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1. 发明公开

EP0629125A1 ENDOVASCULAR ELECTROLYTICALLY DETACHABLE WIRE FOR THROMBUS FORMATION 失效
标题翻译：血管内，电解可分离WIRE血栓。
公开(公告)号：EP0629125A1
公开(公告)日：1994-12-21
申请号：EP92922392.0
申请日：1992-09-30
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TARGET THERAPEUTICS
发明人： GUGLIELMI, Guido , SEPETKA, Ivan
IPC分类号： A61B18 , A61B17 , A61F2 , A61M25 , A61M37 , A61B19
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B90/39 , A61B2017/00292 , A61B2017/12063 , A61B2017/12095 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61M2025/09175
摘要： On pratique l'occlusion d'une malformation artérielle, veineuse, aneurysmale ou vasculaire ou d'une fistule artérielle au moyen de l'introduction endovasculaire d'un fil (56) et/ou d'une pointe (53) en platine dans la cavité vasculaire. Ladite cavité vasculaire est remplie par la pointe (58), afin d'obstruer la circulation sanguine ou l'arrivée de sang dans ladite cavité, de façon à provoquer la coagulation du sang dans la cavité et la formation d'une occlusion. La pointe peut être allongée et souple, de manière à remplir la cavité en se repliant sur elle-même à un nombre multiple de fois ou à cause de sa structure filamenteuse ou expansée. La pointe est ensuite séparée du fil mécaniquement ou par séparation électrolytique. Le fil et le microcathéter (144) sont ensuite retirés tout en laissant la pointe encastrée dans le thrombus qui s'est formé à l'intérieur de la cavité vasculaire. On détecte plus facilement le déplacement du fil dans le microcathéter (144) au moyen d'un marqueur proximal opaque à la radio (110) situé sur ledit microcathéter et d'un marqueur indicateur correspondant (112) situé sur le fil. On provoque l'électrothrombose en plaçant l'électrode de terre (114) à l'extrémité distale du microcathéter et en faisant circuler du courant entre l'électrode du microcathéter et la pointe.

2. 发明授权

EP0484468B2 ENDOVASCULAR ELECTROLYTICALLY DETACHABLE GUIDEWIRE TIP 失效
标题翻译：血管内电解分割的导丝TIP
公开(公告)号：EP0484468B2
公开(公告)日：2005-10-19
申请号：EP91905194.6
申请日：1991-01-03
申请人： The Regents of the University of California
发明人： GUGLIELMI, Guido , SEPETKA, Ivan
IPC分类号： A61B18/00
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B90/39 , A61B2017/00292 , A61B2017/12063 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61M2025/0042 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular electrothrombosis by the endovascular insertion of a platinum guidewire tip (30) into the vascular cavity followed by application of a positive current. The guidewire tip (30) is then separated from the guidewire by electrolytic separation of the tip from the guidewire (10). A portion (26) of the guidewire (10) connected between the tip (30) and the body of the guidewire (10) is comprised of stainless steel and exposed to the bloodstream so that upon continued application of a positive current to the exposed portion, the exposed portion is corroded away at least at one location and the tip (30) is separated from the body of guidewire (10). The guidewire (10) and the microcatheter are thereafter removed leaving the guidewire tip (30) embedded in the thrombus formed within the vascular cavity.

3. 发明授权

EP0484468B1 ENDOVASCULAR ELECTROLYTICALLY DETACHABLE GUIDEWIRE TIP 失效
标题翻译：血管内电解分割的导丝TIP
公开(公告)号：EP0484468B1
公开(公告)日：1999-06-16
申请号：EP91905194.6
申请日：1991-01-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： GUGLIELMI, Guido , SEPETKA, Ivan
IPC分类号： A61B17/36 , A61B17/12 , A61B17/39 , A61M25/01
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B90/39 , A61B2017/00292 , A61B2017/12063 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61M2025/0042 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular electrothrombosis by the endovascular insertion of a platinum guidewire tip (30) into the vascular cavity followed by application of a positive current. The guidewire tip (30) is then separated from the guidewire by electrolytic separation of the tip from the guidewire (10). A portion (26) of the guidewire (10) connected between the tip (30) and the body of the guidewire (10) is comprised of stainless steel and exposed to the bloodstream so that upon continued application of a positive current to the exposed portion, the exposed portion is corroded away at least at one location and the tip (30) is separated from the body of guidewire (10). The guidewire (10) and the microcatheter are thereafter removed leaving the guidewire tip (30) embedded in the thrombus formed within the vascular cavity.

4. 发明公开

EP0484468A1 ENDOVASCULAR ELECTROLYTICALLY DETACHABLE GUIDEWIRE TIP 失效
标题翻译：血管内电解分割的导丝提示。
公开(公告)号：EP0484468A1
公开(公告)日：1992-05-13
申请号：EP91905194.0
申请日：1991-01-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： GUGLIELMI, Guido , SEPETKA, Ivan
IPC分类号： A61B18 , A61B17 , A61M25 , A61B19
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B90/39 , A61B2017/00292 , A61B2017/12063 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61M2025/0042 , A61M2025/09175
摘要： Une artère, une veine, un anéurisme, une malformation vasculaire ou une fistule artérielle peuvent être occluses au moyen de l'électrothrombose endovasculaire par l'insertion endovasculaire d'une extrémité de fil de guidage en platine (30) dans la cavité vasculaire, suivie de l'application d'une charge de courant positif. L'extrémité du fil de guidage (30) est alors séparée dudit fil par la séparation électrolytique de l'extrémité et du fil de guidage (10). Une partie (26) du fil (10), connectée entre l'extrémité (30) et le corps du fil de guidage (10) est composée d'acier inoxydable et exposée au flux sanguin de sorte que, sous l'application continue d'un courant positif à la partie exposée, celle-ci est corrodée en au moins un endroit, et l'extrémité (30) est alors séparée du corps du fil de guidage (10). Le fil de guidage (10) et le micro-cathéter sont ensuite enlevés, laissant l'extrémité du fil (30) implanté dans le thrombus formé à l'intérieur de la cavité vasculaire.

5. 发明授权

EP0585359B1 CATHETER GUIDE WIRE 失效
标题翻译：导尿管导丝
公开(公告)号：EP0585359B1
公开(公告)日：1998-03-18
申请号：EP92912258.8
申请日：1992-05-06
申请人： TARGET THERAPEUTICS, INC.
发明人： SEPETKA, Ivan
IPC分类号： A61M25/01 , A61B5/00
CPC分类号： A61M25/09 , A61M25/0054 , A61M2025/09091 , A61M2025/09166 , A61M2025/09175
摘要： A catheter guide wire (10) comprising: a flexible, torqueable proximal wire section (13), a more flexible intermediate section (14) with a flexible polymer tube covering (19), and a most flexible distal end section (15). A helical ribbon coil (22) is wrapped about the intermediate core segment between the wire core and the polymer tube covering to increase radiopacity and improve torque transmission while retaining flexibility.
摘要翻译：一种导管引导线（10），包括：柔性的可扭转的近端线部分（13），具有柔性聚合物管覆盖物（19）的更柔性的中间部分（14）以及最柔性的远端部分（15）。螺旋带状线圈（22）缠绕在线芯和聚合物管覆盖物之间的中间芯段上，以增加射线不透性并改善扭矩传递，同时保持柔性。

6. 发明授权

EP0473697B1 CATHETER WITH LOW-FRICTION DISTAL SEGMENT 失效
标题翻译：有摩擦POOR末节导管
公开(公告)号：EP0473697B1
公开(公告)日：1996-08-14
申请号：EP90908859.3
申请日：1990-05-22
申请人： TARGET THERAPEUTICS, INC.
发明人： ENGELSON, Erik, T. , SEPETKA, Ivan
IPC分类号： A61M25/00
CPC分类号： A61M25/01 , A61M25/0012 , A61M25/0052 , A61M25/0054 , A61M25/09 , A61M2025/0046 , A61M2025/0047 , A61M2025/09091
摘要： A catheter (12) for accessing a target site along a tortuous, small-vessel pathway. The catheter includes a flexible distal segment (26) which is composed of a flexible polymer tube and a low-friction internal tubular surface. The surface allows the catheter to be advanced over sharp bends and small-diameter loops in a guidewire (14), in advancing the catheter along a small-vessel pathway. Various embodiments of the catheter are disclosed wherein the internal tubular surface of a distal portion of the catheter include a variety of different constructions and are comprised of a variety of different materials so as to best avoid the jamming, sticking or locking of the distal end or any part of the guidewire against the surface. Braided sleeve-like constructions, surfaces embedded with a plurality of small particles and surfaces comprised of various anti-friction materials are used in order to obtain the object of the invention.

7. 发明授权

EP0629125B1 Microcatheter system 失效
标题翻译：微系统
公开(公告)号：EP0629125B1
公开(公告)日：1998-06-24
申请号：EP92922392.3
申请日：1992-09-30
申请人： REGENTS OF THE UNIVERSITY OF CALIFORNIA , TARGET THERAPEUTICS, INC.
发明人： GUGLIELMI, Guido , SEPETKA, Ivan
IPC分类号： A61B17/38
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B90/39 , A61B2017/00292 , A61B2017/12063 , A61B2017/12095 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire (56) and/or tip (53) into the vascular cavity. The vascular cavity is packed with the tip (58) to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion is formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip (104). The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter (144) are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter (144) is more easily tracked by providing a radiopaque proximal marker (110) on the microcatheter and corresponding indicator marker (112) on the wire. Electrothrombosis is facilitated by placing the ground electrode (114) on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

8. 发明授权

EP0726745B1 ELECTROLYTICALLY SEVERABLE JOINT FOR ENDOVASCULAR EMBOLIC DEVICES 失效
标题翻译：血管内栓塞DEVICES电解可分离连接
公开(公告)号：EP0726745B1
公开(公告)日：1998-01-21
申请号：EP95900494.6
申请日：1994-11-01
申请人： TARGET THERAPEUTICS, INC.
发明人： PHAM, Pete Phong , DOAN, Hong , SEPETKA, Ivan
IPC分类号： A61F2/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00004 , A61B2017/12063
摘要： This invention is an apparatus for endovascular occlusion through the formation of thrombi in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas. In particular, it deals with a sacrificial link (106) between an endovascular device (104) which is introducted to and is intended to remain at the desired thrombus formation site and the device (102) used to introduce the device. The invention further includes a method for introduction of the device and its electrolytic separation.

9. 发明授权

EP0616544B1 DETACHABLE PUSHER-VASOOCCLUSION COIL ASSEMBLY WITH THREADED COUPLING 失效
标题翻译：螺纹离合器可分割，可推进血管闭塞性螺旋型装置
公开(公告)号：EP0616544B1
公开(公告)日：1997-09-24
申请号：EP93900854.6
申请日：1992-12-04
申请人： TARGET THERAPEUTICS, INC.
发明人： SEPETKA, Ivan
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/1214 , A61B90/39 , A61B2017/12095
摘要： A pusher-vasoocclusive coil assembly (11) that is advanced through a catheter (24) to a site within a vessel and is manipulated to detach the coil (13) from the assembly. The pusher (12) has a distal end (17) that is initially threaded into the proximal end of the coil (13) and the assembly (11) includes a sleeve (14) that is slid over the pusher (12) and whose distal edge abuts the proximal end of the coil (13) to hold the coil (13) in place while the distal end of the pusher (12) is threaded out of the coil (13) to detach the coil (13) at the site.

10. 发明公开

EP0616544A1 DETACHABLE PUSHER-VASOOCCLUSION COIL ASSEMBLY WITH THREADED COUPLING 失效
标题翻译：具有螺纹联接的可拆卸推杆 - 血管吻合线圈组件
公开(公告)号：EP0616544A1
公开(公告)日：1994-09-28
申请号：EP93900854.0
申请日：1992-12-04
申请人： TARGET THERAPEUTICS, INC.
发明人： SEPETKA, Ivan
IPC分类号： A61F2 , A61B17 , A61B19
CPC分类号： A61B17/12022 , A61B17/1214 , A61B90/39 , A61B2017/12095
摘要： On décrit un ensemble serpentin/poussoir vasoocclusif (11) que l'on fait avancer à travers un cathéter (24) vers un endroit à l'intérieur d'un vaisseau et que l'on manipule pour détacher le serpentin (13) de l'ensemble. Le poussoir (12) comporte une extrémité distale (17) qui est initialement enfilée dans l'extrémité proximale du serpentin (13). L'ensemble (11) comprend un manchon (14) que l'on fait coulisser sur le poussoir (12) et dont la bordure distale aboutit à l'extrémité distale du serpentin (13) afin de maintenir celui-ci en place alors que l'extrémité distale du poussoir (12) est retirée du serpentin (13) afin de détacher ce dernier (13) de l'endroit où il est placé.
摘要翻译：公开了一种血管闭塞性线圈/推动器组件（11），其通过导管（24）前进到血管内的位置并被操纵以将线圈（13）从血管分离。整体。推动器（12）具有最初拧入线圈（13）近端的远端（17）。组件（11）包括在推杆（12）上滑动并且其远端边缘终止于线圈（13）的远端以将线圈保持在适当位置的套筒（14）推动器（12）的远端从线圈（13）移除以将线圈（13）从其放置的位置分离。

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