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1. 发明公开

EP2027851A1 Topical pharmaceutical formulations and methods of treatment 审中-公开
标题翻译： Topische pharmazeutische Formulierungen und Behandlungsverfahren
公开(公告)号：EP2027851A1
公开(公告)日：2009-02-25
申请号：EP07122565.0
申请日：2001-06-26
申请人： Vectura Limited
发明人： Staniforth, John Nicholas , Tobyn, Michael John
IPC分类号： A61K9/20 , A61K9/16
CPC分类号： A61K9/2013
摘要： In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a therapeutic agent and a pharmaceutically acceptable carrier medium therefor, said formulation being solid at ambient temperature and having a softening point of not higher than 35°C, such that when the formulation is placed in continuous contact with the skin of a mammalian patient, it is softened to a consistency to effect substantial application of the unit dose of said therapeutic agent onto a desired skin area of the mammalian patient within a time period of less than 10 minutes.
摘要翻译：在某些实施方案中，本发明涉及用于哺乳动物局部给药的药物制剂，其包含治疗有效量的治疗剂及其药学上可接受的载体介质的单位剂量，所述制剂在环境温度下为固体，并且具有软化点不高于35℃，使得当制剂与哺乳动物患者的皮肤连续接触时，它被软化成一致性，以使所述治疗剂的单位剂量实质上应用于所需的在不到10分钟的时间内哺乳动物患者的皮肤区域。

2. 发明公开

EP1920763A1 Pharmaceutical compositions for inhalation 有权
标题翻译： Pharmazutische Zusammensetzungen zur吸入
公开(公告)号：EP1920763A1
公开(公告)日：2008-05-14
申请号：EP07123922.2
申请日：2001-11-30
申请人： Vectura Limited
发明人： Staniforth, John Nicholas , Harris, Haggis , Morton, David Alexander Vodden , Bannister, Robin
IPC分类号： A61K9/00 , A61K47/28
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention provides microparticles for use in a pharmaceutical composition for pulmomary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.
摘要翻译：本发明提供了用于用于脉冲投药的药物组合物中的微粒，每个微粒包含活性物质的颗粒，其表面上具有适于延迟活性物质溶解的疏水性材料的颗粒。本发明还提供了制备微粒的方法。

3. 发明公开

EP1549294A1 PHARMACEUTICAL EXCIPIENTS COMPRISING INORGANIC PARTICLES IN ASSOCIATION WITH AN ORGANIC POLYMERIC MATERIAL AND FORMING A SOLID RETICULATED MATRIX, COMPOSITIONS, MANUFACTURING AND USE THEREOF 审中-公开
标题翻译：药物中的无机物粒子在与有机高分子材中含有固定，电源等，其成分，生产和使用矩阵形式连接
公开(公告)号：EP1549294A1
公开(公告)日：2005-07-06
申请号：EP03751063.3
申请日：2003-10-10
申请人： Vectura Limited
发明人： Tobyn, Michael , Staniforth, John Nicholas , Clinch, Cheryl , Hearn, Matthew Paul , Walsh, Dominic , Hall, Simon Robert
IPC分类号： A61K9/14 , A61K9/16 , C08J3/215 , C08L5/00 , C08L5/02
CPC分类号： C08L5/00 , A61K9/143 , A61K9/146 , A61K9/1611 , A61K9/1652 , A61K9/1658 , A61K9/2009 , C08L5/02
摘要： A pharmaceutical excipient comprising a solid, reticulated matrix, wherein the matrix comprises an aggregation of inorganic particles in association with an organic polymeric material, defines a plurality of pores with a mean width in the range of about 0.01-500 m, and has a specific surface area of at least about 1 m2/g is described, as are products comprising such excipients, methods of making them and use thereof.

4. 发明授权

EP1232745B1 Powder for use in dry powder inhalers 无效
标题翻译：粉于干粉吸入器
公开(公告)号：EP1232745B1
公开(公告)日：2007-03-07
申请号：EP02007397.9
申请日：1996-01-31
申请人： Vectura Limited
发明人： Staniforth, John Nicholas
IPC分类号： A61K9/00 , A61K9/12
CPC分类号： A61K9/0075 , A61K9/12 , A61K9/145 , A61K31/7012 , Y10S514/951
摘要： A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material (4) on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be released from the carrier particles before actuation of the inhaler. The inclusion of additive material (4) in the powder has been found to give an increased respirable fraction of the active material.

5. 发明授权

EP1920763B1 Pharmaceutical compositions for inhalation 有权
标题翻译：用于吸入的药物组合物
公开(公告)号：EP1920763B1
公开(公告)日：2014-04-02
申请号：EP07123922.2
申请日：2001-11-30
申请人： Vectura Limited
发明人： Staniforth, John Nicholas , Harris, Haggis , Morton, David Alexander Vodden , Bannister, Robin
IPC分类号： A61K9/00 , A61K47/28
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention provides microparticles for use in a pharmaceutical composition for pulmomary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.

6. 发明公开

EP2298285A3 Method of making particles for use in a pharmaceutical composition 审中-公开
标题翻译：在药物组合物中使用颗粒的生产方法
公开(公告)号：EP2298285A3
公开(公告)日：2011-07-27
申请号：EP10183504.9
申请日：2001-11-30
申请人： Vectura Limited
发明人： Staniforth, John Nicholas , Harris, Haggis , Morton, David Alexander Vodden , Bannister, Robin
IPC分类号： A61K9/00 , A61K47/28
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.

7. 发明公开

EP2298279A2 Pharmaceutical compositions for inhalation 有权
标题翻译：用于吸入的药物组合物
公开(公告)号：EP2298279A2
公开(公告)日：2011-03-23
申请号：EP10182218.7
申请日：2001-11-30
申请人： Vectura Limited
发明人： Staniforth, John Nicholas , Harris, Haggis , Morton, David Alexander Vodden , Bannister, Robin
IPC分类号： A61K9/00 , A61K47/28
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention provides microparticles for use in a pharmaceutical composition for pulmomary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.

8. 发明公开

EP1213012A2 Improvements in and relating to powders for use in dry powder inhalers 失效
标题翻译：用于干粉吸入器的粉末的改进
公开(公告)号：EP1213012A2
公开(公告)日：2002-06-12
申请号：EP02003204.1
申请日：1996-07-24
申请人： Vectura Limited
发明人： Staniforth, John Nicholas
IPC分类号： A61K9/00 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/145 , Y10S514/951
摘要： A powder for use in a dry powder inhaler comprises active material and additive material. The additive material comprises an anti-adherent material and the powder includes at least 60% by weight of active material.
The inclusion of the additive material in the powder has been found to give an increased respirable fraction of the active material.
摘要翻译：用于干粉吸入器的粉末包含活性物质和添加剂材料。该添加剂材料包含抗粘附材料并且该粉末包含至少60重量％的活性材料。已经发现将添加剂材料包含在粉末中可提高活性材料的可呼吸部分。

9. 发明公开

EP2298279A3 Pharmaceutical compositions for inhalation 有权
标题翻译：用于吸入的药物组合物
公开(公告)号：EP2298279A3
公开(公告)日：2011-08-03
申请号：EP10182218.7
申请日：2001-11-30
申请人： Vectura Limited
发明人： Staniforth, John Nicholas , Harris, Haggis , Morton, David Alexander Vodden , Bannister, Robin
IPC分类号： A61K9/00 , A61K47/28
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention provides microparticles for use in a pharmaceutical composition for pulmomary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.
摘要翻译：本发明提供用于用于肺部给药的药物组合物的微粒，每个微粒包含活性物质颗粒，所述活性物质颗粒在其表面上具有适于延迟活性物质溶解的疏水材料颗粒。本发明还提供了制造微粒的方法。

10. 发明公开

EP2298285A2 Method of making particles for use in a pharmaceutical composition 审中-公开
标题翻译： HerstellungsverfahrenfürPartikel zur Verwendung in einer Arzneizusammensetzung
公开(公告)号：EP2298285A2
公开(公告)日：2011-03-23
申请号：EP10183504.9
申请日：2001-11-30
申请人： Vectura Limited
发明人： Staniforth, John Nicholas , Harris, Haggis , Morton, David Alexander Vodden , Bannister, Robin
IPC分类号： A61K9/14 , A61K9/72 , A61K9/00
CPC分类号： A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要： The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.
摘要翻译：本发明提供了用于肺部给药的药物组合物中的微粒，每个微粒包含活性物质的颗粒，其表面上具有适于延迟活性物质溶解的疏水性材料的颗粒。本发明还提供了制备微粒的方法。

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