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1. 发明授权

EP2831110B1 ANTI-EMP2 THERAPY REDUCES CANCER STEM CELLS 有权转让
标题翻译：抗-EMP2治疗减少癌症干细胞
公开(公告)号：EP2831110B1
公开(公告)日：2018-05-09
申请号：EP13770310.4
申请日：2013-03-14
申请人： The Regents of the University of California , Paganini Biopharma, Inc.
发明人： WADEHRA, Madhuri , BRAUN, Jonathan , GORDON, Lynn, K. , LAZAR, Gary, S.
IPC分类号： C07K16/00 , A61K39/395 , C07K16/30 , A61K39/00 , A61K45/06 , C07K16/18 , C07K16/22 , C07K16/28 , G01N33/574
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K47/6823 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K2039/505 , A61K2039/55 , C07K16/22 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34 , C07K2317/626 , C07K2317/73 , C07K2317/92 , G01N33/57492 , G01N2333/4703 , G01N2333/70585 , G01N2333/70596 , G01N2333/90203 , A61K2300/00
摘要： Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1α, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.

2. 发明公开

EP2831110A1 ANTI-EMP2 THERAPY REDUCES CANCER STEM CELLS 有权转让
标题翻译： ANTI-EMP2治疗减少癌症干细胞
公开(公告)号：EP2831110A1
公开(公告)日：2015-02-04
申请号：EP13770310.4
申请日：2013-03-14
申请人： The Regents of the University of California , Paganini Biopharma, Inc.
发明人： WADEHRA, Madhuri , BRAUN, Jonathan , GORDON, Lynn, K. , LAZAR, Gary, S.
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K47/6823 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K2039/505 , A61K2039/55 , C07K16/22 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34 , C07K2317/626 , C07K2317/73 , C07K2317/92 , G01N33/57492 , G01N2333/4703 , G01N2333/70585 , G01N2333/70596 , G01N2333/90203 , A61K2300/00
摘要： Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1α, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.

3. 发明授权

EP2536433B1 EPITHELIAL MEMBRANE PROTEIN 2 (EMP2) BINDING REAGENTS AND THEIR THERAPEUTIC USES IN OCULAR DISEASES 失效
标题翻译：上皮膜蛋白2（EMP2）结合试剂及其在眼部疾病治疗中的应用
公开(公告)号：EP2536433B1
公开(公告)日：2017-08-02
申请号：EP11745457.9
申请日：2011-02-22
申请人： The Regents of the University of California , United States Government Department Of Veterans Affairs
发明人： GORDON, Lynn K. , BRAUN, Jonathan , MORALES, Shawn , TELANDER, David, G. , WADEHRA, Madhuri
IPC分类号： C07K16/28 , C12N15/113 , A61K39/395 , A61P27/02 , A61P27/00 , A61K31/7105 , A61K38/16
CPC分类号： C07K16/18 , A61K38/00 , C07K16/28 , C07K2317/21 , C07K2317/35 , C07K2317/76 , C12N15/1138 , C12N2310/14

4. 发明公开

EP3570886A1 TREATMENT OF CANCERS USING ANTI-EMP2 ANTIBODY AND PD-1/PDL-1 PATHWAY ANTAGONIST COMBINATION THERAPY 无效
公开(公告)号：EP3570886A1
公开(公告)日：2019-11-27
申请号：EP18741455.2
申请日：2018-01-22
申请人： The Regents of the University of California
发明人： WADEHRA, Madhuri , BRAUN, Jonathan , GORDON, Lynn K.
IPC分类号： A61K39/395 , A61P35/00 , A61K39/00

5. 发明公开

EP2812354A1 EMP2 REGULATES ANGIOGENESIS IN CANCER CELLS THROUGH INDUCTION OF VEGF 无效
标题翻译： EMP2作为癌症细胞血管生成调节通过感应血管内皮生长因子
公开(公告)号：EP2812354A1
公开(公告)日：2014-12-17
申请号：EP13747090.2
申请日：2013-02-06
申请人： The Regents of the University of California
发明人： WADEHRA, Madhuri , BRAUN, Jonathan , GORDON, Lynn, K.
IPC分类号： C07K16/00 , C07K16/18 , A61K39/395 , A61P35/04
CPC分类号： C07K16/30 , A61K31/69 , A61K38/14 , A61K39/39558 , A61K47/6415 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2857 , C07K2317/24 , C07K2317/34 , C07K2317/622
摘要： Disclosed herein are methods and compositions for modulating neovascularization. The disclosed compositions find particular use in the treatment of uterine cancers, specifically endometrial cancers.

6. 发明公开

EP2766045A2 TREATMENT OF BREAST CANCER WITH COMPANION DIAGNOSTIC 有权转让
标题翻译：乳腺癌的伴随诊断治疗
公开(公告)号：EP2766045A2
公开(公告)日：2014-08-20
申请号：EP12840745.9
申请日：2012-10-15
申请人： The Regents of the University of California
发明人： WADEHRA, Madhuri , BRAUN, Jonathan
IPC分类号： A61K39/395 , A61K38/10 , A61K38/16 , A61K48/00 , A61P35/00
CPC分类号： A61K39/39558 , A61K38/10 , A61K45/06 , A61K2039/505 , C07K16/3015 , C07K16/3069 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/626 , C07K2317/73
摘要： (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/056248 A2 18 April 2013 (18.04.2013) WI PO I P CT (51) International Patent Classification: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, A61K 39/395 (2006.01) A61K 48/00 (2006.01) DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, A61K 38/10 (2006.01) A61P 35/00 (2006.01) HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, A 61K 38/16 (2006.01) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (21) International Application Number: NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, PCT/US2012/060288 RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (22) International Filing Date: TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, 15 October 2012 (15.10.2012) ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (30) Priority Data: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 61/546,982 13 October 2011 (13.10.2011) US TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (71) Applicant: THE REGENTS OF THE UNIVERSITY MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, OF CALIFORNIA [US/US]; 1111 Franklin Street, Oak- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, land, CA 94607-5200 (US). ML, MR, NE, SN, TD, TG). (72) Inventors: WADEHRA, Madhuri; 1604 N. Poinsettia Declarations under Rule 4.17: Avenue, Manhattan Beach, CA 90266 (US). BRAUN, - as to applicant's entitlement to applyfor and be granted a Jonathan; 3924 Hilton Head Way, Tarzana, CA 91356 patent (Rule 4.17(ii) (US). - as to the applicant's entitlement to claim the priority of the (74) Agent: PARENT, Annette; Morgan, Lewis & Bockius earlier application (Rule 4.17(iii)) LLP, One Market, Spear Street Tower, San Francisco, CA 94105 (US). Published: (81) Designated States (unless otherwise indicated, for every with declaration under Article 17(2)(a); without abstract; kind of national protection available): AE, AG, AL, AM, title not checked by the International Searching Authority AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, O (54) Title: TREATMENT OF BREAST CANCER WITH COMPANION DIAGNOSTIC (57) Abstract:

7. 发明公开

EP2536433A2 EPITHELIAL MEMBRANE PROTEIN 2 (EMP2) BINDING REAGENTS AND THEIR THERAPEUTIC USES IN OCULAR DISEASES 失效
标题翻译：装订EPITHELIALMEMBRANENPROTEIN-2（EMP2）及其治疗的试剂用途眼疾
公开(公告)号：EP2536433A2
公开(公告)日：2012-12-26
申请号：EP11745457.9
申请日：2011-02-22
申请人： The Regents of the University of California , United States Government Department Of Veterans Affairs
发明人： GORDON, Lynn K. , BRAUN, Jonathan , MORALES, Shawn , TELANDER, David, G. , WADEHRA, Madhuri
IPC分类号： A61K39/395 , A61P27/02 , A61K31/7105 , A61P27/00 , A61K38/16
CPC分类号： C07K16/18 , A61K38/00 , C07K16/28 , C07K2317/21 , C07K2317/35 , C07K2317/76 , C12N15/1138 , C12N2310/14

8. 发明公开

EP3383497A1 NOVEL ANTIBODIES FOR THE TREATMENT OF CANCERS 审中-实审
公开(公告)号：EP3383497A1
公开(公告)日：2018-10-10
申请号：EP16871734.6
申请日：2016-12-05
申请人： The Regents of the University of California
发明人： WADEHRA, Madhuri , BRAUN, Jonathan
IPC分类号： A61P35/00 , C07K16/28 , C07K16/30 , A61K39/395 , G01N33/574 , G01N33/577 , G01N33/53
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/28 , C07K2317/40 , C07K2317/565 , C07K2317/73 , C07K2317/92 , C07K2317/94 , G01N33/574 , G01N33/577
摘要： Provided herein are novel anti-EMP2 antibodies useful for the treatment and diagnosis of cancers that express or overexpress EMP2. In one aspect, provided herein is an isolated antibody that binds to Epithelial Membrane Protein 2 (EMP2), that includes heavy chain variable region and a light chain variable region. The heavy chain variable region includes three heavy chain complementary determining regions (HCDRs) and the light chain variable region includes three light chain variable regions (LCDRs). In some embodiments, the sequence of HCDR1 is SEQ ID NO: 11, the sequence of HCDR2 is SEQ ID NO: 12, the sequence of HCDR3 is SEQ ID NO: 13, the sequence of LCDR1 is SEQ ID NO:14, the sequence of LCDR2 is SEQ ID NO: 15, and the sequence of LCDR3 is SEQ ID NO: 16.

9. 发明授权

EP2766045B1 TREATMENT OF BREAST CANCER WITH COMPANION DIAGNOSTIC 有权转让
标题翻译：。UNG。。。。。。。。。。。。。
公开(公告)号：EP2766045B1
公开(公告)日：2016-12-07
申请号：EP12840745.9
申请日：2012-10-15
申请人： The Regents of the University of California
发明人： WADEHRA, Madhuri , BRAUN, Jonathan
IPC分类号： C07K16/30 , A61K39/395 , A61K38/10 , A61K38/16 , A61K48/00 , A61P35/00 , A61K39/00 , A61K45/06 , A61K47/48
CPC分类号： A61K39/39558 , A61K38/10 , A61K45/06 , A61K2039/505 , C07K16/3015 , C07K16/3069 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/626 , C07K2317/73

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