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1. 发明授权

EP3109533B1 INNER FACE MODIFIED TUBE AND INNER FACE MODIFIED TUBE MANUFACTURING METHOD 有权
公开(公告)号：EP3109533B1
公开(公告)日：2019-05-01
申请号：EP15751557.8
申请日：2015-02-17
申请人： SofSera Corporation
发明人： KOGAI, Yasumichi , KAWABE, Karl Kazushige
IPC分类号： C23C24/04 , F16L58/04 , F16L11/12 , A61L33/00

2. 发明公开

EP3109533A1 INNER FACE MODIFIED TUBE, INNER FACE MODIFIED TUBE MANUFACTURING METHOD, AND INNER FACE MODIFIED TUBE MANUFACTURING DEVICE 审中-公开
标题翻译：里面修改，PIPE法生产有内修改，并用于生产有内变形设备的
公开(公告)号：EP3109533A1
公开(公告)日：2016-12-28
申请号：EP15751557.8
申请日：2015-02-17
申请人： SofSera Corporation
发明人： KOGAI, Yasumichi , KAWABE, Karl Kazushige
IPC分类号： F16L58/04 , F16L11/12
CPC分类号： C23C4/11 , B05B7/1481 , B05D1/12 , B05D2254/04 , B29C47/20 , B29L2023/22 , C23C24/02 , F16L58/04
摘要： An inner surface-modified tube whose inner surface has been subjected to surface-modifying treatment to provide predetermined functions sufficiently exhibits the provided functions and maintains the provided functions for a long period of time.
In an inner surface-modified tube 100 in which fine particles 120 are buried in an inner surface of a tube 110 with part of surfaces of the fine particles 120 exposed, the fine particles 120 are unevenly distributed such that more fine particles 120 are distributed in a region A2 from a center C of the tube 110 to the inner surface of the tube 110 than in a region A1 from the center C of the tube 110 to an outer surface of the tube 110 based on a thickness direction of the tube 110, a material constituting the fine particles 120 is a material which does not covalently bond or ionically bond to a material constituting the inner surface of the tube 110, an arithmetic average roughness Ra of the inner surface of the tube 110 is 1 nm or more and 100 µm or less, a particle diameter of the fine particles 120 is 10 nm or more and 100 µm or less, and an inner diameter of the tube 110 is 0.01 mm or more and 100 mm or less.
摘要翻译：的内表面改性的管其内表面已经进行过表面改性处理，以提供预定的功能充分显示出所提供的功能和维护提供了一种用于长时间的功能。在一个内表面改性的管，其微粒120 100埋在一个管110的内表面与所述细颗粒120暴露的表面的一部分，所述细颗粒120分布不均搜索做更细颗粒120分布在从管110的中心C到管110的内表面比在从管110的在管110的外表面根据管110的厚度方向的中心C到区域A1的区域A2，构成微细颗粒120的材料是不共价键合或离子键合于构成管110的内表面的材料，以算术的管110的内表面的平均粗糙度Ra的材料为1nm以上且100nm 微米或更小，微粒120的粒径为10nm以上，100微米或更小，并且在管110的内径为0.01mm以上且100mm以下。

3. 发明公开

EP3508228A1 CERAMIC PARTICLE CARRYING MEDICAL TUBE AND/OR CUFF 审中-公开
公开(公告)号：EP3508228A1
公开(公告)日：2019-07-10
申请号：EP17846624.9
申请日：2017-08-30
申请人： SofSera Corporation
发明人： KOGAI, Yasumichi , AOI, Nobuo , NOMI, Daisuke , KAWABE, Karl Kazushige
IPC分类号： A61L29/12 , A61L29/02 , C01B25/32
摘要： It is an object of the present invention to provide a ceramic particle carrying medical tube and/or cuff excellent in cell adhesive property and the like.
A medical tube and/or cuff carrying a ceramic particle in at least a part thereof, wherein: the ceramic particle has a particle diameter within a range of 10 nm to 700 nm; the ceramic particle is a calcium phosphate sintered body particle; and the ceramic particle contains no calcium carbonate.

4. 发明公开

EP2982465A1 METHOD FOR CONTROLLING PARTICLE SIZE OF SILVER PARTICLES, SILVER PARTICLES, ANTIMICROBIAL AGENT CONTAINING SILVER PARTICLES, AND USE THEREOF 审中-公开
标题翻译：用于控制银，银，银抗菌剂的颗粒尺寸及其用途
公开(公告)号：EP2982465A1
公开(公告)日：2016-02-10
申请号：EP14778905.1
申请日：2014-04-03
申请人： SofSera Corporation , Kinki University
发明人： FURUZONO, Tsutomu , KOGAI, Yasumichi , KAWABE, Karl Kazushige
IPC分类号： B22F9/24 , A01N25/12 , A01N59/16 , A01P3/00 , B22F1/00 , B22F1/02
CPC分类号： A01N55/02 , A01N59/16 , A61L31/08 , A61L2300/404 , B22F1/0062 , B22F9/24 , C07F1/005 , A01N25/00
摘要： Silver particles are prepared by aggregating silver ions in accordance with a method including steps of (a), in preparing a mixed solution by adding a thiol compound to a solution containing silver ions, adjusting an amount of the thiol compound added to the solution and (b) adding a reducing agent to the mixed solution. This allows a particle size and antibacterial activity of the silver particles to be easily adjusted.
摘要翻译：银颗粒通过在雅舞蹈与包括（a）在通过添加硫醇化合物以含银离子的溶液中，调节至达到的硫醇化合物，制备混合溶液加入到该溶液中，步骤（a方法聚集的银离子制备 b）添加还原剂到混合溶液中。这使得银粒子的粒径和抗菌活性，可以容易地调整。

5. 发明公开

EP3508462A1 CALCIUM PHOSPHATE SINTERED PARTICLES AND PRODUCTION METHOD THEREFOR 审中-公开
公开(公告)号：EP3508462A1
公开(公告)日：2019-07-10
申请号：EP17846625.6
申请日：2017-08-30
申请人： SofSera Corporation
发明人： KOGAI, Yasumichi , AOI, Nobuo , NOMI, Daisuke , KAWABE, Karl Kazushige
IPC分类号： C04B35/447 , A61K6/033 , A61L27/32 , A61M37/00 , C01B25/32
摘要： This invention has an object to provide a means for providing a calcium phosphate sintered body particle group that does not cause a phenomenon of bubble generation in any use mode thereof, and further has a smaller particle diameter.
There is provided a ceramic particle group containing spherical ceramic particles, which is characterized in that the ceramic particle has a particle diameter within a range of 10 nm to 700 nm, and is a calcium phosphate sintered body particle, and further the ceramic particle group contains no calcium carbonate.

6. 发明公开

EP2409677A1 TOOTH SURFACE REPAIRING MATERIAL 审中-公开
标题翻译：材料ZUR REPARATUR DERZAHNOBERFLÄCHE
公开(公告)号：EP2409677A1
公开(公告)日：2012-01-25
申请号：EP09841873.4
申请日：2009-03-19
申请人： Southcoast Dental Co., Ltd. , Sofsera Corporation
发明人： TAMAKI, Kozo , KAWABE, Karl Kazushige , KOGAI, Yasumichi
IPC分类号： A61K6/00
CPC分类号： A61K8/24 , A61K6/0017 , A61K6/033 , A61K2800/413 , A61Q11/00 , Y10T428/2982
摘要： Provided is a tooth surface repairing material which can produce an effect in a short time while preventing fine particles from shedding. The tooth surface repairing material contains fine calcium phosphate particles, and is characterized in that the fine calcium phosphate particles are highly crystalline sintered calcium phosphate and have an average particle diameter in the range of 20-100 nm.
摘要翻译：提供了能够在短时间内产生效果，同时防止细颗粒脱落的牙齿表面修复材料。牙齿表面修复材料含有细小的磷酸钙颗粒，其特征在于，细磷酸钙颗粒是高度结晶的烧结磷酸钙，其平均粒径在20-100nm的范围内。

7. 发明公开

EP3449953A1 DENTAL PROSTHESIS AND COMPONENT THEREOF 有权转让
公开(公告)号：EP3449953A1
公开(公告)日：2019-03-06
申请号：EP17789567.9
申请日：2017-04-25
申请人： Medical Foundation Natural Smile , Okabe Co., Ltd. , SofSera Corporation
发明人： FUJINAMI, Jun , FUJINAMI, Miwa , OKABE, Shinichi , HIEDA, Yohki , KOGAI, Yasumichi , KAWABE, Karl Kazushige
IPC分类号： A61L27/12 , A61C8/00 , A61K6/033 , A61L27/40
摘要： This invention provides a measure that makes it possible to prevent more effectively, in comparison with the prior art, the invasion of germs from the gap between a dental prosthesis and the gingiva when the dental prosthesis is used in an oral cavity as well as the infection and inflammation associated therewith.
There is a dental prosthesis or a component thereof, characterized in that: the dental prosthesis or the component thereof has hydroxyapatite fine particles on a surface of the dental prosthesis or the component thereof; the hydroxyapatite fine particles are sintered bodies; and the hydroxyapatite fine particles have a mean particle size of 10 to 1,000 nm.

8. 发明公开

EP2647383A1 BREAST ENHANCEMENT ACCELERATOR 审中-公开
标题翻译： BRUSTERWEITERUNGSBESCHLEUNIGER
公开(公告)号：EP2647383A1
公开(公告)日：2013-10-09
申请号：EP11844849.7
申请日：2011-12-01
申请人： SofSera Corporation
发明人： KAWABE, Karl Kazushige , KOGAI, Yasumichi , ISHIKAWA, Yumiko , KOMAMI, Aya
IPC分类号： A61K33/42 , A61K9/16 , A61P17/00 , A61P43/00
CPC分类号： A61K33/42 , A61K8/0241 , A61K8/24 , A61K2800/412 , A61Q19/00
摘要： A novel breast enlargement promoter is provided.
The present inventor perfected the present invention having discovered a novel attribute in which collagen production is promoted when fine particles of calcium phosphate come into contact with fibroblasts, and having further discovered a novel attribute in which breast enlargement effect is obtained by application of such fine particles to the breasts. More specifically, the present invention is a breast enlargement promoter characterized by containing fine particles of calcium phosphate.
摘要翻译：提供了一种新的乳房增大促进剂。本发明人完善了本发明，发现了当磷酸钙的细颗粒与成纤维细胞接触时促进胶原蛋白生成的新颖特征，并且进一步发现了通过施用这种细颗粒获得乳房扩大效果的新颖特征到乳房更具体地，本发明是一种特征在于含有磷酸钙细颗粒的乳房增大促进剂。

9. 发明公开

EP3480166A1 CALCIUM PHOSPHATE SINTERED BODY PARTICLES AND METHOD FOR PRODUCING SAME 审中-公开
公开(公告)号：EP3480166A1
公开(公告)日：2019-05-08
申请号：EP16907363.2
申请日：2016-08-30
申请人： Sofsera Corporation
发明人： KOGAI, Yasumichi , AOI, Nobuo , NOMI, Daisuke , KAWABE, Karl Kazushige
IPC分类号： C01B25/32
摘要： This invention has an object to provide a means for providing a calcium phosphate sintered body particle group that does not cause a phenomenon of bubble generation in any use mode thereof, and further has a smaller particle diameter.
There is provided a ceramic particle group containing spherical ceramic particles, which is characterized in that the ceramic particle has a particle diameter within a range of 10 nm to 700 nm, and is a calcium phosphate sintered body particle, and further the ceramic particle group contains no calcium carbonate.

10. 发明授权

EP2998358B1 BIODEGRADABLE MATERIAL 有权
公开(公告)号：EP2998358B1
公开(公告)日：2019-02-13
申请号：EP13884717.3
申请日：2013-05-16
申请人： SofSera Corporation
发明人： KOGAI, Yasumichi , KAWABE, Karl Kazushige , YAMADA, Kenji
IPC分类号： A61L31/12 , A61L31/14 , C08K3/32 , C08L101/16

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