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1. 发明公开

EP1900432A2 Magnetic bead-packing unit using centrifugal force, microfluidic device including the same, and immunoassay method using the microfluidic device 审中-公开
标题翻译： Zentrifugalkraftbasierte包装单元为磁珠，使得微流体装置和免疫分析方法与微流体装置
公开(公告)号：EP1900432A2
公开(公告)日：2008-03-19
申请号：EP07109720.8
申请日：2007-06-06
申请人： Samsung Electronics Co., Ltd.
发明人： Cho, Yoon-kyoung , Lee, Jeong-gun , Lee, Beom-seok
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/502761 , B01L3/50273 , B01L3/502738 , B01L2300/0806 , B01L2400/0409 , B01L2400/043 , G01N33/5304
摘要： A magnetic bead-packing unit using centrifugal force, a microfluidic device including the same, and an immunoassay method using the microfluidic device are provided. The magnetic bead-packing unit includes a rotary body controllably rotating; a microfluidic channel disposed on the rotary body and including an inlet and an outlet disposed farther from a rotation center of the rotary body than the inlet to provide a channel through which fluid flows from the inlet to the outlet due to centrifugal force, wherein the microfluidic channel comprises a curved portion in which the microfluidic channel first extends away from the rotation center of the rotary body and then turns toward the rotation center of the rotary body; and a magnet disposed to correspond to the curved portion and applying a magnetic force to fluid flowing through the microfluidic channel. The immunoassay method includes preparing a sample solution mixed with magnetic beads in the sample solution chamber; and packing the magnetic beads in the curved portion by passing the sample solution mixed with the magnetic bead through the microfluidic channel due to centrifugal force caused by rotation of the rotary body.
摘要翻译：提供了使用微流体装置磁珠包装利用离心力，微流体装置包括相同的单元，和免疫测定法。磁珠包装单元包括：旋转体可控旋转; 一个微流体通道布置在所述旋转体，并且包括在入口和从所述旋转体比入口的旋转中心更远设置成提供通过从入口到出口由于离心力，流体流动的通道出口，worin微流体通道包括其中所述微流体通道从第一旋转体的旋转中心延伸离开，然后向所述旋转体的旋转中心转动的弯曲部; 和磁铁设置成对应于所述弯曲部分和施加磁力到流过微流体通道的流体。的免疫测定方法包括：准备与所述样品溶液室磁珠混合的样品溶液; 并通过与通过微流体通道中的磁珠混合样品溶液通过由于通过旋转体的旋转引起的离心力填料在弯曲部分中的磁性珠粒。

2. 发明公开

EP1949961A3 Apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup 审中-公开
标题翻译：装置和使用电荷浓度和液体桥悬架喷射液滴的方法
公开(公告)号：EP1949961A3
公开(公告)日：2013-08-28
申请号：EP08150546.3
申请日：2008-01-23
申请人： Samsung Electronics Co., Ltd.
发明人： Lee, Beom-seok , Lee, Jeong-gun , Cho, Hye-jung , Kang, In-seok , Hong, Jin-seok , Moon, Jae-suk
IPC分类号： B01L3/02 , B01J19/00
CPC分类号： B01L3/0262 , B01J19/0046 , B01J2219/00369 , B01J2219/00371 , B01J2219/00527 , B01J2219/00605 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , B01L2300/0819 , B01L2300/0838 , B01L2400/027 , Y10T436/11 , Y10T436/118339 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： Disclosed is an apparatus and method for ejecting droplets using charge concentration and liquid bridge breakup. The droplet ejection apparatus includes a reservoir (20) storing a liquid; a capillary nozzle (10) having a lower end submerged in the liquid stored in the reservoir (20) and an upper end exposed outside the surface of the liquid, the capillary nozzle transferring the liquid to the upper end using capillary force; a potentiostat for applying a voltage to the liquid; a substrate mount (33) on which a substrate (30) is disposed to face the upper end of the capillary nozzle (10); and a distance adjusting unit for reciprocatingly moving the substrate (30) between first and second positions with respect to the capillary nozzle(10), wherein the first position denotes a position where a distance between the upper end of the capillary nozzle and the surface of the substrate is less than a effective distance effective.

3. 发明公开

EP2420319A1 Centrifugal microfluidic device having sample distribution structure and centrifugal microfluidic system including the centrifugal microfluidic device 审中-公开
标题翻译：与样品分配结构和微流体系统离心与微流体离心装置的微流体离心机装置
公开(公告)号：EP2420319A1
公开(公告)日：2012-02-22
申请号：EP11008896.0
申请日：2008-04-24
申请人： Samsung Electronics Co., Ltd
发明人： Lee, Beom-seok , Cho, Yoom-Kyoung , Park, Jong-Myeon , Lee, Jung-Nam
IPC分类号： B01L3/00 , G01N21/07
CPC分类号： B01L3/502738 , B01L3/50273 , B01L2200/0684 , B01L2300/0806 , B01L2300/0861 , B01L2400/0409 , B01L2400/06 , B01L2400/0677 , G01N21/07 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： Provided are a centrifugal microfluidic device having a sample distribution structure and a centrifugal microfluidic system including the centrifugal microfluidic device. The centrifugal microfluidic device includes: a rotatable platform; a sample chamber which is disposed in the rotatable platform and houses a fluid sample; a distribution channel including a first section which is connected to an outlet of the sample chamber and extends in a radial direction of the rotatable platform, and a second section which extends from the first section in a circumferential direction of the rotatable platform, wherein a fluid resistance is the same throughout entire first and second sections; a plurality of non-vented reaction chambers which are disposed in the rotatable platform outside of the distribution channel in the radial direction; and a plurality of inlet channels connecting the second section of the distribution channel with the reaction chambers.
摘要翻译：提供了具有一个样本分布结构和离心力的微流体系统，包括离心微流体装置的离心微流体装置。该离心微流体装置包括：一可旋转的基座平台; 样品室的所有其在可旋转的基座平台布置，并且容纳流体样品; 其连接到在所述样品室的出口并延伸在可旋转基座平台的径向方向上的分配通道，其包括第一部分中的所有，并且其从在可旋转基座平台的圆周方向上的第一部分延伸的第二部分，worin流体电阻是在整个整个第一和第二部分是相同的; 的哪一个被设置在可旋转的基座平台的径向方向上的分配通道的外面，密闭反应室的多元性; 和入口通道的多个连接与所述反应室的分配通道的第二部分。

4. 发明公开

EP1905515A2 Centrifugal Force Based Microfluidic Device Having Thermal Activation Unit, Microfluidic System Including the Same and Method of Operating the Microfluidic System 审中-公开
标题翻译：与热激活单元Zentrifugalkraftbasierte微流体装置，从而使微流体系统和操作该微流体系统的方法
公开(公告)号：EP1905515A2
公开(公告)日：2008-04-02
申请号：EP07115717.6
申请日：2007-09-05
申请人： Samsung Electronics Co., Ltd.
发明人： Cho, Yoon-kyoung , Lee, Jeong-gun , Lee, Beom-seok , Park, Jong-myeon
IPC分类号： B01L3/00
CPC分类号： F16K99/003 , B01L3/502738 , B01L2300/0806 , B01L2300/0867 , B01L2300/0887 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K99/004 , F16K2099/0084
摘要： A centrifugal force based microfluidic device including a thermal activation unit, a microfluidic system including the same, and a method of operating the microfluidic system are provided. The thermal activation unit accompanies a temperature change in order to carry out its functions and having heat generation particles that absorb electromagnetic waves and generate heat in the activation unit therein.
摘要翻译：本发明提供一种基于离心力的微流体装置，其包括热激活单元，微流体系统，其包括相同的，并且操作所述微流体系统的方法。热激活单元伴随着温度变化，以执行其功能并且具有发热颗粒并吸收电磁波并在其中产生在所述激活单元的热量。

5. 发明公开

EP1900432A3 Magnetic bead-packing unit using centrifugal force, microfluidic device including the same, and immunoassay method using the microfluidic device 审中-公开
标题翻译： Zentrifugalkraftbasierte包装单元为磁珠，使得微流体装置和免疫分析方法与微流体装置
公开(公告)号：EP1900432A3
公开(公告)日：2013-07-03
申请号：EP07109720.8
申请日：2007-06-06
申请人： Samsung Electronics Co., Ltd.
发明人： Cho, Yoon-kyoung , Lee, Jeong-gun , Lee, Beom-seok
IPC分类号： B01L3/00 , G01N33/543 , G01N33/53
CPC分类号： B01L3/502761 , B01L3/50273 , B01L3/502738 , B01L2300/0806 , B01L2400/0409 , B01L2400/043 , G01N33/5304
摘要： A magnetic bead-packing unit using centrifugal force, a microfluidic device including the same, and an immunoassay method using the microfluidic device are provided. The magnetic bead-packing unit includes a rotary body controllably rotating; a microfluidic channel disposed on the rotary body and including an inlet and an outlet disposed farther from a rotation center of the rotary body than the inlet to provide a channel through which fluid flows from the inlet to the outlet due to centrifugal force, wherein the microfluidic channel comprises a curved portion in which the microfluidic channel first extends away from the rotation center of the rotary body and then turns toward the rotation center of the rotary body; and a magnet disposed to correspond to the curved portion and applying a magnetic force to fluid flowing through the microfluidic channel. The immunoassay method includes preparing a sample solution mixed with magnetic beads in the sample solution chamber; and packing the magnetic beads in the curved portion by passing the sample solution mixed with the magnetic bead through the microfluidic channel due to centrifugal force caused by rotation of the rotary body.

6. 发明公开

EP1905515A3 Centrifugal Force Based Microfluidic Device Having Thermal Activation Unit, Microfluidic System Including the Same and Method of Operating the Microfluidic System 审中-公开
标题翻译：与热激活单元Zentrifugalkraftbasierte微流体装置，从而使微流体系统和操作该微流体系统的方法
公开(公告)号：EP1905515A3
公开(公告)日：2013-05-22
申请号：EP07115717.6
申请日：2007-09-05
申请人： Samsung Electronics Co., Ltd.
发明人： Cho, Yoon-kyoung , Lee, Jeong-gun , Lee, Beom-seok , Park, Jong-myeon
IPC分类号： B01L3/00
CPC分类号： F16K99/003 , B01L3/502738 , B01L2300/0806 , B01L2300/0867 , B01L2300/0887 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K99/004 , F16K2099/0084
摘要： A centrifugal force based microfluidic device including a thermal activation unit, a microfluidic system including the same, and a method of operating the microfluidic system are provided. The thermal activation unit accompanies a temperature change in order to carry out its functions and having heat generation particles that absorb electromagnetic waves and generate heat in the activation unit therein.

7. 发明公开

EP2295142A1 Microfluidic apparatus having fluid container 有权
标题翻译： MikrofluidischesGerätmitFlüssigkeitsbehälter
公开(公告)号：EP2295142A1
公开(公告)日：2011-03-16
申请号：EP10190475.3
申请日：2008-04-17
申请人： Samsung Electronics Co., Ltd.
发明人： Cho, Yoon-kyoung , Lee, Beom-seok , Lee, Jeong-gun
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/50273 , B01L2200/028 , B01L2300/0803 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , Y10T436/11 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A microfluidic apparatus (100) having a substrate including a channel through which a fluid is conveyed, a fluid container (140) in which at least one kind of fluid is accommodated and which is disposed on the substrate so as to allow the fluid to flow toward the channel, and a fluid flow controller which controls a flow of the fluid toward the channel from the fluid container.
摘要翻译：一种微流体装置（100），其具有包括流体被输送的通道的基板，流体容器（140），其中容纳有至少一种流体并设置在所述基板上，以允许流体流动以及流体流量控制器，其从流体容器控制流体朝向通道的流动。

8. 发明公开

EP1983347A3 Centrifugal Force Based Microfluidic Device, Microfluidic System including the same, and Method of Determining Home Position of the Microfluidic Device 审中-公开
标题翻译： Zentrifugalkraftbasierte微流体装置，用于确定微流体装置的起始位置的微流体系统和方法
公开(公告)号：EP1983347A3
公开(公告)日：2009-06-24
申请号：EP07121889.5
申请日：2007-11-29
申请人： Samsung Electronics Co., Ltd.
发明人： Lee, Jeong-gun , Lee, Beom-seok , Park, Jong-myeon , Yoo, Jung-suk
IPC分类号： G01N35/00 , G01N21/25 , B01L3/00
CPC分类号： G01N35/00069 , B01L3/5027 , B01L2300/0654 , B01L2300/0803 , B01L2400/0409 , G01N35/0092 , G01N2035/00574
摘要： Centrifugal force based microfluidic system including: a microfluidic device (101) including a rotatable platform (102) and an optical path (105) formed to extend horizontally in a straight line from a circumference of the platform; a motor (125) rotating so as to control the microfluidic device; a light emitting unit (130) emitting light towards the microfluidic device; a light receiving unit (133) detecting the light emitted from the light emitting unit; and a controller (135) determining a home position to be the position of the microfluidic device at a point of time when the light emitted from the light emitting unit is detected by the light receiving unit, wherein the light emitted from the light emitting unit passes through the optical path to be incident on the light receiving unit only when the microfluidic device is located in a predetermined position.

9. 发明公开

EP1759759A1 Devices and methods for Printing Biomolecular Droplet on Substrate and Device for Printing Ink on Substrate or Print Paper Using Electric Charge Concentration Effect 审中-公开
标题翻译：装置和用于在基板或纸张上的基板和装置印刷油墨上印刷生物分子的方法通过的电荷浓度效应装置
公开(公告)号：EP1759759A1
公开(公告)日：2007-03-07
申请号：EP06118668.0
申请日：2006-08-09
申请人： Samsung Electronics Co., Ltd.
发明人： Lee, Jeong-gun , Cho, Hye-jung , Huh, Nam , Kang, In-seok , Lee, Beom-seok
IPC分类号： B01J19/00 , B01L3/02
CPC分类号： B01L3/0262 , B01J19/0046 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00574 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00743 , B01L2300/0838 , B01L2400/027
摘要： Provided are a device (100) and method for printing biomolecules on a substrate (30) using an electric charge concentration effect. The device (100) enables the limitation of the material and surface characteristics of a substrate (30) to be overcome, enables the accurate dropping of a biomolecular droplet onto a target surface (31) of the substrate, prevents electric discharge, and thus allows the manufacturing of a high density biochip by depositing numerous biomolecular droplets small in size and volume onto a substrate (30). The device including: a needle-shaped electric field forming electrode (20); a substrate (30) that is disposed below the electric field forming electrode (20), is grounded, and includes a target surface (31); and an open circuit type voltage applying unit (50) which supplies first electric charges to the electric field forming electrode so that the biomolecular droplet drops onto the target surface (31) of the substrate.
摘要翻译：本发明提供一种装置（100）和方法，用于使用在电荷浓度效应的基板（30）进行打印的生物分子。的装置（100）允许的基板（30），要被克服的材料和表面特性的限制，使得生物分子滴的到基底的目标表面（31）中的准确落下，防止放电，并且因此允许通过沉积许多生物分子制造的高密度的生物芯片的微滴的尺寸和体积小到基板（30）。该装置包括：针状的电场成形电极（20）; 一个基片（30）没有设置下面的电场形成用电极（20）被接地，并且包括目标表面（31）; 和供给第一电荷电场成形电极的开路型电压施加单元（50），所以也生物分子液滴落到基底的目标表面（31）。

10. 发明授权

EP2002895B1 Microfluidic device for simultaneously conducting multiple analyses 有权转让
标题翻译：用于同时进行多种分析的微流体装置
公开(公告)号：EP2002895B1
公开(公告)日：2017-08-09
申请号：EP08157496.4
申请日：2008-06-03
申请人： Samsung Electronics Co., Ltd.
发明人： Lee, Beom-seok , Cho, Yoon-kyoung , Park, Jong-myeon , Lee, Jeong-gun
IPC分类号： B01L3/00 , F15C5/00 , G01N35/00 , F16K99/00
CPC分类号： B01L3/502738 , B01L3/502723 , B01L3/502746 , B01L3/502753 , B01L2200/0684 , B01L2200/10 , B01L2300/0636 , B01L2300/0803 , B01L2300/0806 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0677 , B01L2400/084 , B01L2400/086 , F16K99/0001 , F16K99/0019 , F16K99/0032 , F16K99/004 , F16K99/0061 , F16K2099/0084 , G01N35/00069
摘要： Provided is a rotatable microfluidic device (200) for conducting simultaneously two or more assays. The device includes a platform (100) which can be rotated, a first unit which is disposed at one portion of the platform (100) and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform (100) and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.
摘要翻译：提供了用于同时进行两种或更多种测定的可旋转微流体装置（200）。该装置包括：可旋转的平台（100）;第一单元，其设置在平台（100）的一部分处，并使用其上捕获探针选择性地结合到目标材料的表面的样本来检测目标材料; 以及第二单元，其设置在所述平台（100）的另一部分处，并通过与在所述第一单元中进行的反应不同的反应来检测包含在所述样品中的目标材料。

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