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1. 发明公开

EP0611567A1 ULTRAFINE POWDER FOR INHALATION AND PRODUCTION THEREOF 失效
标题翻译： ULTRAFEINES PULVER ZUR INHALATION UNDSEN HERSTELLUNG。
公开(公告)号：EP0611567A1
公开(公告)日：1994-08-24
申请号：EP93913510.9
申请日：1993-06-11
申请人： TEIJIN LIMITED
发明人： SAKON, Kiyoyuki , SAKAGAMI, Masahiro , MAKINO, Yuji , SUZUKI, Yoshiki , KOBAYASHI, Hideki
IPC分类号： A61K9/72 , A61K9/14 , A61K47/38
CPC分类号： A61K9/0075 , Y10S514/951 , Y10S514/958
摘要： An ultrafine powder for inhalation to be transferred mainly to the lower airway, which comprises a drug and hydroxypropylcellulose and/or hydroxypropylmethylcellulose and wherein the particles having diameters in the range of 0.5-10 µm account for 80 wt.% or above.
摘要翻译：用于吸入的超细粉末主要转移到包括药物和羟丙基纤维素和/或羟丙基甲基纤维素的下气道中，其中直径在0.5-10μm范围内的颗粒占80重量％或更高。

2. 发明公开

EP0227844A1 ANTIVIRAL DRUG 失效
标题翻译：反病毒治疗。
公开(公告)号：EP0227844A1
公开(公告)日：1987-07-08
申请号：EP86904397.6
申请日：1986-07-21
申请人： TEIJIN LIMITED
发明人： KAWAGUCHI, Takeo , FUJINAGA, Shigeki , SUZUKI, Yoshiki
IPC分类号： A61K31/70
CPC分类号： C07H19/10 , Y10S514/934
摘要： tiviral drug containing as an effective ingredient a 5-halo-2'-deoxyuridine ester derivative represented by general formula (I), wherein X represents F, Cl, Br or I, and R 1 and R 2 , which may be the same or different, each represents a hydrogen atom, an aliphatic acyl group containing 2 or more carbon atoms, or an aromatic acyl group containing 6 or more carbon atoms, provided that R 1 and R 2 do not represent a hydrogen atom at the same time. This drug has a large therapeutic ratio and show a high-level antiviral effect in a low dosage with less toxicity on normal cells.

3. 发明授权

EP0020777B1 SUSTAINED-RELEASE PREPARATION USED IN ADHESIVE CONTACT WITH WET SURFACE 失效
标题翻译：在湿润表面粘合使用的持续释放准备
公开(公告)号：EP0020777B1
公开(公告)日：1984-05-23
申请号：EP79901518.5
申请日：1979-11-06
申请人： TEIJIN LIMITED
发明人： SUZUKI, Yoshiki , IKURA, Hiroshi , YAMASHITA, Gentaro
IPC分类号： A61K9/24
CPC分类号： A61K9/209 , A61K9/006 , A61K9/70
摘要： Preparation constituted by the two layers of an adhesive layer having an adhesive property to a wet surface and comprising a polymer exhibiting a swelling property upon being wet, and a non-adhesive layer having no adhesive property to a wet surface and being water-soluble or water-degradable, with at least one layer containing a medicine, which is to be used in an adhesive contact with a wet surface such as a mucous membrane or the skin of human being or animal to gradually release the medicine over a long period of time for the treatment or prophylaxis of general or local diseases.

4. 发明授权

EP0331755B2 MEDICINE-CONTAINING FAT EMULSION OF THE TYPE PREPARED IMMEDIATELY BEFORE USE AND PROCESS FOR PREPARING MEDICINE-CONTAINING FAT EMULSION 失效
标题翻译：药物含脂肪乳化型“之前使用由” AND METHOD FOR生产含药脂肪乳剂
公开(公告)号：EP0331755B2
公开(公告)日：2003-02-05
申请号：EP88907808.5
申请日：1988-09-05
申请人： TEIJIN LIMITED
发明人： TAKAHASHI, Ken , MAKINO, Yuji , SUZUKI, Yoshiki , NARUCHI, Tatsuyuki
IPC分类号： A61K9/107
CPC分类号： A61K9/1075
摘要： A kit of a medicine-containing fat emulsion of the type prepared immediately before its use, which comprises a fat emulsion and either (a) a medicinal composition comprising a medicine and at least one solvent selected from among liquid polyalkylene glycols, liquid alkylethanolamines, liquid polyhydric alcohols and water, or (b) a medicinal composition comprising a medicine and an excipient such as a sugar and/or an amino acid, and a process for preparing a medicine-containing fat emulsion therefrom immediately before its use.

5. 发明授权

EP0611567B1 ULTRAFINE POWDER FOR INHALATION AND PRODUCTION THEREOF 失效
标题翻译：超细干粉吸入剂及其制备方法
公开(公告)号：EP0611567B1
公开(公告)日：2002-08-28
申请号：EP93913510.9
申请日：1993-06-11
申请人： TEIJIN LIMITED
发明人： SAKON, Kiyoyuki , SAKAGAMI, Masahiro , MAKINO, Yuji , SUZUKI, Yoshiki , KOBAYASHI, Hideki
IPC分类号： A61K9/48 , A61K9/72 , A61K9/14 , A61K9/00
CPC分类号： A61K9/0075 , Y10S514/951 , Y10S514/958
摘要： An ultrafine powder for inhalation to be transferred mainly to the lower airway, which comprises a drug and hydroxypropylcellulose and/or hydroxypropylmethylcellulose and wherein the particles having diameters in the range of 0.5-10 mu m account for 80 wt.% or above.

6. 发明公开

EP0652022A1 DEVICE AND METHOD FOR DISPENSING POWDERED MEDICINE IN MULTIPLE DOSES 失效
标题翻译：用于以多个剂量分配粉末药物的装置和方法
公开(公告)号：EP0652022A1
公开(公告)日：1995-05-10
申请号：EP94914611.2
申请日：1994-05-12
申请人： TEIJIN LIMITED
发明人： MAKINO, Yuji , SUZUKI, Yoshiki
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M13/00 , A61M2202/064 , A61M2205/075
摘要： A device for dispensing powdered medicine in multiple doses capable of spraying powdered medicine in a fixed amount and in multiple doses having a device main body (1), a storage chamber (3) detachably mounted on said main body for storing as much powdered medicine as can handle multiple doses, and an accomodation chamber (10) having a capacity for a single dose, wherein in order to enable powdered medicine inside said accomodation chamber (10) to be dispensed by causing said accomodation chamber to communicate with said storage chamber at a loading position (3a) and causing said accomodation chamber to communicate with the external portion of said main device at a dispensing position (5a) there are provided rotor (6) movably mounted on said main body for dispensing a fixed amount of powdered medicine, a cap (20) for moving said rotor between said loading position and said dispensing position and a pump (8) for injecting air at said loading position into said storage chamber via said accommodation chamber so as to stir powdered medicine in said storage chamber, whereby a fixed amount of powdered medicine after stirred is loaded into said accommodation chamber from said storage chamber by virtue of a suction force by said pump means and/or its own gravity.
摘要翻译：一种用于分配多剂量粉末药物的装置，其能够以固定量和多剂量喷射粉末药物，具有装置主体（1），可拆卸地安装在所述主体上的储存室（3），用于储存与药物一样多的粉末药物可以处理多个剂量，以及具有单次剂量容量的容纳室（10），其中为了通过使所述容纳室与所述储存室在一个位置处连通来分配所述容纳室（10）内的粉状药物（3a）并使所述容纳室在分配位置（5a）与所述主装置的外部连通，设有可移动地安装在所述主体上用于分配固定量的粉末药物的转子（6），a （20），用于在所述装载位置和所述分配位置之间移动所述转子;以及泵（8），其用于将所述装载位置处的空气经由所述a 以便在所述储存室中搅拌粉状药物，由此借助于所述泵装置的抽吸力和/或其自身重力将搅拌后的固定量的粉状药物从所述储存室装载到所述容纳室中。

7. 发明授权

EP0328685B1 POWDERY MEDICINE APPLICATOR DEVICE 失效
标题翻译：粉末医学应用器材
公开(公告)号：EP0328685B1
公开(公告)日：1992-05-13
申请号：EP88907366.4
申请日：1988-08-17
申请人： TEIJIN LIMITED
发明人： IKURA, Hiroshi , SUZUKI, Yoshiki
IPC分类号： A61M13/00
CPC分类号： A61M15/00 , A61M15/0028 , A61M15/0033 , A61M2202/062 , A61M2202/064 , A61M2205/075
摘要： A powdery medicine applicator device comprising a medicine-holding portion (1) having a powdery medicine (7) sealed therein, which has an opening formed at the head thereof to spray or inhale the powdery medicine (7), an air-introducing means (3, 10), and, if desired, a desiccantholding portion (9). The end of the applicator may be opened either by breaking off a knob (5) formed thereon or by perforation using a cap having a projection (6). The powdery medicine (7) is separated from the air-introducing means (3, 10) by an air-permeable partition wall (2).

8. 发明授权

EP0227844B1 ANTIVIRAL DRUG 失效
标题翻译：抗病毒药物
公开(公告)号：EP0227844B1
公开(公告)日：1992-05-13
申请号：EP86904397.6
申请日：1986-07-21
申请人： TEIJIN LIMITED
发明人： KAWAGUCHI, Takeo , FUJINAGA, Shigeki , SUZUKI, Yoshiki
IPC分类号： A61K31/70
CPC分类号： C07H19/10 , Y10S514/934
摘要： Antiviral drug containing as an effective ingredient a 5-halo-2'-deoxyuridine ester derivative represented by general formula (I), wherein X represents F, Cl, Br or I, and R1 and R2, which may be the same or different, each represents a hydrogen atom, an aliphatic acyl group containing 2 or more carbon atoms, or an aromatic acyl group containing 6 or more carbon atoms, provided that R1 and R2 do not represent a hydrogen atom at the same time. This drug has a large therapeutic ratio and show a high-level antiviral effect in a low dosage with less toxicity on normal cells.

9. 发明授权

EP0667163B1 POWDER FOR NASAL ADMINISTRATION OF PEPTIDIC OR PROTEINACEOUS DRUG 失效
标题翻译：粉鼻腔给药的肽或蛋白质药物
公开(公告)号：EP0667163B1
公开(公告)日：2002-04-03
申请号：EP94921840.8
申请日：1994-07-29
申请人： TEIJIN LIMITED
发明人： DOHI, Masahiko , NISHIBE, Yoshihisa , MAKINO, Yuji , SUZUKI, Yoshiki
IPC分类号： A61K38/00 , A61K38/23 , A61K38/28 , A61K38/08 , A61K38/04 , A61K38/27 , A61K38/26 , A61K38/21 , A61K47/18 , A61K47/20 , A61K9/00 , A61K38/09 , A61K38/25
CPC分类号： B60H1/00485 , A61K9/0043 , A61K38/09 , A61K38/23 , A61K38/25 , A61K47/183

10. 发明公开

EP0667166A1 EMULSION BASED ON 1-ALPHA,24-DIHYDROXY-VITAMINE D3 失效
标题翻译：乳化助剂基础维生素1-ALPHA，24-二羟基维生素D3。
公开(公告)号：EP0667166A1
公开(公告)日：1995-08-16
申请号：EP94925612.7
申请日：1994-09-01
申请人： TEIJIN LIMITED
发明人： MAKINO, Yuji , MATUGI, Hideo , SUZUKI, Yoshiki
IPC分类号： A61K47/44
CPC分类号： A61K9/0014 , A61K31/59 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/44
摘要： A 1a,24-(OH) 2 -vitamin D 3 cream comprising: (a) a therapeutically available quantity of 1a,24-(OH) 2 -vitamin D 3 ; (b) an oily phase component comprising: (i) a solid oil component comprising 5-20 parts by weight of white vaseline and 5-15 parts by weight of a higher alcohol, and (ii) a liquid oil component comprising 3-10 parts by weight of squalane; (c) an aquous phase component; and (d) 2.5-7.5 parts by weight of two or more surfactants, wherein the ratio of the solid oil component to the liquid oil component is about 2 or above, the higher alcohol is a mixture of stearyl alcohol with cetyl alcohol with the weight ratio of stearyl alcohol to the mixture being about 0.65 to about 0.9, at least 50 % by weight of the surfactants is at least one surfactant having an HLB value of about 5 or less, and the HLB value of the surfactants as a whole is about 8 to about 18.
摘要翻译： 1α，24-（OH）2维生素D3霜剂，其包含：（a）治疗上可用量的1α，24-（OH）2维生素D3; （b）油相组分，其包含：（i）包含5-20重量份白凡士林和5-15重量份高级醇的固体油组分，和（ii）包含3-10重量份的液体油组分重量份的角鲨烷; （c）水相成分; 和（d）2.5-7.5重量份的两种或多种表面活性剂，其中固体油组分与液体油组分的比例为约2或更高，高级醇为硬脂醇与鲸蜡醇的混合物，重量硬脂醇与混合物的比例为约0.65至约0.9，至少50重量％的表面活性剂是至少一种HLB值为约5或更小的表面活性剂，并且整个表面活性剂的HLB值约为 8到大约18.

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