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2. 发明公开

EP4267608A1 METHODS FOR OBTAINING ANTIBODIES THAT BIND TRANSMEMBRANE PROTEINS AND CELLS THAT PRODUCE THE SAME 审中-实审
公开(公告)号：EP4267608A1
公开(公告)日：2023-11-01
申请号：EP21847855.0
申请日：2021-12-22
申请人： REGENERON PHARMACEUTICALS, INC.
发明人： CHEN, Gang , SHI, Ergang , LEE, Wen-Yi , SUH, David , FARR, Glen , BABB, Robert
IPC分类号： C07K16/00 , C07K16/18 , C07K16/28 , G01N33/68

3. 发明公开

EP3901274A1 EFFICIENT SELECTIVITY OF RECOMBINANT PROTEINS 审中-公开
公开(公告)号：EP3901274A1
公开(公告)日：2021-10-27
申请号：EP20211902.0
申请日：2015-08-19
申请人： Regeneron Pharmaceuticals, Inc.
发明人： DESHPANDE, Dipali , BURAKOV, Darya , CHEN, Gang , FANDL, James
IPC分类号： C12P21/06 , C12N15/00 , C12P21/00 , C12N15/85
摘要： The invention provides a new expression system comprising a mammalian selectable marker (tunicamycin-resistant UDP-N-acetylglucosamine: dolichol phosphateN-acetylglucosamine-1-P transferase) that promotes desirable post-translational modifications of glycoproteins. In particular, the invention includes methods and compositions for optimal recombinant protein expression in mammalian cells by employing a selection marker system based on GPT genes of mammalian origin. The invention includes methods that facilitate selectivity and enhanced expression copies as well as protein yield of recombinant proteins in mammalian cells, and methods of using GPT expression systems.

4. 发明公开

EP3870602A1 NY-ESO-1 T CELL RECEPTORS AND METHODS OF USE THEREOF 审中-实审
公开(公告)号：EP3870602A1
公开(公告)日：2021-09-01
申请号：EP19804919.9
申请日：2019-10-23
申请人： Regeneron Pharmaceuticals, Inc.
发明人： BABB, Robert , BOWERMAN, Natalie , CHEN, Gang , GURER, Cagan , HANSEN, Johanna , LEE, Wen-Yi , MEAGHER, Thomas , SUH, David
IPC分类号： C07K14/725

5. 发明公开

EP3504328A1 HOST CELL PROTEIN MODIFICATION 审中-公开
公开(公告)号：EP3504328A1
公开(公告)日：2019-07-03
申请号：EP17798018.2
申请日：2017-08-24
申请人： Regeneron Pharmaceuticals, Inc.
发明人： CHEN, Gang , LI, Ning , GOREN, Michael , BURAKOV, Darya , LI, Chen
IPC分类号： C12N9/20 , C12N9/18 , C12N9/80 , C07K16/00

6. 发明公开

EP3279326A1 FUCOSYLATION-DEFICIENT CELLS 有权
标题翻译：未成纤维细胞
公开(公告)号：EP3279326A1
公开(公告)日：2018-02-07
申请号：EP17192430.1
申请日：2010-06-01
申请人： Regeneron Pharmaceuticals, Inc.
发明人： CHEN, Gang , BURAKOV, Darya , FANDL, James, P
IPC分类号： C12N15/53 , C12N9/04 , C12N5/10 , C12P21/00 , C07K16/00
CPC分类号： C12P21/005 , C07K16/00 , C07K16/2863 , C07K16/2866 , C07K2317/14 , C07K2317/41 , C12N9/0006 , C12N15/00 , C12Y101/01271 , Y02P20/52
摘要： An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a combination thereof is provided. Cells having a gene encoding a modified FX protein are provided, wherein the cells exhibit a reduced ability to fucosylate a glycoprotein at a first temperature, but exhibit the ability to fucosylate the glycoprotein at a second temperature. Methods and compositions for making glycoproteins with reduced fucosylation are provided.
摘要翻译：提供了编码FX蛋白的分离的核酸，其具有79位的丝氨酸，90位的赖氨酸，136位的亮氨酸，211位的精氨酸，289位的丝氨酸及其组合。提供了具有编码修饰的FX蛋白的基因的细胞，其中所述细胞在第一温度表现出降低糖蛋白岩藻糖基化的能力，但表现出在第二温度下糖基化糖蛋白的能力。提供了用于制备具有降低的岩藻糖基化的糖蛋白的方法和组合物。

7. 发明公开

EP2920208A2 RECOMBINANT CELL SURFACE CAPTURE PROTEINS 有权
标题翻译：重组细胞表面捕获蛋白
公开(公告)号：EP2920208A2
公开(公告)日：2015-09-23
申请号：EP13798483.7
申请日：2013-11-14
申请人： Regeneron Pharmaceuticals, Inc.
发明人： DESHPANDE, Dipali , CHEN, Gang , BURAKOV, Darya , FANDL, James , ALDRICH, Thomas , KAMAT, Vishal
IPC分类号： C07K16/18 , C07K16/42 , C12N15/10
摘要： Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Methods for detecting and isolating cells expressing heterodimeric proteins are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).
摘要翻译：提供了用于分离和检测产生具有免疫球蛋白CH3结构域和/或取代CH3结构域的分泌型异源二聚体蛋白质（POI）的细胞的重组细胞表面捕获蛋白和检测分子。还提供了分离和检测双特异性抗体的重组细胞表面捕获蛋白和检测分子。本发明还提供能够识别和结合包含CH3结构域和/或修饰的CH3结构域的感兴趣的蛋白质的重组抗原结合蛋白，所述CH3结构域例如在H95和Y96处具有或不具有氨基酸取代的CH3结构域（IMGT ）。

8. 发明公开

EP2516466A2 HUMAN ANTIBODIES TO HUMAN ANGIOPOIETIN-LIKE PROTEIN 4 有权
标题翻译：的人抗体ANGIOPOIETINÄHNLICHES蛋白4
公开(公告)号：EP2516466A2
公开(公告)日：2012-10-31
申请号：EP10798240.7
申请日：2010-12-23
申请人： Regeneron Pharmaceuticals, Inc.
发明人： SLEEMAN, W., Mark , GUSAROVA, Viktoria , KIM, Jee, H. , CHEN, Gang
IPC分类号： C07K16/22
CPC分类号： C07K16/26 , A61K31/216 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/567 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： A fully human antibody or antigen -binding fragment of a human antibody that specifically binds and inhibits human angiopoietin - like protein 4 (hANGPTL4) is provided. The human anti- hANGPTL4 antibodies are useful in treating diseases or disorders associated with ANGPTL4, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti -hANGPTL4 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases; acute pancreatitis; nonalcoholic steatohepatitis (NASH); diabetes; obesity.

9. 发明公开

EP4453942A2 OFF-TARGET PREDICTION METHOD FOR ANTIGEN-RECOGNITION MOLECULES BINDING TO MHC-PEPTIDE TARGETS 失效
公开(公告)号：EP4453942A2
公开(公告)日：2024-10-30
申请号：EP22854692.5
申请日：2022-12-20
申请人： Regeneron Pharmaceuticals, Inc.
发明人： DHANIK, Ankur , KUNDU, Kunal , LEE, Wen-Yi , SUH, David , CHEN, Gang , SALZLER, Robert , BABB, Robert
IPC分类号： G16B15/00 , G01N33/50
CPC分类号： G16B15/00 , G16B35/20 , G01N33/6878 , G01N33/56977 , G01N2333/7053920130101

10. 发明公开

EP4419691A1 CONTROLLED TRANSCRIPTION OF POLYNUCLEOTIDES 审中-实审
公开(公告)号：EP4419691A1
公开(公告)日：2024-08-28
申请号：EP22818153.3
申请日：2022-10-18
申请人： Regeneron Pharmaceuticals, Inc.
发明人： ZHAO, Yu , BURAKOV, Darya , CHEN, Gang
IPC分类号： C12N15/63 , C12N15/85
CPC分类号： C12N15/63 , C12N15/85 , C12N2830/0020130101 , C12N2830/1520130101 , C12N15/635 , C12N2830/00320130101 , C12N2750/1412220130101

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