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1. 发明授权

EP3099680B1 BISTRIFILATE-BASED FLUOROGENIC PROBES FOR DETECTION OF SUPEROXIDE ANION RADICAL 有权转让
公开(公告)号：EP3099680B1
公开(公告)日：2020-08-12
申请号：EP15742817.8
申请日：2015-01-30
申请人： The University of Hong Kong
发明人： YANG, Dan , HU, Jun , WONG, Nai Kei
IPC分类号： C07D407/02 , C07F7/10 , C07F7/08 , B41M5/327 , B41M5/20

2. 发明公开

EP1943254A1 REAGENTS FOR HIGHLY SPECIFIC DETECTION OF PEROXYNITRITE 审中-公开
标题翻译：化试剂过氧化亚硝酸盐高特异性检测
公开(公告)号：EP1943254A1
公开(公告)日：2008-07-16
申请号：EP06775495.2
申请日：2006-08-25
申请人： The University of Hong Kong
发明人： YANG, Dan , WANG, Huali , SUN, Zhenning , SHEN, Jiangang
IPC分类号： C07D493/10 , C07D403/06 , C07F5/02 , C07C49/213 , G01N31/22
CPC分类号： C07D207/34 , C07D493/10 , Y10T436/17
摘要： This invention provides compositions which specifically reacts with peroxynitrite rather than other reactive oxygen species and reactive nitrogen species. This invention also provides related agents for measuring peroxynitrite. This invention also provides related methods for measuring peroxynitrite in a sample, high-throughput screening fluorescent methods for detecting peroxynitrite and high-throughput methods for screening compounds that increase or decrease the production of peroxynitrite comprising using such compositions and agents.

3. 发明授权

EP2809666B1 DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE 有权转让
公开(公告)号：EP2809666B1
公开(公告)日：2018-10-10
申请号：EP13742931.2
申请日：2013-01-30
申请人： The University of Hong Kong
发明人： YANG, Dan , PENG, Tao , SHEN, Jiangang , CHEN, Xingmiao
IPC分类号： C07D407/02 , C09K3/00 , B41M5/327 , B41M5/20 , C07D311/82 , C07D311/90 , C07D491/052 , C07F9/6561 , C07D493/10 , C07D493/20 , C09B11/08 , C09B11/24 , C09B69/00 , G01N31/22 , G01N33/84 , C07F7/08
CPC分类号： G01N31/227 , C07D311/82 , C07D311/90 , C07D491/052 , C07D493/10 , C07D493/20 , C07F7/0816 , C07F7/2208 , C07F7/30 , C07F9/6561 , C09B11/08 , C09B11/24 , C09B11/245 , C09B69/008 , G01N33/582 , G01N33/84 , Y10T436/170769
摘要： Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.

4. 发明公开

EP3099680A1 BISTRIFILATE-BASED FLUOROGENIC PROBES FOR DETECTION OF SUPEROXIDE ANION RADICAL 有权转让
标题翻译： BISTRIFILAT-BASIERTE FLORGENE SONDEN ZUR ERKENNUNG VON SUPEROXID-ANIONENRADIKALEN
公开(公告)号：EP3099680A1
公开(公告)日：2016-12-07
申请号：EP15742817.8
申请日：2015-01-30
申请人： The University of Hong Kong
发明人： YANG, Dan , HU, Jun , WONG, Nai Kei
IPC分类号： C07D407/02 , C07F7/10 , C07F7/08 , B41M5/327 , B41M5/20
摘要： The invention provides fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening superoxide. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. The invention further provides fluorogenic compounds for selectively staining superoxide in the mitochondria of living cells. The invention also provides methods that can be used to measure, directly or indirectly, the presence and/or amount of superoxide in chemical samples and biological samples such as cells and tissues in living organisms, and a high-throughput screening methods for detecting or screening superoxide or compounds that can increase or decrease the level of superoxide in chemical and biological samples.
摘要翻译：本发明提供可用作测量，检测和/或筛选超氧化物的试剂的荧光化合物和探针。本发明的荧光化合物可以产生荧光颜色，例如绿色，黄色，红色或远红色。本发明还提供了用于选择性染色活细胞线粒体中超氧化物的荧光化合物。本发明还提供了可用于直接或间接测量化学样品和生物样品如生物体中的细胞和组织的超氧化物的存在和/或量的方法，以及用于检测或筛选的高通量筛选方法超氧化物或化合物，可以增加或降低化学和生物样品中超氧化物的含量。

5. 发明公开

EP2809666A1 DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE 有权转让
标题翻译：荧光素SONDEN AUF DIARYLAMINBASIS ZUR ERKENNUNG VON PEROXYNITRIT
公开(公告)号：EP2809666A1
公开(公告)日：2014-12-10
申请号：EP13742931.2
申请日：2013-01-30
申请人： The University of Hong Kong
发明人： YANG, Dan , PENG, Tao , SHEN, Jiangang , CHEN, Xingmiao
IPC分类号： C07D407/02 , C09K3/00 , B41M5/327 , B41M5/20
CPC分类号： G01N31/227 , C07D311/82 , C07D311/90 , C07D491/052 , C07D493/10 , C07D493/20 , C07F7/0816 , C07F9/6561 , C09B11/08 , C09B11/24 , C09B11/245 , C09B69/008 , G01N33/582 , G01N33/84 , Y10T436/170769
摘要： Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.
摘要翻译：本文提供了可用作测量，检测和/或筛选过氧亚硝酸盐的试剂的改进的荧光化合物和探针。本发明的荧光化合物可以产生荧光颜色，例如绿色，黄色，红色或远红色。本文还提供了用于在活细胞线粒体中选择性染色过氧亚硝酸盐的荧光化合物。本文还提供了可用于直接或间接测量化学样品和生物样品（例如活生物体中的细胞和组织）中过氧亚硝酸盐的存在和/或量的方法。还提供了用于检测或筛选过氧亚硝酸盐或可以增加或降低化学和生物样品中过氧亚硝酸盐水平的化合物的高通量筛选方法。

6. 发明公开

EP1730117A2 THIOUREA COMPOSITIONS AND USES THEREOF 有权
标题翻译：硫脲组合物及其用途
公开(公告)号：EP1730117A2
公开(公告)日：2006-12-13
申请号：EP05732549.0
申请日：2005-03-28
申请人： The University of Hong Kong
发明人： YANG, Dan , CHEN, Yingchun
IPC分类号： C07D233/16 , C07D235/02 , C07D239/70 , C07D243/04 , C07D245/04 , C07D403/10 , C07D233/14
CPC分类号： C07D233/42 , C07C1/321 , C07C2/861 , C07C41/30 , C07C45/68 , C07C67/343 , C07C201/12 , C07C227/10 , C07C335/16 , C07C2531/22 , C07D239/10 , C07D243/04 , C07C15/14 , C07C15/50 , C07C15/52 , C07C49/784 , C07C49/796 , C07C47/546 , C07C69/618 , C07C69/76 , C07C69/65 , C07C69/738 , C07C229/44 , C07C205/06 , C07C205/11 , C07C205/56 , C07C43/215 , C07C43/205 , C07C43/225
摘要： The invention provides N,N'-disubstituted monothiourea or bisthiourea-Pd(0) complexes that are useful as catalysts for palladium-catalyzed Heck reaction of aryl iodides and bromides with olefins, and as catalysts for palladium catalyzed Suzuki reactions of organoboric compounds and aryl halides (Formula A).
摘要翻译：本发明提供N，N'-二取代的一硫脲或二硫脲-Pd（0）配合物，其用作芳基碘化物和溴化物与烯烃的钯催化的Heck反应的催化剂，以及用作钯催化的有机硼化合物和芳基卤化物（式A）。

7. 发明授权

EP1730117B1 THIOUREA COMPOSITIONS AND USES THEREOF 有权
标题翻译：硫脲组合物及其用途
公开(公告)号：EP1730117B1
公开(公告)日：2015-12-02
申请号：EP05732549.0
申请日：2005-03-28
申请人： The University of Hong Kong
发明人： YANG, Dan , CHEN, Yingchun
IPC分类号： C07D233/16 , C07D235/02 , C07D239/70 , C07D243/04 , C07D245/04 , C07D403/10 , C07D233/14 , C07F15/00 , C07C335/16
CPC分类号： C07D233/42 , C07C1/321 , C07C2/861 , C07C41/30 , C07C45/68 , C07C67/343 , C07C201/12 , C07C227/10 , C07C335/16 , C07C2531/22 , C07D239/10 , C07D243/04 , C07C15/14 , C07C15/50 , C07C15/52 , C07C49/784 , C07C49/796 , C07C47/546 , C07C69/618 , C07C69/76 , C07C69/65 , C07C69/738 , C07C229/44 , C07C205/06 , C07C205/11 , C07C205/56 , C07C43/215 , C07C43/205 , C07C43/225

8. 发明公开

EP2928875A1 ANTIFUNGAL COMPOUND AND USES THEREOF 审中-公开
标题翻译： FUNGIZIDE VERBINDUNG UND VERWENDUNGEN DAVON
公开(公告)号：EP2928875A1
公开(公告)日：2015-10-14
申请号：EP13861069.6
申请日：2013-12-04
申请人： The University of Hong Kong
发明人： SENEVIRATNE, Chaminda Jayampath , KAO, Yi Tsun Richard , SAMARANAYAKE, Lakshman Perera , YUEN, Kwok Yung , YANG, Dan , WANG, Yu , WONG, Sze Wah, Sarah
IPC分类号： C07D309/34 , A61K31/351 , A61P31/10 , A61P31/18
CPC分类号： A61K31/351 , A01N43/40 , A01N59/00 , A61K9/0019 , A61K9/08 , A01N25/34
摘要： Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.
摘要翻译：本文公开了一种新型抗真菌化合物，其用于治疗真菌感染的衍生物。在具体实施方案中，化合物是小分子。在具体实施方案中，本文所述的化合物在分子浓度较低的条件下，在稳定的菌丝诱导条件下，抑制酵母进行菌丝体转化。还公开了包含抗真菌化合物的组合物。在具体实施方案中，组合物是药物组合物。还公开了使用所公开的化合物治疗和/或预防真菌感染的方法。所公开的化合物在稍高的浓度下对广泛的真菌种类显示出抗真菌活性。本文公开的抗真菌化合物用作抗真菌感染的抗生物膜剂。

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