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1. 发明公开

EP2654939A2 SPRAY DRYING TECHNIQUES 审中-公开
标题翻译：喷雾干燥工艺
公开(公告)号：EP2654939A2
公开(公告)日：2013-10-30
申请号：EP11813839.5
申请日：2011-12-20
申请人： President and Fellows of Harvard College , BASF SE
发明人： ABATE, Adam, R. , THIELE, Julian, W.P. , WEITZ, David, A. , WINDBERGS, Maike , HOLTZE, Christian
IPC分类号： B01J2/04 , B05B7/04
CPC分类号： B01D1/18 , A61K31/58 , F26B3/12
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfiuidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.

2. 发明公开

EP2750787A2 SYSTEMS AND METHODS FOR SHELL ENCAPSULATION 审中-公开
标题翻译：用于壳体封装的系统和方法
公开(公告)号：EP2750787A2
公开(公告)日：2014-07-09
申请号：EP12751233.3
申请日：2012-08-15
申请人： President and Fellows of Harvard College , BASF SE
发明人： WEITZ, David, A. , SHUM, Ho, Cheung , ZHAO, Yuanjin , SUN, Bingjie , HOLTZE, Christian
IPC分类号： B01J13/20
CPC分类号： B01J13/203 , A01N25/28 , A23L29/015 , A23P10/30 , A61K9/501 , A61K9/5036 , A61K9/5089 , C09B67/0097 , C11D17/0039 , A01N59/02 , A01N59/06 , A01N59/16
摘要： The present invention generally relates to particles, including particles for drug delivery and other applications. Certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to enhance the containment of the interior, for example to reduce transport of an agent into or out of the interior. Such particles may exhibit increased ability to encapsulate agents and/or increased storage life (e.g., due to reduced leakage). For instance, in certain embodiments, any defects, such as cracks, pores, etc. within the shell may be sealed or otherwise treated to reduce transport therethrough, for example, with a solid. In some embodiments, for instance, a first reactant in the interior of a particle may come into contact with a second reactant outside of the particle to form a solid, or other suitable product. The shell may also be treated, e.g., at a later point in time, to cause release of an agent contained within the interior, in certain aspects. For example, the shell may be heated to cause the release of the agent from the particle, or the shell may be exposed to chemical or enzymatic degradation, or a change in osmolarity, to cause release of an agent. Still other aspects of the present invention are generally directed to methods of making or using such particles, kits or devices including such particles, or the like.
摘要翻译：本发明一般涉及颗粒，包括用于药物递送和其他应用的颗粒。本发明的某些方面通常涉及包含壳和至少部分由壳包含的内部的颗粒。在一些实施方案中，可对颗粒进行处理以增强内部的容纳，例如以减少试剂进入或离开内部的运输。这样的颗粒可以表现出增加的包封剂的能力和/或增加的存储寿命（例如，由于泄漏降低）。例如，在某些实施例中，壳体内的任何缺陷（例如裂纹，孔隙等）可被密封或以其他方式处理以减少通过其中的运输，例如用固体。在一些实施例中，例如，颗粒内部的第一反应物可以与颗粒外部的第二反应物接触以形成固体或其他合适的产物。在某些方面，壳还可以例如在稍后的时间点被处理，以引起包含在内部内的试剂的释放。例如，壳可以被加热以引起药剂从颗粒中释放，或壳可以暴露于化学或酶降解或渗透压变化，以引起药剂的释放。本发明的其他方面通常涉及制造或使用这种颗粒，包括这种颗粒的试剂盒或装置等的方法。

3. 发明公开

EP2608772A2 PARTICLES FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：用颗粒释放活性和其他应用程序
公开(公告)号：EP2608772A2
公开(公告)日：2013-07-03
申请号：EP11749695.0
申请日：2011-08-23
申请人： President and Fellows of Harvard College , BASF SE
发明人： FAN, Ben , KOLTZENBURG, Roland, S. , RIEGER, Jens, B. , WEITZ, David, A.
IPC分类号： A61K9/14 , A61K9/16 , A61K31/565 , A61K31/58
CPC分类号： A61K9/143 , A61K9/1694 , A61K31/565 , A61K31/58
摘要： The present invention generally relates to particles for drug delivery and other applications. In one aspect, the present invention relates to a technique for reacting precursor compounds in the presence of a pharmaceutically- active agent to form product (e.g., in the form of particles) in which the agent is substantially contained within the product, and the product is soluble within typical gastric fluid of a mammal. In another aspect, the present invention is generally directed to particles comprising an inorganic pharmaceutically acceptable carrier, such as CaCO
3 , and an agent. In some cases, at least some of the agent contained within the particles is fluidically inaccessible from externally of the particle. For instance, the agent may be present in isolated domains within the particle. In another aspect, the present invention is generally directed to methods of creating particles. For instance, according to one set of embodiments, two fluids containing reactants are mixed where, upon reaction of the reactants, an insoluble product is formed, which precipitates to form particles. In one example, a first fluid containing dissolved carbonate ions and a second fluid containing dissolved calcium ions and a pharmaceutically- active agent are mixed together; upon mixing of the first and second fluids, the calcium ions and the carbonate ions form calcium carbonate, which precipitates to form a co-precipitate with the pharmaceutically- active agent. Yet other aspects of the present invention are directed to particles formed from such reactions, methods of using such reactions, methods of promoting such reactions, kits involving particles, or the like.

4. 发明公开

EP2547436A2 MELT EMULSIFICATION 审中-公开
标题翻译：融乳化
公开(公告)号：EP2547436A2
公开(公告)日：2013-01-23
申请号：EP11716682.7
申请日：2011-03-17
申请人： President and Fellows of Harvard College , BASF SE
发明人： SHUM, Ho, Cheung , SUN, Bingjie , WEITZ, David, A. , HOLTZE, Christian
IPC分类号： B01J13/00 , B01J13/04 , A01N25/28 , A61K9/50 , C09B67/00 , C11D3/50 , C11D17/00
CPC分类号： B01J13/0086 , B01F3/0807 , B01F13/0062 , B01F2005/0034 , B01J13/04 , C09B67/0009 , C09B67/0097 , G01N2015/1413
摘要： The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.

5. 发明公开

EP2897719A2 SYSTEMS AND METHODS FOR SPRAY DRYING IN MICROFLUIDIC AND OTHER SYSTEMS 审中-公开
标题翻译：系统和方法在微流控等系统喷雾干燥
公开(公告)号：EP2897719A2
公开(公告)日：2015-07-29
申请号：EP13774283.9
申请日：2013-09-19
申请人： President and Fellows of Harvard College , BASF SE
发明人： AMSTAD, Esther , HOLTZE, Christian , WEITZ, David, A.
IPC分类号： B01J2/02
CPC分类号： B01D1/20 , B01J2/02 , B01J2/04 , F26B3/12
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. By at least partially drying fluids within a microfluidic channel, instead of or in addition to conventional spray drying techniques, better control of the drying process can be achieved in certain aspects of the invention. In addition, various embodiments of the invention are generally directed to systems and methods for drying fluids contained within a channel such as a microfluidic channel. For example, a fluid may be partially or completely dried within a microfluidic channel, prior to being sprayed into a collection region. In some embodiments, gases such as air may be directed into a channel containing a fluid, which may facilitate drying of the fluid. In some cases, the fluid may be accelerated due to the introduction of gases into the channel, and in certain embodiments, droplets of fluid may be disrupted to form smaller droplets as a result. In certain cases, the fluids may also be dried to form supersaturated droplets.

6. 发明公开

EP2571491A2 FOAMS, INCLUDING MICROCELLULAR FOAMS, CONTAINING COLLOIDAL PARTICULATES 审中-公开
标题翻译：与胶粒微孔发泡泡沫
公开(公告)号：EP2571491A2
公开(公告)日：2013-03-27
申请号：EP11726537.1
申请日：2011-05-20
申请人： President and Fellows of Harvard College , BASF SE
发明人： LADAVAC, Kosta , GUERRA, Rodrigo, E. , KAZ, David , MANOHARAN, Vinothan , RIEGER, Jens, B. , KOLTZENBURG, Roland, Sebastian , WEITZ, David, A.
IPC分类号： A61K9/12 , A61K9/14 , A61K9/51
CPC分类号： A61K9/122 , A61K9/143 , A61K9/146 , A61K9/5115
摘要： The present invention generally relates to foams and particles made from such foams, for applications such as drug delivery. The foams or particles may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foams may include colloidal particulates. A first aspect of the present invention is generally related to polymer-based foams or particles containing pharmaceutically active agents. In some cases, the foam or particle may contain smaller colloidal particulates therein. Such colloidal particulates may be used, for example, to limit the amount of material within certain regions of the foam, or exclude pharmaceutically active agents from being located within certain portions of the foam, which may useful for enhancing release of pharmaceutically active agents from the foam. In some cases, the colloidal particulates may cause the foam or particle to have an unexpectedly high specific surface area. The foam, in certain embodiments, can exhibit a relatively high loading of the pharmaceutically active agent. The foam may be microcellular in certain instances. The foam may also be created using a supercritical fluid, for example, supercritical C0
2 . For instance, a precursor to the foam, containing a pharmaceutically active agent, a pharmaceutically acceptable polymeric carrier, and colloidal particulates, can be mixed with a foaming agent. The pressure may then be decreased, thereby causing the foaming agent to expand and causing a foam to form. The foam may also be ground or milled, or otherwise processed, to form particles such as nanoparticles.

7. 发明公开

EP2571490A2 FOAM OR PARTICLES FOR APPLICATIONS SUCH AS DRUG DELIVERY 审中-公开
标题翻译：泡沫或颗粒的应用，如-RELEASE
公开(公告)号：EP2571490A2
公开(公告)日：2013-03-27
申请号：EP11726001.8
申请日：2011-05-20
申请人： President and Fellows of Harvard College , BASF SE
发明人： LADAVAC, Kosta , GUERRA, Rodrigo, E. , KAZ, David , MANOHARAN, Vinotham , RIEGER, Jens, B. , KOLTZENBURG, Roland, Sebastian , WEITZ, David, A.
IPC分类号： A61K9/12 , A61K47/32 , A61K9/14
CPC分类号： A61K9/122 , A61K9/146 , A61K47/32
摘要： The present invention generally relates to foams and, in particular, to foams for applications such as drug delivery, and particles that are made from such foams. One aspect relates to foams or particles containing pharmaceutically active agents. The foam may comprise a pharmaceutically acceptable polymeric carrier. In some cases, the foam or particle has an unexpectedly high specific surface area. A high specific surface area may, in some cases, facilitate delivery or release of the pharmaceutically active agent when the foam or particles made from the foam (e.g., by milling) are administered to a subject. The foam may also exhibit a relatively high loading of the pharmaceutically active agent. In some cases, the foam may be a microcellular foam. In one set of embodiments, the foam is created using a supercritical fluid, such as supercritical C02. For example, a precursor to the foam, containing a pharmaceutically active agent, may be mixed with a foaming agent, then the pressure decreased to cause the foaming agent to expand, thereby causing a foam to form. The foam may then be subsequently ground or milled, or otherwise processed to form particles.

8. 发明公开

EP2405999A2 SYSTEMS AND METHODS OF TEMPLATING USING PARTICLES SUCH AS COLLOIDAL PARTICLES 审中-公开
标题翻译： TEMPLATIERSYSTEME和过程中使用粒子如何胶粒
公开(公告)号：EP2405999A2
公开(公告)日：2012-01-18
申请号：EP10712186.5
申请日：2010-03-12
申请人： President and Fellows of Harvard College , BASF SE
发明人： WEITZ, David, A. , KOLTZENBURG, Roland, S. , RIEGER, Jens, B. , STUDART, Andre, R. , WILKING, James, N.
IPC分类号： B01J2/22 , B01J2/08
CPC分类号： B01J2/22 , B01J2/08 , Y10T428/249954
摘要： The present invention generally relates to systems and methods for using particle templating, e.g., to produce composites, discrete particles, or the like. In some embodiments, the present invention generally relates to the production of particles using the interstitial spaces between templating elements in a template structure. For example, a plurality of templating elements, which can include colloidal particles, may be arranged to form a template structure. The interstices of the templating elements can provide regions in which a fluid may be introduced. The fluid may be hardened (e.g., solidified) in some cases, e.g., to form a composite comprising the templating elements and the interstitial segments. In certain embodiments, the template structure may then be broken down to release the hardened fluid, e.g., as a plurality of discrete particles.

9. 发明公开

EP2473262A2 MULTIPLE EMULSIONS CREATED USING JUNCTIONS 审中-公开
标题翻译：几种化合物生产的乳液
公开(公告)号：EP2473262A2
公开(公告)日：2012-07-11
申请号：EP10814398.3
申请日：2010-09-01
申请人： President and Fellows of Harvard College , BASF SE
发明人： WEITZ, David, A. , ROMANOWSKY, Mark , HOLTZE, Christian
IPC分类号： B01F5/00 , B01F3/08 , B01F15/04
CPC分类号： B01F13/0084 , B01F3/0807 , B01F2003/0838 , Y10T137/0318 , Y10T137/87571
摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed using a plurality of channels, such as microfluidic channels, that meet at a common intersection. The multiple emulsions may be created at a single common intersection in some embodiments, unlike other prior art systems where multiple channel intersections are required to create multiple emulsions. For instance, in one set of embodiments, three, four, or more microfluidic channels may intersect at a common intersection, with two or three serving as inlets and one serving as the outlet. In some embodiments, a first fluidic channel may be relatively hydrophobic, while a second fluidic channel is relatively hydrophilic. The third channel, if present, may be relatively hydrophilic or hydrophobic, depending on the application. The outlet channel may be hydrophobic, hydrophilic, or may comprise at least one portion that is relatively hydrophilic and at least one portion that is relatively hydrophilic. By controlling the flow of fluids through the hydrophilic and hydrophobic portions of the channels, multiple emulsions may be created proximate the common intersection, due to interactions between the fluids entering the common intersection. In other embodiments, different patterns of hydrophilic or hydrophobic channels may be used. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.

10. 发明公开

EP4090740A1 DEVICES AND METHODS FOR DETERMINING NUCLEIC ACIDS USING DIGITAL DROPLET PCR AND RELATED TECHNIQUES 审中-实审
公开(公告)号：EP4090740A1
公开(公告)日：2022-11-23
申请号：EP21741543.9
申请日：2021-01-13
申请人： President and Fellows of Harvard College
发明人： WEITZ, David, A. , ZHANG, Huidan
IPC分类号： C12N15/09 , C12N15/10 , C12Q1/68 , C12Q1/6806 , C12Q1/6809 , C12Q1/6834

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