专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2610893B1 Multireflection time-of-flight mass spectrometer 有权
标题翻译：飞行时间质谱仪，多次反射
公开(公告)号：EP2610893B1
公开(公告)日：2017-02-01
申请号：EP13161735.9
申请日：2008-12-22
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Makarov, Alexander , Grinfeld, Dmitry, E. , Monastyrskiy, Mikhail, A.
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： The present invention provides a method of reflecting ions in a multireflection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof. Apparatus for carrying out the method is also disclosed.

2. 发明授权

EP2613339B1 Multireflection time-of-flight mass spectrometer 有权
标题翻译：飞行时间质谱仪，多次反射
公开(公告)号：EP2613339B1
公开(公告)日：2016-11-16
申请号：EP13161726.8
申请日：2008-12-22
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Makarov, Alexander , Grinfeld, Dmitry, E. , Monastyrskiy, Mikhail, A.
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： The present invention provides a method of reflecting ions in a multireflection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof. Apparatus for carrying out the method is also disclosed.

3. 发明公开

EP3086353A1 A METHOD OF PRODUCING A MASS SPECTRUM 审中-公开
标题翻译：一种生产质谱的方法
公开(公告)号：EP3086353A1
公开(公告)日：2016-10-26
申请号：EP15165127.0
申请日：2015-04-24
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Aizikov, Konstantin , Grinfeld, Dmitry , Makarov, Alexander
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , H01J49/10 , H01J49/38 , H01J49/425
摘要： A method of producing a mass spectrum from a time-varying transient signal detected in a mass spectrometer, the method comprising: performing a Fourier transform of the transient signal to produce a first set of complex amplitudes wherein each of the complex amplitudes corresponds to a respective frequency of a first set of frequencies; generating a second set of complex amplitudes, wherein each of the complex amplitudes corresponds to a respective frequency of a second set of frequencies with a minimum spacing less than the inverse of the duration of the transient signal; optimizing the second set of complex amplitudes to produce an improved second set; generating a mass spectrum from at least some of the improved second set of complex amplitudes; wherein optimizing the second set of complex amplitudes to produce an improved second set of complex amplitudes is based on an objective function subject to some phase constraints.
摘要翻译：一种根据在质谱仪中检测到的时变瞬态信号产生质谱的方法，该方法包括：对该瞬态信号执行傅里叶变换以产生第一组复振幅，其中每个复振幅对应于相应的第一组频率的频率; 产生第二组复振幅，其中每个复振幅对应于第二组频率的相应频率，其中最小间隔小于瞬态信号的持续时间的倒数; 优化第二组复振幅以产生改进的第二组; 根据所述改进的第二组复振幅中的至少一些生成质谱; 其中优化所述第二组复振幅以产生改进的第二组复振幅是基于经历一些相位约束的目标函数。

4. 发明公开

EP2447980A1 Method of generating a mass spectrum having improved resolving power 有权
标题翻译： Verfahren zur Herstellung eines Massenspektrums mit verbicultemAuflösungsvermögen
公开(公告)号：EP2447980A1
公开(公告)日：2012-05-02
申请号：EP10189667.8
申请日：2010-11-02
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Makarov, Alexander
IPC分类号： H01J49/36 , H01J49/00
CPC分类号： H01J49/0036 , G06F19/70 , H01J49/027 , H01J49/38
摘要： A method of generating a mass spectrum, e.g. for Fourier transform mass spectrometry, having improved resolving power, comprising:
acquiring a plurality of mass spectra from a mass spectrometer using image current detection wherein most of the peaks are due to the detection of individual ions;
determining the centroids of at least some of the peaks which are due to the individual ions and which have a sufficient signal-to-noise (S/N) ratio so that the variation of the centroid of each such peak from the plurality of mass spectra is significantly lower than the full-width at half-maximum, dM, of the peak in the m/z domain; and
generating a histogram of the centroids determined from the plurality of acquired mass spectra thereby forming a composite mass spectrum wherein the composite mass spectrum comprises peaks and the full-width at half-maximum, dMC, of these peaks in the m/z domain is significantly narrower than the peak width, dM, of the corresponding peaks in the plurality of acquired mass spectra.
摘要翻译：生成质谱的方法，例如。用于傅立叶变换质谱，具有改进的分辨能力，包括：使用图像电流检测从质谱仪获取多个质谱，其中大部分峰值是由于各个离子的检测; 确定由于各个离子而导致的并且具有足够的信噪比（S / N）比的至少一些峰的质心，使得每个这样的峰的质心与多个质谱的变化明显低于m / z域中峰的半峰全宽（dM）; 并且生成从多个获取的质谱确定的质心的直方图，从而形成复合质谱，其中复合质谱包括峰，并且m / z域中这些峰的半峰全长（dMC）为明显窄于多个获取质谱中相应峰的峰宽dM。

5. 发明授权

EP2447980B1 Method of generating a mass spectrum having improved resolving power 有权
公开(公告)号：EP2447980B1
公开(公告)日：2019-05-22
申请号：EP10189667.8
申请日：2010-11-02
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Makarov, Alexander
IPC分类号： H01J49/36 , H01J49/00 , H01J49/38 , G06F19/00 , H01J49/02

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式