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1. 发明公开

EP1221487A2 Polynucleotide molecules encoding neospora proteins 审中-公开
标题翻译：编码新孢子虫蛋白的多核苷酸分子
公开(公告)号：EP1221487A2
公开(公告)日：2002-07-10
申请号：EP02002961.7
申请日：1999-03-09
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Madura (née Coleman), Rebecca Anne , Durtschi, Becky Ann , Krishnan, Balakrishnan Rajendra , Yoder, Susan Christine
IPC分类号： C12N15/30 , C12N15/85 , C12N5/10 , C07K14/44 , C07K16/20 , A61K39/002
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , Y02A50/489
摘要： The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum , as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1 / MAG1 promoter of N. caninum . The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.
摘要翻译：本发明提供了分离的多核苷酸分子，其包含编码来自新孢子虫的GRA1，GRA2，SAG1，MIC1和MAG1蛋白的核苷酸序列，以及重组载体，转化的宿主细胞和重组表达的蛋白。本发明进一步提供了包含犬新孢子虫的双向GRA1 / MAG1启动子的核苷酸序列的多核苷酸分子。本发明进一步提供基于本发明的多核苷酸分子的遗传构建体，其可用于制备新孢子虫细胞的修饰菌株以用于抗新孢子虫病的疫苗。

2. 发明公开

EP0898969A2 Neospora vaccine 无效
标题翻译：新生儿暴发
公开(公告)号：EP0898969A2
公开(公告)日：1999-03-03
申请号：EP98306431.2
申请日：1998-08-12
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Campos, Manuel
IPC分类号： A61K39/002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides an homogenate prepared from cells of Neospora , and vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.
摘要翻译：本发明提供由新孢子虫细胞制备的匀浆，以及由其制备的针对新孢子虫病的疫苗，其可用于预防哺乳动物的临床疾病和流产。

3. 发明公开

EP1221486A3 Polynucleotide molecules encoding neospora proteins 审中-公开
标题翻译：对于Neosporaproteine编码的多聚
公开(公告)号：EP1221486A3
公开(公告)日：2002-10-23
申请号：EP02002960.9
申请日：1999-03-09
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Madura (née Coleman), Rebecca Anne , Durtschi, Becky Ann , Krishnan, Balakrishnan Rajendra , Yoder, Susan Christine
IPC分类号： C12N15/30 , C12N15/85 , C12N5/10 , C07K14/44 , C07K16/20 , A61K39/002
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , Y02A50/489
摘要： The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum, as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1 / MAG1 promoter of N . caninum. The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.

4. 发明公开

EP0953641A3 Polynucleotide molecules encoding neospora proteins 审中-公开
标题翻译：新孢子虫的蛋白质编码的多核苷酸分子
公开(公告)号：EP0953641A3
公开(公告)日：2002-03-13
申请号：EP99301746.6
申请日：1999-03-09
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Madura (née Coleman), Rebecca Anne , Durtschi, Becky Ann , Krishnan, Balakrishnan Rajendra , Yoder, Susan Christine
IPC分类号： C12N15/30 , C07K14/44 , C07K16/20 , C12N5/16 , A61K39/002
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , Y02A50/489
摘要： The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum , as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1/MAG1 promoter of N. caninum. The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.

5. 发明公开

EP1221486A2 Polynucleotide molecules encoding neospora proteins 审中-公开
公开(公告)号：EP1221486A2
公开(公告)日：2002-07-10
申请号：EP02002960.9
申请日：1999-03-09
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Madura (née Coleman), Rebecca Anne , Durtschi, Becky Ann , Krishnan, Balakrishnan Rajendra , Yoder, Susan Christine
IPC分类号： C12N15/30 , C12N15/85 , C12N5/10 , C07K14/44 , C07K16/20 , A61K39/002
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , Y02A50/489
摘要： The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum, as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1 / MAG1 promoter of N . caninum. The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.

6. 发明公开

EP1221485A2 Polynucleotide molecules encoding neospora proteins 审中-公开
标题翻译：新孢子虫蛋白多糖（Polynukleinsäuren）
公开(公告)号：EP1221485A2
公开(公告)日：2002-07-10
申请号：EP02002959.1
申请日：1999-03-09
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Madura (née Coleman), Rebecca Anne , Durtschi, Becky Ann , Krishnan, Balakrishnan Rajendra , Yoder, Susan Christine
IPC分类号： C12N15/30 , C12N15/85 , C12N5/10 , C07K14/44 , C07K16/20 , A61K39/002
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , Y02A50/489
摘要： The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum , as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1 / MAG1 promoter of N. caninum. The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.
摘要翻译：本发明提供了包含编码来自新孢子虫的GRA1，GRA2，SAG1，MIC1和MAG1蛋白的核苷酸序列以及重组载体，转化的宿主细胞和重组表达的蛋白质的分离的多核苷酸分子。本发明还提供了包含N.caninum的双向GRA1 / MAG1启动子的核苷酸序列的多核苷酸分子。本发明还提供了基于本发明的多核苷酸分子的遗传构建体，其可用于制备用于抗新孢子虫病疫苗的新孢子虫细胞的修饰菌株。

7. 发明公开

EP1477184A2 Neospora vaccine 审中-公开
标题翻译：新生儿暴发
公开(公告)号：EP1477184A2
公开(公告)日：2004-11-17
申请号：EP04019906.9
申请日：1998-08-12
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Campos, Manuel
IPC分类号： A61K39/002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides a vaccine to protect a mammal against neosporosis comprising an immunologically effective amount of an homoganate prepared from cells of Neospora which is capable of inducing a protective response against neosporosis in a mammal, and a veterinarily acceptable carrier; wherein the Neospora cells from which the homogenate is prepared have been modified to delete the expression of one or more antigenic components normally associated with Neospora cells or a homogenate prepared therefrom; and antibodies specific to antigenic components present in homoganates of Neospora cells.
摘要翻译：本发明提供一种用于保护哺乳动物免受新孢子虫病的疫苗，其包含免疫有效量的由新生孢子细胞制备的能够在哺乳动物中诱导针对新孢子虫病的保护性反应的同源物和兽医学上可接受的载体; 其中制备匀浆的新孢子虫细胞已被修饰以删除通常与新孢子虫细胞或由其制备的匀浆相关的一种或多种抗原成分的表达; 以及存在于新孢子虫细胞的同源物中的抗原成分的抗体。

8. 发明授权

EP0898969B1 Neospora vaccine 无效
标题翻译：新生儿暴发
公开(公告)号：EP0898969B1
公开(公告)日：2004-09-29
申请号：EP98306431.2
申请日：1998-08-12
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Campos, Manuel
IPC分类号： A61K39/002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides a vaccine to protect a mammal against neosporosis comprising an immunologically effective amount of an homoganate prepared from cells of Neospora which is capable of inducing a protective response against neosporosis in a mammal, and a veterinarily acceptable carrier; wherein the Neospora cells from which the homogenate is prepared have been modified to delete the expression of one or more antigenic components normally associated with Neospora cells or a homogenate prepared therefrom; and antibodies specific to antigenic components present in homoganates of Neospora cells.

9. 发明公开

EP0953641A2 Polynucleotide molecules encoding neospora proteins 审中-公开
标题翻译：新孢子虫蛋白多糖多克隆蛋白酶Moleküle
公开(公告)号：EP0953641A2
公开(公告)日：1999-11-03
申请号：EP99301746.6
申请日：1999-03-09
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Madura (nee Coleman), Rebecca Anne , Durtschi, Becky Ann , Krishnan, Balakrishnan Rajendra , Yoder, Susan Christine
IPC分类号： C12N15/30 , C07K14/44 , C07K16/20 , C12N5/16 , A61K39/002
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , Y02A50/489
摘要： The present invention provides isolated polynucleotide molecules comprising nucleotide sequences encoding GRA1, GRA2, SAG1, MIC1 and MAG1 proteins from Neospora caninum , as well as recombinant vectors, transformed host cells, and recombinantly-expressed proteins. The present invention further provides a polynucleotide molecule comprising the nucleotide sequence of the bidirectional GRA1/MAG1 promoter of N. caninum. The present invention further provides genetic constructs based on the polynucleotide molecules of the present invention that are useful in preparing modified strains of Neospora cells for use in vaccines against neosporosis.
摘要翻译：本发明提供了包含编码来自新孢子虫的GRA1，GRA2，SAG1，MIC1和MAG1蛋白的核苷酸序列以及重组载体，转化的宿主细胞和重组表达的蛋白质的分离的多核苷酸分子。本发明还提供了包含N.caninum的双向GRA1 / MAG1启动子的核苷酸序列的多核苷酸分子。本发明还提供了基于本发明的多核苷酸分子的遗传构建体，其可用于制备用于抗新孢子虫病疫苗的新孢子虫细胞的修饰菌株。

10. 发明公开

EP1477184A3 Neospora vaccine 审中-公开
标题翻译：新孢子虫疫苗
公开(公告)号：EP1477184A3
公开(公告)日：2006-04-12
申请号：EP04019906.9
申请日：1998-08-12
申请人： Pfizer Products Inc.
发明人： Brake, David Alan , Campos, Manuel
IPC分类号： A61K39/002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides a vaccine to protect a mammal against neosporosis comprising an immunologically effective amount of an homoganate prepared from cells of Neospora which is capable of inducing a protective response against neosporosis in a mammal, and a veterinarily acceptable carrier; wherein the Neospora cells from which the homogenate is prepared have been modified to delete the expression of one or more antigenic components normally associated with Neospora cells or a homogenate prepared therefrom; and antibodies specific to antigenic components present in homoganates of Neospora cells.

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