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1. 发明授权

EP2481710B1 POLYMER-COATED FERRITE MICROPARTICLES AND PRODUCTION METHOD FOR SAME 有权
标题翻译：聚合物涂覆的铁氧体微粒及其生产方法
公开(公告)号：EP2481710B1
公开(公告)日：2018-02-28
申请号：EP10826341.9
申请日：2010-10-28
申请人： Tokyo Institute of Technology
发明人： HANDA, Hiroshi , HATAKEYAMA, Mamoru , SAKAMOTO, Satoshi , KISHI, Hiroshi
IPC分类号： C01G49/06 , A61K47/02 , A61K49/18 , H01F1/34 , A61K9/50 , C09C1/22 , C09C1/24 , H01F1/00 , A61K41/00 , C01G49/00 , C01G49/08
CPC分类号： A61K41/0052 , A61K9/5026 , A61K9/5089 , A61K9/5094 , A61K47/02 , A61K49/1854 , B82Y5/00 , B82Y25/00 , B82Y30/00 , C01G49/0072 , C01G49/08 , C01P2004/03 , C01P2004/64 , C09C1/22 , C09C1/24 , H01F1/0054 , H01F1/344
摘要： [Object] To provide a polymer coated ferrite fine particles being possible to control a particle size uniformly while having high aqueous dispersibility and preferred biomolecule immobilization ability and an easy method for preparing the same. [Means Addressing Object] In an aqueous solvent, iron ion is protected by chelating polyacrylic acid and then alkaline is added. Thereafter, a reaction system is heated under pressurized condition to produce simultaneous precipitation of the ferrite fine particles and coating thereof. As the result, the polymer coated ferrite fine particles having uniform particle size may be prepared in one step with excellent reproducibility. The polymer coated ferrite fine particles of the present invention has high water dispersibility and has preferred biomolecule immobilization performance by carboxyl groups coming from the polyacrylic acid.

2. 发明公开

EP2873976A1 DETECTION SYSTEM OF TEST SUBSTANCE 审中-公开
标题翻译：检测系统FÜREINE TESTSUBSTANZ
公开(公告)号：EP2873976A1
公开(公告)日：2015-05-20
申请号：EP13814000.9
申请日：2013-07-02
申请人： Toppan Printing Co., Ltd. , Tokyo Institute of Technology
发明人： HIRASE, Takumi , NAKAYAMA, Masato , HANDA, Hiroshi , SAKAMOTO, Satoshi , NAITO, Yasuyuki
IPC分类号： G01N33/543 , G01N21/64
CPC分类号： G01N33/54326 , G01N21/6428 , G01N21/645
摘要： A detection system of a test substance (10), includes: a magnetic body (2) that is modified by a first substance (3) capable of being bound to the test substance (10) at a first binding site of the test substance; a marker (4) that is modified by a second substance (3) capable of being bound to the test substance (10) at a second binding site of the test substance (10), the second binding site being a different site from the first binding site; a development medium (20) that has a flow passage (24) into which liquid, in which the magnetic body (2) and the marker (4) is dispersed, flows by a capillary phenomenon, the development medium having a detection position for detecting the marker (4) in a portion of the flow passage (24), the development medium having light transparency at least in the detection position; and a magnetic force generating portion (30) that is equipped in the development medium (20) in order to hold the magnetic body (2) in a portion of the flow passage (24).
摘要翻译：测试物质（10）的检测系统包括：被测物质的第一结合位点被能够与测试物质（10）结合的第一物质（3）改性的磁体（2）; 由能够在被检物质（10）的第二结合位点与被检物质（10）结合的第二物质（3）修饰的标记物（4），所述第二结合位点是与所述第一物质结合位点; 具有流路（24）的显影介质（20），其中分散有磁性体（2）和标记物（4）的液体通过毛细管现象流动，所述显影介质具有检测位置在所述流路（24）的一部分中的所述标记（4），所述显影介质至少在所述检测位置具有透光性; 以及设置在显影介质（20）中以将磁体（2）保持在流路（24）的一部分中的磁力产生部分（30）。

3. 发明授权

EP2333007B1 POLYMER PARTICLES CONTAINING FLUORESCENT MOLECULE AND PROCESS FOR PRODUCING SAME 有权
标题翻译：具有产生荧光分子和过程聚合物粒子
公开(公告)号：EP2333007B1
公开(公告)日：2014-11-05
申请号：EP09812888.7
申请日：2009-09-10
申请人： Tokyo Institute of Technology
发明人： HANDA, Hiroshi , HATAKEYAMA, Mamoru , SAKAMOTO, Satoshi , MOCHIZUKI, Yusuke , KAWADA, Shintaro
IPC分类号： C08J3/12 , G01N33/543 , H01F1/00 , H01F1/06 , H01F1/09 , G01N33/533
CPC分类号： G01N33/533 , C08J3/12 , C08J3/128 , C08J2327/12 , G01N33/54326 , H01F1/06 , H01F1/09

4. 发明授权

EP2184262B1 PROCESS FOR PRODUCTION OF SURFACE-COATED INORGANIC PARTICLES 有权
标题翻译：用于生产表面被覆无机颗粒
公开(公告)号：EP2184262B1
公开(公告)日：2012-12-26
申请号：EP08791605.2
申请日：2008-07-25
申请人： Tokyo Institute of Technology
发明人： HANDA, Hiroshi , HATAKEYAMA, Mamoru , ABE, Masanori , SAKAMOTO, Satoshi , MASAIKE, Yuka , NISHIO, Kosuke , KITA, Yoshinori , KISHI, Hiroshi
IPC分类号： C01G49/00 , A61K49/00 , B22F1/02 , H01F1/20 , H01F1/34 , H01F1/36
CPC分类号： H01F1/0045 , A61K41/0052 , A61K49/183 , A61K49/1833 , A61K49/1836 , A61K49/1851 , A61K49/1854 , B22F1/0022 , B22F1/0062 , B82Y25/00 , B82Y30/00 , C01G49/00 , C01P2006/42 , C09C1/24 , C09C3/08 , C09C3/10 , C09C3/12 , G01N33/53 , G01N33/54393 , H01F1/0054

5. 发明公开

EP2333007A1 POLYMER PARTICLES CONTAINING FLUORESCENT MOLECULE AND PROCESS FOR PRODUCING SAME 有权
标题翻译：聚合物麻省麻醉药物FLUORESZENTEMMOLEKÜLUND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2333007A1
公开(公告)日：2011-06-15
申请号：EP09812888.7
申请日：2009-09-10
申请人： Tokyo Institute of Technology
发明人： HANDA, Hiroshi , HATAKEYAMA, Mamoru , SAKAMOTO, Satoshi , MOCHIZUKI, Yusuke , KAWADA, Shintaro
IPC分类号： C08J3/12 , G01N33/543 , H01F1/00
CPC分类号： G01N33/533 , C08J3/12 , C08J3/128 , C08J2327/12 , G01N33/54326 , H01F1/06 , H01F1/09
摘要： [Object] To provide polymer particles which contain fluorescent molecules with high presence ratio in a polymer layer thereof and a method for preparing thereof.
[Means for Solving Object] Polymer particles are swelled in a non-aqueous solution excluding exclusively water preferably promotes selling of the polymer layer and transfer of the fluorescent molecules to the polymer layer could not protected by water molecules such that much more fluorescent molecule may be introduced into inside of the polymer layer. Furthermore, since the water is added to the reaction system prior to evaporation removal of the non-aqueous solvent, dry-up of the polymer particles is prevented by the water remained in the reaction system and the polymer particles including fluorescent molecules with high presence ratio of the fluorescent molecules preferably keep high dispersibility using the above described procedures.
摘要翻译：提供含有聚合物层中具有高存在比例的荧光分子的聚合物颗粒及其制备方法。 [解决对象的手段]聚合物颗粒在除水之外的非水溶液中膨胀，优选促进聚合物层的销售并且荧光分子转移到聚合物层不能被水分子保护，使得更多的荧光分子可以是引入聚合物层的内部。此外，由于在蒸发除去非水溶剂之前将水加入到反应体系中，聚合物颗粒的干燥可以通过反应体系中残留的水来防止，聚合物颗粒包括具有高存在比的荧光分子的荧光分子优选使用上述方法保持高分散性。

6. 发明公开

EP2246702A1 BIOSENSING METHOD USING COATED MAGNETIC MICROPARTICLES AND BIOSENSING DEVICE TO BE USED IN THE METHOD 有权转让
标题翻译：生物传感方法使用涂磁微颗粒中的过程;适用生物传感器件
公开(公告)号：EP2246702A1
公开(公告)日：2010-11-03
申请号：EP08857449.6
申请日：2008-12-01
申请人： Tokyo Institute of Technology
发明人： HANDA, Hiroshi , ABE, Masanori , HATAKEYAMA, Mamoru , SAKAMOTO, Satoshi , NISHIO, Kosuke , MOCHIZUKI, Yusuke
IPC分类号： G01N33/543 , G01N5/02 , G01N21/27 , G01N33/553
CPC分类号： G01N33/54333 , G01N21/553
摘要： An object of the present invention is to provide a novel biosensing method as the novel application development of the magnetic particles in the biosensing. In an affinity reaction of biosensing, ligands are immobilized to magnetic fine particles and the magnetic fine particles are forced to reaction fields of the affinity reaction by magnetic guiding so as to bring the affinity reaction, which is the velocity controlling factor in the sensing, to high rates. According to the present invention, coated magnetic fine particles with having both of the high dispersion performance and high magnetic responsibility as the above described magnetic fine particles and the affinity reaction occurs quickly and in high density such that the present invention makes it possible to obtain relatively large signals within significantly short time duration when compared to the conventional art.
摘要翻译：本发明的一个目的是提供一种新颖的生物传感方法作为生物感测磁性粒子的新颖的应用开发。在生物传感中的亲和反应中，配体固定到磁性微粒和磁性微粒被强制由磁性引导所述亲和反应的反应场，以便使所述亲和反应中，所有这一切是速度感测控制因素，以高利率。。根据本发明，包被的磁性微粒与具有两个高分散性能和高磁响应性与上述磁性细颗粒和亲和反应的发生快速和高密度检测所做的本发明使得有可能获得相对值得注意的是短的持续时间内大信号。当相比于常规技术。

7. 发明公开

EP2481710A1 POLYMER-COATED FERRITE MICROPARTICLES AND PRODUCTION METHOD FOR SAME 有权
标题翻译：聚合物涂层的铁氧体微粒及其制造方法
公开(公告)号：EP2481710A1
公开(公告)日：2012-08-01
申请号：EP10826341.9
申请日：2010-10-28
申请人： Tokyo Institute of Technology
发明人： HANDA, Hiroshi , HATAKEYAMA, Mamoru , SAKAMOTO, Satoshi , KISHI, Hiroshi
IPC分类号： C01G49/06 , A61K47/02 , A61K49/00 , H01F1/34
CPC分类号： A61K41/0052 , A61K9/5026 , A61K9/5089 , A61K9/5094 , A61K47/02 , A61K49/1854 , B82Y5/00 , B82Y25/00 , B82Y30/00 , C01G49/0072 , C01G49/08 , C01P2004/03 , C01P2004/64 , C09C1/22 , C09C1/24 , H01F1/0054 , H01F1/344
摘要： [Object] To provide a polymer coated ferrite fine particles being possible to control a particle size uniformly while having high aqueous dispersibility and preferred biomolecule immobilization ability and an easy method for preparing the same.
[Means Addressing Object] In an aqueous solvent, iron ion is protected by chelating polyacrylic acid and then alkaline is added. Thereafter, a reaction system is heated under pressurized condition to produce simultaneous precipitation of the ferrite fine particles and coating thereof. As the result, the polymer coated ferrite fine particles having uniform particle size may be prepared in one step with excellent reproducibility. The polymer coated ferrite fine particles of the present invention has high water dispersibility and has preferred biomolecule immobilization performance by carboxyl groups coming from the polyacrylic acid.

8. 发明公开

EP2184262A1 PROCESS FOR PRODUCTION OF SURFACE-COATED INORGANIC PARTICLES 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VONOBERFLÄCHENBESCHICHTETENANORGANISCHEN TEILCHEN
公开(公告)号：EP2184262A1
公开(公告)日：2010-05-12
申请号：EP08791605.2
申请日：2008-07-25
申请人： Tokyo Institute of Technology
发明人： HANDA, Hiroshi , HATAKEYAMA, Mamoru , ABE, Masanori , SAKAMOTO, Satoshi , MASAIKE, Yuka , NISHIO, Kosuke , KITA, Yoshinori , KISHI, Hiroshi
IPC分类号： C01G49/00 , A61K49/00 , B22F1/02 , H01F1/20 , H01F1/34 , H01F1/36
CPC分类号： H01F1/0045 , A61K41/0052 , A61K49/183 , A61K49/1833 , A61K49/1836 , A61K49/1851 , A61K49/1854 , B22F1/0022 , B22F1/0062 , B82Y25/00 , B82Y30/00 , C01G49/00 , C01P2006/42 , C09C1/24 , C09C3/08 , C09C3/10 , C09C3/12 , G01N33/53 , G01N33/54393 , H01F1/0054
摘要： Nano-sized inorganic particles having uniform particle sizes and precisely controlled particle diameters have already been produced by synthesis in an organic solvent, but these nano-sized inorganic particles are hindered from dispersing in a polar solvent because of the adsorption of a long-chain fatty acid on the surfaces of the particles. Further, it was difficult to form nano-sized inorganic particles dispersible in a polar solvent by replacing the long-chain fatty acid coats. According to the invention, various surface-coated inorganic particles dispersible in polar solvents can be produced from fatty acid-coated inorganic particles by adding a temporary coating substance such as thiomalic acid to a nonpolar solvent containing fatty acid-coated inorganic particles dispersed therein to replace the fatty acid coats by the temporary coating substance, dispersing the inorganic particles coated with the temporary coating substance in a polar solvent, and then adding a coating substance dispersible in a polar solvent, e.g., citric acid to the obtained dispersion to replace the temporary coating substance coats covering the inorganic particles by the coating substance dispersible in a polar solvent.
摘要翻译：已经通过在有机溶剂中合成来制备具有均匀粒径和精确控制的粒径的纳米尺寸的无机颗粒，但这些纳米尺寸的无机颗粒由于吸附长链脂肪而被阻碍分散在极性溶剂中酸在颗粒的表面上。此外，通过代替长链脂肪酸涂层，难以形成分散在极性溶剂中的纳米级无机颗粒。根据本发明，分散在极性溶剂中的各种表面涂覆的无机颗粒可以通过向包含分散在其中的含脂肪酸涂覆的无机颗粒的非极性溶剂添加例如硫代酸的临时涂层物质，由脂肪酸包覆的无机颗粒制备，以代替通过临时涂布物质的脂肪酸涂层，将涂覆有临时涂层物质的无机颗粒分散在极性溶剂中，然后将分散在极性溶剂（例如柠檬酸）中的涂覆物质加入到所得分散体中以代替临时涂层通过可分散在极性溶剂中的涂层物质覆盖无机颗粒的物质外套。

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