可扩张医疗装置（200; 200'）恢复到未膨胀的第一直径。

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