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1. 发明授权

EP2936124B1 METHODS FOR EVALUATING MEDICAL MEASUREMENT CURVES 有权转让
标题翻译： VERFAHREN ZUR BEURTEILUNG MEDISINISCHER MESSKURVEN
公开(公告)号：EP2936124B1
公开(公告)日：2017-03-15
申请号：EP13811932.6
申请日：2013-12-19
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： AIGNER, Simon , CHEMNITIUS, Gabriele , HORN, Carina , LIMBURG, Bernd , OTTENSTEIN, Timo , PETRICH, Wolfgang , PLUM, Markus , RINGEMANN, Christian , SERR, Markus
IPC分类号： G01N21/77 , G01N21/84 , G01N21/27
CPC分类号： G06F19/24 , G01N21/274 , G01N21/77 , G01N21/8483 , G01N33/66 , G01N33/80 , G01N2201/129 , Y10T436/144444

2. 发明公开

EP4060347A1 METHOD FOR SCREENING A SUBJECT FOR THE RISK OF CHRONIC KIDNEY DISEASE AND COMPUTER-IMPLEMENTED METHOD 审中-公开
公开(公告)号：EP4060347A1
公开(公告)日：2022-09-21
申请号：EP21162683.3
申请日：2021-03-15
申请人： F. Hoffmann-La Roche AG , Roche Diabetes Care GmbH
发明人： RINGEMANN, Christian , HUSCHTO, Tony , KÖNIG, Helena
IPC分类号： G01N33/68
摘要： A method for screening a subject for the risk of chronic kidney disease (CKD) is provided, the method comprising: receiving marker data indicative for a plurality of marker parameters for a subject, such plurality of marker parameters indicating at least an age value, a time since diagnosis value indicative of a time since a diabetes diagnosis for the subject, a sample level of creatinine, an estimated glomerular filtration rate, a sample level of albumin, and a sample level of blood urea nitrogen; and determining a risk factor indicative of the risk of suffering CKD for the subject from the plurality of marker parameters. Further, a computer-implemented method for screening a subject for the risk of CKD is provided. Also, a system comprising a processor and a non-transitory memory storing a program causing the processor to perform the method for screening a subject for the risk of CKD is provided. In another aspect, a computer program product comprising instructions which, when the program is executed by a computer, cause the computer to carry out the method for screening a subject for the risk of CKD is provided.

3. 发明公开

EP3913640A1 METHOD AND SYSTEM FOR GENERATING A SOFTWARE-IMPLEMENTED MODULE FOR DETERMINING AN ANALYTE VALUE, COMPUTER PROGRAM PRODUCT, AND METHOD AND SYSTEM FOR DETERMINING AN ANALYTE VALUE 审中-实审转让
公开(公告)号：EP3913640A1
公开(公告)日：2021-11-24
申请号：EP20175348.0
申请日：2020-05-19
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG , International Business Machines Corporation
发明人： HUSCHTO, Tony , RINGEMANN, Christian , KLOPFENSTEIN, Yannick , BÜSSER, Alexander , RINDERKNECHT, Mike , MESTERHAZY, David , BECKA, Larissa
IPC分类号： G16H50/20 , G16H50/50
摘要： A method is disclosed for generating a software-implemented module for determining an analyte value, comprising, in an arrangement of one or more data processors: providing a first set of input data indicative of first values measured for a plurality of input parameters, the input parameters comprising a first and a second input parameter; and providing a second set of input data indicative of second values for the plurality of input parameters, the second values comprising an augmented value for at least one input parameter from the plurality of input parameters, the augmented value being different from the first value measured for the at least one input parameter and determined by augmenting the first value; and the first value for at least one remaining input parameter from the plurality of input parameters. The method further comprises: determining first analyte data indicative of a first plurality of analyte values for an analyte by processing the first set of input data by a physiological model; determining second analyte data indicative of a second plurality of analyte values for the analyte by processing the second set of input data by the physiological model; determining a set of training data from both the first analyte data and the second analyte data; determining a set of test data, the set test data being different from the set training data; providing a software-implemented machine learning model configured to determine an analyte value for the analyte; training the software-implemented machine learning model by the set of training data; and testing the software-implemented machine learning model by the set of test data. Furthermore, a system for generating a software-implemented module for determining an analyte value, a computer program product for generating a software-implemented module for determining an analyte value, a method for determining an analyte value, and a system for determining an analyte value are provided.

4. 发明授权

EP2976643B1 METHOD / DEVICE FOR GENERATING A CORRECTED VALUE OF AN ANALYTE CONCENTRATION IN A SAMPLE OF A BODY FLUID 有权转让
公开(公告)号：EP2976643B1
公开(公告)日：2019-06-05
申请号：EP14710588.6
申请日：2014-03-18
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： HOENES, Joachim , RINGEMANN, Christian , WELLER, Andreas
IPC分类号： G01N33/543

5. 发明公开

EP3327598A1 A SYSTEM AND A METHOD FOR AUTOMATICALLY ANALYZING CONTINUOUS GLUCOSE MONITORING DATA INDICATIVE OF GLUCOSE LEVEL IN A BODILY FLUID 审中-公开
公开(公告)号：EP3327598A1
公开(公告)日：2018-05-30
申请号：EP16200766.0
申请日：2016-11-25
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： RINGEMANN, Christian
IPC分类号： G06F19/00
CPC分类号： G16H50/70 , G16H20/13 , G16H20/60 , G16H40/63 , G16H50/20
摘要： The disclosure relates to a system for automatically analyzing continuous glucose monitoring data indicative of a glucose level in a bodily fluid, the system comprising an input device (3), a data processing device (1), an output device (4), and machine readable instructions that are executed by the data processing device (1), wherein the machine readable instructions cause the data processing device (1) to receive continuous glucose monitoring data via the input device (3), receive personal behavioral data, the personal behavioral data representing one or more behavioral parameters and, for the one or more behavioral parameters, indicating sensor signals sampled over time for the person; determine a plurality of glucose profiles from the continuous glucose monitoring data; cluster the plurality of glucose profiles into clustered groups; assign a selected behavioral parameter or a selected pattern of behavioral parameters from the one or more behavioral parameters to each glucose profile in a first clustered group, and provide analysis data to the output device. Further, a method and a computer program product are disclosed

6. 发明公开

EP3242233A1 SENSOR DEVICE FOR DETECTING AT LEAST ONE ANALYTE IN A BODY FLUID OF A USER 有权
标题翻译：用于检测用户身体流体中的至少一个分析物的传感器装置
公开(公告)号：EP3242233A1
公开(公告)日：2017-11-08
申请号：EP16168149.9
申请日：2016-05-03
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： RINGEMANN, Christian , STEIGER, Bernd
IPC分类号： G06F19/00
CPC分类号： G16H10/40 , G06F19/00 , G16H40/63
摘要： A sensor device (112) for detecting at least one analyte in a body fluid of a user is disclosed. The sensor device (112) comprises at least one evaluation device (134) configured for evaluating a data stream of time-dependent concentrations c of the analyte. The evaluation device (134) comprises at least one comparator device (140) configured for comparing a current value c(t) of the concentration c with at least one first threshold value L and with at least one second threshold value H, with H > L. The evaluation device (134) is configured to define a tolerance time interval (158). Further, the evaluation device (134), by using the comparator device (140), is configured to detect if the concentration c rises and exceeds the first threshold value L during the tolerance time interval (158) and to prepare a warning signal W accordingly. The evaluation device (134) is configured to suppress an output of the warning signal W at least until the tolerance time interval (158) expires, under the precondition that c(t)
摘要翻译：公开了一种用于检测用户的体液中的至少一种分析物的传感器装置（112）。传感器装置（112）包括至少一个评估装置（134），其被配置用于评估分析物的时间依赖性浓度c的数据流。评估装置（134）包括至少一个比较器装置（140），其被配置用于将浓度c的当前值c（t）与至少一个第一阈值L和至少一个第二阈值H进行比较，H> L.评估装置（134）被配置成限定公差时间间隔（158）。此外，通过使用比较装置（140），评估装置（134）被配置为检测浓度c是否在公差时间间隔（158）期间上升并超过第一阈值L并相应地准备警告信号W 。评估装置（134）被配置为在公差时间间隔（158）期间c（t）

7. 发明授权

EP3380839B1 METHOD AND APPARATUS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A BODY FLUID 有权
公开(公告)号：EP3380839B1
公开(公告)日：2019-11-06
申请号：EP16800918.1
申请日：2016-11-21
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： IBACH, Alexander , RINGEMANN, Christian , STEPHAN, Peter
IPC分类号： G01N21/84 , G01N21/78 , C12Q1/00

8. 发明授权

EP2936155B1 METHOD FOR ANALYZING A SAMPLE OF A BODY FLUID 有权转让
公开(公告)号：EP2936155B1
公开(公告)日：2018-12-12
申请号：EP13811219.8
申请日：2013-12-19
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： RINGEMANN, Christian , PLUM, Markus , PETRICH, Wolfgang , OTTENSTEIN, Timo
IPC分类号： G01N33/557 , C12Q1/54 , G01N33/66 , G01N21/88 , G01N21/27 , G06F19/00
CPC分类号： G01N21/8483 , C12Q1/54 , G01N21/274 , G01N33/66 , G01N2201/12 , G01N2201/129 , G06F19/707
摘要： Methods are provided for deriving/determining an analyte concentration that include recording measurement values during a time development indicating a progress of a detection reaction of at least one test substance and a body fluid sample and providing at least one measurement curve F(t) containing the measurement values, where the detection reaction is known to be influenced by the analyte concentration and at least one disturbance variable Y. The methods also include deriving an end value of the measurement curve to form a first variable x1, and deriving at least one fit parameter by taking into account an exponential characteristic of the measurement curve, and where the fit parameter forms at least one second variable x2. The methods further include deriving/determining the analyte concentration by using at least one multivariate evaluation algorithm adapted to combine x1 and x2. Also provided are computer programs and devices that incorporate the same.

9. 发明公开

EP3236851A1 METHOD AND SYSTEM FOR DETERMINING A BLOOD GLUCOSE LEVEL FOR A PATIENT 有权
标题翻译：确定患者血糖水平的方法和系统
公开(公告)号：EP3236851A1
公开(公告)日：2017-11-01
申请号：EP15808629.8
申请日：2015-12-14
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： SCHMELZEISEN-REDEKER, Günther , SCHMITT, Nikolaus , RINGEMANN, Christian
IPC分类号： A61B5/1486 , A61B5/1495 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/1451 , A61B5/1473 , A61B5/1495 , A61B5/4839 , A61B5/6801 , A61B5/7221 , A61B5/742 , A61M5/14244 , A61M5/1723 , G16H40/63 , G16H50/50
摘要： The present disclosure refers to a method for determining a blood glucose level for a patient, the method comprising detecting a present sensor signal in a present continuous interstitial blood glucose measurement for a patient; providing measurement data representing the present sensor signal; providing sensor signal correction data representing a patient-specific signal correction, the sensor signal correction data being determined from a former interstitial blood glucose measurement for the patient and comprising at least one of time delay data representing a patient-specific time delay Δt between a blood glucose value measured in a continuous interstitial blood glucose measurement and a blood glucose reference value measured in a capillary blood glucose measurement, and sensor sensitivity data representing, for the patient, a patient-specific sensor sensitivity for the sensor, determining corrected measurement data representing a corrected present sensor signal by applying the sensor signal correction data to the present sensor signal; and determining a blood glucose level for the patient from the corrected measurement data.
摘要翻译：本公开涉及一种用于确定患者的血糖水平的方法，该方法包括：在用于确定患者的血糖水平的系统中，检测患者的当前连续间质血糖测量中的当前传感器信号 ; 提供表示当前传感器信号的测量数据; 提供代表患者特定患者信号校正的传感器信号校正数据，所述传感器信号校正数据根据患者的前间质血糖测量值确定，并且包括时间延迟数据中的至少一个，所述时间延迟数据代表患者，患者特定的时间延迟在连续间质血糖测量中测量的血糖值与毛细血管血糖测量中测量的血糖参考值之间，血糖值和血糖参考值参考相同的血糖为患者表示针对患者的患者特异性传感器信号偏移的传感器偏移数据，以及表示针对患者的患者特定传感器灵敏度的传感器灵敏度数据，确定表示校正的当前传感器信号的校正测量数据通过将传感器信号校正数据应用于当前传感器信号; 以及从校正的测量数据确定患者的血糖水平。此外，提供了用于确定患者的血糖水平的系统。

10. 发明授权

EP3236851B1 METHOD AND SYSTEM FOR DETERMINING A BLOOD GLUCOSE LEVEL FOR A PATIENT 有权
公开(公告)号：EP3236851B1
公开(公告)日：2019-07-17
申请号：EP15808629.8
申请日：2015-12-14
申请人： Roche Diabetes Care GmbH , F. Hoffmann-La Roche AG
发明人： SCHMELZEISEN-REDEKER, Günther , SCHMITT, Nikolaus , RINGEMANN, Christian
IPC分类号： A61B5/1486 , A61B5/1495 , G16H10/00

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