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1. 发明授权

EP3166629B1 LOW VISCOSITY EMD 有权
公开(公告)号：EP3166629B1
公开(公告)日：2019-04-24
申请号：EP15738878.6
申请日：2015-07-09
申请人： Straumann Holding AG
发明人： APICELLA, Alessandra , HEUNEMANN, Peggy
IPC分类号： A61K38/39 , A61P19/00

2. 发明公开

EP3166629A1 LOW VISCOSITY EMD 审中-公开
标题翻译：低粘度EMD
公开(公告)号：EP3166629A1
公开(公告)日：2017-05-17
申请号：EP15738878.6
申请日：2015-07-09
申请人： Straumann Holding AG
发明人： APICELLA, Alessandra , HEUNEMANN, Peggy
IPC分类号： A61K38/39 , A61P19/00
CPC分类号： A61L27/54 , A61K38/39 , A61K47/12 , A61L27/56 , A61L2400/12 , A61L2430/12
摘要： The present invention discloses a low viscosity composition comprising enamel matrix derivative (EMD) proteins in a suitable pharmaceutical carrier, said composition having a pH between pH 3.8-4.2, and a viscosity of less than 50 mPa s at 22° C., which, when applied to a porous bone graft material, improves and/or enhances bioactivity and osteoconduction of said bone graft material. The present invention consequently discloses a bone graft material which has been bioactivated using a low viscosity composition comprising enamel matrix derivative (EMD) proteins and which displays enhanced biocompatibility and improved bone regeneration after implantation.
摘要翻译：本发明公开了一种低粘度组合物，其包含在合适的药物载体中的釉基质衍生物（EMD）蛋白质，所述组合物具有在pH3.8-4.2之间的pH和在22℃下小于50mPa s的粘度，当施用涉及一种多孔骨移植物材料，改善和/或增强所述骨移植物材料的生物活性和骨传导性。因此，本发明公开了一种骨移植材料，其使用包含牙釉质基质衍生物（EMD）蛋白的低粘度组合物进行生物活化，并且在植入后显示增强的生物相容性和改善的骨再生。

3. 发明授权

EP3094308B1 PROCESS FOR PRODUCING EMD OF INCREASED STABILITY 有权
公开(公告)号：EP3094308B1
公开(公告)日：2018-12-26
申请号：EP15702962.0
申请日：2015-01-19
申请人： Straumann Holding AG
发明人： APICELLA, Alessandra , HEUNEMANN, Peggy
IPC分类号： A61K8/64 , A61Q11/00 , A61K8/73 , A61K38/17 , A61K6/00 , A61K6/027
CPC分类号： A61K6/0038 , A61K6/0041 , A61K6/0047 , A61K6/0067 , A61K6/027 , A61K8/36 , A61K8/44 , A61K8/64 , A61K8/733 , A61K8/735 , A61K35/32 , A61K38/17 , A61K47/183 , A61K47/61 , A61K2800/52 , A61K2800/591 , A61K2800/60 , A61K2800/805 , A61K2800/84 , A61Q11/00
摘要： The present invention relates to a process for producing a pharmaceutical, dental and/or cosmetic formulation comprising purified enamel matrix proteins and/or enamel matrix derivative (EMD) proteins, which is heat stable. In particular, the present invention is related to a process for producing stable formulations of enamel matrix proteins and/or enamel matrix derivative (EMD) proteins, wherein said proteins and/or derivatives are solved in a low pH formulation before being subjected to a heat-treatment step.

4. 发明公开

EP3094308A1 PROCESS FOR PRODUCING EMD OF INCREASED STABILITY 有权
标题翻译：用于生产EMD稳定性增加
公开(公告)号：EP3094308A1
公开(公告)日：2016-11-23
申请号：EP15702962.0
申请日：2015-01-19
申请人： Straumann Holding AG
发明人： APICELLA, Alessandra , HEUNEMANN, Peggy
IPC分类号： A61K8/64 , A61K38/00 , A61Q11/00 , A61K8/73 , A61K6/00
CPC分类号： A61K6/0038 , A61K6/0041 , A61K6/0047 , A61K6/0067 , A61K6/027 , A61K8/36 , A61K8/44 , A61K8/64 , A61K8/733 , A61K8/735 , A61K35/32 , A61K38/17 , A61K47/183 , A61K47/61 , A61K2800/52 , A61K2800/591 , A61K2800/60 , A61K2800/805 , A61K2800/84 , A61Q11/00
摘要： The present invention relates to a process for producing a pharmaceutical, dental and/or cosmetic formulation comprising purified enamel matrix proteins and/or enamel matrix derivative (EMD) proteins, which is heat stable. In particular, the present invention is related to a process for producing stable formulations of enamel matrix proteins and/or enamel matrix derivative (EMD) proteins, wherein said proteins and/or derivatives are solved in a low pH formulation before being subjected to a heat-treatment step.

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