发明公开
EP2569628A2 PROCÉDÉ D'ÉVALUATION TOXICOLOGIQUE, PROCÉDÉ DE CRIBLAGE TOXICOLOGIQUE ET SYSTÈME ASSOCIÉ
有权
转让
基本信息:
- 专利标题： PROCÉDÉ D'ÉVALUATION TOXICOLOGIQUE, PROCÉDÉ DE CRIBLAGE TOXICOLOGIQUE ET SYSTÈME ASSOCIÉ
- 专利标题（英）：Method of toxicological evaluation, method of toxicological screening and associated system
- 专利标题（中）：方法毒理学评价，毒理学筛选方法和相关系统
- 申请号：EP11719026.4 申请日：2011-05-12
- 公开(公告)号：EP2569628A2 公开(公告)日：2013-03-20
- 发明人： DUMAS, Marc-Emmanuel , LECLERC, Eric , SHINTU, Laetitia , BAUDOIN, Regis , LEGALLAIS, Cécile , TOULHOAT, Pierre , BROCHOT, Céline
- 申请人： Universite Technologie De Compiegne-UTC , Centre National de la Recherche Scientifique CNRS , Ecole Normale Superieure De Lyon , Institut National De L'environnement Industriel Etdes Risques
- 申请人地址： Centre Benjamin Franklin Rue Roger Couttolen 60203 Compiegne cedex FR
- 专利权人： Universite Technologie De Compiegne-UTC,Centre National de la Recherche Scientifique CNRS,Ecole Normale Superieure De Lyon,Institut National De L'environnement Industriel Etdes Risques
- 当前专利权人： INSTITUT NATIONAL DE L'ENVIRONNEMENT INDUSTRIEL ET
- 当前专利权人地址： INSTITUT NATIONAL DE L'ENVIRONNEMENT INDUSTRIEL ET
- 代理机构： Regimbeau
- 优先权： FR1053732 20100512
- 国际公布： WO2011151148 20111208
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; G06F19/00
摘要：
The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the bioartificial tissue or organ in the form of biomarkers associated with the components of the data set that are adopted for the model. The present invention also relates to a method of toxicological screening and to a system for this purpose.