专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP4028130A1 BENZYL AMINE-CONTAINING 5,6-HETEROAROMATIC COMPOUNDS USEFUL AGAINST MYCOBACTERIAL INFECTION 审中-实审
公开(公告)号：EP4028130A1
公开(公告)日：2022-07-20
申请号：EP20863977.3
申请日：2020-09-10
申请人： Shionogi & Co., Ltd , Hsiri Therapeutics, Inc.
发明人： FUJITANI, Manabu , IWAKI, Tsutomu , NAKAMURA, Rina , MILLER, Marvin J. , MORASKI, Garrett C.
IPC分类号： A61P31/04 , C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/498 , A61K31/499 , A61K31/4995

2. 发明公开

EP2952503A1 HIV REPLICATION INHIBITOR 审中-公开
标题翻译： HIV复制抑制剂
公开(公告)号：EP2952503A1
公开(公告)日：2015-12-09
申请号：EP14746481.2
申请日：2014-01-30
申请人： Shionogi & Co., Ltd.
发明人： TOMITA, Kenji , TAODA, Yoshiyuki , IWAKI, Tsutomu , KAWASUJI, Takashi , AKIYAMA, Toshiyuki , SUGIYAMA, Shuichi , TAMURA, Yoshinori , IWATSU, Masafumi
IPC分类号： C07D209/58 , A61K31/395 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/473 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , A61K31/554 , A61P31/18 , A61P43/00 , C07D221/12 , C07D223/18 , C07D225/08 , C07D279/02 , C07D281/02
CPC分类号： C07D498/06 , C07D209/80 , C07D221/12 , C07D221/18 , C07D223/18 , C07D225/08 , C07D237/36 , C07D241/44 , C07D243/04 , C07D243/12 , C07D243/38 , C07D265/34 , C07D267/20 , C07D273/01 , C07D275/06 , C07D279/02 , C07D281/02 , C07D285/36 , C07D291/08 , C07D311/80 , C07D335/10 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/06 , C07D471/10 , C07D487/04 , C07D491/056 , C07D491/06 , C07D495/04 , C07D495/14 , C07D498/04 , C07D513/04 , C07D513/06
摘要： The present invention provides a novel compound having an antiviral activity, in particular, an HIV replication inhibiting activity, as well as a pharmaceutical composition, in particular, an anti-HIV agent.

wherein ring A is substituted or unsubstituted carbocycle or substituted or unsubstituted heterocycle; R 1 is substituted or unsubstituted alkyl etc.; R 2 is substituted or unsubstituted alkyloxy etc.; n is 1 or 2; R 3 is substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl; R 4 is a hydrogen atom etc.; R 6 is substituted or unsubstituted alkyl etc.
摘要翻译：本发明提供具有抗病毒活性，特别是HIV复制抑制活性的新型化合物，以及药物组合物，特别是抗HIV剂。其中环A是取代或未取代的碳环或取代或未取代的杂环; R1是取代或未取代的烷基等; R2是取代或未取代的烷氧基等; n是1或2; R3是取代或未取代的碳环基或取代或未取代的杂环基; R4是氢原子等; R6是取代或未取代的烷基等

3. 发明授权

EP2772480B1 HIV REPLICATION INHIBITOR 有权
公开(公告)号：EP2772480B1
公开(公告)日：2018-05-23
申请号：EP12844636.6
申请日：2012-10-25
申请人： Shionogi & Co., Ltd.
发明人： IWAKI, Tsutomu , TOMITA, Kenji
IPC分类号： C07C205/56 , A61K31/192 , A61K31/27 , A61P31/18 , C07C229/40 , C07C233/33 , C07C233/63 , C07C233/81 , C07C255/57 , C07C271/22 , C07C275/42 , C07C311/14 , C07C311/19 , C07D319/18 , C07D319/20 , C07D417/12
CPC分类号： C07D311/58 , C07C205/56 , C07C229/42 , C07C233/54 , C07C233/63 , C07C233/81 , C07C255/59 , C07C271/28 , C07C275/42 , C07C311/10 , C07C311/14 , C07C311/21 , C07C317/48 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D215/14 , C07D215/227 , C07D235/26 , C07D265/36 , C07D277/82 , C07D307/79 , C07D307/83 , C07D307/88 , C07D307/89 , C07D311/74 , C07D317/60 , C07D319/12 , C07D319/16 , C07D319/18 , C07D319/20 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/12 , C07D491/06
摘要： The present invention provides a novel compound having an antiviral action, in particular, an HIV replication inhibiting action, as well as a pharmaceutical composition, in particular, an anti-HIV agent. wherein, a broken line means the presence or absence of a bond; R 1 is substituted or unsubstituted alkyl etc., R 2 is substituted or unsubstituted alkyloxy etc.; n is 1 or 2; R 3 is a substituted or unsubstituted aromatic carbocyclic group; R 4 is a hydrogen atom etc.; R 5 is a substituted or unsubstituted aromatic carbocyclic group etc.; Y is a single bond etc.; R 6 is substituted or unsubstituted alkyl; R 7 is -Z-R 71 etc.; Z is - NR 72 -CO- etc.; R 71 is substituted or unsubstituted alkyl etc.; R 72 is a hydrogen atom etc.

4. 发明公开

EP2772480A1 HIV REPLICATION INHIBITOR 有权
标题翻译： HIV复制抑制剂
公开(公告)号：EP2772480A1
公开(公告)日：2014-09-03
申请号：EP12844636.6
申请日：2012-10-25
申请人： Shionogi & Co., Ltd.
发明人： IWAKI, Tsutomu , TOMITA, Kenji
IPC分类号： C07C205/56 , A61K31/192 , A61K31/27 , A61P31/18 , C07C229/40 , C07C233/33 , C07C233/63 , C07C233/81 , C07C255/57 , C07C271/22 , C07C275/42 , C07C311/14 , C07C311/19
CPC分类号： C07D311/58 , C07C205/56 , C07C229/42 , C07C233/54 , C07C233/63 , C07C233/81 , C07C255/59 , C07C271/28 , C07C275/42 , C07C311/10 , C07C311/14 , C07C311/21 , C07C317/48 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D215/14 , C07D215/227 , C07D235/26 , C07D265/36 , C07D277/82 , C07D307/79 , C07D307/83 , C07D307/88 , C07D307/89 , C07D311/74 , C07D317/60 , C07D319/12 , C07D319/16 , C07D319/18 , C07D319/20 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/12 , C07D491/06
摘要： The present invention provides a novel compound having an antiviral action, in particular, an HIV replication inhibiting action, as well as a pharmaceutical composition, in particular, an anti-HIV agent.

wherein, a broken line means the presence or absence of a bond; R 1 is substituted or unsubstituted alkyl etc., R 2 is substituted or unsubstituted alkyloxy etc.; n is 1 or 2; R 3 is a substituted or unsubstituted aromatic carbocyclic group; R 4 is a hydrogen atom etc.; R 5 is a substituted or unsubstituted aromatic carbocyclic group etc.; Y is a single bond etc.; R 6 is substituted or unsubstituted alkyl; R 7 is -Z-R 71 etc.; Z is - NR 72 -CO- etc.; R 71 is substituted or unsubstituted alkyl etc.; R 72 is a hydrogen atom etc.
摘要翻译：本发明提供具有抗病毒作用，特别是HIV复制抑制作用的新型化合物，以及药物组合物，特别是抗HIV剂。其中，虚线表示键的存在或不存在; R1为取代或未取代的烷基等，R2为取代或未取代的烷氧基等。 n是1或2; R3是取代或未取代的芳族碳环基团; R4是氢原子等; R5是取代或未取代的芳族碳环基团等; Y是单键等; R6是取代或未取代的烷基; R7是-Z-R71等; Z是-NR 72 -CO-等; R71是取代或未取代的烷基等; R72是氢原子等

5. 发明公开

EP2030982A1 GLYCOPEPTIDE ANTIBIOTIC DERIVATIVE 审中-公开
标题翻译：抗生素治疗糖尿病
公开(公告)号：EP2030982A1
公开(公告)日：2009-03-04
申请号：EP07744107.9
申请日：2007-05-25
申请人： SHIONOGI & CO., LTD.
发明人： NISHITANI, Yasuhiro , YOSHIDA, Osamu , IWAKI, Tsutomu , KATO, Issei
IPC分类号： C07K9/00 , A61K38/00 , A61P31/04 , C07K7/06 , C07K14/36
CPC分类号： C07K9/008 , A61K38/00 , A61K38/04
摘要： The present invention provides a novel glycopeptide antibiotic derivative.
These derivatives are represented by the formula (I)

or a pharmaceutically acceptable salt or solvate thereof,
wherein
R A is

-X 1 -Ar 1 -X 2 -Y-X 3 -Ar 2

wherein
X 1 , X 2 and X 3 are single bond; heteroatom-containing group selected from the group consisting of -N=, =N-, - NR 1 - (R 1 is hydrogen or lower alkyl), -O-, -S-, -SO- and -SO 2 -, or a linkage thereof; or alkylene or alkenylene optionally substituted and optionally interrupted by one or more of said heteroatom-containing group;
Y is -NR 2 CO-, -CONR 2 - (R 2 is hydrogen or lower alkyl), or a group of the formula (II) wherein R 3 is alkylene;
Ar 1 and Ar 2 are a carbocycle or a heterocycle which is optionally substituted and may have an unsaturated bond;
R B is

-NHNR X R Y or -NR Z OR W

wherein
R X is hydrogen or lower alkyl;
R Y is hydrogen, optionally substituted lower alkyl, C(=NH)NH 2 , CSNH 2 , COCONH 2 , CN, optionally substituted heterocyclic group, and optionally substituted carbamoyl;
R Z is hydrogen or lower alkyl;
R W is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted heterocyclic group, optionally substituted heterocyclic carbonyl or optionally substituted carbamoyl;
R C is hydrogen or optionally substituted alkyl, wherein said alkyl may be interrupted by a heteroatom-containing group selected from N=, =N-, -NR 1 - (R 1 is hydrogen or lower alkyl), -O-, -S-, -SO- and -SO 2 -; and
R is optionally substituted alkyl.
摘要翻译：本发明提供了一种新型糖肽抗生素衍生物。这些衍生物由式（I）表示或其药学上可接受的盐或溶剂化物，其中RA为€ƒ€ƒ€ƒ€ƒ€ƒ-X 1 -Ar 1 -X 2 -YX 3 -Ar 2其中X 1，X 2和X 3为单键; 选自-N =，= N - ， - NR 1 - （R 1为氢或低级烷基）， - O - ， - S - ， - SO-和-SO 2 - 的含杂原子的基团，或其联系; 或任选被取代并任选被一个或多个所述含杂原子基团中断的亚烷基或亚烯基; Y是-NR 2 CO-，-CONR 2 - （R 2是氢或低级烷基）或式（II）的基团，其中R 3是亚烷基; Ar 1和Ar 2是任选被取代并可具有不饱和键的碳环或杂环; R B是€ƒ€ƒ€ƒ€ƒ€ƒ-NHNR X R Y或-NR Z OR W其中R X是氢或低级烷基; R Y是氢，任选取代的低级烷基，C（= NH）NH 2，CSNH 2，COCONH 2，CN，任选取代的杂环基和任选取代的氨基甲酰基; R Z是氢或低级烷基; R W是氢，任选取代的低级烷基，任选取代的低级烯基，任选取代的杂环基，任选取代的杂环羰基或任选取代的氨基甲酰基; RC是氢或任选取代的烷基，其中所述烷基可以被选自N =，N-，-NR 1 - （R 1是氢或低级烷基），-O-，-S- ，-SO-和-SO 2 - ; 和R是任选取代的烷基。

6. 发明授权

EP2772480B2 HIV REPLICATION INHIBITOR 有权
公开(公告)号：EP2772480B2
公开(公告)日：2020-12-09
申请号：EP12844636.6
申请日：2012-10-25
申请人： Shionogi & Co., Ltd.
发明人： IWAKI, Tsutomu , TOMITA, Kenji
IPC分类号： C07C205/56 , A61K31/192 , A61K31/27 , A61P31/18 , C07C229/40 , C07C233/33 , C07C233/63 , C07C233/81 , C07C255/57 , C07C271/22 , C07C275/42 , C07C311/14 , C07C311/19 , C07D319/18 , C07D319/20 , C07D417/12

7. 发明公开

EP2208729A1 OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING 审中-公开
标题翻译： OXAZOLIDINONDERIVAT MIT 7-GLIEDRIGEM HETERORING
公开(公告)号：EP2208729A1
公开(公告)日：2010-07-21
申请号：EP08836063.1
申请日：2008-10-01
申请人： Research Foundation Itsuu Laboratory , Shionogi&Co., Ltd.
发明人： SUZUKI, Hideyuki , UTSUNOMIYA, Iwao , SHUDO, Koichi , IWAKI, Tsutomu , YASUKATA, Tatsuro
IPC分类号： C07D413/10 , A61K31/55 , A61K31/553 , A61P31/04 , C07D413/14 , C07D471/14 , C07D487/04
CPC分类号： C07D413/14 , C07D271/02 , C07D413/10 , C07D471/14 , C07D487/04 , Y02P20/55
摘要： The present invention provides a novel oxazolidinone derivative of the formula (I):

wherein
Ring A is

(A-1) a 7-membered monocyclic heterocycle containing three N atoms;
(A-2) a 7-membered monocyclic heterocycle containing two N atoms and one O atom; or
(A-3) a 7-membered monocyclic heterocycle containing two N atoms and one S atom, SO or SO 2 ,
wherein said monocyclic heterocycle is optionally substituted, optionally unsaturated and optionally fused with another ring;
X 1 is a single bond, or a heteroatom-containing group selected from the group consisting of -O-, -S-, -NR 2 -, -CO-, -CS-, -CONR 3 -, -NR 4 CO-, -SO 2 NR 5 -, and -NR 6 SO 2 -, wherein R 2 , R 3 , R 4 , R 5 and R 6 are independently hydrogen or lower alkyl, or lower alkylene or lower alkenylene each optionally interrupted by said heteroatom-containing group;
Ring B is optionally substituted carbocycle or optionally substituted heterocycle; and
R 1 is hydrogen, or an organic residue which is able to bind to the 5-position of the oxazolidinone ring in oxazolidinone antimicrobial agents,
pharmaceutically acceptable salts and solvates thereof which are useful as an antibacterial agent.
摘要翻译：本发明提供了式（I）的新型恶唑烷酮衍生物：其中环A为（A-1）含有三个N原子的7-元单环杂环; （A-2）含有两个N原子和一个O原子的7-元单环杂环; 或（A-3）含有两个N原子和一个S原子，SO或SO 2的7-元单环杂环，其中所述单环杂环任选被取代，任选地不饱和并任选地与另一个环稠合; X 1是单键或选自-O - ， - S - ， - NR 2 - ， - CO - ， - CS - ， - CONR 3 - ， - NR 4 CO- ，-SO 2 NR 5 - 和-NR 6 SO 2 - ，其中R 2，R 3，R 4，R 5和R 6独立地为氢或低级烷基，或低级亚烷基或低级亚烯基，各自任意地被所述杂原子包含组; 环B是任选取代的碳环或任选取代的杂环; R 1为氢的化合物，或可用作抗菌剂的恶唑烷酮抗微生物剂，其药学上可接受的盐和溶剂合物中能够结合恶唑烷酮环的5-位的有机残基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式