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1. 发明公开

EP4026536A1 CATIONIC NANODRUG, PREPARATION METHOD THEREFOR, AND DRUG-LOADED IMPLANTABLE MEDICAL DEVICE 审中-实审
公开(公告)号：EP4026536A1
公开(公告)日：2022-07-13
申请号：EP20860383.7
申请日：2020-09-01
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： LI, Meng , WANG, Yufu , LI, Junfei
IPC分类号： A61K9/00 , A61L31/10 , A61L31/16 , A61L31/08 , A61L31/14 , A61M31/00
摘要： Disclosed are a cationic nanodrug, a preparation method therefor, and a drug-loaded implantable medical device, wherein the cationic nanodrug comprises a vector and a drug loaded on the vector, and the vector comprises one or more of a cationic amphipathic compound and a cationic modifier; the cationic amphipathic compound is a cationic amphipathic compound containing amino and/or acyl; and the cationic modifier is a cationic modifier containing amino and/or acyl. The cationic nanodrug greatly improves the uptake of a drug by cells and has a good slow-release effect.

2. 发明公开

EP3730164A1 DRUG-LOADED IMPLANTED MEDICAL DEVICE AND PREPARATION METHOD THEREFOR 审中-公开
公开(公告)号：EP3730164A1
公开(公告)日：2020-10-28
申请号：EP18893291.7
申请日：2018-08-17
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： CHEN, Lu , HU, Yan , LI, Junfei , WANG, Xuan , HU, Qifeng
IPC分类号： A61L31/14 , A61L31/16
摘要： A drug-loaded implanted medical device and a preparation method therefor. The drug-loaded implanted medical device comprises a device body and grooves (2) distributed on the surface of the device body, and at least one of the grooves (2) is loaded with a solid drug (11); the solid drug (11) is a crystal or has a form in which a crystal coexists with an amorphous body. The preparation method is implemented by loading the solid drug (11) into at least one of the grooves (2) by means of solution crystallization.

3. 发明公开

EP4309687A1 MEDICAL DEVICE 审中-实审
公开(公告)号：EP4309687A1
公开(公告)日：2024-01-24
申请号：EP22784093.1
申请日：2022-04-07
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： WANG, Jiaojiao , SUN, Can , ZHOU, Qi , YAO, Yao , LI, Junfei
IPC分类号： A61L31/02 , A61L31/08 , A61L31/12 , C23C14/00 , C23C28/00 , C25D3/04 , C25D3/50 , C25D3/54 , C25D3/56 , C25D9/04
摘要： The present disclosure relates to a medical device. The medical device comprises a matrix and a first coating coated on the matrix. The matrix contains a metal element X having a content of ≥5wt%; the first coating is at least one of an elemental metal layer of the metal element X, an alloy layer of the metal element X, and a metal-ceramic layer of the metal element X; and the first coating does not contain nickel and cobalt. The medical device has good use safety, reliability, and biocompatibility, so that a product can meet a use requirement of large plastic deformation, and has good reliability during use. The medical device can particularly meet requirements of product with large plastic deformation during use, such as medical implant devices.

4. 发明公开

EP4180552A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MANUFACTURING SAME, AND METHOD FOR MANUFACTURING STENT 审中-实审
公开(公告)号：EP4180552A1
公开(公告)日：2023-05-17
申请号：EP21847092.0
申请日：2021-06-22
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： WANG, Jiaojiao , ZHOU, Xinyu , YAO, Yao , ZHOU, Qi , LI, Junfei
IPC分类号： C23C30/00 , A61F2/89
摘要： Provided are an implantable medical device (100) and a method for manufacturing the same, and a method for manufacturing a stent. The implantable medical device (100) comprises a metal base (110) and a cladding layer (120). The cladding layer (120) is a nickel-free and cobalt-free metal layer which is deposited on the metal base (110) by means of a metal bond. The arrangement of the cladding layer (120) of the implantable medical device (100) on the metal substrate (110) can prevent carcinogenic elements in the metal base (110) such as nickel and cobalt from dissolution. Moreover, the cladding layer (120) is a nickel-free and cobalt-free metal layer, such that the implantable medical device (100) is free from problems of nickel or cobalt dissolution, thereby improving the biological safety of the implantable medical device (100).

5. 发明公开

EP4056207A1 DRUG-LOADED IMPLANTED MEDICAL DEVICE AND PREPARATION METHOD THEREFOR 审中-实审
公开(公告)号：EP4056207A1
公开(公告)日：2022-09-14
申请号：EP20894424.9
申请日：2020-11-25
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： LI, Meng , LI, Junfei , WANG, Yufu
IPC分类号： A61L31/00 , A61L31/04 , A61L31/16 , A61M37/00
摘要： A drug-loaded implanted medical device (10) and a preparation method therefor. The drug-loaded implanted medical device (10) comprises a device body (100), a hydrophilic coating layer (200) loaded on the device body (100), and crystalline drug particles (300) loaded on the hydrophilic coating layer (200). The hydrophilic coating layer (200) comprises a graft polymer containing a photo-crosslinked group. The medical device (10) uses a hydrophilic coating layer (200) as a carrier, effectively avoiding the risk of embolism, encouraging the crystalline drug particles to fall off, and helping to achieve a target tissue concentration. The invention can also effectively increase the anchoring effect between the carrier and the device, and reduce toxicity.

6. 发明公开

EP3744264A1 OCCLUDER, AND MEDICAL DEVICE 有权转让
公开(公告)号：EP3744264A1
公开(公告)日：2020-12-02
申请号：EP19761116.3
申请日：2019-02-27
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： ZHOU, Yi , ZHOU, Ting , YAO, Yao , LI, Junfei
IPC分类号： A61B17/12
摘要： The present invention provides an occluder and a medical device. The occluder comprises: an occluding unit having a remote end and a near end; and a position-limiting unit connected to the remote end and the near end for limiting an extension distance therebetween. The position-limiting unit is connected to the remote end and the near end of the occluding unit to limit the extension distance therebetween, such that the occluder is in an entirely or partially collapsed state when in a sheath, thereby preventing the issue of the occluder occupying an excessive length of the sheath. The occluder is not fully extended while in the sheath, but instead remains in an entirely or partially collapsed state, so as to better maintain the dimensions of the occluder after the same is released from the sheath.

7. 发明公开

EP3698729A1 LEFT ATRIAL APPENDAGE OCCLUSION DEVICE AND LEFT ATRIAL APPENDAGE OCCLUSION SYSTEM 审中-公开
公开(公告)号：EP3698729A1
公开(公告)日：2020-08-26
申请号：EP17928917.8
申请日：2017-10-17
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： WANG, Zhen , YAO, Yao , ZHOU, Yi , LI, Junfei
IPC分类号： A61B17/12
摘要： Disclosed are a left atrial appendage occlusion device (100, 300) and a left atrial appendage occlusion system. A connecting member (140, 240, 340, 440) comprises a first unit (140a, 240a, 440a) and a second unit (140b, 240b, 440b), wherein the first unit (140a, 240a, 440a) is connected to a first frame (110, 310, 410), the second unit (140b, 240b, 440b) is connected to a second frame (120, 320, 420), and the first unit (140a, 240a, 440a) is rotatably connected to the second unit (140b, 240b, 440b). Alternatively, the connecting member (140, 240, 340, 440) comprises the first unit (140a, 240a, 440a), the second unit (140b, 240b, 440b) and a third unit (140c, 240c), wherein the first unit (140a, 240a, 440a) is connected to the first frame (110, 310, 410), the second unit (140b, 240b, 440b) is connected to the second frame (120, 320, 420), the first unit (140a, 240a, 440a) is rotatably connected to the third unit (140c, 240c), and the second unit (140b, 240b, 440b) is rotatably connected to the third unit (140c, 240c). Thereby, with regard to left atrial appendages having lumens of different shapes, the relative positions of the first frame (110, 310, 410) and the second frame (120, 320, 420) can be changed by means of the connecting member (140, 240, 340, 440), i.e., the shape of the left atrial appendage occlusion device (100, 300) is adjusted so as to be capable of being adapted to left atrial appendages having lumens of different shapes.

8. 发明公开

EP4295891A1 DRUG-LOADED MEDICAL INSTRUMENT AND PREPARATION METHOD THEREFOR 审中-实审
公开(公告)号：EP4295891A1
公开(公告)日：2023-12-27
申请号：EP22755493.8
申请日：2022-01-24
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： LI, Meng , DU, Qiran , LI, Junfei
IPC分类号： A61M25/10 , A61M25/00 , A61L29/16 , A61L29/00
摘要： The present application relates to the field of pharmaceutical technology, in particular, to a drug-loaded medical device, including a medical device body and at least one drug coating, the drug coating is attached to at least one side of a surface of the medical device body. The main component of the drug coating includes a macrolide drug. The drug coating includes elongated prismatic crystals each with at least three lateral edges, and/or the drug coating includes crystal clusters of the elongated prismatic crystals each with at least three lateral edges. An aspect ratio of each elongated prismatic crystal is in a range from 1: 1 to 40: 1. The drug-loaded medical device can effectively improve the drug transfer to the blood vessel wall and prolong the concentration of drug in tissue.

9. 发明公开

EP4070825A1 DRUG-LOADED IMPLANTABLE MEDICAL INSTRUMENT AND MANUFACTURING METHOD THEREFOR 审中-实审
公开(公告)号：EP4070825A1
公开(公告)日：2022-10-12
申请号：EP20904609.3
申请日：2020-11-25
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： LI, Meng , LI, Junfei , WANG, Yufu
IPC分类号： A61L31/10 , A61L31/16
摘要： Provided are a drug-loaded implantable medical instrument and a manufacturing method therefor. The drug-loaded implantable medical instrument (10) comprises an instrument body (100), a microporous membrane (200) fixed on the instrument body (100), and a nanocrystal medicament (300) loaded on the microporous membrane (200).

10. 发明公开

EP3884987A1 DRUG ELUTING BALLOON AND BALLOON CATHETER 无效
公开(公告)号：EP3884987A1
公开(公告)日：2021-09-29
申请号：EP19887738.3
申请日：2019-10-31
申请人： Shanghai MicroPort Medical (Group) Co., Ltd.
发明人： LI, Meng , CHEN, Lu , LI, Junfei
IPC分类号： A61M25/10
摘要： Disclosed is a drug eluting balloon for a balloon catheter. The drug eluting balloon comprises a balloon body (100) and a coating (200), and the coating (200) comprises a water-soluble adhesive layer (210), an isolating layer (220) and a drug layer (230) from the inside out. After the drug eluting balloon is pushed to a diseased part, the balloon body (100) is expanded, and the water-soluble adhesive layer (210) dissolves due to scouring by a blood flow, such that the isolating layer (220) and the drug layer (230) are separated from an outer surface of the balloon body (100) and adhere to a blood vessel wall. The provision of the isolating layer (220) can effectively suppress the water-soluble adhesive layer (210) from removing part of the drug layer (230) during dissolution, and after the drug layer (230) adheres to and makes contact with the blood vessel wall, the isolating layer can also reduce the scouring effect on the drug layer (230) by the blood flow, thereby reducing the loss of drugs, allowing the drugs to be taken in by the blood vessel wall to the greatest extent, greatly improving the utilization rate of the drugs and improving the treatment effect while also preventing toxic and side effects brought about by large doses of the drugs. Moreover, the isolating layer (220) can also realize the slow release of the drug layer (230), such that the drug layer (230) can provide treatment for a long time, and a good treatment effect can be obtained.

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