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1. 发明授权

EP3118223B8 ANTI MIF ANTIBODIES FOR USE IN TREATING INFLAMMATORY DISEASES 有权转让
公开(公告)号：EP3118223B8
公开(公告)日：2020-04-15
申请号：EP16183733.1
申请日：2008-12-30
申请人： Baxalta Incorporated , Baxalta GmbH , Dyax Corporation
发明人： Kerschbaumer, Randolf , Scheiflinger, Friedrich , Rieger, Manfred , Thiele, Michael , Mudde, C. Geert , Muellberg, Jürgen , Hoet, Rene
IPC分类号： C07K16/24 , A61K39/395 , C12N15/13 , A61P35/00 , A61P1/00 , A61P13/12

2. 发明公开

EP3607955A1 NON-ANTICOAGULANT SULFATED OR SULFONATED SYNTHETIC POLYMERS 审中-公开
公开(公告)号：EP3607955A1
公开(公告)日：2020-02-12
申请号：EP19179032.8
申请日：2013-01-30
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： Dockal, Michael , Scheiflinger, Fritz , Knappe, Sabine , Till, Susanne , Hai, Ton , Sanders, Paul
IPC分类号： A61K31/795 , A61P7/04
摘要： The present invention provides pharmaceutical formulations including a non-anticoagulant, non-saccharide polymer that with at least one sulfate or sulfonate moiety. The pharmaceutical formulations of the invention are of use to improve blood clotting in a subject. Also provided are useful analytical methods utilizing these polymers, to query the dynamics of blood clotting in vitro .

3. 发明公开

EP3578184A1 RESORPTION ENHANCERS AS ADDITIVES TO IMPROVE THE ORAL FORMULATION OF LOW MOLECULAR WEIGHT HEPARINS 审中-公开
公开(公告)号：EP3578184A1
公开(公告)日：2019-12-11
申请号：EP19173011.8
申请日：2014-01-21
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： TURECEK, Peter , VEJDA, Susanne
IPC分类号： A61K31/727 , A61P1/04 , A61P1/00
摘要： Aspects of the invention include methods for treating or preventing a thromboembolic disease in a subject. In practicing methods according to certain embodiments, an amount of a low molecular weight heparin (LMWH) and a synergistically effective combination of two or more gastrointestinal epithelial barrier permeation enhancers is orally administered to a subject in a manner sufficient to treat the thromboembolic disease in the subject. Compositions and kits for practicing methods of the invention are also described.

4. 发明公开

EP3552624A1 TREATMENT OF ALZHEIMER'S DISEASE SUBPOPULATIONS WITH POOLED IMMUNOGLOBULIN G 审中-公开
公开(公告)号：EP3552624A1
公开(公告)日：2019-10-16
申请号：EP19175106.4
申请日：2014-05-05
申请人： Baxalta Incorporated , Baxalta GmbH
发明人： Gelmont, David M. , Singer, Julia , Fritsch, Sandor , Schwarz, Hans-Peter
IPC分类号： A61K39/00 , A61K38/47 , C07K16/06 , A61K39/395 , C07K16/00 , G01N33/68 , A61P25/28
摘要： The present invention provides, among other aspects, methods for the treatment of Alzheimer's disease in a subject in need thereof, the method including administration of a therapeutically effective amount of a pooled human immunoglobulin G (IgG) composition to a subject with moderately severe Alzheimer's disease, a subject carrying an ApoE4 allele, or both, where the amount of pooled human IgG is from 300 mg/kg to 800 mg/kg body weight of the subject per two week period, and where the amount is administered in one or more doses during the two week period after initiation of a therapeutic regimen. Also provided, are methods for selecting a treatment regimen for a subject with Alzheimer's disease, including diagnosing the severity of the Alzheimer's disease, determining if the subject carries an APOE4 allele, or both, and assigning a treatment regimen including administration of pooled human immunoglobulin G and/or an anti-beta amyloid monoclonal antibody.

5. 发明授权

EP2569009B1 OSPA CHIMERAS AND USE THEREOF IN VACCINES 有权转让
公开(公告)号：EP2569009B1
公开(公告)日：2019-10-09
申请号：EP11722243.0
申请日：2011-05-13
申请人： Baxalta Incorporated , Baxalta GmbH
发明人： CROWE, Brian, A. , LIVEY, Ian , O'ROURKE, Maria , SCHWENDINGER, Michael
IPC分类号： A61K39/02 , C07K14/20

6. 发明授权

EP2921180B1 Albumin-free factor VIII formulations 有权
公开(公告)号：EP2921180B1
公开(公告)日：2019-08-14
申请号：EP15154020.0
申请日：2000-02-22
申请人： University of Connecticut , Baxalta GmbH , Baxalta Incorporated
发明人： Besman, Marc , Jameel, Feroz , Bjornson, Erik , Kashi, Ramesh , Pikal, Michael , Tchessalov, Serguei , Carpenter, John
IPC分类号： A61K47/10 , A61K47/18 , A61K47/02 , A61K9/19 , A61P7/04 , A61K47/38 , A61K38/37

7. 发明公开

EP3370800A1 PACKAGING UNIT FOR SINGLE MEDICAL DEVICE 审中-公开
公开(公告)号：EP3370800A1
公开(公告)日：2018-09-12
申请号：EP16788359.4
申请日：2016-10-17
申请人： Baxalta Incorporated , Baxalta GmbH
发明人： SCHILL, Nicholas John , RYAN, Patrick John , DELVILLE, Stephan , CHERKANI, Ibrahim
IPC分类号： A61M5/00
CPC分类号： A61M5/002 , B65D77/22
摘要： A packaging unit is provided for accommodating a syringe having a barrel for slidingly receiving a plunger at one end, and having an opposite needle end, and includes a housing defining a chamber for receiving the syringe. Included in the housing are a first cavity for receiving the syringe plunger, and having a first set of side walls for directly engaging a head portion of the plunger without engaging a middle portion of the plunger; a second cavity for receiving the syringe barrel, and having a set of upper walls for directly engaging an upper surface of a flange portion of the barrel; and a third cavity for receiving the needle end of the syringe, and having a second set of side walls for directly engaging a cover for enclosing the needle end. The second cavity is in fluid communication with the first and third cavities.

8. 发明公开

EP3235489A1 ASSEMBLY TO FACILITATE USER RECONSTITUTION 审中-公开
标题翻译：装配以便于用户重新组装
公开(公告)号：EP3235489A1
公开(公告)日：2017-10-25
申请号：EP17161182.5
申请日：2011-08-25
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： Houghton, Frederick Charles II , Roush, Daniel E. , Ariagno, Scott
IPC分类号： A61J1/20
CPC分类号： A61J1/2089 , A61J1/201 , A61J1/2013 , A61J1/2065 , A61J1/2075 , A61J1/2082 , A61J1/2086
摘要： A reconstitution assembly includes a housing including a lower sleeve and an upper sleeve, including a first container and a second container disposed vertically opposite the first container. A transfer set assembly is disposed within the housing between the first container and the second container. The transfer set assembly includes an upper spike housing and a lower spike housing, with a flow path defined through the upper spike housing and the lower spike housing. The transfer set assembly is configured to access contents of the first container and then upon the activation of a triggering mechanism, create a fluid pathway between the first container and the second container. The triggering mechanism includes trigger fingers which ensure the transfer set assembly sequentially accesses the contents of the first container before accessing the contents of the second container. The disposition of the first container activates the triggering mechanism.
摘要翻译：重构组件包括具有下部套筒和上部套筒的壳体，所述下部套筒和上部套筒包括第一容器和与第一容器竖直相对设置的第二容器。传送组件组件布置在第一容器和第二容器之间的壳体内。传输组件组件包括上部钉壳和下部钉壳，流动路径限定为穿过上部钉壳和下部钉壳。传送组件组件构造成访问第一容器的内容物，然后在启动触发机构时在第一容器和第二容器之间形成流体通路。触发机构包括扳机指状件，其确保传送组件在访问第二容器的内容物之前顺序地访问第一容器的内容物。第一个容器的配置激活触发机制。

9. 发明授权

EP2295547B1 Recombinant co-expression of vitamin K epoxide reductase subunit 1 to improve vitamin K dependant protein expression 有权
标题翻译：重组共表达维生素K环氧化物还原酶亚基1以改善维生素K依赖性蛋白质表达
公开(公告)号：EP2295547B1
公开(公告)日：2017-09-20
申请号：EP10010933.9
申请日：2006-01-27
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： Scheiflinger, Friedrich , Boehm, Ernst
IPC分类号： C12N9/04
CPC分类号： C12N9/0006

10. 发明公开

EP3081233A1 GLYCOPOLYSIALYLATION OF PROTEINS OTHER THAN BLOOD COAGULATION PROTEINS 有权
标题翻译：葡萄糖ON ON ON ON EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP3081233A1
公开(公告)日：2016-10-19
申请号：EP16168473.3
申请日：2010-07-26
申请人： Baxalta GmbH , Baxalta Incorporated , Lipoxen Technologies Limited
发明人： Jain, Sanjay , Gregoriadis, Gregory , Dwivedi, Archana , Nath, Srijit , Siekmann, Juergen , Haider, Stefan , Rottensteiner, Hanspeter , Turecek, Peter
IPC分类号： A61K47/48
CPC分类号： A61K47/6455 , A61K47/60 , A61K47/61 , A61K47/65
摘要： A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.
摘要翻译：将水溶性聚合物，特别是聚唾液酸（PSA）或修饰的PSA（mPSA）与不同于凝血蛋白的糖蛋白的氧化碳水化合物部分缀合或通过使氧化的碳水化合物部分接触而与神经节苷脂或药物递送系统其中所述水溶性聚合物含有氨基氧基，并且在水溶性聚合物上的氧化碳水化合物部分和氨基氧基之间形成肟键，或者其中所述水溶性聚合物含有酰肼基，腙键是形成在水溶性聚合物上的氧化碳水化合物部分和酰肼基团之间。因此得到氨基氧基或酰肼 - 水溶性聚合物如PSA和mPSA的结合物，其中PSA或mPSA通过碳水化合物部分连接。

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