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1. 发明公开

EP2017359A3 Method for the elution of 18F fluoride trapped on an anion-exchange resin in a form suitable for efficient radiolabeling without any evaporation step 审中-公开
标题翻译：一种用于在窗体，而不蒸发步骤洗脱捕获的在阴离子交换树脂18 F-氟化物适于有效的放射性标记形式的方法
公开(公告)号：EP2017359A3
公开(公告)日：2009-08-05
申请号：EP07447036.0
申请日：2007-06-11
申请人： Trasis S.A. , Université de Liège
发明人： Aerts, Joel , Lemaire, Christian , Lignon, Steve , Luxen, André , Morelle, Jean-Luc , Philippart, Gauthier , Voccia, Samuel
IPC分类号： C22B3/42 , G21G1/10 , A61K51/00 , B01D15/36 , C07B59/00
CPC分类号： C22B3/42 , A61K51/04 , B01D15/363 , B01D15/426 , C01B9/08 , C02F2001/422 , C02F2101/14 , G21G4/08 , Y02P10/234
摘要： The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step, characterised in that the eluting solution is a low water content, preferably
- a first compound (A) which is a tertiary alcohol-function bearing molecule,
- a second compound (B) which is a phase transfer agent suitable for radiolabeling and which is necessary to the anion exchange process.

2. 发明公开

EP2017359A2 Method for the elution of 18F fluoride trapped on an anion-exchange resin in a form suitable for efficient radiolabeling without any evaporation step 审中-公开
标题翻译：一种用于在窗体，而不蒸发步骤洗脱捕获的在阴离子交换树脂18 F-氟化物适于有效的放射性标记形式的方法
公开(公告)号：EP2017359A2
公开(公告)日：2009-01-21
申请号：EP07447036.0
申请日：2007-06-11
申请人： Trasis S.A. , Université de Liège
发明人： Aerts, Joel , Lemaire, Christian , Lignon, Steve , Luxen, André , Morelle, Jean-Luc , Philippart, Gauthier , Voccia, Samuel
IPC分类号： C22B3/42 , G21G1/10 , A61K51/00 , B01D15/36 , C07B59/00
CPC分类号： C22B3/42 , A61K51/04 , B01D15/363 , B01D15/426 , C01B9/08 , C02F2001/422 , C02F2101/14 , G21G4/08 , Y02P10/234
摘要： The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step, characterised in that the eluting solution is a low water content, preferably
- a first compound (A) which is a tertiary alcohol-function bearing molecule,
- a second compound (B) which is a phase transfer agent suitable for radiolabeling and which is necessary to the anion exchange process.
摘要翻译：本发明涉及一种方法，以提取出wässrige溶液，浓缩和/或重新配制[18 F]氟化物没有任何蒸发步骤，DASS洗提液是低水含量，优选水<3％时，含有有机溶液至少包括： - 第一化合物（A），所有这些是叔醇功能轴承分子， - 第二化合物（B）的所有其适用于放射性标记的相转移剂和所有所必需的阴离子交换过程。

3. 发明公开

EP2845608A1 Method for purification of 18F-labeled choline analogues 审中-公开
标题翻译： Verfahren zur Reinigung von 18F-markierten Cholinanalogstoffen
公开(公告)号：EP2845608A1
公开(公告)日：2015-03-11
申请号：EP13183543.1
申请日：2013-09-09
申请人： Trasis S.A.
发明人： Morelle, Jean-Luc , Otabashi, Muhammad , Philippart, Gauthier , Voccia, Samuel
IPC分类号： A61K51/04 , C07B59/00
CPC分类号： A61K51/0406 , A61K51/04 , C07B59/00 , C07B59/001 , C07C213/10
摘要： The present invention relates to a method for the purification of 18F-labeled choline analogues in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (SPE) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18F-labeled choline analogues
摘要翻译：本发明涉及一种在使用非气体合成路径制备的向患者注射的溶液中纯化18 F标记的胆碱类似物的方法，该方法包括使用固体支持物进行固相萃取（SPE）纯化步骤，其中在固相萃取纯化中使用的固体支持物具有从溶液中保留杂质和试剂而不是18F标记的胆碱类似物的特征

4. 发明公开

EP2062630A1 Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium by the use of strong organic bases 审中-公开
标题翻译：用于无功18F-氟化物从阴离子交换树脂的直接洗脱在有机介质中通过使用的强有机碱的方法
公开(公告)号：EP2062630A1
公开(公告)日：2009-05-27
申请号：EP07447064.2
申请日：2007-11-20
申请人： Trasis S.A. , Université de Liège
发明人： Lemaire, Christian , Voccia, Samuel , Aerts, Joel , Luxen, Andre , Morelle, Jean-Luc , Philippart, Gauthier
IPC分类号： B01D15/36
CPC分类号： B01D15/363
摘要： The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step characterised in that the eluting solution is a low water content, preferably
- a first compound (A) which is a molecule containing at least one acidic hydrogen and
- a second compound (B) which is a base sufficiently strong to be able to tear off the acidic hydrogen of first compound (A) in an acid-base reaction leading to the formation of a salt (S).
摘要翻译：本发明涉及一种方法，以提取出wässrige溶液，浓缩和/或重新配制[18 F]，没有任何蒸发步骤DASS洗提液氟化物是低水含量，优选水<3％时，在含有有机溶液至少包括： - 第一化合物（A）的所有其为包含至少一个酸性氢和分子 - 第二化合物（B）的所有其是碱足够强以能够撕下第一化合物（A）的酸性氢与酸碱反应导致的盐（S）的形成。

5. 发明公开

EP1933330A1 Electrochemical 18F extraction, concentration and reformulation method for radiolabeling 审中-公开
标题翻译： Elektrochemisches 18F-Extraktions-，Konzentrations- und Reformulierungsverfahren zur radioaktiven Markierung
公开(公告)号：EP1933330A1
公开(公告)日：2008-06-18
申请号：EP06447128.7
申请日：2006-12-11
申请人： Trasis S.A.
发明人： Morelle, Jean-Luc , Voccia, Samuel , Philippart, Gauthier
IPC分类号： G21G4/00
CPC分类号： G21G4/08 , G21G2001/0015 , G21H5/02
摘要： The present invention is related to a method to extract out of water, concentrate and reformulate [18F] fluorides wherein:
- a dilute aqueous [18F] fluoride solution enters by an inlet (1) in a cavity (6) embodying an electrochemical cell with at least two electrodes (3, 4, 5) used either as a cathode or as an anode, passes through the cavity (6) and comes out of the cavity (6) by an outlet (2), an external voltage being applied to the electrodes, one electrode (4) being used as an extraction electrode, another one (3) being used for polarizing the solution;
- among the electrodes (3, 4, 5), at least one electrode (4) is in contact with and polarizes a large surface area conducting material (7);
- a flush of gas is possibly injected into the cavity (6) to purge the electrochemical cell and recover most of the remaining water therein, whilst keeping the extracted ions inside the electrochemical cell.
摘要翻译：本发明涉及一种提取水，浓缩和重整[18 F]氟化物的方法，其中： - 通过入口（1）在体积为电化学电池的空腔（6）中进入稀氟离子水溶液，用作阴极或阳极的至少两个电极（3,4,5）通过空腔（6）并通过出口（2）离开空腔（6），外部电压施加到电极，一个电极（4）用作提取电极，另一个电极（3）用于使溶液极化; - 在所述电极（3,4,5）中，至少一个电极（4）与大的表面区域导电材料（7）接触并极化; - 可以将空气冲洗注入空腔（6）以清除电化学电池并回收大部分剩余的水，同时将提取的离子保持在电化学电池内。

6. 发明公开

EP1990310A1 Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step 审中-公开
标题翻译：工艺的反应性18 F-氟化物的生产和用于放射性示踪剂的标记使用改性非离子型固体载体和没有任何蒸发步骤
公开(公告)号：EP1990310A1
公开(公告)日：2008-11-12
申请号：EP07008220.1
申请日：2007-04-23
申请人： Trasis S.A. , Université de Liège
发明人： Voccia, Samuel , Aerts, Joel , Lemaire, Christian , Luxen, André , Morelle, Jean-Luc , Philippart, Gauthier
IPC分类号： C01B9/08 , C07B59/00
CPC分类号： C01B9/08 , C01P2006/88 , C02F2001/422 , C02F2101/006 , C02F2101/14
摘要： The present invention is related to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step, said extraction, concentration and/or reformulation process comprising a steps of passing said aqueous [18F] fluoride solution through a solid phase extraction column containing a modified non-ionic solid support (SS) so that that said [18F] fluorides are trapped on the solid support. The modification of the non-ionic SS has been performed prior to the [18F] fluoride extraction process, by causing the adsorption of a trapping agent (TA) on the SS, said TA being selected for its ability to trap the (18F) fluoride in an anion exchange process so that to form a TA-[18F] species, itself able to remain adsorbed on the SS, the couple SS-TA being selected in such a way that most of the TA is able to remain on the SS during the transit of the aqueous [18F] fluoride solution through the column.
摘要翻译：本发明涉及以提取出wässrige溶液的方法，浓缩和/或重新配制[18 F]氟化物没有任何蒸发步骤，所述萃取，浓缩和/或再形成过程包括以下步骤使所述wässrige的[18F]氟化物通过固相萃取柱含有改性非离子型固体载体（SS），以便所述thatthat [18 F]氟化物捕集在固体载体上的解决方案。所述非离子型SS的修饰已经通过使捕集剂上的SS（TA）的吸附前的[18F]氟化物萃取过程进行，说TA被选择用于其能力来捕获（18F）氟在阴离子交换过程，从而没有形成TA [18F]物质，本身能够对SS保持吸附，在寻求的方式选择了SS-TA对夫妇做了大部分的TA的是能够在保持对SS 通过柱的wässrige[18F]氟化物溶液的过境。

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