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1. 发明授权

EP2794632B1 PROCESS FOR ALKYNYLATING 16-SUBSTITUTED-17-KETO STEROIDS 有权转让
标题翻译：方法ALKINILIERUNG 16 - 取代17-酮类固醇
公开(公告)号：EP2794632B1
公开(公告)日：2016-03-16
申请号：EP12805684.3
申请日：2012-12-19
申请人： Crystal Pharma S.A.U , THE POPULATION COUNCIL, INC.
发明人： GUTIÉRREZ FUENTES, Luis Gerardo , SANDOVAL RODRÍGUEZ, Celso Miguel
IPC分类号： C07J7/00 , C07J75/00
CPC分类号： C07J75/00 , C07J1/0011 , C07J1/0059 , C07J1/0081 , C07J1/0096 , C07J7/00 , C07J7/0055 , C07J7/0075 , C07J7/009 , C07J31/006 , C07J51/00

2. 发明公开

EP2953629A1 INTRAVAGINAL RING FOR THE DELIVERY OF UNIQUE COMBINATIONS OF ANTIMICROBIAL COMPOSITIONS 审中-公开
标题翻译： INTRAVAGINALRING TO MAKE抗菌组合物的某些组合
公开(公告)号：EP2953629A1
公开(公告)日：2015-12-16
申请号：EP14705007.4
申请日：2014-02-04
申请人： THE POPULATION COUNCIL, INC.
发明人： ZYDOWSKY, Thomas M. , UGAONKAR, Shweta , SEIDOR, Samantha
IPC分类号： A61K31/731 , A61K31/315 , A61K31/44
CPC分类号： A61K9/0036 , A61K31/44 , A61K31/731 , A61K33/30 , A61K47/36 , A61K2300/00
摘要： Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified antiretroviral agents comprising NNRTIs and NRTIs. Also disclosed are methods for making and using the compositions. Also disclosed are intravaginal rings for delivering water-soluble compounds, and preferably high molecular weight water-soluble polymers at essentially a zero order rate. The rings include an outer layer of non-water-swellable elastomer, and preferably high molecular weight water-soluble polymer and an inner layer of the water-soluble polymer, which is imbedded in the outer layer, and an aperture through the outer layer for release thereof only through that aperture.

3. 发明公开

EP2485710A1 CARRAGEENAN-CONTAINING AQUEOUS ANTIMICROBIAL COMPOSITIONS 有权
标题翻译：卡拉胶含水性，抗菌活性化合物
公开(公告)号：EP2485710A1
公开(公告)日：2012-08-15
申请号：EP10762850.5
申请日：2010-10-04
申请人： THE POPULATION COUNCIL, INC.
发明人： MAGUIRE, Robin, A. , THORN, Mitchell , PHILLIPS, David, M. , RUTENBERG, Naomi
IPC分类号： A61K9/00 , A61K9/08 , A61K47/36 , A61K31/7072 , A61K33/00
CPC分类号： A61K9/08 , A61K9/0031 , A61K9/0034 , A61K31/715 , A61K31/731 , A61K45/06 , A61K47/36 , A61K2300/00
摘要： Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified antiretro viral agents comprising NNRTIs and NRTIs. Also disclosed are methods for making and using the compositions.

4. 发明公开

EP2456421A1 MULTI-LAYERED GRADIENT VAGINAL RING 有权
标题翻译： MEHRSCHICHTIGER VAGINALRING MIT GRADIENT
公开(公告)号：EP2456421A1
公开(公告)日：2012-05-30
申请号：EP10714730.8
申请日：2010-04-07
申请人： THE POPULATION COUNCIL, INC.
发明人： VARIANO, Bruce , SPECK, Jeffrey , SALLENT, Maria, Teresa , EVANS, Simone
IPC分类号： A61K9/00 , A61K31/565
CPC分类号： A61K9/0036 , A61K31/565 , A61K2300/00
摘要： Multi-layered vaginal rings 2 comprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer 4, a middle layer 5, and an outer layer 6. After extrusion and simultaneous curing, however, the ring 2 includes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s) 4 to the outer layer (s) 6. Methods of producing these vaginal rings and of using them are also disclosed.
摘要翻译：公开了包含硅氧烷弹性体和药物活性成分的多层阴道环2。环包括多个层，其中至少一个含有药物活性成分，并且其中每一层均为硅氧烷弹性体。多层优选由不同组成的这些层制成，包括内层4，中间层5和外层6.然而，在挤压和同时固化之后，环2包括连续的主体，其包括连续的硅氧烷身体提供药物活性成分从内层4到外层的无阻碍扩散。6.还公开了制备这些阴道环并使用它们的方法。

5. 发明授权

EP0866798B1 PREPARATION OF ESTER DERIVATIVES OF STEROIDS 失效
标题翻译： PRESENTATION类固醇酯衍生物
公开(公告)号：EP0866798B1
公开(公告)日：2003-05-14
申请号：EP96912447.8
申请日：1996-03-20
申请人： THE POPULATION COUNCIL, INC.
发明人： LI, Fang
IPC分类号： C07J5/00 , C07J7/00 , C07J31/00 , C07J41/00 , C07J51/00 , C07J75/00
CPC分类号： C07J7/0055
摘要： The present invention relates to a method of using a perchloric acid catalyzed reaction to make acyl derivatives of norprogesterone compounds and, in particular, 16-methylene-17 alpha -hydroxy-19-norpregn-4-ene-3,20-dione.

6. 发明公开

EP0134671A1 Contraceptive membrane ring 失效
标题翻译： EmpfängnisverhütenderMembranring。
公开(公告)号：EP0134671A1
公开(公告)日：1985-03-20
申请号：EP84304889.3
申请日：1984-07-18
申请人： THE POPULATION COUNCIL, INC.
发明人： Luukkainen, Tapani
IPC分类号： A61F5/46
CPC分类号： A61F6/08
摘要： @ This invention relates to a contraceptive membrane ring designed to cover the cervical os which comprises a flexible ring (18) having a top and bottom surface, a sperm impermeable flexible membrane (20) stretched across and attached to the bottom surface of the ring, a disposable flexible insert (22) resting on the sperm impermeable membrane made of an absorbent material having a diameter slightly larger than the inner diameter of the ring and impregnated with a spermicide and a flexible permeable cover (24) positioned over the insert and pressing against the inner circumference of the ring having a diameter approximately equal to the inner diameter of the ring (18).
摘要翻译：本发明涉及一种设计用于覆盖宫颈口的避孕膜环，其包括具有顶部和底部表面的柔性环（18），跨越并连接到环的底部表面的精子不渗透柔性膜（20），一次性柔性插入物（22）搁置在由吸收材料制成的精子不透性膜上，该吸收材料的直径略大于环的内径，并且浸渍有杀精剂和柔性可渗透盖（24），其位于插入物上并压靠环的内圆周的直径近似等于环（18）的内径。

7. 发明公开

EP3986375A1 SYSTEM FOR PROVIDING BIRTH CONTROL 审中-公开
公开(公告)号：EP3986375A1
公开(公告)日：2022-04-27
申请号：EP20737731.8
申请日：2020-06-19
申请人： THE POPULATION COUNCIL, INC.
发明人： VARIANO, Bruce
IPC分类号： A61K9/00 , A61K31/567 , A61K31/57 , A61P15/18 , A61F6/06

8. 发明公开

EP2745847A1 Progestins for preventing or reducing neurodeneration or ischemic damage 审中-公开
标题翻译：孕激素Zur Vorbeugung oder Verminderung von Neurodegeneration oderischämischemSchädingungen
公开(公告)号：EP2745847A1
公开(公告)日：2014-06-25
申请号：EP13199399.0
申请日：2013-12-23
申请人： THE POPULATION COUNCIL, INC.
发明人： Sitruk-Ware, Regine , Schumacher, Michael Maria Helmut , Brinton, Roberta , El-Etr, Martine , Ghoumari, Abdelmouman , Guennoun, Rachida
IPC分类号： A61K45/06 , A61K31/565 , A61K31/57 , A61K31/573 , A61K31/575 , A61K31/585 , A61P25/28
CPC分类号： A61K31/565 , A61K31/57 , A61K31/573 , A61K31/575 , A61K31/585 , A61K45/06 , A61K2300/00
摘要： Methods for treating neurodegeneration and/or myelination in patients are disclosed comprising treating the patient with a progestin compound which exerts binding to progesterone receptors and elicits progesterone-receptor-induced biological responses without interacting with the androgen receptor and without inducing androgen or glucocorticoid biological responses at a dosage sufficient to prevent or reduce neurodegeneration. The progestin compound preferably comprises 16-methylene-17α-acetoxy-19-norpregn-4-ene-3,20-dione, and the methods include combining the progestin compound with an estrogen compound to provide both contraception and treatment for myelin repair and neurodegeneration, and include effects on stroke and TBI.
摘要翻译：公开了用于治疗患者神经变性和/或髓鞘形成的方法，其包括用与孕酮受体结合的孕激素化合物治疗患者，并引发孕激素受体诱导的生物反应而不与雄激素受体相互作用并且不诱导雄激素或糖皮质激素生物反应足以预防或减少神经变性的剂量。孕激素化合物优选包含16-亚甲基-17± - 乙酰氧基-19-去甲孕-4-烯-3,20-二酮，并且所述方法包括将孕激素化合物与雌激素化合物组合以提供髓鞘修复的避孕和治疗，神经变性，包括对中风和TBI的影响。

9. 发明公开

EP2246062A1 Methods and compositions for emergency contraception using endothelin receptor antagonists 有权
标题翻译：方法和组合物用于紧急避孕相关的使用内皮素受体拮抗剂
公开(公告)号：EP2246062A1
公开(公告)日：2010-11-03
申请号：EP10168520.4
申请日：2006-07-19
申请人： THE POPULATION COUNCIL, INC.
发明人： Bagchi, Indrani , Sitruk-Ware, Regine
IPC分类号： A61K38/00 , A61K31/454
CPC分类号： A61K38/06 , A61K38/05 , A61K38/2285
摘要： Disclosed are methods and compositions containing endothelin receptor antagonists for emergency contraception.
摘要翻译：本发明公开了包含用于紧急避孕内皮素受体拮抗剂的方法和组合物。

10. 发明公开

EP1768625A2 SUSTAINED RELEASE COMPOSITIONS CONTAINING PROGESTERONE RECEPTOR MODULATORS 有权
标题翻译：用黄体酮受体调节剂缓释组合物
公开(公告)号：EP1768625A2
公开(公告)日：2007-04-04
申请号：EP05771439.6
申请日：2005-07-08
申请人： THE POPULATION COUNCIL, INC. , Laboratoire HRA Pharma
发明人： SITRUK-WARE, Regine , TSONG, Yun-Yen
IPC分类号： A61F6/14
CPC分类号： A61F6/08 , A61K9/0036 , A61K47/24
摘要： Disclosed are sustained release compositions for vaginal or transdermal administration that contain a progesterone receptor modulator such as CDB-2914 (also referred to as VA-2914), and methods of using them for long term contraception or therapeutic purposes. Also disclosed are methods for making the compositions.

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