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1. 发明公开

EP1477184A3 Neospora vaccine 审中-公开
标题翻译：新孢子虫疫苗
公开(公告)号：EP1477184A3
公开(公告)日：2006-04-12
申请号：EP04019906.9
申请日：1998-08-12
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Campos, Manuel
IPC分类号： A61K39/002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides a vaccine to protect a mammal against neosporosis comprising an immunologically effective amount of an homoganate prepared from cells of Neospora which is capable of inducing a protective response against neosporosis in a mammal, and a veterinarily acceptable carrier; wherein the Neospora cells from which the homogenate is prepared have been modified to delete the expression of one or more antigenic components normally associated with Neospora cells or a homogenate prepared therefrom; and antibodies specific to antigenic components present in homoganates of Neospora cells.

2. 发明公开

EP0898969A3 Neospora vaccine 无效
标题翻译：新孢子虫疫苗
公开(公告)号：EP0898969A3
公开(公告)日：2001-02-07
申请号：EP98306431.2
申请日：1998-08-12
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Campos, Manuel
IPC分类号： A61K39/002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides an homogenate prepared from cells of Neospora , and vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.

3. 发明授权

EP1035133B1 Fusion proteins comprising carriers that can induce a dual immune response 有权
标题翻译：诱导的载体的双重免疫应答的融合蛋白
公开(公告)号：EP1035133B1
公开(公告)日：2005-01-05
申请号：EP00301103.8
申请日：2000-02-14
申请人： Pfizer Products Inc.
发明人： Campos, Manuel , Martinod, Serge Rene , Durtschi, Becky Ann , Yule, Terecita Dolores
IPC分类号： C07K19/00 , C12N15/62 , C12N15/70 , C12N15/79 , A61K39/385 , A61K39/00 , A61K39/245
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0006 , C07K7/23 , C07K16/26 , C07K19/00 , C07K2319/00 , C12N2710/16722

4. 发明公开

EP0898969A2 Neospora vaccine 无效
标题翻译：新生儿暴发
公开(公告)号：EP0898969A2
公开(公告)日：1999-03-03
申请号：EP98306431.2
申请日：1998-08-12
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Campos, Manuel
IPC分类号： A61K39/002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides an homogenate prepared from cells of Neospora , and vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.
摘要翻译：本发明提供由新孢子虫细胞制备的匀浆，以及由其制备的针对新孢子虫病的疫苗，其可用于预防哺乳动物的临床疾病和流产。

5. 发明公开

EP1477184A2 Neospora vaccine 审中-公开
标题翻译：新生儿暴发
公开(公告)号：EP1477184A2
公开(公告)日：2004-11-17
申请号：EP04019906.9
申请日：1998-08-12
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Campos, Manuel
IPC分类号： A61K39/002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides a vaccine to protect a mammal against neosporosis comprising an immunologically effective amount of an homoganate prepared from cells of Neospora which is capable of inducing a protective response against neosporosis in a mammal, and a veterinarily acceptable carrier; wherein the Neospora cells from which the homogenate is prepared have been modified to delete the expression of one or more antigenic components normally associated with Neospora cells or a homogenate prepared therefrom; and antibodies specific to antigenic components present in homoganates of Neospora cells.
摘要翻译：本发明提供一种用于保护哺乳动物免受新孢子虫病的疫苗，其包含免疫有效量的由新生孢子细胞制备的能够在哺乳动物中诱导针对新孢子虫病的保护性反应的同源物和兽医学上可接受的载体; 其中制备匀浆的新孢子虫细胞已被修饰以删除通常与新孢子虫细胞或由其制备的匀浆相关的一种或多种抗原成分的表达; 以及存在于新孢子虫细胞的同源物中的抗原成分的抗体。

6. 发明授权

EP0898969B1 Neospora vaccine 无效
标题翻译：新生儿暴发
公开(公告)号：EP0898969B1
公开(公告)日：2004-09-29
申请号：EP98306431.2
申请日：1998-08-12
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Campos, Manuel
IPC分类号： A61K39/002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides a vaccine to protect a mammal against neosporosis comprising an immunologically effective amount of an homoganate prepared from cells of Neospora which is capable of inducing a protective response against neosporosis in a mammal, and a veterinarily acceptable carrier; wherein the Neospora cells from which the homogenate is prepared have been modified to delete the expression of one or more antigenic components normally associated with Neospora cells or a homogenate prepared therefrom; and antibodies specific to antigenic components present in homoganates of Neospora cells.

7. 发明公开

EP1035133A3 Fusion proteins comprising carriers that can induce a dual immune response 有权
标题翻译：诱导的载体的双重免疫应答的融合蛋白
公开(公告)号：EP1035133A3
公开(公告)日：2002-09-25
申请号：EP00301103.8
申请日：2000-02-14
申请人： Pfizer Products Inc.
发明人： Campos, Manuel , Martinod, Serge Rene , Durtschi, Becky Ann , Yule, Terecita Dolores
IPC分类号： C07K19/00 , C12N15/62 , C12N15/70 , C12N15/79 , A61K39/385 , A61K39/00 , A61K39/245 , A61P31/22
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0006 , C07K7/23 , C07K16/26 , C07K19/00 , C07K2319/00 , C12N2710/16722
摘要： The subject invention provides a fusion protein for producing a dual immune response in a vertebrate, which fusion protein comprises: (a) a first proteinaceous portion analogous to all or part of a peptide endogenously synthesized within the vertebrate, the activity of which peptide is to be inhibited within the vertebrate, and which proteinaceous portion by itself is incapable of eliciting an effective immunoinhibitory response in said vertebrate; connected to (b) a second proteinaceous portion analogous to all or part of an immunogen from a pathogen, which pathogen is capable of pathogenically infecting the vertebrate; the portion (b) causing the vertebrate's immune system to recognize the portion (a) and produce a response that: (i) inhibits the activity of the peptide endogenously synthesized within the vertebrate; and (ii) protects the vertebrate from infection by the pathogen, when the vertebrate is vaccinated with an effective amount of the fusion protein. The subject invention also provides fusion proteins which comprise a proteinaceous portion (b) that is a carrier that is analogous to all or part of a BHV-1 antigen, which fusion proteins induce in a vertebrate vaccinated with an effective amount of such fusion protein an immune response that inhibits the activity of a peptide as recited in (a), above.

8. 发明公开

EP1035133A2 Fusion proteins comprising carriers that can induce a dual immune response 有权
标题翻译： Fusionsproteine mitTrägernwelche eine doppelte Immunantwort induzieren
公开(公告)号：EP1035133A2
公开(公告)日：2000-09-13
申请号：EP00301103.8
申请日：2000-02-14
申请人： Pfizer Products Inc.
发明人： Campos, Manuel , Martinod, Serge Rene , Durtschi, Becky Ann , Yule, Terecita Dolores
IPC分类号： C07K19/00 , C12N15/62 , C12N15/70 , C12N15/79 , A61K39/385 , A61K39/00 , A61K39/245 , A61P31/22
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0006 , C07K7/23 , C07K16/26 , C07K19/00 , C07K2319/00 , C12N2710/16722
摘要： The subject invention provides a fusion protein for producing a dual immune response in a vertebrate, which fusion protein comprises: (a) a first proteinaceous portion analogous to all or part of a peptide endogenously synthesized within the vertebrate, the activity of which peptide is to be inhibited within the vertebrate, and which proteinaceous portion by itself is incapable of eliciting an effective immunoinhibitory response in said vertebrate; connected to (b) a second proteinaceous portion analogous to all or part of an immunogen from a pathogen, which pathogen is capable of pathogenically infecting the vertebrate; the portion (b) causing the vertebrate's immune system to recognize the portion (a) and produce a response that: (i) inhibits the activity of the peptide endogenously synthesized within the vertebrate; and (ii) protects the vertebrate from infection by the pathogen, when the vertebrate is vaccinated with an effective amount of the fusion protein. The subject invention also provides fusion proteins which comprise a proteinaceous portion (b) that is a carrier that is analogous to all or part of a BHV-1 antigen, which fusion proteins induce in a vertebrate vaccinated with an effective amount of such fusion protein an immune response that inhibits the activity of a peptide as recited in (a), above.
摘要翻译：本发明提供了用于在脊椎动物中产生双重免疫应答的融合蛋白，所述融合蛋白包含：（a）类似于在脊椎动物内部合成的全部或部分肽的第一蛋白质部分，其肽的活性在脊椎动物内被抑制，哪个蛋白质部分本身不能在所述脊椎动物中引发有效的免疫抑制反应; 与（b）类似于来自病原体的全部或部分免疫原的第二蛋白质部分，该病原体能够病原体感染脊椎动物; 所述部分（b）使脊椎动物的免疫系统识别部分（a）并产生以下响应：（i）抑制在脊椎动物内内生的合成的肽的活性; 和（ii）当脊椎动物接种有效量的融合蛋白时，保护脊椎动物免受病原体的感染。本发明还提供融合蛋白，其包含蛋白质部分（b），其是类似于全部或部分BHV-1抗原的载体，所述融合蛋白在用有效量的这种融合蛋白接种的脊椎动物中诱导，如上文（a）所述抑制肽的活性的免疫应答。

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