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1. 发明授权

EP3006559B1 LAYERED CELL SHEET INCORPORATING HYDROGEL 有权转让
公开(公告)号：EP3006559B1
公开(公告)日：2019-11-06
申请号：EP14803665.0
申请日：2014-05-30
申请人： iHeart Japan Corporation
发明人： YAMASHITA, Jun , TABATA, Yasuhiko , MATSUO, Takehiko
IPC分类号： C12N5/077 , A61L27/38 , C12N5/0735 , A61L27/00 , A61P9/00 , C12N5/07 , C12N5/10 , A61L27/52 , A61L27/36

2. 发明授权

EP3138906B1 CD82-POSITIVE CARDIAC PROGENITOR CELLS 有权转让
公开(公告)号：EP3138906B1
公开(公告)日：2019-08-21
申请号：EP15785970.3
申请日：2015-04-16
申请人： iHeart Japan Corporation
发明人： YAMASHITA, Jun , TAKEDA, Masafumi
IPC分类号： C12N5/10 , A61K35/12 , A61P9/00 , A61K35/28

3. 发明公开

EP2826855A1 METHOD FOR PRODUCING CARDIAC AND VASCULAR CELL MIXTURE FROM ARTIFICIAL PLURIPOTENT STEM CELLS 有权转让
标题翻译：方法生产人造多能干细胞的心脏和血管的细胞混合物
公开(公告)号：EP2826855A1
公开(公告)日：2015-01-21
申请号：EP13760866.7
申请日：2013-03-15
申请人： iHeart Japan Corporation
发明人： YAMASHITA, Jun , MASUMOTO, Hidetoshi
IPC分类号： C12N5/071 , A61K35/12 , A61L27/00 , A61P9/00
CPC分类号： A61L27/3886 , A61K35/34 , A61K35/44 , A61K35/545 , A61L27/3804 , A61L27/3808 , A61L27/3826 , A61L27/3834 , A61L27/3839 , A61L27/3895 , A61L27/50 , A61L27/54 , A61L2300/608 , A61L2300/64 , A61L2430/20 , C12N5/0602 , C12N5/0657 , C12N5/069 , C12N5/0697 , C12N2500/44 , C12N2501/115 , C12N2501/16 , C12N2501/165 , C12N2501/727 , C12N2502/1329 , C12N2502/28 , C12N2506/45 , C12N2539/10 , A61K2300/00
摘要： The present invention provides: a method for producing mixed cells comprising cardiomyocytes, endothelial cells and mural cells from induced pluripotent stem cells, the method comprising (a) a step of producing cardiomyocytes from induced pluripotent stem cells and (b) a step of culturing the cardiomyocytes in the presence of VEGF; and a therapeutic agent for heart diseases, comprising the mixed cells produced by the method.
摘要翻译：本发明提供：用于制造混合的细胞包括心肌细胞，内皮细胞和周细胞从诱导的多能干细胞的方法，该方法包括（A）从诱导的多能干细胞和（b）培养所述的步骤生产的心肌细胞的步骤心肌细胞在血管内皮生长因子的存在; 和用于心脏疾病，包括由该方法产生的混合的细胞治疗剂。

4. 发明公开

EP3138906A1 CD82-POSITIVE CARDIAC PROGENITOR CELLS 有权转让
标题翻译： CD82阳性HERZVORLÄUFERZELLEN
公开(公告)号：EP3138906A1
公开(公告)日：2017-03-08
申请号：EP15785970.3
申请日：2015-04-16
申请人： iHeart Japan Corporation
发明人： YAMASHITA, Jun , TAKEDA, Masafumi
IPC分类号： C12N5/10 , A61K35/12 , A61P9/00
CPC分类号： C12N5/0657 , A61K35/12 , A61K35/28 , C12N5/10 , C12N2506/45
摘要： An object of the present invention is to provide a myocardial progenitor cell that is specifically induced to differentiate into a cardiomyocyte, and a method for preparing the myocardial progenitor cell. A method for preparing a CD82-positive cell includes, in sequence, a step (a) of obtaining stem cells, a step (b) of subjecting the stem cells to induction treatment of differentiation into cardiovascular cells, and a step (c) of separating, from the stem cells having been subjected to the induction treatment of differentiation in the step (b), a CD82-positive cell being negative for at least one cell surface marker selected from CD73, CD44, CD105, CD121a, CD18, and CD120a. This method enables preparation of a CD82-positive cell for use as a myocardial progenitor cell.
摘要翻译：本发明的目的是提供特异性诱导分化成心肌细胞的心肌祖细胞，以及心肌祖细胞的制备方法。制备CD82阳性细胞的方法依次包括获得干细胞的步骤（a），使干细胞诱导分化为心血管细胞的诱导处理步骤（b），和从步骤（b）中进行分化诱导处理的干细胞与选自CD73，CD44，CD105，CD121a，CD18和CD120a的至少一种细胞表面标志物阴性的CD82阳性细胞分离。该方法能够制备用作心肌祖细胞的CD82阳性细胞。

5. 发明授权

EP2826855B1 MYOCARDIAL SHEET 有权转让
公开(公告)号：EP2826855B1
公开(公告)日：2018-08-29
申请号：EP13760866.7
申请日：2013-03-15
申请人： iHeart Japan Corporation
发明人： YAMASHITA, Jun , MASUMOTO, Hidetoshi
IPC分类号： C12N5/071 , A61K35/12 , A61L27/00 , A61P9/00
CPC分类号： A61L27/3886 , A61K35/34 , A61K35/44 , A61K35/545 , A61L27/3804 , A61L27/3808 , A61L27/3826 , A61L27/3834 , A61L27/3839 , A61L27/3895 , A61L27/50 , A61L27/54 , A61L2300/608 , A61L2300/64 , A61L2430/20 , C12N5/0602 , C12N5/0657 , C12N5/069 , C12N5/0697 , C12N2500/44 , C12N2501/115 , C12N2501/16 , C12N2501/165 , C12N2501/727 , C12N2502/1329 , C12N2502/28 , C12N2506/45 , C12N2539/10 , A61K2300/00
摘要： The present invention provides: a method for producing mixed cells comprising cardiomyocytes, endothelial cells and mural cells from induced pluripotent stem cells, the method comprising (a) a step of producing cardiomyocytes from induced pluripotent stem cells and (b) a step of culturing the cardiomyocytes in the presence of VEGF; and a therapeutic agent for heart diseases, comprising the mixed cells produced by the method.

6. 发明公开

EP3006559A1 LAYERED CELL SHEET INCORPORATING HYDROGEL 有权转让
标题翻译：用水凝胶层状细胞层
公开(公告)号：EP3006559A1
公开(公告)日：2016-04-13
申请号：EP14803665.0
申请日：2014-05-30
申请人： iHeart Japan Corporation
发明人： YAMASHITA, Jun , TABATA, Yasuhiko , MATSUO, Takehiko
IPC分类号： C12N5/0735 , A61L27/00 , A61P9/00 , C12N5/07 , C12N5/10
摘要： The present invention relates to layered cell sheets comprising living cells and methods for producing the same. Specifically, the present invention provides methods for layering cell sheets, comprising layering cell sheets using hydrogel or preferably gelatin hydrogel. The present invention also provides layered cell sheets produced by such methods, and pharmaceutical compositions or therapeutic agents comprising layered cell sheets.

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