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1. 发明公开

EP1369405A1 PROCESS FOR PRODUCING 1-CHLORO-4-ARYLBUTANE 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON 1-CHLOR-4-ARYLBUTAN
公开(公告)号：EP1369405A1
公开(公告)日：2003-12-10
申请号：EP02702871.1
申请日：2002-03-11
申请人： SUMITOMO CHEMICAL COMPANY LIMITED , ONO PHARMACEUTICAL CO., LTD.
发明人： HIBINO, Hiroaki , OHTSUKA, Susumu , MIYAMOTO, Yasunobu , OKUMOTO, Itsuo
IPC分类号： C07C17/263 , C07C22/04
CPC分类号： C07C41/30 , C07C17/2632 , C07C22/04 , C07C43/225
摘要： There is provided an industrially advantageous process for producing a 1-chloro-4-arylbutane represented by the general formula (2):
wherein R represents hydrogen, lower alkyl, or lower alkoxy, characterized by reacting 1-bromo-3-chloropropane with a compound represented by the general formula (1):
wherein R is as defined above; and X represents chlorine, bromine, or iodine, in a solvent.
摘要翻译：提供了用于生产由通式（2）表示的1-氯-4-芳基丁烷的工业上有利的方法：其中R表示氢，低级烷基或低级烷氧基，其特征在于使1-溴-3- 氯化丙烷与通式（1）表示的化合物：其中R如上定义; X表示氯，溴或碘。

2. 发明授权

EP1369405B1 PROCESS FOR PRODUCING 1-CHLORO-4-ARYLBUTANE 有权
标题翻译：用于生产1-氯-4- ARYLBUTAN
公开(公告)号：EP1369405B1
公开(公告)日：2007-09-19
申请号：EP02702871.1
申请日：2002-03-11
申请人： Sumitomo Chemical Company, Limited , ONO PHARMACEUTICAL CO., LTD.
发明人： HIBINO, Hiroaki , OHTSUKA, Susumu , MIYAMOTO, Yasunobu , OKUMOTO, Itsuo
IPC分类号： C07C17/263 , C07C22/04
CPC分类号： C07C41/30 , C07C17/2632 , C07C22/04 , C07C43/225
摘要： An industrially advantageous process for producing a 1-chloro-4-arylbutane represented by the general formula (2) (2) (wherein R represents hydrogen, lower alkyl, or lower alkoxy), characterized by reacting 1-bromo-3-chloropropane with a compound represented by the general formula (1) (1) (wherein R has the same meaning as defined above; and X represents chlorine, bromine, or iodine) in a solvent.

3. 发明公开

EP1479667A1 PROCESS FOR PRODUCING CHROMONE COMPOUND 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER CHROMONVERBINDUNG
公开(公告)号：EP1479667A1
公开(公告)日：2004-11-24
申请号：EP03707123.0
申请日：2003-02-27
申请人： Sumitomo Chemical Company, Limited , ONO PHARMACEUTICAL CO., LTD.
发明人： HIBINO, Hiroaki , OHTSUKA, Susumu , MIYAMOTO, Yasunobu , YOSHIDA, Tomoyasu , OKUMOTO, Itsuo
IPC分类号： C07C201/12 , C07C205/37 , C07C67/307 , C07C69/63 , C07D311/24
CPC分类号： C07C205/37 , C07C201/12 , C07D311/24
摘要： A process for producing a dicarboxylic acid compound represented by the formula (4):
wherein R 1 and R 2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2):
wherein R 1 , R 2 and the wavy line have the same meanings as the above, and one of X 2 and X 3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3):
in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5):
wherein R 1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.
摘要翻译：一种由式（4）表示的二羧酸化合物的制备方法：其中R 1和R 2相同或不同，表示低级烷基，波浪线表示该化合物为E - 或Z-异构体或它们的混合物，其特征在于使由式（2）表示的化合物：其中R 1，R 2和波浪线具有与上述相同的含义;和 X 2和X 3之一表示氢，另一个表示卤素，与式（3）表示的硝基苯酚：在碱存在下反应; 一种制备由式（5）表示的硝基色酮化合物的方法：其中R 1具有与上述相同的含义的，其特征在于使二羧酸化合物或其羧酸与酸反应; 制备氨基色酮化合物的方法，其包括还原硝基色酮化合物; 并提供了包括酰化所述氨基色酮化合物的酰氨基色酮化合物的制备方法。

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