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1. 发明公开

EP2456421A1 MULTI-LAYERED GRADIENT VAGINAL RING 有权
标题翻译： MEHRSCHICHTIGER VAGINALRING MIT GRADIENT
公开(公告)号：EP2456421A1
公开(公告)日：2012-05-30
申请号：EP10714730.8
申请日：2010-04-07
申请人： THE POPULATION COUNCIL, INC.
发明人： VARIANO, Bruce , SPECK, Jeffrey , SALLENT, Maria, Teresa , EVANS, Simone
IPC分类号： A61K9/00 , A61K31/565
CPC分类号： A61K9/0036 , A61K31/565 , A61K2300/00
摘要： Multi-layered vaginal rings 2 comprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer 4, a middle layer 5, and an outer layer 6. After extrusion and simultaneous curing, however, the ring 2 includes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s) 4 to the outer layer (s) 6. Methods of producing these vaginal rings and of using them are also disclosed.
摘要翻译：公开了包含硅氧烷弹性体和药物活性成分的多层阴道环2。环包括多个层，其中至少一个含有药物活性成分，并且其中每一层均为硅氧烷弹性体。多层优选由不同组成的这些层制成，包括内层4，中间层5和外层6.然而，在挤压和同时固化之后，环2包括连续的主体，其包括连续的硅氧烷身体提供药物活性成分从内层4到外层的无阻碍扩散。6.还公开了制备这些阴道环并使用它们的方法。

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