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1. 发明授权

EP1525856B1 Apparatus for applying a biopsy site marker 有权
标题翻译：设备安装一个活检标记物
公开(公告)号：EP1525856B1
公开(公告)日：2008-08-27
申请号：EP05000690.7
申请日：2000-06-28
申请人： Senorx, Inc.
发明人： Burbank, Fred H. , Lubock, Paul , Jones, Michael L. , Forcier, Nancy
IPC分类号： A61B19/00
CPC分类号： A61K49/006 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3933 , A61B2090/395 , A61B2090/3987 , A61M37/0069

2. 发明公开

EP2886135A1 POROUS BIOABSORBABLE IMPLANT 有权转让
标题翻译： Porösesbioabsorbierbares Implantat
公开(公告)号：EP2886135A1
公开(公告)日：2015-06-24
申请号：EP15150927.0
申请日：2009-09-22
申请人： Senorx, Inc.
发明人： Govil, Amit , Jones, Michael L. , Lubock, Paul
IPC分类号： A61L27/20 , A61L27/50 , A61L27/56 , A61L27/58
摘要： The bioabsorbable implant described has a porous body formed of bioabsorbable materials that have an in vivo life span of at least 2 weeks, preferably at least three weeks and not greater than 20 weeks, preferably no greater than ten weeks. The implant has a scaffolding structure which facilitates tissue in-growth and ultimately tissue replacement of the scaffolding structure. The implant has a radiopaque imaging agent at least at the exterior margins and an orientation plurality of radiopaque elements in the interior of implant. The implant preferably has three radiopaque elements within the interior that form a plane within the implant interior.
摘要翻译：所描述的生物可吸收植入物具有由生物可吸收材料形成的多孔体，其具有至少2周，优选至少3周且不超过20周，优选不超过10周的体内寿命。植入物具有促进组织生长并最终组织替代脚手架结构的脚手架结构。植入物至少在外部边缘处具有不透射线的成像剂，并且在植入物内部具有多个不透射线的元件。植入物优选地在内部内具有三个不透射线的元件，其在植入物内部形成平面。

3. 发明公开

EP2486957A2 Tissue irradiation with shielding 审中-公开
标题翻译： Gewebebestrahlung mit Abschirmung
公开(公告)号：EP2486957A2
公开(公告)日：2012-08-15
申请号：EP12166143.3
申请日：2006-11-13
申请人： Senorx, Inc.
发明人： Lubock, Paul , Jones, Michael L. , Louw, Frank R.
IPC分类号： A61N5/10 , A61M36/04
CPC分类号： A61N5/1015 , A61B2017/3419 , A61N2005/1005
摘要： Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.
摘要翻译：公开了用于治疗围绕体腔或其他体内部位的组织的装置和方法，例如在去除组织后，例如，癌症。这种装置包括在装置的远端部分上的处理位置，其中一个或多个辐射屏蔽部件在治疗位置部分地环绕辐射源以控制来自辐射源的辐射。该装置最小化对体腔或其他部位周围的健康组织的辐射损伤，同时照射不被辐射屏蔽部件屏蔽的组织。体现本发明特征的装置可包括密封构件，该密封构件位于靠近治疗位置的装置的轴的位置处，以密封通向体腔的通道。

4. 发明公开

EP2025292A1 Breast biopsy system 审中-公开
标题翻译： Brustbiopsiesystem
公开(公告)号：EP2025292A1
公开(公告)日：2009-02-18
申请号：EP08019132.3
申请日：1999-03-02
申请人： Senorx, Inc.
发明人： Burbank, Fred H. , Jones, Michael L. , Lubock, Paul
IPC分类号： A61B10/00 , A61B17/32 , A61B17/22
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of "clean" margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possible cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen. Once the tissue specimen is isolated, it may be segmented by further manipulation of the cutting element, after which the tissue segments are preferably individually removed from the patient's body through a cannula or the like. Alternatively, the specimen may be encapsulated and removed as an intact piece.
摘要翻译：提供了一种用于精确地分离患者体内组织中的靶病变的装置和方法，导致当其被去除用于诊断和/或治疗时，对病变的“清洁”边缘的高可能性。这种方法有利地经常导致仅使用单一经皮手术来诊断和治疗恶性病变的能力，而不需要随访的经皮或外科手术，同时最小化可能的癌细胞从病变迁移到周围的风险组织或血液。特别地，该装置包括具有适于进入患者身体的远端的活检器械，纵向轴和沿轴设置的切割元件。切割元件可在径向缩回位置和径向延伸位置之间致动。有利地，仪器可以在径向延伸的位置围绕其轴线旋转，以通过围绕组织标本限定周边边界来隔离期望的组织样本与周围组织。一旦组织样本被分离，可以通过进一步操纵切割元件来分割组织样本，之后组织段优选通过套管等从患者身体单独地移除。或者，样品可以作为完整的片段被包封和去除。

5. 发明公开

EP1974686A3 Apparatus for applying a biopsy site marker 审中-公开
标题翻译：一种用于活检部位标记的应用装置
公开(公告)号：EP1974686A3
公开(公告)日：2011-05-18
申请号：EP08160420.9
申请日：2000-06-28
申请人： Senorx, Inc.
发明人： Burbank, Fred H. , Lubock, Paul , Jones, Michael L. , Forcier, Nancy
IPC分类号： A61B19/00
CPC分类号： A61K49/006 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3933 , A61B2090/395 , A61B2090/3987 , A61M37/0069
摘要： Disclosed is a combination of an applicator tube having an internal lumen, an open end and a closed end and an opening in proximity of the closed end; a rod dimensioned to fit into and be slidable in the internal lumen, and a plurality of biopsy site markers which are formed of dehydrated hydratable material in the internal lumen of the applicator tube from where they can be pushed out with the rod through the opening into a biopsy site and which at least one thereof has an X-ray detectable body with an identifiable non-biological shape embedded therein.

6. 发明公开

EP2033580A1 Breast biopsy system 审中-公开
标题翻译：伤寒系统
公开(公告)号：EP2033580A1
公开(公告)日：2009-03-11
申请号：EP08019228.9
申请日：1999-03-02
申请人： Senorx, Inc.
发明人： Burbank, Fred H. , Jones, Michael L. , Lubock, Paul
IPC分类号： A61B10/00 , A61B17/32 , A61B17/22 , A61B19/00
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of "clean" margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possible cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument (10) having a distal end (11) adapted for entry into the patient's body, a longitudinal shaft, and a cutting element (20) disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen. Once the tissue specimen is isolated, it may be segmented by further manipulation of the cutting element, after which the tissue segments are preferably individually removed from the patient's body through a cannula or the like. Alternatively, the specimen may be encapsulated and removed as an intact piece.
摘要翻译：提供了一种用于精确地分离患者体内组织中的靶病变的装置和方法，导致当其被去除用于诊断和/或治疗时，对病变的“清洁”边缘的高可能性。这种方法有利地经常导致仅使用单一经皮手术来诊断和治疗恶性病变的能力，而不需要随访的经皮或外科手术，同时最小化可能的癌细胞从病变迁移到周围的风险组织或血液。特别地，该装置包括具有适于进入患者体内的远端（11）的活检器械（10），纵向轴和沿轴设置的切割元件（20）。切割元件可在径向缩回位置和径向延伸位置之间致动。有利地，仪器可以在径向延伸的位置围绕其轴线旋转，以通过围绕组织标本限定周边边界来隔离期望的组织样本与周围组织。一旦组织样本被分离，可以通过进一步操纵切割元件来分割组织样本，之后组织段优选通过套管等从患者身体单独地移除。或者，样品可以作为完整的片段被包封和去除。

7. 发明公开

EP1525856A3 Apparatus for applying a biopsy site marker 有权
标题翻译：设备安装一个活检标记物
公开(公告)号：EP1525856A3
公开(公告)日：2005-06-01
申请号：EP05000690.7
申请日：2000-06-28
申请人： Senorx, Inc.
发明人： Burbank, Fred H. , Lubock, Paul , Jones, Michael L. , Forcier, Nancy
IPC分类号： A61B19/00
CPC分类号： A61K49/006 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3933 , A61B2090/395 , A61B2090/3987 , A61M37/0069
摘要： An apparatus for applying a biopsy site marker comprising: an applicator tube having an internal lumen, an open end (32) and a closed end (36) and an opening (34) in proximity of the closed end (36); a rod (28) dimensioned to fit into and be slidable in the internal lumen, and a plurality of biopsy site markers (20) which are formed of dehydrated hydratable material in the internal lumen of the applicator tube from where they can be pushed out with the rod (28) through the opening (34) into a biopsy site and which at least one thereof has an X-ray detectable body with an identifiable non-biological shape embedded therein.

8. 发明公开

EP2486957A3 Tissue irradiation with shielding 审中-公开
标题翻译：组织照射屏蔽
公开(公告)号：EP2486957A3
公开(公告)日：2013-07-10
申请号：EP12166143.3
申请日：2006-11-13
申请人： Senorx, Inc.
发明人： Lubock, Paul , Jones, Michael L. , Louw, Frank R.
IPC分类号： A61N5/10 , A61M36/04
CPC分类号： A61N5/1015 , A61B2017/3419 , A61N2005/1005
摘要： Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.

9. 发明公开

EP2277553A1 Preparations for time-limited marking of biopsy sites 审中-公开
标题翻译： Präparatezur zeitbegrenzte Markierung von Biopsie-Orten
公开(公告)号：EP2277553A1
公开(公告)日：2011-01-26
申请号：EP10185263.0
申请日：2000-01-26
申请人： Senorx, Inc.
发明人： Burbank, Fred H. , Lubock, Paul , Jones, Michael L. , Forcier, Nancy
IPC分类号： A61K49/00
CPC分类号： A61B90/39 , A61B10/02 , A61B2017/00004 , A61B2090/3788 , A61B2090/3908 , A61B2090/3925 , A61B2090/3929 , A61B2090/3933 , A61B2090/395 , A61B2090/3975 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61M37/0069
摘要： Detectable markers that may be introduced into a cavity created by removal of a biopsy specimen to mark the location of the biopsy site so that it may be located in a subsequent medical/surgical procedure. The markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.
摘要翻译：可以被引入通过去除活组织检查样本而产生的空腔中的可检测标记，以标记活组织检查部位的位置，使得其可以位于随后的医疗/外科手术中。标记物以足够的量保持存在，以允许在引入后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除或以其他方式不干扰第二次活检部位附近的组织的成像时间点（如5-7个月）。

10. 发明公开

EP1974686A2 Apparatus for applying a biopsy site marker 审中-公开
标题翻译： Vorrichtung zur Anwendung eines Biopsiestellenmarkers
公开(公告)号：EP1974686A2
公开(公告)日：2008-10-01
申请号：EP08160420.9
申请日：2000-06-28
申请人： Senorx, Inc.
发明人： Burbank, Fred H. , Lubock, Paul , Jones, Michael L. , Forcier, Nancy
IPC分类号： A61B19/00
CPC分类号： A61K49/006 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3933 , A61B2090/395 , A61B2090/3987 , A61M37/0069
摘要： Disclosed is a combination of an applicator tube having an internal lumen, an open end and a closed end and an opening in proximity of the closed end; a rod dimensioned to fit into and be slidable in the internal lumen, and a plurality of biopsy site markers which are formed of dehydrated hydratable material in the internal lumen of the applicator tube from where they can be pushed out with the rod through the opening into a biopsy site and which at least one thereof has an X-ray detectable body with an identifiable non-biological shape embedded therein.
摘要翻译：公开了一种具有内腔，开口端和封闭端以及封闭端附近的开口的施用管的组合; 一个定尺寸适合并能够在内腔中滑动的杆;以及多个活检部位标记，其由施加管的内腔中的脱水可水合材料形成，从那里它们可以通过该开口被杆推出活检部位，并且其至少一个具有嵌入其中的具有可识别的非生物形状的X射线可检测体。

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