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2. 发明公开

EP3077500A1 INSTALLATION DE COUPLAGE D'UN BIORÉACTEUR AVEC UN APPAREIL D'ANALYSE PHYSICO-CHIMIQUE OU DE COLLECTE D'ÉCHANTILLONS 有权
标题翻译：系统配对与设备用于生物反应器理化分析或取样
公开(公告)号：EP3077500A1
公开(公告)日：2016-10-12
申请号：EP14806236.7
申请日：2014-12-01
申请人： Université Technologie de Compiègne-UTC , Centre National de la Recherche Scientifique (CNRS)
发明人： LECLERC, Eric , PAULLIER, Patrick , MERLIER, Franck
IPC分类号： C12M3/06 , C12M1/00 , C12M1/34
CPC分类号： C12M33/04 , C12M23/16 , C12M29/04 , C12M29/10 , C12M41/12 , C12M41/32 , C12M41/34 , C12M43/00 , C12Q1/02
摘要： The invention concerns a facility for coupling a bioreactor (1) for culturing bio-organisms, in dynamic mode, with at least one device (2) for physicochemically analysing a fluid from this bioreactor or collecting samples of this fluid, the device (2) being equipped with a pump (20) and an injector (21), the bioreactor (1) being equipped with means (10) for supplying culture medium and xenobiotic(s). The facility is remarkable in that the bioreactor (1) is connected to a closed perfusion loop (11) provided with a pump (12), fitted with a sampling loop (13) and in that the facility comprises: - a device for injecting a cleaning product (6) into said sampling loop (13), - two six-way valves (3, 4), the first valve (3) being connected to the closed perfusion loop (11), to the sampling loop (13) and to a cleaning loop (14), the second valve (4) being connected to the cleaning loop (14) and an injection loop (15) that connects the injector (21) to at least one of the devices (2).
摘要翻译：本发明涉及一种设备，用于培养生物有机体，在动态模式下耦合的生物反应器（1），与至少一个装置（2），用于物理化学成就从该生物反应器中分析流体或收集该流体样本，所述装置（2）被配备有用于供给培养基和异生素（多个）的泵（20）和在喷射器（21），所述生物反应器（1）配备有装置（10）。该设施是显着的中所做的生物反应器（1）连接到设置有泵（12），配有取样循环（13）的封闭灌注回路（11）和在DASS模具设备包括： - 一个设备用于注入清洁产品（6）进入所述取样循环（13）， - 两个六通阀（3，4），所述第一阀（3）连接到所述封闭灌注回路（11）到采样环路（13）和到清洁环（14），所述第二阀（4）被连接到所述清洁环（14）和喷射环（15）没有连接所述喷射器（21）的装置的至少一个（2）。

3. 发明公开

EP3426768A1 METHOD OF DIFFERENTIATING PLURIPOTENT STEM CELLS 有权
公开(公告)号：EP3426768A1
公开(公告)日：2019-01-16
申请号：EP16729045.1
申请日：2016-03-07
申请人： Centre National de la Recherche Scientifique (CNRS) , The Foundation for the Promotion of Industrial Science
发明人： LECLERC, Eric , SAKAI, Yasuyuki , KIMURA, Keiichi , MIYAJIMA, Atsushi , KIDO, Taketomo
IPC分类号： C12N5/071 , C12N5/0735 , C12N5/074

4. 发明授权

EP2699339B1 PROCEDE ET SYSTEME DE PRODUCTION DE MICROCAPSULES CALIBREES 有权
标题翻译： VERFAHREN UND SYSTEM ZUR HERSTELLUNG VON KALIBRIERTEN MIKROKAPSELN
公开(公告)号：EP2699339B1
公开(公告)日：2015-05-27
申请号：EP12719311.8
申请日：2012-04-23
申请人： Université Technologie de Compiègne-UTC , Centre National de la Recherche Scientifique (CNRS)
发明人： LECLERC, Eric , SALSAC, Anne-Virginie , BARTHES-BIESEL, Dominique , CHU, Thi Xuan
IPC分类号： B01J13/14
CPC分类号： B01J13/00 , B01J13/14 , G05D7/0694

5. 发明授权

EP2480654B1 DISPOSITIF ET SYSTEME DE FILTRATION 有权
标题翻译：过滤和SYSTEM
公开(公告)号：EP2480654B1
公开(公告)日：2015-06-17
申请号：EP10757102.8
申请日：2010-09-23
申请人： Université Technologie de Compiègne-UTC , Centre National de la Recherche Scientifique (CNRS)
发明人： PAULLIER, Patrick , OULD DRIS, Aïssa , LECLERC, Eric
IPC分类号： C12M3/06 , B01D35/30 , B81B1/00
CPC分类号： C12M29/04 , C12M23/16 , C12M23/26 , C12M25/02

6. 发明公开

EP2699339A1 PROCEDE ET SYSTEME DE PRODUCTION DE MICROCAPSULES CALIBREES 有权
标题翻译：方法和准备设备校准的微囊
公开(公告)号：EP2699339A1
公开(公告)日：2014-02-26
申请号：EP12719311.8
申请日：2012-04-23
申请人： Universite Technologie De Compiegne-UTC , Centre National de la Recherche Scientifique (CNRS)
发明人： LECLERC, Eric , SALSAC, Anne-Virginie , BARTHES-BIESEL, Dominique , CHU, Thi Xuan
IPC分类号： B01J13/14
CPC分类号： B01J13/00 , B01J13/14 , G05D7/0694
摘要： The present invention relates to a method for producing microcapsules having a calibrated diameter and at least one parameter characteristic of the mechanical properties of an equally calibrated microcapsule, characterized in that the method includes the steps of: producing microcapsules by means of injection into a microsystem (10) of three fluids (f1, f2, f3); deforming the microcapsules by means generating a flow within a capillary tube (20); observing and acquiring the outline of at least one deformed microcapsule observed by an optical acquisition means (30); comparing the acquired outline with outlines from a collection of reference microcapsule outlines; determining the diameter and said at least one parameter characteristic of the mechanical properties of the observed microcapsule; and modifying the flow rates (Q1, Q2, and/or Q3) of the fluids (f1, f2, f3). The present invention also relates to a system for producing calibrated microcapsules.

7. 发明公开

EP2569628A2 PROCÉDÉ D'ÉVALUATION TOXICOLOGIQUE, PROCÉDÉ DE CRIBLAGE TOXICOLOGIQUE ET SYSTÈME ASSOCIÉ 有权转让
标题翻译：方法毒理学评价，毒理学筛选方法和相关系统
公开(公告)号：EP2569628A2
公开(公告)日：2013-03-20
申请号：EP11719026.4
申请日：2011-05-12
申请人： Universite Technologie De Compiegne-UTC , Centre National de la Recherche Scientifique CNRS , Ecole Normale Superieure De Lyon , Institut National De L'environnement Industriel Etdes Risques
发明人： DUMAS, Marc-Emmanuel , LECLERC, Eric , SHINTU, Laetitia , BAUDOIN, Regis , LEGALLAIS, Cécile , TOULHOAT, Pierre , BROCHOT, Céline
IPC分类号： G01N33/50 , G06F19/00
CPC分类号： G01N33/5014 , G01N33/5041 , G01N33/5088 , G06F19/704 , G06F19/707
摘要： The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the bioartificial tissue or organ in the form of biomarkers associated with the components of the data set that are adopted for the model. The present invention also relates to a method of toxicological screening and to a system for this purpose.

8. 发明公开

EP2480654A2 DISPOSITIF ET SYSTEME DE FILTRATION 有权
标题翻译： FILTRIERVORRICHTUNG系统
公开(公告)号：EP2480654A2
公开(公告)日：2012-08-01
申请号：EP10757102.8
申请日：2010-09-23
申请人： Universite Technologie De Compiegne-UTC , Centre National de la Recherche Scientifique CNRS
发明人： PAULLIER, Patrick , OULD DRIS, Aïssa , LECLERC, Eric
IPC分类号： C12M3/06 , B01D35/30 , B81B1/00
CPC分类号： C12M29/04 , C12M23/16 , C12M23/26 , C12M25/02
摘要： The invention relates to a filtration device (100), characterized in that it includes: a first block (101) having a cavity forming a first chamber (110) comprising a bottom wall (111) having a set of microstructures including micro-walls and micro-contacts, the set of microstructures defining micro-chambers and micro-channels on the bottom wall (111) of the culture chamber; a second block (102) having a cavity forming a second chamber (120); and a filtration membrane (130), the first block (101), the membrane (130), and the second block (102) being arranged such that the membrane (130) is located between the first chamber (110) and the second chamber (120), adjacent to each of the first and second chambers (110, 120); as well as a first opening and a second opening for enabling a first fluid to pass into the second chamber (120) which is separated from the first chamber (110) by the membrane (130).
摘要翻译：本发明涉及一种过滤装置（100），其特征在于它包括：第一块（101），其具有形成第一室（110）的空腔，所述第一室包括具有一组微结构的底壁（111），所述微结构包括微壁和微接触，该组微结构限定培养室底壁（111）上的微室和微通道; 具有形成第二室（120）的空腔的第二块（102）; 和过滤膜（130），第一块（101），膜（130）和第二块（102）被布置成使得膜（130）位于第一室（110）和第二室（120），邻近所述第一和第二腔室（110,120）中的每一个; 以及用于使第一流体能够进入通过膜（130）与第一室（110）分离的第二室（120）的第一开口和第二开口。

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