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1. 发明公开

EP2653127A1 Systems and methods for delivering energy to passageways in a patient 有权转让
标题翻译：系统zur Abgabe von Energie aDurchgängebei einem Patienten
公开(公告)号：EP2653127A1
公开(公告)日：2013-10-23
申请号：EP13003642.9
申请日：2008-06-05
申请人： ASTHMATX, INC.
发明人： Webster, Noah , Dalbec, Timothy, R. , Phan, Huy , Wizeman, William, J. , Evans, William , Presta, Matthew
IPC分类号： A61B18/14 , A61B18/00 , A61B17/00
CPC分类号： A61B18/1492 , A61B18/0206 , A61B18/082 , A61B18/1815 , A61B18/20 , A61B2017/00092 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00541 , A61B2018/00577 , A61B2018/0091 , A61B2018/1465 , A61B2018/1467 , A61B2018/1475
摘要： A device for delivering energy to an airway of a lung, the device comprising:
an elongate member including a proximal end, a distal end, and a lumen extending therebetween;
an actuating member operably coupled to the proximal end;
an electrode assembly operably coupled to the distal end, wherein the electrode assembly includes a plurality of electrodes; and
an operating member extending from the actuating member, through the lumen of the elongate member, and coupled to a distal end of the electrode assembly, wherein the operating member is configured to move reciprocally relative to the elongate member via actuation of the actuating member, wherein reciprocal movement of the operating member is configured to transition the electrode assembly between a first configuration and a second configuration, and wherein the operating member is biased distally by a resilient member in the actuating member.
摘要翻译：一种用于向肺的气道递送能量的装置，所述装置包括：细长构件，包括近端，远端和在其间延伸的内腔; 可操作地联接到所述近端的致动构件; 电极组件，其可操作地耦合到所述远端，其中所述电极组件包括多个电极; 以及操作构件，其从所述致动构件延伸穿过所述细长构件的内腔，并且联接到所述电极组件的远端，其中所述操作构件被构造成通过所述致动构件的致动而相对于所述细长构件往复移动，其中所述操作构件的往复运动被配置为在第一构型和第二构造之间转动所述电极组件，并且其中所述操作构件通过所述致动构件中的弹性构件向远侧偏压。

2. 发明公开

EP1618850A3 Control system and process for application of energy to airway walls and other mediums 审中-公开
标题翻译：控制系统和方法用于将能量供应到气道壁或其它媒体
公开(公告)号：EP1618850A3
公开(公告)日：2006-04-05
申请号：EP05019417.4
申请日：2001-10-17
申请人： ASTHMATX, INC.
发明人： Biggs, Michael , Stern, Roger, A. , Danek, Christopher, James
IPC分类号： A61B18/12 , A61B18/14
CPC分类号： A61B18/08 , A61B18/1206 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00083 , A61B2018/00214 , A61B2018/00267 , A61B2018/00541 , A61B2018/00678 , A61B2018/00791 , A61B2018/00803 , A61B2018/00821 , A61B2018/00898 , A61B2018/1417
摘要： The present invention includes a system for delivering energy to an airway wall of a lung comprising an energy delivering apparatus and a PID controller having one or more variable gain factors which are rest after energy deliver has begun. The energy delivering apparatus may include a flexible elongated member and a distal expandable basket having at least one electrode for transferring energy to the airway wall and at least one temperature sensor for measuring temperature. The PID controller determines a new power set point base on an error between a preset temperature and the measured temperature. The algorithm can be Pi+1 = Pi + G(αe i + βe i-1 + γ e i-2 ) where α, β and γ are preset values and α is from 1 to 2; β is from -1 to -2; and γ is from -0.5 to 0-5. In another variation, the controller is configured to shut down if various measured parameters are exceeded such as, for example, energy, impedance, temperature, temperature differences, activation time and combinations thereof. Methods for treating a target medium using a PID algorithm are also provided.

3. 发明授权

EP1173103B1 MODIFICATION OF AIRWAYS BY APPLICATION OF ENERGY 有权
标题翻译：空中航线THROUGH能源使用改性
公开(公告)号：EP1173103B1
公开(公告)日：2005-10-19
申请号：EP00930131.8
申请日：2000-04-21
申请人： ASTHMATX, INC.
发明人： DANEK, Christopher, James , KEAST, Thomas , LOOMAS, Bryan , BIGGS, Michael , BURGER, Keith, M. , HAUGAARD, Dave , ROSS, John, Arthur
IPC分类号： A61B18/14
CPC分类号： A61B18/12 , A61B17/22004 , A61B18/00 , A61B18/08 , A61B18/14 , A61B18/1485 , A61B18/1492 , A61B2017/00115 , A61B2017/00292 , A61B2017/003 , A61B2017/22062 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00541 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/044 , A61B2018/046 , A61B2018/1807 , A61B2090/3614 , A61M25/0043 , A61M29/00 , A61M2025/0096 , A61M2210/1039 , A61N5/0601
摘要： This relates to treating an asthmatic lung and more particularly, relates to advancing a treatment device into the lung and treating the lung with the device. This also includes additional steps of treating the airway wall, applying energy or heat to the airway wall in an asthmatic lung.

4. 发明授权

EP2902069B1 IMPROVED ENERGY DELIVERY DEVICE 有权
公开(公告)号：EP2902069B1
公开(公告)日：2019-01-16
申请号：EP15152687.8
申请日：2005-11-14
申请人： ASTHMATX, INC.
发明人： Danek,Christopher J. , Wizeman, Wiliiam J.
IPC分类号： A61M29/00 , A61B18/14

5. 发明授权

EP1326548B1 CONTROL SYSTEM AND PROCESS FOR APPLICATION OF ENERGY TO AIRWAY WALLS AND OTHER MEDIUMS 有权
标题翻译：控制系统和方法的电力供应空中航线墙壁或其他媒体
公开(公告)号：EP1326548B1
公开(公告)日：2006-01-18
申请号：EP01979858.6
申请日：2001-10-17
申请人： ASTHMATX, INC.
发明人： BIGGS, Michael , STERN, Roger, A. , DANEK, Christopher, James
IPC分类号： A61B18/12 , A61B18/14
CPC分类号： A61B18/08 , A61B18/1206 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00083 , A61B2018/00214 , A61B2018/00267 , A61B2018/00541 , A61B2018/00678 , A61B2018/00791 , A61B2018/00803 , A61B2018/00821 , A61B2018/00898 , A61B2018/1417
摘要： The present invention includes a system for delivering energy to an airway wall of a lung comprising an energy delivering apparatus and a PID controller having one or more variable gain factors which are rest after energy deliver has begun. The energy delivering apparatus may include a flexible elongated member and a distal expandable basket having at least one electrode for transferring energy to the airway wall and at least one temperature sensor for measuring temperature. The PID controller determines a new power set point base on an error between a preset temperature and the measured temperature. The algorithm can be Pi+1 = Pi + G(αei+βei-1+ηei-2) where α, β and η are preset values and α is from 1 to 2; β is from -1 to -2; and η is from -0.5 to 0-5. In another variation, the controller is configured to shut down if various measured parameters are exceeded such as, for example, energy, impedance, temperature, temperature differences, activation time and combinations thereof. Methods for treating a target medium using a PID algorithm are also provided.

6. 发明公开

EP2902069A1 IMPROVED ENERGY DELIVERY DEVICES AND METHODS 审中-公开
标题翻译： VERBESSERTE VORRICHTUNGEN UND VERFAHREN ZURENERGIEÜBERTRAGUNG
公开(公告)号：EP2902069A1
公开(公告)日：2015-08-05
申请号：EP15152687.8
申请日：2005-11-14
申请人： ASTHMATX, INC.
发明人： Danek,Christopher J. , Wizeman, Wiliiam J.
IPC分类号： A61M29/00 , A61B18/14
CPC分类号： A61B18/1492 , A61B18/02 , A61B18/08 , A61B90/30 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00541 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61N7/022
摘要： This relates to methods and devices for improving treatment to a wall, a cavity or passageway with a medical device when used in tortuous anatomy
摘要翻译：这涉及用于在曲折解剖学中使用时用于改善对具有医疗装置的壁，空腔或通道的治疗的方法和装置

7. 发明公开

EP1618850A2 Control system and process for application of energy to airway walls and other mediums 审中-公开
标题翻译： Kontrollsystemfürdie Energiezufuhr zuLuftwegewändenoder anderen Medien
公开(公告)号：EP1618850A2
公开(公告)日：2006-01-25
申请号：EP05019417.4
申请日：2001-10-17
申请人： ASTHMATX, INC.
发明人： Biggs, Michael , Stern, Roger, A. , Danek, Christopher, James
IPC分类号： A61B18/08 , A61B18/12 , A61B18/14
CPC分类号： A61B18/08 , A61B18/1206 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00083 , A61B2018/00214 , A61B2018/00267 , A61B2018/00541 , A61B2018/00678 , A61B2018/00791 , A61B2018/00803 , A61B2018/00821 , A61B2018/00898 , A61B2018/1417
摘要： The present invention includes a system for delivering energy to an airway wall of a lung comprising an energy delivering apparatus and a PID controller having one or more variable gain factors which are rest after energy deliver has begun. The energy delivering apparatus may include a flexible elongated member and a distal expandable basket having at least one electrode for transferring energy to the airway wall and at least one temperature sensor for measuring temperature. The PID controller determines a new power set point base on an error between a preset temperature and the measured temperature. The algorithm can be Pi+1 = Pi + G(αe i + βe i-1 + γ e i-2 ) where α, β and γ are preset values and α is from 1 to 2; β is from -1 to -2; and γ is from -0.5 to 0-5. In another variation, the controller is configured to shut down if various measured parameters are exceeded such as, for example, energy, impedance, temperature, temperature differences, activation time and combinations thereof. Methods for treating a target medium using a PID algorithm are also provided.
摘要翻译：本发明包括一种用于向肺气道壁输送能量的系统，包括能量输送装置和具有一个或多个可变增益因子的PID控制器，所述可变增益因子在能量传递开始之后休息。能量输送装置可以包括柔性细长构件和远端可膨胀篮，其具有用于将能量传递到气道壁的至少一个电极和用于测量温度的至少一个温度传感器。 PID控制器根据预设温度和测量温度之间的误差确定新的功率设定点。该算法可以是Pi + 1 = Pi + G（±e i +²ei-1 +³e i-2）其中±，²和³是预设值，±是1到2; ²为-1至-2; ³为-0.5〜0-5。在另一变型中，控制器被配置为如果超过了各种测量参数，例如能量，阻抗，温度，温度差，激活时间及其组合，则关闭。还提供了使用PID算法处理目标介质的方法。

8. 发明授权

EP2653127B1 Systems for delivering energy to passageways in a patient 有权转让
标题翻译：用于向患者的通道输送能量的系统
公开(公告)号：EP2653127B1
公开(公告)日：2017-11-22
申请号：EP13003642.9
申请日：2008-06-05
申请人： ASTHMATX, INC.
发明人： Webster, Noah , Dalbec, Timothy, R. , Phan, Huy , Wizeman, William, J. , Evans, William , Presta, Matthew
IPC分类号： A61B18/14 , A61B18/00 , A61B17/00 , A61B18/20 , A61B18/08 , A61B18/18 , A61B18/02
CPC分类号： A61B18/1492 , A61B18/0206 , A61B18/082 , A61B18/1815 , A61B18/20 , A61B2017/00092 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00541 , A61B2018/00577 , A61B2018/0091 , A61B2018/1465 , A61B2018/1467 , A61B2018/1475
摘要： A device for delivering energy to an airway of a lung, the device comprising: an elongate member including a proximal end, a distal end, and a lumen extending therebetween; an actuating member operably coupled to the proximal end; an electrode assembly operably coupled to the distal end, wherein the electrode assembly includes a plurality of electrodes; and an operating member extending from the actuating member, through the lumen of the elongate member, and coupled to a distal end of the electrode assembly, wherein the operating member is configured to move reciprocally relative to the elongate member via actuation of the actuating member, wherein reciprocal movement of the operating member is configured to transition the electrode assembly between a first configuration and a second configuration, and wherein the operating member is biased distally by a resilient member in the actuating member.

9. 发明授权

EP1326549B1 MODIFICATION OF AIRWAYS BY APPLICATION OF ENERGY 有权
标题翻译：应用能量修正航路
公开(公告)号：EP1326549B1
公开(公告)日：2005-12-21
申请号：EP00973613.3
申请日：2000-10-17
申请人： ASTHMATX, INC.
发明人： DANEK, Christopher, James , BIGGS, Michael , BURGER, Keith, M. , LOOMAS, Bryan , KEAST, Thomas , HAUGAARD, Dave
IPC分类号： A61B18/14
CPC分类号： A61B18/08 , A61B18/1206 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00083 , A61B2018/00214 , A61B2018/00267 , A61B2018/00541 , A61B2018/00678 , A61B2018/00791 , A61B2018/00803 , A61B2018/00821 , A61B2018/00898 , A61B2018/1417
摘要： This relates to methods and devices for treating reversible chronic obstructive pulmonary disease, and more particularly, relates to a device for exchanging energy with airway tissue such as that found in the airway of human lungs. The exchange of energy with this airway tissue in the airways reduces the ability of the air ways to constrict and/or reduces the resistance within the airway to the flow of air through the airway. This also relates to a method for decreasing responsiveness or decreasing resistance to airflow of airways involves the transfer of energy to or from the airway walls to prevent or reduce airway constriction and other symptoms of lung diseases. The treatment reduces the ability of the airway to contract during an acute narrowing of the airways, reduces mucus plugging of the airways, and/or increases the airway diameter. The methods according to the present invention provide a longer duration and/or more effective treatment for lung diseases than currently used drug treatments, and obviate patient compliance issues. This also includes additional steps that reduce the ability of the lung to produce at least one of the symptoms of reversible obstructive pulmonary disease and to reduce the resistance to the flow of air through a lung.
摘要翻译：这涉及用于治疗可逆性慢性阻塞性肺病的方法和装置，并且更具体地涉及用于与例如在人肺的气道中发现的气道组织交换能量的装置。气道中的这种气道组织的能量交换降低了气道对气道内阻力和/或减小通过气道的气流阻力的能力。这也涉及降低对气道气流的反应性或降低气流阻力的方法，涉及将能量传递到气道壁或从气道壁传递，以防止或减少气道收缩和肺病的其他症状。该治疗降低了气道急剧变窄期间气道收缩的能力，减少气道粘液堵塞和/或增加气道直径。根据本发明的方法比目前使用的药物治疗提供更长的持续时间和/或更有效的肺部疾病治疗，并且消除了患者依从性问题。这还包括减少肺部产生可逆性阻塞性肺病症状中的至少一种的能力并减少对通过肺的空气流动的阻力的附加步骤。

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