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1. 发明授权

EP2119505B1 Method of fabricating a valve unit 有权转让
标题翻译：一种用于制造阀装置的过程
公开(公告)号：EP2119505B1
公开(公告)日：2011-12-21
申请号：EP09160093.2
申请日：2009-05-13
申请人： Samsung Electronics Co., Ltd.
发明人： Park, Jong-myeon , Chung, Jong-suk , Lee, Jeong-gun
IPC分类号： B01L3/00 , F16K99/00
CPC分类号： F16K99/0001 , B01L3/502707 , B01L3/502738 , B01L2300/0803 , B01L2300/0864 , B01L2300/0887 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , Y10T29/49405

2. 发明公开

EP2108449A2 Microfluidic device and method of fabricating the same 审中-公开
标题翻译： Mikrofluidische Vorrichtung und Herstellungsverfahrendafür
公开(公告)号：EP2108449A2
公开(公告)日：2009-10-14
申请号：EP09157486.3
申请日：2009-04-07
申请人： Samsung Electronics Co., Ltd.
发明人： Park, Jong-myeon , Lee, Jeong-gun
IPC分类号： B01L3/00 , B29C65/48
CPC分类号： B81C3/001 , B01L3/502707 , B01L3/502738 , B01L2200/0689 , B01L2300/0803 , B01L2300/0816 , B01L2300/0887 , B01L2400/0677 , B29C65/14 , B29C65/1406 , B29C65/483 , B29C65/4845 , B29C65/52 , B29C65/526 , B29C66/112 , B29C66/114 , B29C66/1142 , B29C66/242 , B29C66/244 , B29C66/342 , B29C66/53461 , B29C66/54 , B29C66/71 , B29C2035/0827 , B29L2031/756 , B81B2201/051 , B81C2201/019 , B81C2203/032 , Y10T137/206 , Y10T137/2164 , Y10T137/2169 , B29K2033/08 , B29K2033/12 , B29K2083/00
摘要： A microfluidic device and a method of fabricating the microfluidic device are provided. The microfluidic device includes: a platform including an upper substrate and a lower substrate that are bonded to face each other; a microfluidic structure obtained by forming grooves in the lower substrate; a lower substrate protrusion pattern including an outline protrusion that protrudes from the lower substrate toward the upper substrate along an outline of the microfluidic structure; and an adhesive layer disposed between the lower substrate protrusion pattern and the upper substrate in order to bond the upper substrate and the lower substrate to each other. The lower substrate protrusion pattern only supports the upper substrate, and remaining portions of the lower substrate except for the lower substrate protrusion pattern do not have structures for supporting the upper substrate.
摘要翻译：提供微流体装置和制造微流体装置的方法。微流体装置包括：平台（10），其包括被粘合以彼此面对的上基板（14）和下基板（12）; 通过在下基板（12）中形成槽而获得的微流体结构（20）; 下部基板突出图案（30），其包括沿着所述微流体结构（20）的轮廓从所述下基板（12）朝向所述上基板（14）突出的轮廓突起（31）以及设置在下基板突起图案（30）和上基板（14）之间的粘合层（40H），以将上基板（14）和下基板（12）彼此粘合。下基板突起图案（30）仅支撑上基板（14），除了下基板突起图案（30）之外，下基板（12）的剩余部分不具有用于支撑上基板（14）的结构。

3. 发明公开

EP1905515A2 Centrifugal Force Based Microfluidic Device Having Thermal Activation Unit, Microfluidic System Including the Same and Method of Operating the Microfluidic System 审中-公开
标题翻译：与热激活单元Zentrifugalkraftbasierte微流体装置，从而使微流体系统和操作该微流体系统的方法
公开(公告)号：EP1905515A2
公开(公告)日：2008-04-02
申请号：EP07115717.6
申请日：2007-09-05
申请人： Samsung Electronics Co., Ltd.
发明人： Cho, Yoon-kyoung , Lee, Jeong-gun , Lee, Beom-seok , Park, Jong-myeon
IPC分类号： B01L3/00
CPC分类号： F16K99/003 , B01L3/502738 , B01L2300/0806 , B01L2300/0867 , B01L2300/0887 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K99/004 , F16K2099/0084
摘要： A centrifugal force based microfluidic device including a thermal activation unit, a microfluidic system including the same, and a method of operating the microfluidic system are provided. The thermal activation unit accompanies a temperature change in order to carry out its functions and having heat generation particles that absorb electromagnetic waves and generate heat in the activation unit therein.
摘要翻译：本发明提供一种基于离心力的微流体装置，其包括热激活单元，微流体系统，其包括相同的，并且操作所述微流体系统的方法。热激活单元伴随着温度变化，以执行其功能并且具有发热颗粒并吸收电磁波并在其中产生在所述激活单元的热量。

4. 发明公开

EP1662008A3 Apparatus for and method of purifying nucleic acids by using beads with different laser absorption 有权
标题翻译：通过用不同的激光吸收特性粒子的装置的设备和方法的核酸Aufreinignug
公开(公告)号：EP1662008A3
公开(公告)日：2007-05-09
申请号：EP05015561.3
申请日：2005-07-18
申请人： Samsung Electronics Co., Ltd
发明人： Lee, Jeong-gun , Kwon, Young-nam 104-306 , Lee, Myo-yong 306-1102 LG Xi Apt. , Yoo, Shin-i 101-2102 Ssangyong Apt. , Cho, Yeon-ja 1-132 Jeonnong 3-dong , Kim, Young-a 245-1804
IPC分类号： C12Q1/68
CPC分类号： B01L3/502753 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2400/0487
摘要： An apparatus for and method of purifying nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples, magnetic beads, and a solid support are introduced; a vibrator attached to the capillary and mixing the samples, magnetic beads, and solid support in the capillary; a laser generator attached to the capillary and irradiating a laser beam onto the capillary; a magnetic force generator attached to the capillary and fixing the magnetic beads to a capillary wall; a waste chamber attached to the capillary and discharging a lysate; an elution buffer chamber attached to the capillary and eluting nucleic acids from the solid support having nucleic acids bound thereto; and a neutralization buffer chamber attached to the capillary and supplying a neutralization buffer for neutralizing the eluted nucleic acid solution. According to the apparatus and method, PCR inhibitors can be removed to increase PCR yield and nucleic acids can be purified using a silicon substrate or silica beads. Thus, the apparatus and method can be applied to LOC fabrication.

5. 发明公开

EP1721667A1 Device for printing biomolecules on substrate using electrohydrodynamic effect 有权
标题翻译：装置用于通过利用电 - 流体动力效应在基底上印刷生物分子
公开(公告)号：EP1721667A1
公开(公告)日：2006-11-15
申请号：EP06009257.4
申请日：2006-05-04
申请人： SAMSUNG ELECTRONICS CO., LTD.
发明人： Lee, Jeong-gun , Choi, Jeong-woo , Huh, Nam , Cho, Hye-jung
IPC分类号： B01L3/00
CPC分类号： B01L3/0244 , B01J2219/0036 , B01J2219/00378 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01L3/0241 , B01L2300/0819
摘要： Provided is a device for printing a biomolecule solution onto a substrate using an electrohydrodynamic (EHD) effect. The device can deposit drops of the biomolecule solution with small size and volume and print more of the biomolecule solution onto a substrate, thereby enabling the manufacture of a high density biochip. The device includes a first electric field forming electrode that is shaped like a needle, is made of a conductive material, is disposed vertically, and includes an accommodating area in which the biomolecule solution is accommodated and an outlet formed on a bottom end of the accommodating area through which the biomolecule solution is discharged; a substrate disposed below the first electric field forming electrode, and including a target surface onto which the biomolecule solution discharged from the outlet of the first electric field forming electrode is deposited; a second electric field forming electrode made of a conductive material and disposed below the first electric field forming electrode; and a voltage applying device which is electrically connected to the first and second electric field forming electrodes to apply a voltage between the first and second electric field forming electrodes so that an electric field is generated around the biomolecule solution suspended in the outlet, wherein, due to the interaction between the electric field and a difference between dielectric constants of the biomolecule solution having a free surface and the surrounding atmosphere, the electric force acts inward on the biomolecule solution, thereby causing a predetermined amount of the biomolecule solution to drop onto the target surface of the substrate.
摘要翻译：本发明提供一种设备，用于印刷到使用电水动力学（EHD）效应的基板的生物分子的溶液。该装置可以沉积具有小尺寸和体积和打印多个生物分子溶液的生物分子溶液的液滴到基片，从而使高密度的生物芯片的制造。该装置包括一个第一电场形成电极也形状像一根针，是由导电材料制成的，被垂直地布置，并且包括在其中的生物分子溶液被容纳在形成在所述容置的底端出口容置区哪个区域通过所述生物分子溶液排出; 下方设置第一电场成形电极，并且包括在其上由所述第一电场成形电极的出口排出所述生物分子溶液沉积在目标表面上的底物; 第二电场成形电极由导电材料制成的和所述第一电场形成电极的正下方; 和电压施加装置的所有电连接至第一和第二电场成形电极，以所述第一和第二电场成形电极在电场所以没有围绕悬浮在出口处，worin生物分子溶液中产生之间施加电压时，由于电场和具有自由表面的生物分子溶液的介电常数和周围大气之间的差之间的相互作用，在电场力向内作用于生物分子溶液中，从而使生物分子溶液的规定量，以放置到目标基板的表面上。

6. 发明公开

EP1683873A1 Method of removing nucleic acid amplification inhibitor from biological sample and a Micro-PCR system 有权
标题翻译：在einer生物制药中的Verfahren zur Entfernung vonNukleinsäureamplifikationsinhibitorenProbe und Mikro-PCR System
公开(公告)号：EP1683873A1
公开(公告)日：2006-07-26
申请号：EP06001259.8
申请日：2006-01-20
申请人： Samsung Electronics Co., Ltd.
发明人： Kim, Kui-hyun , Kim, Young-a, 245-1804 Hwanggol Maeul , Min, Jun-hong , Lee, Jeong-gun , Lee, In-ho, 505-1201 Geumhwa Maeul
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6848 , B01L3/5027 , C12Q2563/149 , C12Q2527/125
摘要： Provided is a method of removing a nucleic acid amplification inhibitor from a biological sample. The method includes contacting the biological sample to a carboxyl group-coated solid support. Provided is also a micro-PCR system including a sample pretreatment chamber including a carboxyl group-coated solid support; a PCR chamber; and a channel connecting the sample pretreatment chamber and the PCR chamber.
摘要翻译：提供从生物样品中除去核酸扩增抑制剂的方法。该方法包括使生物样品与羧基涂覆的固体支持物接触。还提供了一种微型PCR系统，其包括包含羧基的固体支持物的样品预处理室; PCR室; 以及连接样品预处理室和PCR室的通道。

7. 发明公开

EP1662008A2 Apparatus for and method of purifying nucleic acids by using beads with different laser absorption 有权
标题翻译：通过用不同的激光吸收特性粒子的装置的设备和方法的核酸Aufreinignug
公开(公告)号：EP1662008A2
公开(公告)日：2006-05-31
申请号：EP05015561.3
申请日：2005-07-18
申请人： Samsung Electronics Co, Ltd
发明人： Lee, Jeong-gun , Kwon, Young-nam 104-306 , Lee, Myo-yong 306-1102 LG Xi Apt. , Yoo, Shin-i 101-2102 Ssangyong Apt. , Cho, Yeon-ja 1-132 Jeonnong 3-dong , Kim, Young-a 245-1804
IPC分类号： C12Q1/68
CPC分类号： B01L3/502753 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2400/0487
摘要： An apparatus for and method of purifying nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples, magnetic beads, and a solid support are introduced; a vibrator attached to the capillary and mixing the samples, magnetic beads, and solid support in the capillary; a laser generator attached to the capillary and irradiating a laser beam onto the capillary; a magnetic force generator attached to the capillary and fixing the magnetic beads to a capillary wall; a waste chamber attached to the capillary and discharging a lysate; an elution buffer chamber attached to the capillary and eluting nucleic acids from the solid support having nucleic acids bound thereto; and a neutralization buffer chamber attached to the capillary and supplying a neutralization buffer for neutralizing the eluted nucleic acid solution. According to the apparatus and method, PCR inhibitors can be removed to increase PCR yield and nucleic acids can be purified using a silicon substrate or silica beads. Thus, the apparatus and method can be applied to LOC fabrication.
摘要翻译：提供了用于纯化细胞或病毒的核酸的方法的装置和。核酸净化装置包括：具有供样品，磁珠，和固体支持物的样品入口的细胞裂解毛细管被引入; 附接到所述毛细管和混合的样品中，磁珠，并在毛细管固体载体上的振动器; 附接到所述毛细管和将激光束照射在毛细管的激光发生器; 磁力发生器附接至毛细管和固定磁珠到毛细管壁; 附接到所述毛细管和排出裂解物废料室; 洗脱缓冲液室连接到毛细管和由具有核酸结合到其上的固体支持物上洗脱核酸的; 和中和缓冲室附接到所述毛细管和供给的中和缓冲液中和洗脱的核酸溶液。。根据该设备和方法，PCR抑制剂可以被去除以增加PCR产量，并且可以使用硅衬底或硅珠纯化的核酸。因此，该装置和方法可以适用于制造LOC。

8. 发明公开

EP1552887A3 Device and method for printing biomolecules onto substrate using electrohydrodynamic effect 有权
标题翻译：装置和方法，用于打印的生物分子上利用静电流体动力效应的基板
公开(公告)号：EP1552887A3
公开(公告)日：2006-04-26
申请号：EP04026799.9
申请日：2004-11-11
申请人： SAMSUNG ELECTRONICS CO., LTD.
发明人： Cho, Hye-jung , Lee, Jeong-gun
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J2219/00371 , B01J2219/00527 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01L3/0262 , B01L2300/0838 , B01L2400/027 , B01L2400/0415 , C40B40/06 , C40B40/10 , C40B60/14
摘要： A device and a method for printing biomolecules onto a substrate using an electrohydrodynamic (EHD) effect are provided. The device for printing biomolecules onto a substrate using an electrohydrodynamic (EHD) effect includes at least one capillary having an outlet through which a feeding solution of biomolecules selected from the group consisting of nucleic acids, proteins, and oligopeptides is discharged, the nucleic acids being selected from the group consisting of probe DNA, RNA, peptide nucleic acid (PNA), and LNA and the proteins being selected from the group consisting of antigen and antibody; a printer body supporting the at least one capillary; a substrate below the outlet having a target surface onto which the biomolecules are deposited; a first electric field forming electrode located on the printer body around the circumference of the outlet; a second electric field forming electrode spaced apart from the first electrode by a predetermined distance; and a voltage applying unit which is electrically connected to the first electrode and the second electrode to apply an alternating current (AC) voltage between the first electrode and the second electrode so that an electric field may be formed around the biomolecule solution suspended in the outlet, and due to the interaction of the electric field and a difference in dielectric constant between the biomolecule solution having a free surface and the surrounding atmosphere, the electric force acts inward on the biomolecule solution from the surroundings, thereby dropping a predetermined amount of the biomolecule solution onto the target surface of the substrate. By using an EHD effect, the advantages of the device and method are that the process is quick, the biomolecule spots are uniform and easily aligned, and especially it is possible to spot the biomolecules correctly and reproducibly even when the printer body is not fully aligned with the substrate. In addition, the device and method are applicable to proteins which are sensitive to heat and biomolecules which have neutral charges.

9. 发明公开

EP2537586A3 Hydrodynamic filter unit, hydrodynamic filter including the hydrodynamic filter unit, and method of filtering target material by using the hydrodynamic filter unit and the hydrodynamic filter 失效
标题翻译：与所述液压动力过滤单元和方法，用于与流体动力学过滤器单元和流体力学滤波器靶材料的过滤流体动力学过滤器单元流体动力滤波器
公开(公告)号：EP2537586A3
公开(公告)日：2014-03-05
申请号：EP12165239.0
申请日：2012-04-24
申请人： Samsung Electronics Co., Ltd.
发明人： Kim, Min-seok , Lee, Won-ho , Kim, Sun-soo , Kim, Jin-hoon , Lee, Jeong-gun , Sim, Tae-seok
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2400/086
摘要： A hydrodynamic filter unit (100) includes an inlet channel (20) connected to a fluid chamber (10), into which a fluid including a target material is introduced, and a plurality of outlet channels (30) connected to the fluid chamber (10), through which the fluid is discharged. A filtering method includes introducing a fluid including a target material into the hydrodynamic filter unit (100) through the inlet channel (20), capturing the target material in the hydrodynamic filter unit (100), and discharging a remaining part of the fluid outside of the hydrodynamic filter unit (100) through an outlet channel (30).

10. 发明公开

EP1900432A3 Magnetic bead-packing unit using centrifugal force, microfluidic device including the same, and immunoassay method using the microfluidic device 审中-公开
标题翻译： Zentrifugalkraftbasierte包装单元为磁珠，使得微流体装置和免疫分析方法与微流体装置
公开(公告)号：EP1900432A3
公开(公告)日：2013-07-03
申请号：EP07109720.8
申请日：2007-06-06
申请人： Samsung Electronics Co., Ltd.
发明人： Cho, Yoon-kyoung , Lee, Jeong-gun , Lee, Beom-seok
IPC分类号： B01L3/00 , G01N33/543 , G01N33/53
CPC分类号： B01L3/502761 , B01L3/50273 , B01L3/502738 , B01L2300/0806 , B01L2400/0409 , B01L2400/043 , G01N33/5304
摘要： A magnetic bead-packing unit using centrifugal force, a microfluidic device including the same, and an immunoassay method using the microfluidic device are provided. The magnetic bead-packing unit includes a rotary body controllably rotating; a microfluidic channel disposed on the rotary body and including an inlet and an outlet disposed farther from a rotation center of the rotary body than the inlet to provide a channel through which fluid flows from the inlet to the outlet due to centrifugal force, wherein the microfluidic channel comprises a curved portion in which the microfluidic channel first extends away from the rotation center of the rotary body and then turns toward the rotation center of the rotary body; and a magnet disposed to correspond to the curved portion and applying a magnetic force to fluid flowing through the microfluidic channel. The immunoassay method includes preparing a sample solution mixed with magnetic beads in the sample solution chamber; and packing the magnetic beads in the curved portion by passing the sample solution mixed with the magnetic bead through the microfluidic channel due to centrifugal force caused by rotation of the rotary body.

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