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1. 发明授权

EP2997355B1 DEGRADABLE CATIONIC SURFACTANTS AND USE THEREOF IN ENHANCING CHEMILUMINESCENCE 有权
公开(公告)号：EP2997355B1
公开(公告)日：2019-11-20
申请号：EP14798016.3
申请日：2014-05-13
申请人： Siemens Healthcare Diagnostics Inc.
发明人： NATRAJAN, Anand , WEN, David
IPC分类号： G01N21/76

2. 发明授权

EP2872489B1 SYNTHESIS OF ACRIDINIUM COMPOUNDS BY N-ALKYLATION OF ACRIDANS 有权
标题翻译：吖啶的合成吖啶酮的N-烷基化
公开(公告)号：EP2872489B1
公开(公告)日：2016-12-21
申请号：EP13817300.0
申请日：2013-07-10
申请人： Siemens Healthcare Diagnostics Inc.
发明人： MATRAJAN, Anand , WEN, David
IPC分类号： C07D219/04
CPC分类号： C07D219/04

4. 发明公开

EP3019575A1 HYDROPHILIC HIGH QUANTUM YIELD ACRIDINIUM ESTERS WITH IMPROVED STABILITY AND FAST LIGHT EMISSION 有权
标题翻译：具有改进的稳定性和快速发光的亲脂性高量子产率的吖啶酯
公开(公告)号：EP3019575A1
公开(公告)日：2016-05-18
申请号：EP14823526.0
申请日：2014-07-04
申请人： Siemens Healthcare Diagnostics Inc.
发明人： NATRAJAN, Anand , SHARPE, David , JIANG, Qingping , WEN, David
IPC分类号： C09K11/07 , G01N21/76 , C07D219/04 , G01N33/58
CPC分类号： C07D219/06 , C09K11/07 , F21K2/06 , G01N21/76 , G01N33/582
摘要： Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.
摘要翻译：公开了亲水性，高量子产率，具有增加的光输出，改善的稳定性，快速的光发射和减少的非特异性结合的化学发光吖啶鎓化合物。化学发光吖啶鎓酯在吖啶鎓核的C2和/或C7位具有亲水的，支化的给电子官能团。

5. 发明公开

EP2997355A2 DEGRADABLE CATIONIC SURFACTANTS AND USE THEREOF IN ENHANCING CHEMILUMINESCENCE 有权
标题翻译：可降解阳离子表面活性剂及其在增强化学发光中的用途
公开(公告)号：EP2997355A2
公开(公告)日：2016-03-23
申请号：EP14798016.3
申请日：2014-05-13
申请人： Siemens Healthcare Diagnostics Inc.
发明人： NATRAJAN, Anand , WEN, David
IPC分类号： G01N21/76
摘要： The present invention relates to methods of enhancing chemiluminescence from a chemiluminescent label comprising contacting a chemiluminescent label with an acid in the presence of a degradable cationic surfactant and hydrogen peroxide followed by the addition of a base. Related kits containing such degradable cationic surfactant are also provided. The degradable cationic surfactant can compress light emission time of the chemiluminescent label to an extent that is comparable to or shorter than conventional surfactants. The degradable cationic surfactant can also increase chemiluminescence of the chemiluminescent label, providing increased light emission output that is comparable to conventional surfactants.
摘要翻译：本发明涉及增强来自化学发光标记的化学发光的方法，其包括使化学发光标记与酸在可降解的阳离子表面活性剂和过氧化氢存在下接触，然后加入碱。还提供了包含这种可降解阳离子表面活性剂的相关试剂盒。可降解的阳离子表面活性剂可将化学发光标签的发光时间压缩到与常规表面活性剂相当或更短的程度。可降解的阳离子表面活性剂还可以增加化学发光标签的化学发光，提供与常规表面活性剂相当的增加的光发射输出。

6. 发明公开

EP2872489A1 SYNTHESIS OF ACRIDINIUM COMPOUNDS BY N-ALKYLATION OF ACRIDANS 有权
标题翻译：通过ACRIDANS的N-烷基化合成吖啶化合物
公开(公告)号：EP2872489A1
公开(公告)日：2015-05-20
申请号：EP13817300.0
申请日：2013-07-10
申请人： Siemens Healthcare Diagnostics Inc.
发明人： MATRAJAN, Anand , WEN, David
IPC分类号： C07D219/04
CPC分类号： C07D219/04
摘要： A method is provided for N-alkylation of acridine compounds by reduction of acridines to corresponding acridans to improve the reactivity of the acridine nitrogen, and subsequent N-alkylation of the acridans in ionic liquid solvents to provide the corresponding acridinium compounds in high yield. This inventive process improves chemical conversion, and does not require the use of highly toxic alkylating agents, such as 1,3 -propane sultone.
摘要翻译：本发明提供了一种通过将吖啶还原成相应的吖啶使吖啶化合物N-烷基化以改善吖啶氮的反应性并随后在离子液体溶剂中对吖啶酮进行N-烷基化以高收率地提供相应的吖啶鎓化合物的方法。本发明的方法改进了化学转化，并且不需要使用高毒性烷基化剂，例如1,3-丙烷磺内酯。

7. 发明授权

EP2215063B1 FACILE N-ALKYLATION OF ACRIDINE COMPOUNDS IN IONIC LIQUIDS 有权
标题翻译：吖EASY N-烷基化在离子液体
公开(公告)号：EP2215063B1
公开(公告)日：2013-10-30
申请号：EP08851092.0
申请日：2008-11-18
申请人： Siemens Healthcare Diagnostics Inc.
发明人： NATRAJAN, Anand , WEN, David
IPC分类号： C07D219/04
CPC分类号： C07D219/04

8. 发明公开

EP2571487A2 ZWITTERIONIC REAGENTS 有权
标题翻译：两性离子试剂
公开(公告)号：EP2571487A2
公开(公告)日：2013-03-27
申请号：EP11784156.9
申请日：2011-05-18
申请人： Siemens Healthcare Diagnostics Inc.
发明人： NATRAJAN, Anand , SHARPE, David , WEN, David , JIANG, Qingping
IPC分类号： A61K9/00
CPC分类号： C07D207/452 , A61K47/48061 , A61K47/48284 , A61K47/545 , A61K47/643 , C07C309/14 , C07D207/46 , C07D403/12 , C07D493/10 , C07D495/04 , C07F9/091 , C07K1/13 , C07K7/06 , C07K14/765 , C09B11/24 , G01N33/5306
摘要： Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.

9. 发明公开

EP2215063A1 FACILE N-ALKYLATION OF ACRIDINE COMPOUNDS IN IONIC LIQUIDS 有权
标题翻译：吖EASY N-烷基化在离子液体
公开(公告)号：EP2215063A1
公开(公告)日：2010-08-11
申请号：EP08851092.0
申请日：2008-11-18
申请人： Siemens Healthcare Diagnostics Inc.
发明人： NATRAJAN, Anand , WEN, David
IPC分类号： C07D219/00
CPC分类号： C07D219/04
摘要： A method is provided for N-alkylation of acridine compounds, typically with a 1,3- propane sultone alkylating reagent, in ionic liquid solvents to provide the corresponding acridinium compounds in high yeild.

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