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    • 1. 发明公开
    • GENE, MICROORGANISM, CONVERSION METHOD, AND PRODUCTION METHOD
    • GEN,MIKORORGANISMUS,UMWANDLUNGSVERFAHREN UND HERSTELLUNGSVERFAHREN
    • EP2899273A1
    • 2015-07-29
    • EP13838813.7
    • 2013-09-19
    • Showa Denko K.K.
    • AOKI, HirobumiKOKIDO, YuzuruYONEDA, Tadashi
    • C12N15/09C12N1/19C12N1/21C12N9/02C12N9/88C12P7/18
    • C12Y402/01017C12N9/88C12P7/16C12P7/18Y02E50/10
    • A gene described in any of undermentioned (a) - (c), wherein the gene in combination with a gene that codes enoyl-CoA hydratase is able to provide a microbe or a culture of the microbe with an ability to convert 3-hydroxybutyryl-CoA into 4-hydroxybutyryl-CoA or 4-hydroxybutyryl-CoA into 3-hydroxybutyryl-CoA.
      (a) a gene that has a base sequence of sequence number 1
      (b) a gene that has a base sequence such that one or more bases are deleted, substituted, or added in a base sequence of sequence number 1, wherein the gene has a base sequence with an identity greater than or equal to 90% with respect to the base sequence of sequence number 1
      (c) a gene that hybridizes with a gene that has a base sequence complimentary with a gene that has a base sequence described in sequence number 1 on a stringent condition
    • 下述(a) - (c)中任一项所述的基因,其中与编码烯酰辅酶A水合酶的基因组合的基因能够提供微生物或微生物培养物,其具有将3-羟基丁酰基 - 将CoA转化成4-羟基丁酰辅酶A或4-羟基丁酰辅酶A至3-羟基丁酰辅酶A。 (a)具有序列号1(b)的碱基序列的基因,其具有碱基序列,使得一个或多个碱基在序列号1的碱基序列中被缺失,取代或加入,其中所述基因具有 相对于序列号1(c)的碱基序列具有大于或等于90%的同一性的碱基序列(c)与具有与序列中所述的碱基序列的基因互补的碱基序列的基因杂交的基因 1号严格条件