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1. 发明公开

EP2289572A3 Therapeutic agent delivery device with controlled therapeutic agent release rates 有权
标题翻译：一种用于与多种物质的受控释放递送的治疗性物质的设备。
公开(公告)号：EP2289572A3
公开(公告)日：2012-04-04
申请号：EP10011830.6
申请日：2004-03-29
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Parker, Theodore J.
IPC分类号： A61L27/34 , A61L29/08 , A61L29/16 , A61L31/12 , A61L31/10 , A61L31/16
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0068 , A61L31/041 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/60 , A61L2300/602 , A61L2420/08 , Y10S623/92
摘要： A method for preparing an implantable medical device comprises providing an implantable medical device with a plurality of holes; loading into the plurality of holes an amount of a therapeutic agent, which amount is sufficient to form a therapeutic agent layer; loading into the plurality of holes an amount of a composition which amount is sufficient to liquify a portion of the therapeutic agent layer, thereby allowing a portion of the therapeutic agent layer to be disposed within a mixing layer wherein an amount of therapeutic agent contained within the mixing layer is smaller than an amount of therapeutic agent contained in the therapeutic agent layer; repeating the previous step sequentially at least once with a substantially identical composition, whereby the layers take on a concentration gradient in the plurality of holes. An implantable medical device comprises an implantable device body having a plurality of holes; a therapeutic agent provided in a therapeutic agent layer contained within the plurality of holes in the device body; and at least one mixing layer provided adjacent the therapeutic agent layer in the plurality of holes, wherein the at least one mixing layer comprises at least one pharmaceutically acceptable bioresorbable polymer for allowing the therapeutic agent to be released as the polymer is resorbed; wherein the therapeutic agent layer and the at least one mixing layer together contain a concentration gradient of said therapeutic agent for allowing for the controlled release of the therapeutic agent, and wherein the therapeutic agent layer comprises at least one pharmaceutically acceptable polymer different from the polymer of the mixing layer.

2. 发明公开

EP2289572A2 Therapeutic agent delivery device with controlled therapeutic agent release rates 有权
标题翻译：一种用于与多种物质的受控释放递送的治疗性物质的设备。
公开(公告)号：EP2289572A2
公开(公告)日：2011-03-02
申请号：EP10011830.6
申请日：2004-03-29
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Parker, Theodore J.
IPC分类号： A61L27/34 , A61L29/08 , A61L29/16 , A61L31/12
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0068 , A61L31/041 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/60 , A61L2300/602 , A61L2420/08 , Y10S623/92
摘要： A method for preparing an implantable medical device comprises providing an implantable medical device with a plurality of holes; loading into the plurality of holes an amount of a therapeutic agent, which amount is sufficient to form a therapeutic agent layer; loading into the plurality of holes an amount of a composition which amount is sufficient to liquify a portion of the therapeutic agent layer, thereby allowing a portion of the therapeutic agent layer to be disposed within a mixing layer wherein an amount of therapeutic agent contained within the mixing layer is smaller than an amount of therapeutic agent contained in the therapeutic agent layer; repeating the previous step sequentially at least once with a substantially identical composition, whereby the layers take on a concentration gradient in the plurality of holes. An implantable medical device comprises an implantable device body having a plurality of holes; a therapeutic agent provided in a therapeutic agent layer contained within the plurality of holes in the device body; and at least one mixing layer provided adjacent the therapeutic agent layer in the plurality of holes, wherein the at least one mixing layer comprises at least one pharmaceutically acceptable bioresorbable polymer for allowing the therapeutic agent to be released as the polymer is resorbed; wherein the therapeutic agent layer and the at least one mixing layer together contain a concentration gradient of said therapeutic agent for allowing for the controlled release of the therapeutic agent, and wherein the therapeutic agent layer comprises at least one pharmaceutically acceptable polymer different from the polymer of the mixing layer.
摘要翻译：一种用于可植入医疗装置的制备包括：提供可植入的医疗装置具有孔的多元性方法; 加载到上的治疗剂，该量是足以形成治疗剂层的量孔的多元性; 装入孔上的组合物，其量足以液化所述治疗剂层的一部分，从而允许治疗剂层的一部分中包含在所述治疗剂的量的混合层worin内以设置的量的多元化混合层比包含在所述治疗剂层的治疗剂的量较小; 具有基本上相同的组合物，由此所述层呈现在孔的多个A浓度梯度重复先前的步骤按顺序至少一次。具有孔的多个可植入装置主体的一种可植入医疗装置包括; 在包含于所述装置主体的孔的多元性内的治疗剂层提供的治疗剂; 和作为聚合物被再吸收相邻设置的至少一个混合层被释放在孔中，所述worin至少一个混合层包含至少一种药学上可接受的生物可吸收的聚合物用于使治疗剂的多个治疗剂层; worin治疗剂层和所述至少一个混合层一起包含所述治疗剂的浓度梯度，用于允许对所述治疗剂的控制释放，并且worin治疗剂层包括从所述聚合物不同的至少一种药学上可接受的聚合物混合层。

3. 发明授权

EP1905477B1 Beneficial agent delivery system 有权
标题翻译：系统治疗剂的释放
公开(公告)号：EP1905477B1
公开(公告)日：2009-08-19
申请号：EP07023181.6
申请日：2004-03-29
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Parker, Theodore J. , Eigler, Neal L.
IPC分类号： A61M31/00 , A61F2/82 , A61K9/00
CPC分类号： A61M25/007 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2250/0068 , A61M25/10 , A61M29/02 , A61M31/002 , A61M2025/105

4. 发明公开

EP1905477A1 Beneficial agent delivery system 有权
标题翻译：系统zur Freisetzung eines Heilmittels
公开(公告)号：EP1905477A1
公开(公告)日：2008-04-02
申请号：EP07023181.6
申请日：2004-03-29
申请人： Conor Medsystems, Inc.
发明人： Shanley, John F. , Parker, Theodore J. , Eigler, Neal L.
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61M25/007 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2250/0068 , A61M25/10 , A61M29/02 , A61M31/002 , A61M2025/105
摘要： The application discloses a beneficial agent delivery system comprising: an implantable medical device (10) including a beneficial agent arranged for delivery to an implantation site within a patient, the beneficial agent configured to be modulated after implantation within the patient by an activating/deactivating means (200); and a selective modulation catheter having an activating/deactivating means (200) configured to activate or deactivate the beneficial agent on a first region of the medical device (10) to create a different delivery profile than the beneficial agent on a second region of the medical device (10).
摘要翻译：本申请公开了一种有益药物递送系统，包括：可植入医疗装置（10），其包括布置成输送到患者内的植入部位的有益药物，所述有益药剂被配置为通过激活/去激活装置在患者体内植入后进行调节（200）; 以及选择性调节导管，其具有激活/去激活装置（200），其被配置为在所述医疗装置（10）的第一区域上激活或去激活所述有益药剂以产生与所述医疗器械的第二区域上的有益药剂不同的递送曲线装置（10）。

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