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1. 发明公开

EP3185858A4 COMPOSITIONS FOR MODULATING CANCER STEM CELLS AND USES THEREFOR 审中-公开
公开(公告)号：EP3185858A4
公开(公告)日：2017-12-27
申请号：EP15835730
申请日：2015-08-25
申请人： UNIV OF CANBERRA
发明人： RAO SUDHA , ZAFAR ANJUM
IPC分类号： A61P35/00 , A61K31/137 , A61K31/166 , A61K31/337 , A61K31/496 , A61K31/713 , A61K38/00 , A61K45/06
CPC分类号： A61K31/166 , A61K31/137 , A61K31/337 , A61K31/496 , A61K31/713 , A61K38/00 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Y114/11 , G01N33/574 , G01N33/57415 , G01N33/57492 , G01N33/57496 , G01N2333/47 , G01N2333/70585 , G01N2333/70596 , G01N2333/912 , A61K2300/00
摘要： Disclosed are compositions and methods for modulating cancer stem cells. More particularly, the present invention discloses the use of lysine demethylase (LSD) inhibitors and protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of LSD- and/or PKC-θ-overexpressing cells including cancer stem cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells, for treating cancer, including non-metastatic and metastatic cancer and/or for preventing cancer recurrence.

2. 发明公开

EP2822593A4 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：组合物和治疗癌症的方法
公开(公告)号：EP2822593A4
公开(公告)日：2015-10-14
申请号：EP13758403
申请日：2013-03-11
申请人： LANKENAU INST MEDICAL RES
发明人： GEORGE-WEINSTEIN MINDY , GILMOUR SUSAN , GERHART JACQUELYN
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K47/54 , A61K47/549 , C12Q1/6886 , C12Q2600/158 , G01N33/57484 , G01N33/57492 , G01N2333/70585 , G01N2800/50

3. 发明公开

EP2032716A4 BIOMARKERS FOR DETECTION AND DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA 审中-公开
标题翻译：生物标志物的头部和颈部的检测和鳞状细胞癌的诊断
公开(公告)号：EP2032716A4
公开(公告)日：2010-03-17
申请号：EP07794829
申请日：2007-05-14
申请人： UNIV MIAMI
发明人： FRANZMANN ELIZABETH J , LOKESHWAR VINATA B
IPC分类号： C12Q1/00 , G01N33/574
CPC分类号： G01N33/57407 , G01N33/573 , G01N33/57488 , G01N2333/70585 , G01N2333/924 , G01N2333/926 , G01N2400/40 , G01N2800/52
摘要： Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.

4. 发明授权

EP1418931B1 NEW ANGIOGENESIS INHIBITORS BASED ON SOLUBLE CD44 RECEPTOR HYALURONIC ACID BINDING DOMAIN 有权
标题翻译：基于可溶性透明质酸NEW血管生成抑制剂的CD44受体结合结构域
公开(公告)号：EP1418931B1
公开(公告)日：2008-06-25
申请号：EP02760977.5
申请日：2002-08-26
申请人： Celecure AS
发明人： Staffan Strömblad , Kogerman, Priit , Päll, Taavi
IPC分类号： A61K38/00 , C07K14/705 , G01N33/566
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/70585 , C07K16/2884 , C07K2317/76 , C07K2319/00 , G01N33/5011 , G01N33/5029 , G01N33/5064 , G01N33/68 , G01N2333/70585 , G01N2500/00

5. 发明公开

EP3359200A1 MICRO-AND NANO-DEVICE FOR CARTILAGE INJURY DETECTION AND TREATMENT 有权转让
公开(公告)号：EP3359200A1
公开(公告)日：2018-08-15
申请号：EP16854239.7
申请日：2016-10-05
申请人： Board of Regents, The University of Texas System , Borrelli, Joseph
发明人： BORRELLI, Joseph , TANG, Liping , ZHOU, Jun
IPC分类号： A61K47/36 , A61K31/728 , C08B37/08 , C08J3/075
CPC分类号： A61K49/0054 , A61K9/0019 , A61K38/1841 , A61K38/195 , A61K47/551 , A61K47/61 , A61K47/6939 , A61K49/0032 , A61K49/0052 , A61K49/0091 , A61K49/0093 , C08B37/0072 , G01N33/6872 , G01N33/82 , G01N2333/70585 , G01N2800/105
摘要： The present invention provides targeting probe, imaging probes, and probes for use as a medicament to treat damaged cartilage, where the probe targets injured tissue and can then be imaged and/or release agents to trigger the migration of surrounding chondrocytes from healthy tissue to injured tissue and/or recruit synovial stem cells.

6. 发明公开

EP3010541A4 A METHOD OF INCREASING GIPCR SIGNALIZATION IN THE CELLS OF A SCOLIOTIC SUBJECT 审中-公开
标题翻译： VENFAHREN ZURERHÖHUNGDER GIPCR-SIGNALISIERUNG IN DEN ZELLEN EINER SKOLIOTISCHEN PERSON
公开(公告)号：EP3010541A4
公开(公告)日：2017-05-10
申请号：EP14814185
申请日：2014-06-17
申请人： CHU SAINTE-JUSTINE
发明人： MOREAU ALAIN , AKOUME NDONG MARIE-YVONNE
IPC分类号： A61K39/395 , A61K31/713 , A61P19/08 , C07H21/00 , C12Q1/68 , G01N33/48 , G01N33/53
CPC分类号： C07K16/2839 , A61K31/713 , A61K39/3955 , C07K16/24 , C07K16/2884 , C07K2317/76 , C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G01N33/74 , G01N2333/70585 , G01N2800/10 , G01N2800/50
摘要： There is provided a method of increasing GIPCR signalization in the cells of a subject in need thereof comprising administering to the subject an effective amount of an inhibitor of integrin alpha5beta1 expression and/or activity, whereby GiPCR signalization is increased in the cells of the subject. An inhibitor of integrin alph5beta1 may be, for example, an agent that inhibits the interaction between f osteopontin (OPN) and integrin alpha5beta1. Also provided are methods of determining the risk of developing a scoliosis and based on the presence of at least one copy of a CD44 risk allele and methods of stratifying a subject having a scoliosis and kits for performing these methods. In particular, the method of determining risk identifies SNP rs1467558; an isoleucine to threonine mutation at position 230 of CD44.
摘要翻译：提供了在有此需要的受试者的细胞中增加GIPCR信号化的方法，其包括向受试者施用有效量的整联蛋白α5β1表达和/或活性的抑制剂，由此GiPCR信号在受试者的细胞中增加。整联蛋白alph5beta1的抑制剂可以是例如抑制骨桥蛋白（OPN）和整联蛋白α5β1之间的相互作用的药剂。还提供了确定发生脊柱侧凸的风险的方法，并且基于至少一个CD44风险等位基因的拷贝的存在以及分层具有脊柱侧弯的对象的方法和用于执行这些方法的试剂盒。具体而言，确定风险的方法识别SNP rs1467558; CD44位置230处的异亮氨酸至苏氨酸突变。

7. 发明公开

EP3120144A1 DEVICE FOR DETECTION OF DISEASE STATES AND APPLICATIONS OF SAME 审中-公开
标题翻译： VORRICHTUNG ZUR ERKENNUNG VONKRANKHEITSZUSTÄNDENUND VERWENDUNGEN DAVON
公开(公告)号：EP3120144A1
公开(公告)日：2017-01-25
申请号：EP15764518.5
申请日：2015-03-19
申请人： Vigilant Biosciences, Inc.
发明人： BOHANNON, Robert C. , BOHANNON, Seven C. , KIM, Matthew H.J.
IPC分类号： G01N33/52 , G01N33/68 , G01N21/62
CPC分类号： G01N33/523 , G01N21/8483 , G01N33/54386 , G01N33/558 , G01N33/6827 , G01N2333/70585
摘要： A device for testing a biological sample includes a test strip. The test strip includes a substrate having a first surface and an opposite, second surface; a first sample pad and a second sample pad disposed on the first surface and the second surface respectively, and configured to receive the biological sample; a first test pad disposed on the first surface, in contact with the first sample pad, and configured to test the biological sample received from the first sample pad; and a second test pad disposed on the second surface, in contact with the second sample pad, and configured to test the biological sample received from the second sample pad. The first and second sample pads may be configured to evaluate the CD44 protein and total protein of the sample, and used for early detection of neck squamous cell carcinoma (HNSCC).
摘要翻译：用于测试生物样品的装置包括测试条。测试条包括具有第一表面和相对的第二表面的基底; 第一样品垫和第二样品垫，分别设置在第一表面和第二表面上，并且被配置为接收生物样品; 第一测试垫，设置在第一表面上，与第一样品垫接触，并且被配置为测试从第一样品垫接收的生物样品; 以及设置在所述第二表面上的与所述第二样品垫接触并且被配置为测试从所述第二样品垫接收的生物样品的第二测试垫。第一和第二样品垫可以被配置为评估样品的CD44蛋白和总蛋白，并用于早期检测颈鳞状细胞癌（HNSCC）。

8. 发明公开

EP2446275A1 ORDERED ASSEMBLY OF MEMBRANE PROTEINS DURING DIFFERENTIATION OF ERYTHROBLASTS 审中-公开
标题翻译：结构化膜蛋白形成过程中红细胞分化
公开(公告)号：EP2446275A1
公开(公告)日：2012-05-02
申请号：EP10726770.0
申请日：2010-06-23
申请人： New York Blood Center, Inc.
发明人： AN, Xiuli , NARLA, Mohandas , LIU, Jin , HECK, Susanne
IPC分类号： G01N33/80
CPC分类号： G01N33/56966 , G01N33/80 , G01N2333/70585 , G01N2800/22
摘要： Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring
ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors.

9. 发明公开

EP2354254A1 Biomarkers for assessing response to C-met treatment 审中-公开
标题翻译： Biomarker zurÜberprüfungder Reaktion auf eine C-Met-Behandlung
公开(公告)号：EP2354254A1
公开(公告)日：2011-08-10
申请号：EP10195317.2
申请日：2007-08-29
申请人： Ortho-McNeil Pharmaceutical, Inc.
发明人： Connors, Richard W.
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/5011 , G01N33/57484 , G01N2333/52 , G01N2333/70585 , G01N2800/52
摘要： Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of the biomarkers is reduced upon treatment with c-met inhibitor compounds, thus indicating that these biomarkers are involved in c-met activity.
摘要翻译：公开了与抑制c-met的药物治疗相关的生物标志物。已经显示这些生物标志物可用于评估对化合物的反应。在用c-met抑制剂化合物治疗后，生物标志物的表达水平降低，从而表明这些生物标志物参与c-met活性。

10. 发明公开

EP2061904A2 BIOMARKERS FOR ASSESSING RESPONSE TO C-MET TREATMENT 审中-公开
标题翻译：生物标记审查响应于C-MET的治疗
公开(公告)号：EP2061904A2
公开(公告)日：2009-05-27
申请号：EP07841509.8
申请日：2007-08-29
申请人： Ortho-McNeil Pharmaceutical, Inc.
发明人： CONNORS, Richard W.
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/5011 , G01N33/57484 , G01N2333/52 , G01N2333/70585 , G01N2800/52
摘要： Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of the biomarkers is reduced upon treatment with c-met inhibitor compounds, thus indicating that these biomarkers are involved in c-met activity.

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