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1. 发明公开

EP2754672A4 ANTIBODY CAPABLE OF BINDING TO SPECIFIC REGION OF PERIOSTIN, AND METHOD FOR MEASURING PERIOSTIN USING SAME 有权转让
标题翻译：抗体结合骨膜和方法的特定区域FOR PERIOSTINMESSUNG SO
公开(公告)号：EP2754672A4
公开(公告)日：2015-09-02
申请号：EP12829373
申请日：2012-09-06
申请人： SHINO TEST CORP , UNIV SAGA , UNIV KURUME
发明人： IZUHARA KENJI , OHTA SHOICHIRO , ARIMA KAZUHIKO , SHIRAISHI HIROSHI , SUZUKI SHOICHI , HOSHINO TOMOAKI , AZUMA YOSHINORI , ONO JUNYA
IPC分类号： C07K16/18 , G01N33/68
CPC分类号： G01N33/6893 , C07K16/18 , C07K2317/14 , C07K2317/33 , G01N2333/47 , G01N2800/12
摘要： The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin or a cleavage product thereof. The method and the reagent for measuring periostin and the method for improving accuracy in periostin measurement of the present invention is characterized by detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin. The method of testing for pulmonary fibrosis or interstitial pneumonia of the present invention includes the steps of a) measuring the amount or concentration of periostin in a sample derived from a subject, which measuring includes detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin and b) comparing the amount or concentration of the periostin in the sample derived from the subject with an amount or concentration of periostin in a sample derived from a living body not suffering from pulmonary fibrosis and interstitial pneumonia.
摘要翻译：本发明提供一种方法和用于测量包含以提高的精度，对于骨膜素的测量提高精度的方法的样品中骨膜素的试剂，和检测的肺纤维化或以提高的精度间质性肺炎的方法。本发明的抗体结合选自下组的EMI区域与区域R1到R2区域的选择的至少一个区域，以及骨膜素的R3区或其裂解产物。该方法和用于测量的骨膜素的试剂以及在本发明的骨膜素的测量精度提高的方法是通过检测选自一个EMI区域的其中R1区域，其中R 2区域，以及R3中的至少一种为特征的区域骨膜的区域。测试肺纤维化或本发明的间质性肺炎的方法，包括的测量来自受试者，该测量包括检测选自以下的一个中选择的至少一个区域的样品中的量或骨膜素的浓度的步骤） EMI区域，其中R 1区域，其中R 2区域，以及骨膜素的R3区和b）比较来自活体的样品中来自受试者在量或骨膜素的浓度与衍生样品中的骨膜素的量或浓度不从肺纤维化和间质性肺炎。

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